NFS Journal最新文献

{"title":"Isolation and identification of a bioactive compound from Japanese red pine (Pinus densiflora) tea and its antioxidative effects on vascular endothelial cells","authors":"WenQian Jiang ,&nbsp;Yuka Hattori ,&nbsp;WonJune Lee ,&nbsp;YiQian Zhang ,&nbsp;KaiNing Zhang ,&nbsp;Shojiro Hishiyama ,&nbsp;Tomoko Shimokawa ,&nbsp;Hitoshi Miyazaki ,&nbsp;Shigeki Yoshida","doi":"10.1016/j.nfs.2023.100153","DOIUrl":"https://doi.org/10.1016/j.nfs.2023.100153","url":null,"abstract":"<div><p>The bioactive compound, which showed a potent nitric oxide production stimulation effect, was isolated from Japanese red pine tea and identified as (+)-catechin. Compared with (−)-epigallocatechin 3-<em>O</em>-gallate and (−)-catechin, (+)-catechin exhibited greater NO production promotion and protection from H₂O₂-induced oxidative stress in vascular endothelial cells. The (+)-catechin content of Japanese red pine tea was found to be higher than that of buckwheat or green tea, both of which are known to contain (+)-catechin. This study indicated that (+)-catechin could be used as a potential functional ingredient for endothelium function protection and provides a basis for the use of red pine tea in endothelium dysfunction prevention in the future.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"33 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50176671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical composition, anti-amylase and anti-acetylcholinesterase activities of leaf extracts and herbal tea of Dolichandrone serrulata (DC.) seem","authors":"Sirikul Thummajitsakul ,&nbsp;Kullanat Nattee ,&nbsp;Pornapa Nathunli ,&nbsp;Chompoonick Promprieng ,&nbsp;Rujisaya Anekwasinchai ,&nbsp;Kun Silprasit","doi":"10.1016/j.nfs.2023.100152","DOIUrl":"https://doi.org/10.1016/j.nfs.2023.100152","url":null,"abstract":"<div><p>The number of elderly population is continually growing in Thailand. Major health problems mostly occurred in the elder are non-communicable diseases namely Alzheimer's disease and type 2 diabetes mellitus. In current study, phytochemical composition, anti-amylase and anti-acetylcholinesterase activities of leaf extracts and herbal tea from <em>Dolichandrone serrulata</em> (DC.) Seem were determined. The result showed that extracts and herbal tea samples of <em>D. serrulata</em> leaves had effective in inhibition of amylase (an effective concentration at half maximum (EC₅₀) = 1.21 to 23.80 mg/ml) and acetylcholinesterase activities (EC₅₀ = 2.63 to 49.55 mg/ml). The effect of infusion time on the inhibition of amylase indicated that the best infusion time for preparing herbal tea beverage was 3 min, while the inhibition of acetylcholinesterase was 5 min. The fourier transform infrared spectroscopy (FTIR) and gas chromatograph - mass spectrometer (GC–MS) data indicated the presence of phytochemicals in the extracts and herbal tea samples related to phenolic compounds and flavonoids. The principal component analysis (PCA) result from FTIR data could discriminate herbal tea samples from the ethanol and aqueous extracts better than the PCA biplot of anti-amylase activity and anti-acetylcholinesterase activity.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"33 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50176668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micronutrients and the evolution of the human brain","authors":"Hans K. Biesalski","doi":"10.1016/j.nfs.2023.100150","DOIUrl":"https://doi.org/10.1016/j.nfs.2023.100150","url":null,"abstract":"<div><p>Several theories describe the increasing enlargement of the human brain because of environmental changes or dietary alterations. The environmental changes led to a change in diet quality (micronutrient density) because of changes in food foraging, which ensured that a growing brain was adequately supplied with energy and essential micronutrients for growth. The hippocampus is a direct link between nutrition and the environment, which is necessary for adapting to a changing climate. The adaptation then improves foraging success and enables better food quality and thus favors the development of the hippocampus, which in turn influences the development of other brain regions.</p><p>The extraordinary ability of our ancestors for persistent running not only favored hunting but also had direct effects on hormones that support brain development. The connection between physical exercise, nutrition, and plasticity of the hippocampus and the resulting adaptation to changing environmental conditions is essential for triggering or stimulating brain development. As the <em>variability selection hypothesis</em> proposes, fluctuations in environmental conditions need a short adaptive answer, which may become genetically fixed and selected. The presented hypothesis allows a meaningful combination of the different theories of brain development (pulse climate, variability selection, amplifier lakes) and nutrition theories (aquatic, cooking, energy).