Neurosciences最新文献_第2页

WHO PREQUALIFIES DIAGNOSTIC TEST TO SUPPORT SAFER ADMINISTRATION OF P. VIVAX MALARIA TREATMENTS.

IF 1.2 4区医学

Neurosciences Pub Date : 2025-04-01

引用次数: 0

MILESTONE: COVID-19 FIVE YEARS AGO.

IF 1.2 4区医学

Neurosciences Pub Date : 2025-04-01

引用次数: 0

STUDY REVEALS LINKS BETWEEN MANY PESTICIDES AND PROSTATE CANCER.

IF 1.2 4区医学

Neurosciences Pub Date : 2025-04-01

引用次数: 0

Do people with multiple sclerosis in Saudi Arabia want to know their prognosis? A cross-sectional nationwide study.

IF 1.2 4区医学

Neurosciences Pub Date : 2025-04-01 DOI: 10.17712/nsj.2025.2.20240094

Yaser M Al Malik, Awad S Alharbi, Mohammed A Alfurayh, Abdulaziz A Aldalaan, Abdulazeez M Alzailaie, Eid D Alanazi, Ahmad A Abulaban, Seraj O Makkawi, Asma A Alanazi

{"title":"Do people with multiple sclerosis in Saudi Arabia want to know their prognosis? A cross-sectional nationwide study.","authors":"Yaser M Al Malik, Awad S Alharbi, Mohammed A Alfurayh, Abdulaziz A Aldalaan, Abdulazeez M Alzailaie, Eid D Alanazi, Ahmad A Abulaban, Seraj O Makkawi, Asma A Alanazi","doi":"10.17712/nsj.2025.2.20240094","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20240094","url":null,"abstract":"Objectives: To investigate whether Persons with MS (pwMS) in Saudi Arabia want to discuss their long-term prognosis (LTP) and the factors influencing this decision using a self-administered online questionnaire.Methods: In this cross-sectional study, an online questionnaire was distributed from December 2022 to July 2023 across Saudi Arabia to determine pwMS interest in discussing their LTP. Participants included patients over 18 years, of any gender, diagnosed with MS. A nonprobability convenience sampling technique was used, with questionnaires sent through MS organizations and channels.Results: Almost two-thirds (66-68%) of the 375 respondents reported that their LTP had never been discussed during neurologist appointments and expressed uncertainty about it. Additionally, 23.5% noted discrepancies in information provided by different neurologists. Most (81.6%) expressed a desire for a prognostic tool at diagnosis. In this study, MS patients' desire to learn about a tool for assessing long-term prognosis was significantly associated with age, education level (p<0.001), and gender (p=0.02). A higher percentage of women (65.7%) showed interest in learning about the tool compared to men (34.3%).Conclusion: While more than half of pwMS are curious about their prognosis, only about one-third have optimal discussions about LTP with neurologists. Many desire information on prognostic tools. Further research is needed to assess patients' knowledge of their prognosis and improve communication with physicians.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"108-116"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motherhood and pregnancy concerns of Saudi females with multiple sclerosis in Riyadh city: A quantitative analysis.

IF 1.2 4区医学

Neurosciences Pub Date : 2025-04-01 DOI: 10.17712/nsj.2025.2.20230122

Abdullah S Alshehri, May H AlQahtani, Hana A AlZuabi, Waad S Alshahrani, Halah O Alamawi, Aseel A Almandeel, Faisal A Al-Suwaidan, Ahmed Saleh

{"title":"Motherhood and pregnancy concerns of Saudi females with multiple sclerosis in Riyadh city: A quantitative analysis.","authors":"Abdullah S Alshehri, May H AlQahtani, Hana A AlZuabi, Waad S Alshahrani, Halah O Alamawi, Aseel A Almandeel, Faisal A Al-Suwaidan, Ahmed Saleh","doi":"10.17712/nsj.2025.2.20230122","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20230122","url":null,"abstract":"Objectives: To explore the concerns among females in Riyadh city with multiple sclerosis (MS) regarding motherhood and pregnancy outcomes.Methods: In this cross-sectional study, data were collected using an online questionnaire. Women who were aged 18-50 years and diagnosed with MS by a neurologist and had a disease duration of at least one year were included. The questionnaire consisted of 7 sections designed to collect information on the respondents' sociodemographic characteristics; past and current medical history; pre-pregnancy, pregnancy, and postpartum concerns; physical and psychological concerns about parenthood; and psychological and social support.Results: A total of 176 women were included in the final analysis. Fatigue was the most common MS symptom, reported by 85.2% of the respondents, and 58% of the respondents had concerns about their disease and medication having adverse effects on their pregnancy and fetal outcomes. We found a statistically significant association between the level of perceived social support and patient care during pregnancy and concerns that they would not be able to prepare food for their children (p=0.037, respectively).Conclusion: We have identified several significant concerns of Saudi women with MS related to various aspects of pregnancy, delivery, and fetal outcomes. These concerns may be linked to a lack of adequate knowledge on the subject. Thus, receiving appropriate counseling, information, and support could greatly benefit these women and result in a more positive and comfortable pregnancy and delivery experience.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"150-156"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ranking the difficulty of the cognitive tasks in Dual-Tasks during walking in healthy adults.

