Dylan Powell, Fanny Burrows, Geraint Lewis, Stephen Gilbert
{"title":"How might Hospital at Home enable a greener and healthier future?","authors":"Dylan Powell, Fanny Burrows, Geraint Lewis, Stephen Gilbert","doi":"10.1038/s41746-024-01249-8","DOIUrl":"10.1038/s41746-024-01249-8","url":null,"abstract":"Traditional healthcare delivery models face mounting pressure from rising costs, increasing demand, and a growing environmental footprint. Hospital at Home (HaH) has been proposed as a potential solution, offering care at home through in-person, virtual, or hybrid approaches. Despite focus on expanding HaH provision and capacity, research has primarily explored patient care outcomes, patient satisfaction economic costs with a key gap in its environmental impact. By reducing this evidence gap, HaH may be better placed as a positive enabler in delivering healthier planet and population. This article explores the environmental opportunities and challenges associated with HaH compared to traditional hospital care and reinforces the case for further research to comprehensively quantify the environmental impact including any co-benefits. Our aim for this article is to spark conversation, and begin to help prioritise future research and analysis.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-4"},"PeriodicalIF":12.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01249-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew Quanbeck, Ming-Yuan Chih, Linda Park, Xiang Li, Qiang Xie, Alice Pulvermacher, Samantha Voelker, Rachel Lundwall, Katherine Eby, Bruce Barrett, Randall Brown
{"title":"A randomized trial testing digital medicine support models for mild-to-moderate alcohol use disorder","authors":"Andrew Quanbeck, Ming-Yuan Chih, Linda Park, Xiang Li, Qiang Xie, Alice Pulvermacher, Samantha Voelker, Rachel Lundwall, Katherine Eby, Bruce Barrett, Randall Brown","doi":"10.1038/s41746-024-01241-2","DOIUrl":"10.1038/s41746-024-01241-2","url":null,"abstract":"This paper reports the results of a hybrid effectiveness-implementation randomized trial that systematically varied levels of human oversight required to support the implementation of a digital medicine intervention for persons with mild-to-moderate alcohol use disorder (AUD). Participants were randomly assigned to three groups representing possible digital health support models within a health system: self-monitored use (SM; n = 185), peer-supported use (PS; n = 186), or a clinically integrated model CI; (n = 187). Across all three groups, the percentage of self-reported heavy drinking days dropped from 38.4% at baseline (95% CI [35.8%, 41%]) to 22.5% (19.5%, 25.5%) at 12 months. The clinically integrated group showed significant improvements in mental health and quality of life compared to the self-monitoring group (p = 0.011). However, higher attrition rates in the clinically integrated group warrant consideration in interpreting this result. Results suggest that making a self-guided digital intervention available to patients may be a viable option for health systems looking to promote alcohol risk reduction. This study was prospectively registered at clinicaltrials.gov on 7/03/2019 (NCT04011644).","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":12.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01241-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harvey Jia Wei Koh, Dragan Gašević, David Rankin, Stephane Heritier, Mark Frydenberg, Stella Talic
{"title":"Variational Bayes machine learning for risk adjustment of general outcome indicators with examples in urology","authors":"Harvey Jia Wei Koh, Dragan Gašević, David Rankin, Stephane Heritier, Mark Frydenberg, Stella Talic","doi":"10.1038/s41746-024-01244-z","DOIUrl":"10.1038/s41746-024-01244-z","url":null,"abstract":"Risk adjustment is often necessary for outcome quality indicators (QIs) to provide fair and accurate feedback to healthcare professionals. However, traditional risk adjustment models are generally oversimplified and not equipped to disentangle complex factors influencing outcomes that are out of a healthcare professional’s control. We present VIRGO, a novel variational Bayes model trained on routinely collected, large administrative datasets to risk-adjust outcome QIs. VIRGO uses detailed demographics, diagnosis, and procedure codes to provide individualized risk adjustment and explanations on patient factors affecting outcomes. VIRGO achieves state-of-the-art on external datasets and features capabilities of uncertainty expression, explainable features, and counterfactual analysis capabilities. VIRGO facilitates risk adjustment by explaining how patient factors led to adverse outcomes and expresses the uncertainty of each prediction, allowing healthcare professionals to not only explore patient factors with unexplained variance that are associated with worse outcomes but also reflect on the quality of their clinical practice.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-11"},"PeriodicalIF":12.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01244-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manuela Fritz, Michael Grimm, Ingmar Weber, Elad Yom-Tov, Benedictus Praditya