</p><p>The assumption that the hippocampus, as a “central sensory organ”, detects new events and enables an adaptive response is not an isolated assumption for the hippocampus since other brain regions can also react similarly with synaptic plasticity. Through adult hippocampal neurogenesis (AHN), which is unique only in the hippocampus and synaptic plasticity, there is the possibility of detection and (neurological) storage of previously unknown events and linking them to other cortical areas, which may increase cortical volume.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"33 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50176670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected lactobacilli isolated from Thai foods for production of fermented dairy products with cholesterol lowering potential","authors":"Pornchanok Paongphan ,&nbsp;Srivikorn Ditudompo ,&nbsp;Porntipha Vitheejongjaroen ,&nbsp;Ulisa Pachekrepapol ,&nbsp;Malai Taweechotipatr","doi":"10.1016/j.nfs.2023.100151","DOIUrl":"https://doi.org/10.1016/j.nfs.2023.100151","url":null,"abstract":"<div><p>One of the benefits of probiotics is reduction of cholesterol by bile salt hydrolase (BSH) enzyme. This study aims to investigate the BSH activity of probiotics derived from fermented foods and to investigate the potential use of selected isolates in fermented dairy products. In this study, 55 isolates of lactic acid bacteria (LAB) were evaluated for their potential BSH activity. Three isolates identified as <em>Lactiplantibacillus paraplantarum</em> MN, <em>Lactiplantibacillus plantarum</em> MN2 and <em>Lactobacillus gasseri</em> SM were selected for their strong BSH activity. All three strains exhibited resistance to pH 3.0 and 4.0 with the number of survival cells around 7.8 and 8.1 log CFU/ml, respectively. They also survived in bile concentration of 0.3% and 0.8% and possessed moderate hydrophobicity. The selected strains and the mixed of three strains at ratio 1:1:1 were used in the production of fermented milk products. All strains and the mixture of three could maintain BSH activity in fermented milk products and survived throughout the storage duration of 28 days. With the properties of good probiotics, these strains could be potentially used in functional dairy products with cholesterol reduction property.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"33 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50176669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mung bean seed coat water extract restores insulin sensitivity via upregulation of antioxidant defense system and downregulation of inflammation in insulin-resistant HepG2 cells","authors":"Vipawanee Pavasutti ,&nbsp;Chomdao Sinthuvanich ,&nbsp;Ngampuk Tayana ,&nbsp;Sumet Kongkiatpaiboon ,&nbsp;Sudathip Sae-tan","doi":"10.1016/j.nfs.2023.100145","DOIUrl":"10.1016/j.nfs.2023.100145","url":null,"abstract":"<div><p>Insulin resistance is the main cause of type 2 diabetes. Mung bean possesses many health benefits mainly related to polyphenols, which is abundant in mung bean seed coat. Total phenolic content in mung bean seed coat water extract (MSWE) was 0.62 ± 0.00 mg gallic acid equivalents (GAE)/g extract with antioxidant activity (IC₅₀ = 0.16 ± 0.01 mg/mL). Vitexin and isovitexin were the major flavonoids in MSWE. MSWE increased cellular glucose uptake and reduced intracellular reactive oxygen species (ROS) in insulin-resistant HepG2 cells. MSWE upregulated IRS-1, FGFR1, PI3K, and AKT expression, while downregulated FOXO1, PEPCK, and GSK3. MSWE modulated the expression of antioxidant genes including NRF2, KEAP1, HO-1, and NQO1. MSWE also downregulated genes related to inflammation (IL-6, IL-1β, TNF-α, PTP<img>1B, and p53). In conclusion, MSWE restored insulin sensitivity possibly through the reduction of ROS-associated inflammation by regulating GSK3/NRF2/KEAP1, downregulating PTP-1B and p53, as well as upregulating IRS-1/FGFR1/PI3K/AKT in insulin-resistant HepG2 cells.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"32 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43520150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation of drinkable yogurt (Laban) from Camel milk with fruit purees improves its quality and sensory properties","authors":"Bhawna Sobti,&nbsp;Rayyan Mohamed Saeed Alhefeiti,&nbsp;Fatima Alsayedahmed Alahdali,&nbsp;Maitha Ali Mohammed Al Samri,&nbsp;Afaf Kamal-Eldin","doi":"10.1016/j.nfs.2023.100143","DOIUrl":"10.1016/j.nfs.2023.100143","url":null,"abstract":"<div><h3>Background</h3><p>Camel milk (CM) and its fermentation products have acclaimed nutritional and health benefits, although they are often associated with low marketability because of a unique flavor, which is unpleasant to certain consumers. Incorporating fruit purees is an attractive method of adding a pleasant taste and masking the undesirable flavor in such dairy products.</p></div><div><h3>Methods</h3><p>We investigated the effects of supplementing plain fermented CM laban with pectin (0.2%) and a fruit puree (apricot, blueberry, mango, peach, pineapple, or strawberry) of varying concentrations (0%, 5%, 15%, and 25%) on the products' physicochemical, rheological, antioxidant, and sensory properties. The labans were analyzed for dry matter content, color (L*, a*, b*), pH, titratable acidity, and rheology. Total phenolic content and antioxidant property were determined using Folin–Ciocalteu and ABTS methods and sensory profile was studied using quantitative descriptive analysis.