IF 1.2 4区医学

Neurosciences Pub Date : 2025-04-01 DOI: 10.17712/nsj.2025.2.20240106

Jaser S Almutairi, Shady A Alshewier, Abdulaziz A Alkathiry

{"title":"Ranking the difficulty of the cognitive tasks in Dual-Tasks during walking in healthy adults.","authors":"Jaser S Almutairi, Shady A Alshewier, Abdulaziz A Alkathiry","doi":"10.17712/nsj.2025.2.20240106","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20240106","url":null,"abstract":"Objectives: To rank the cognitive tasks commonly used in clinical practices based on their difficulties in healthy adults while walking. Dual tasks have been widely used in clinical settings for different purposes such as detecting early cognitive impairments and identifying fall risk factors among the population of neurological diseases.Methods: This cross-sectional study, conducted from January to March 2021, included a sample of 26 healthy adults who were asked to demonstrate six different cognitive tasks at random while performing a gait speed test. An accelerometer positioned on the lower back at the umbilical level was used to measure participants' sway. After each task, participants rated the task's difficulty using the perceived difficulty scale.Results: (1) The cognitive tasks showed no significant effect on sway (p> 0.05). (2) A statistically significant effect was observed for the cognitive tasks on perceived difficulty scale rating. (3) Statistically significant correlations were found between the perceived difficulty scale and the acceleration measures.Conclusion: This study was able to rank the cognitive tasks based on the participants' perceived difficulty scale. Furthermore, significant correlations were identified between the perceived difficulty and the sway measurements.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"124-130"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thunderclap headache management among Emergency Department visitors in tertiary care center in Makkah City: Retrospective cohort study.

IF 1.2 4区医学

Neurosciences Pub Date : 2025-04-01 DOI: 10.17712/nsj.2025.2.20240098

Fadi S Althobaiti, Saud Y Alsharif, Muhannad A Alhazmi, Abdullah H BinMelieh, Abdulaziz A Almqaiti, Ziyad K Alsaedi, Amal M Alkhotani, Bassam G Sef

{"title":"Thunderclap headache management among Emergency Department visitors in tertiary care center in Makkah City: Retrospective cohort study.","authors":"Fadi S Althobaiti, Saud Y Alsharif, Muhannad A Alhazmi, Abdullah H BinMelieh, Abdulaziz A Almqaiti, Ziyad K Alsaedi, Amal M Alkhotani, Bassam G Sef","doi":"10.17712/nsj.2025.2.20240098","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20240098","url":null,"abstract":"Objectives: To evaluate adherence to the guidelines in managing thunderclap headache (TCH) at King Abdullah Medical City Specialist Hospital (KAMC) in Makkah. A thunderclap headache, a severe and sudden onset headache, often signals a subarachnoid hemorrhage (SAH). The International Classification of Headache Disorders, 3rd edition (ICHD-3), recommends a diagnostic approach for TCH, including computed tomography (CT), lumbar puncture (LP), vascular studies, and magnetic resonance imagining (MRI).Methods: This retrospective cohort study included adult patients presenting with TCH, as defined by ICHD-3, from December 2018 to June 2023. Non-probability convenience sampling was used to select patients.Results: Of 377 initial records, 173 patients met the inclusion criteria. The mean age was 52.6 years, with males comprising 57.2%. Hypertension (39.9%) and diabetes mellitus (20.2%) were common comorbidities. Key clinical features included nausea/vomiting (41.0%) and loss of consciousness (27.7%). Compliance with ICHD-3 guidelines was 96.5%, with 99.3% undergoing CT within 6 hours. Most patients (91.3%) were diagnosed with hemorrhagic conditions, primarily SAH (85.5%), with a recovery rate of 89.2%. However, 8.1% of patients died, primarily due to complications like rebleeding and infection.Conclusion: High adherence to ICHD-3 guidelines in TCH management led to favorable outcomes, demonstrating the effectiveness of systematic evaluation. The study highlights the importance of timely intervention and suggests that demographic factors may not significantly influence TCH outcomes. Further research should explore guideline adherence in varied settings.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"131-137"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DOES WORK-RELATED STRESS COMPROMISE CARDIOVASCULAR HEALTH? 工作压力会损害心血管健康吗？