{"title":"Can social media encourage diabetes self-screenings? A randomized controlled trial with Indonesian Facebook users","authors":"Manuela Fritz, Michael Grimm, Ingmar Weber, Elad Yom-Tov, Benedictus Praditya","doi":"10.1038/s41746-024-01246-x","DOIUrl":"10.1038/s41746-024-01246-x","url":null,"abstract":"Nudging individuals without obvious symptoms of non-communicable diseases (NCDs) to undergo a health screening remains a challenge, especially in middle-income countries, where NCD awareness is low but the incidence is high. We assess whether an awareness campaign implemented on Facebook can encourage individuals in Indonesia to undergo an online diabetes self-screening. We use Facebook’s advertisement function to randomly distribute graphical ads related to the risk and consequences of diabetes. Depending on their risk score, participants receive a recommendation to undergo a professional screening. We were able to reach almost 300,000 individuals in only three weeks. More than 1400 individuals completed the screening, inducing costs of about US$0.75 per person. The two ads labeled “diabetes consequences” and “shock” outperform all other ads. A follow-up survey shows that many high-risk respondents have scheduled a professional screening. A cost-effectiveness analysis suggests that our campaign can diagnose an additional person with diabetes for about US$9.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-13"},"PeriodicalIF":12.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01246-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer M. Radin, Julia Moore Vogel, Felipe Delgado, Erin Coughlin, Matteo Gadaleta, Jay A. Pandit, Steven R. Steinhubl
{"title":"Long-term changes in wearable sensor data in people with and without Long Covid","authors":"Jennifer M. Radin, Julia Moore Vogel, Felipe Delgado, Erin Coughlin, Matteo Gadaleta, Jay A. Pandit, Steven R. Steinhubl","doi":"10.1038/s41746-024-01238-x","DOIUrl":"10.1038/s41746-024-01238-x","url":null,"abstract":"To better understand the impact of Long COVID on an individual, we explored changes in daily wearable data (step count, resting heart rate (RHR), and sleep quantity) for up to one year in individuals relative to their pre-infection baseline among 279 people with and 274 without long COVID. Participants with Long COVID, defined as symptoms lasting for 30 days or longer, following a SARS-CoV-2 infection had significantly different RHR and activity trajectories than those who did not report Long COVID and were also more likely to be women, younger, unvaccinated, and report more acute-phase (first 2 weeks) symptoms than those without Long COVID. Demographic, vaccine, and acute-phase sensor data differences could be used for early identification of individuals most likely to develop Long COVID complications and track objective evidence of the therapeutic efficacy of any interventions. Trial Registration: https://classic.clinicaltrials.gov/ct2/show/NCT04336020 .","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-4"},"PeriodicalIF":12.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01238-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Results and implications for generative AI in a large introductory biomedical and health informatics course","authors":"William Hersh, Kate Fultz Hollis","doi":"10.1038/s41746-024-01251-0","DOIUrl":"10.1038/s41746-024-01251-0","url":null,"abstract":"Generative artificial intelligence (AI) systems have performed well at many biomedical tasks, but few studies have assessed their performance directly compared to students in higher-education courses. We compared student knowledge-assessment scores with prompting of 6 large-language model (LLM) systems as they would be used by typical students in a large online introductory course in biomedical and health informatics that is taken by graduate, continuing education, and medical students. The state-of-the-art LLM systems were prompted to answer multiple-choice questions (MCQs) and final exam questions. We compared the scores for 139 students (30 graduate students, 85 continuing education students, and 24 medical students) to the LLM systems. All of the LLMs scored between the 50th and 75th percentiles of students for MCQ and final exam questions. The performance of LLMs raises questions about student assessment in higher education, especially in courses that are knowledge-based and online.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-7"},"PeriodicalIF":12.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01251-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A randomized controlled trial investigating experiential virtual reality communication on prudent antibiotic use","authors":"Adéla Plechatá, Guido Makransky, Robert Böhm","doi":"10.1038/s41746-024-01240-3","DOIUrl":"10.1038/s41746-024-01240-3","url":null,"abstract":"Antimicrobial resistance (AMR) is a global health threat. This randomized controlled trial evaluates the impact of experiential virtual reality (VR) versus information provision via VR or leaflet on prudent antibiotic use. A total of 249 (239 analyzed) participants were randomized into three conditions: VR Information + Experience, VR Information, or Leaflet Information. All participants received AMR information, while those in the VR Information + Experience condition additionally engaged in a game, making treatment decisions for their virtual avatar’s infection. Participants in the VR Information + Experience condition showed a significant increase in prudent use intentions from baseline (d = 1.48). This increase was significantly larger compared to the VR Information (d = 0.50) and Leaflet Information (d = 0.79) conditions. The increase in intentions from baseline remained significant at follow-up in the VR Information + Experience condition (d = 1.25). Experiential VR communication shows promise for promoting prudent antibiotics use.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-8"},"PeriodicalIF":12.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01240-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jack Gallifant, Danielle S. Bitterman, Leo Anthony Celi, Judy W. Gichoya, Joao Matos, Liam G. McCoy, Robin L. Pierce