</p></div><div><h3>Results and discussion</h3><p>The labans fortified with 15% and 25% purees had higher dry matter content than the control samples. Addition of fruit purees darkened the color of the laban samples and lowered the L* value but did not affect their titratable acidity, except for the apricot puree. Labans containing blueberry, pineapple, and strawberry purees had higher whey-off than those containing peach, apricot, mango, or the control samples. The storage and loss moduli, and viscosity values of laban samples supplemented with peach or pineapple puree (at 15% and 25%, and at 25%, respectively) were increased compared to the other samples. The power law model sufficiently explained the flow of all labans, indicating a shear-thinning behavior. The addition of purees increased the total phenolic content and antioxidant activities of all labans, while peach puree in particular, improved the sensory quality of the CM laban, owing to its high fiber and protein content and low total soluble solids.</p></div><div><h3>Conclusion</h3><p>A 25% peach puree significantly improved all sensory properties of CM labans.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"32 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44442355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compositional analysis of phytochemicals and polysaccharides from Senegalese plant ingredients: Adansonia digitata (baobab), Moringa oleifera (moringa) and Hibsicus sabdariffa (hibiscus)","authors":"Hawi Debelo ,&nbsp;Chelsey Fiecke ,&nbsp;Anton Terekhov ,&nbsp;Bradley Reuhs ,&nbsp;Bruce Hamaker ,&nbsp;Mario G. Ferruzzi","doi":"10.1016/j.nfs.2023.100144","DOIUrl":"10.1016/j.nfs.2023.100144","url":null,"abstract":"<div><p>Certain indigenous African plant materials, including <em>Adansonia digitata</em> (baobab), <em>Moringa oleifera</em> (moringa), and <em>Hibiscus sabdariffa</em> (hibiscus) could be leveraged in food-to-food fortification strategies due to their high content of nutrients, dietary fiber, and phenolic compounds. However, more studies are needed to understand the nutritional composition of commercially available food ingredients. The objective of this study was to examine the phytochemical and polysaccharide compositions of commercially available baobab, moringa, and hibiscus ingredients from Senegal. Characterization of carotenoids, tocopherols, phenolic compounds, monosaccharide composition, and glycosyl linkage was carried out. We observed that moringa contained the greatest content of carotenoids and tocopherols. Moringa also contained significant amounts of the flavonols quercetin 3-<em>O</em>-glucoside and quercetin 3-<em>O</em>-rutinoside, while baobab had greater concentrations of flavan-3-ols. Substantial content of anthocyanins was observed for hibiscus, but not moringa or baobab. The predominant monosaccharide in baobab was xylose, while hibiscus was a combination of xylose, galactose, and glucose. The primary monosaccharides in moringa were galactose and glucose. Based on our glycosyl linkage analysis, (1 → 2)- and (1 → 2,4)-linked rhamnose were attributed to rhamnogalacturonan-I, while (1 → 4)-linked glucose and (Terminal →)-linked xylose were attributed to xyloglucans. The phytochemical and polysaccharide characterization of baobab, moringa, and hibiscus suggested that delivery of micronutrients, such as iron and carotenoids, could be impacted when applied as functional food ingredients.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"32 ","pages":"Article 100144"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44813467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aronia juice improves working memory and suppresses δ-secretase activity in 5XFAD mice","authors":"Takuya Yamane ,&nbsp;Momoko Imai ,&nbsp;Satoshi Handa ,&nbsp;Hideo Ihara ,&nbsp;Tatsuji Sakamoto ,&nbsp;Tetsuo Ishida ,&nbsp;Takenori Nakagaki ,&nbsp;Susumu Uchiyama","doi":"10.1016/j.nfs.2023.100146","DOIUrl":"10.1016/j.nfs.2023.100146","url":null,"abstract":"<div><p>Asparagine endopeptidase (AEP) cleaves amyloid precursor protein to facilitate amyloid β (Aβ) production in the brain. Aronia berry (<em>Aronia melanocarpa</em>) has various beneficial effects on health through inhibition of enzymes such as dipeptidyl peptidase IV. In this study, to examine neuroprotective effects of aronia juice (AJ), AJ was given to male 5XFAD Alzheimer's disease model mice via drinking bottles over a period from 2 weeks to 12 weeks of age. AJ intake improved the performance of Y-maze test in 5XFAD mice, and suppressed the δ-secretase activity in the mouse brains. AJ intake reduced significantly Aβ deposition in the brain. AJ reduced δ-secretase activity in human neuroblastoma SH-SY5Y cells. Out of five fractions (F1–F5) obtained from AJ, only F5 reduced δ-secretase activity in SH-SY5Y cells in a dose-dependent manner. LC-MS/MS analysis suggested that F5 contains three quercetin glycosides. AJ has neuroprotective function through inhibition of δ-secretase activity of AEP.