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01

引用次数: 0

Marchiafava-Bignami disease post-bariatric surgery: A case report and review of similar cases. 减肥手术后Marchiafava-Bignami病1例报告及类似病例回顾

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240036

Sohaila A Alshimemeri, Abdulaziz M Alshoumar, Abdullah Y Alfaifi, Abdulaziz I Almohanna

{"title":"Marchiafava-Bignami disease post-bariatric surgery: A case report and review of similar cases.","authors":"Sohaila A Alshimemeri, Abdulaziz M Alshoumar, Abdullah Y Alfaifi, Abdulaziz I Almohanna","doi":"10.17712/nsj.2025.1.20240036","DOIUrl":"10.17712/nsj.2025.1.20240036","url":null,"abstract":"Marchiafava-Bignami disease (MBD) is a rare neurological disorder typically occurring in alcoholic patients. The main disease mechanism is hypothesized to be vitamin B-complex deficiency due to malnutrition. In the literature, there have been few reported cases of the disease occurring in patients who have undergone bariatric surgery. This paper presents a case study of a 45-year-old non-alcoholic female who underwent a laparoscopic sleeve gastrectomy presenting with progressive worsening weakness of her lower limbs and slurred speech. Her condition continued to deteriorate, and she became mute and bedbound. The MRI revealed distinctive characteristics consistent with MBD. The diagnosis was confirmed following the exclusion of all other possible diagnoses. She was treated with multivitamins and had a significant improvement. Additionally, we conduct a review of similar cases of this condition occurring after bariatric surgery. This report sheds light on the occurrence of this uncommon condition after the bariatric procedures.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"64-69"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of key lncRNA related to Parkinson's disease based on gene co-expression weight networks. 基于基因共表达权重网络的帕金森病相关关键lncRNA分析

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20230112

Wenwen Liang, Wei Zhao, Binghan Li, Jiaying Luo, Xuemei Li, Weihua Jia

{"title":"Analysis of key lncRNA related to Parkinson's disease based on gene co-expression weight networks.","authors":"Wenwen Liang, Wei Zhao, Binghan Li, Jiaying Luo, Xuemei Li, Weihua Jia","doi":"10.17712/nsj.2025.1.20230112","DOIUrl":"10.17712/nsj.2025.1.20230112","url":null,"abstract":"Objectives: To identify a key Long chain non-coding RNAs (lncRNAs) related to PD and provide a new perspective on the role of LncRNAs in Parkinson's disease (PD) pathophysiology.Methods: Our study involved analyzing gene chips from the substantia nigra and white blood cells, both normal and PD-inclusive, in the Gene Expression Omnibus (GEO) database, utilizing a weighted gene co-expression network analysis (WGCNA). The technique of WGCNA facilitated the examination of differentially expressed genes (DEGs) in the substantia nigra and the white blood cells of individuals with PD. When merged with clinical data, gene modules containing crucial clinical details were chosen for network integration in GO and KEGG enrichment analysis.Results: A pair of LncRNA modules were identified. The crucial component in GSE7621 was the turquoise module. The DEGs were acquired using GSE133347. GO functions focused on phosphatidylinositol phosphate binding, inflammatory responses, and the regulation of nerves and synapses. KEGG analyses were largely enriched within the P13K-Akt, FaxO, mTOR, Oxytocin, and cGMP-PKG signaling pathways. A Venn diagram revealed that the two key LncRNA were CH17-189H20.1 and RP11-168O16.1.Conclusion: Using the WGCNA method, we obtained PD-related modules, identified biologically significant gene modules, obtained core LncRNAs, and found potential target genes for enrichment analysis. The objective of our research was to advance more detailed and efficient treatment methods for lncRNAs associated with PD.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"20-29"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0