{"title":"Ethical debates amidst flawed healthcare artificial intelligence metrics","authors":"Jack Gallifant, Danielle S. Bitterman, Leo Anthony Celi, Judy W. Gichoya, Joao Matos, Liam G. McCoy, Robin L. Pierce","doi":"10.1038/s41746-024-01242-1","DOIUrl":"10.1038/s41746-024-01242-1","url":null,"abstract":"Healthcare AI faces an ethical dilemma between selective and equitable deployment, exacerbated by flawed performance metrics. These metrics inadequately capture real-world complexities and biases, leading to premature assertions of effectiveness. Improved evaluation practices, including continuous monitoring and silent evaluation periods, are crucial. To address these fundamental shortcomings, a paradigm shift in AI assessment is needed, prioritizing actual patient outcomes over conventional benchmarking.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-3"},"PeriodicalIF":12.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01242-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James Truslow, Angela Spillane, Huiming Lin, Katherine Cyr, Adeeti Ullal, Edith Arnold, Ron Huang, Laura Rhodes, Jennifer Block, Jamie Stark, James Kretlow, Alexis L. Beatty, Andreas Werdich, Deepali Bankar, Matt Bianchi, Ian Shapiro, Jaime Villalpando, Sharon Ravindran, Irida Mance, Adam Phillips, John Earl, Rahul C. Deo, Sumbul A. Desai, Calum A. MacRae
{"title":"Understanding activity and physiology at scale: The Apple Heart & Movement Study","authors":"James Truslow, Angela Spillane, Huiming Lin, Katherine Cyr, Adeeti Ullal, Edith Arnold, Ron Huang, Laura Rhodes, Jennifer Block, Jamie Stark, James Kretlow, Alexis L. Beatty, Andreas Werdich, Deepali Bankar, Matt Bianchi, Ian Shapiro, Jaime Villalpando, Sharon Ravindran, Irida Mance, Adam Phillips, John Earl, Rahul C. Deo, Sumbul A. Desai, Calum A. MacRae","doi":"10.1038/s41746-024-01187-5","DOIUrl":"10.1038/s41746-024-01187-5","url":null,"abstract":"Physical activity or structured exercise is beneficial in a wide range of circumstances. Nevertheless, individual-level data on differential responses to various types of activity are not yet sufficient in scale, duration or level of annotation to understand the mechanisms of discrete outcomes nor to support personalized recommendations. The Apple Heart & Movement Study was designed to passively collect the dense physiologic data accessible on Apple Watch and iPhone from a large real-world cohort distributed across the US in order to address these knowledge gaps.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-11"},"PeriodicalIF":12.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01187-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin Rader, Neil K. R. Sehgal, Julie Michelman, Stefan Mellem, Marinanicole D. Schultheiss, Tom Hoddes, Jamie MacFarlane, Geoff Clark, Shawn O’Banion, Paul Eastham, Gaurav Tuli, James A. Taylor, John S. Brownstein
{"title":"Adherence to non-pharmaceutical interventions following COVID-19 vaccination: a federated cohort study","authors":"Benjamin Rader, Neil K. R. Sehgal, Julie Michelman, Stefan Mellem, Marinanicole D. Schultheiss, Tom Hoddes, Jamie MacFarlane, Geoff Clark, Shawn O’Banion, Paul Eastham, Gaurav Tuli, James A. Taylor, John S. Brownstein","doi":"10.1038/s41746-024-01223-4","DOIUrl":"10.1038/s41746-024-01223-4","url":null,"abstract":"In pandemic mitigation, strategies such as social distancing and mask-wearing are vital to prevent disease resurgence. Yet, monitoring adherence is challenging, as individuals might be reluctant to share behavioral data with public health authorities. To address this challenge and demonstrate a framework for conducting observational research with sensitive data in a privacy-conscious manner, we employ a privacy-centric epidemiological study design: the federated cohort. This approach leverages recent computational advances to allow for distributed participants to contribute to a prospective, observational research study while maintaining full control of their data. We apply this strategy here to explore pandemic intervention adherence patterns. Participants (n = 3808) were enrolled in our federated cohort via the “Google Health Studies” mobile application. Participants completed weekly surveys and contributed empirically measured mobility data from their Android devices between November 2020 to August 2021. Using federated analytics, differential privacy, and secure aggregation, we analyzed data in five 6-week periods, encompassing the pre- and post-vaccination phases. Our results showed that participants largely utilized non-pharmaceutical intervention strategies until they were fully vaccinated against COVID-19, except for individuals without plans to become vaccinated. Furthermore, this project offers a blueprint for conducting a federated cohort study and engaging in privacy-preserving research during a public health emergency.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-7"},"PeriodicalIF":12.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01223-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}