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"32 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47680280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine-active and endocrine-disrupting compounds in food – occurrence, formation and relevance","authors":"Constanze Stiefel ,&nbsp;Florian Stintzing","doi":"10.1016/j.nfs.2023.03.004","DOIUrl":"10.1016/j.nfs.2023.03.004","url":null,"abstract":"<div><p>Over the last decades, global concerns regarding possible adverse health effects of chemical pollutants on the hormonal systems of living organisms in wildlife and humans are constantly growing. Endocrine-active and endocrine-disrupting chemicals (EDC) belong to a heterogeneous class of exogenous chemicals, including various persistent anthropogenic contaminants, pesticides, distinct substances used in consumer products, and also natural compounds. Exposure through the food chain is considered essential for most EDC, while they may enter the food chain as residues from animal- or plant-based food production (e.g. pesticides or pharmaceutical residues), may be released from food contact materials, may be present due to natural contamination (e.g. mycoestrogens), may enter via a polluted environment and also as natural plant food ingredients (e.g. phytoestrogens). The complexity of the subject is due to: a) the ubiquitous occurrence and hardly possible avoidance of many substances with supposed endocrine properties, b) the scientific disagreement among experts and the huge number of partly controversial study outcomes and c) the increasing pressure of the public, necessitating a higher level of transparency and clear-cut orientation with respect to avoidance and reduction strategies.</p><p>In this light, the current review intends to provide an overview of the historical and regulatory developments regarding the topic of EDC, discusses the important difference between endocrine-active and disruptive substances and presents some key characteristics of endocrine acting substances for a better understanding of their relevance for the food chain including possible long-term effects, windows of sensitivity, low-dose and possible “cocktail” effects. In addition, a comprehensive overview on the different exposure paths of endocrine-active and disruptive substances in the food chain is given, with both a focus on naturally occurring food ingredients and possible contaminations from external sources.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"31 ","pages":"Pages 57-92"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42008795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fermenting with Lacticaseibacillus rhamnosus GG on quality attributes and storage stability of buffalo milk yogurt incorporated with bael (Aegle marmelos) fruit pulp","authors":"Dinusha Yapa ,&nbsp;D.M.D. Rasika ,&nbsp;W.A.D.V. Weerathilake ,&nbsp;Jithmi Siriwardhana ,&nbsp;Hasitha Priyashantha","doi":"10.1016/j.nfs.2023.04.002","DOIUrl":"10.1016/j.nfs.2023.04.002","url":null,"abstract":"<div><h3>Background</h3><p>Producing functional food by adding fruits or fruit pulps have attracted great attention. Simultaneously, buffalo milk is gaining an increasing demand as an alternative to cow milk. Thus, value addition and diversification of buffalo milk products have gained much commercial and research interest. Hence, we aimed to investigate the potentials of developing and characterizing probiotic enriched buffalo milk yogurts with bael fruit pulp using exopolysaccharides producing probiotic <em>Lacticaseibacillus rhamnosus</em> GG (LGG).</p></div><div><h3>Methods</h3><p>Four types of buffalo milk yogurts were tested, e.g. fermenting with the yogurt starter culture only (e.g., control) and fermenting with the combination of yogurt starter culture and LGG with varying levels (<em>w</em>/<em>v</em>) of bael fruit pulp incorporations, i.e., 0%, 5% and 10%. Variation in pH, syneresis, hardness, probiotic viability and sensory attributes during 21 days of storage in 4 °C were assessed for all treatments.</p></div><div><h3>Results</h3><p>Fermenting with LGG had a positive effect on post-acidification and syneresis rate compared to the control yogurt. Bael incorporation did not affect the post-acidification, but significantly decreased the level of syneresis at the end of storage. All probiotic formulations maintained LGG counts of &gt;10⁷ CFU/mL and the highest counts were observed in 5% (<em>w</em>/<em>v</em>) bael incorporated yogurt.</p></div><div><h3>Conclusions</h3><p>Results confirmed the possibility of using buffalo milk yogurt as an ideal matrix to deliver LGG with promising probiotic capacity. The use of 5% bael incorporation provides an optimal combination for synbiotic product development.</p></div>","PeriodicalId":19294,"journal":{"name":"NFS Journal","volume":"31 ","pages":"Pages 102-109"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48337307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}