Neurosciences最新文献

{"title":"Obituary for Major General Dr. Ketab Alotaibi (1943- 2024).","authors":"Fahdah Alokaily, Ali M Albarrak","doi":"10.17712/nsj.2025.2.2.20241751","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.2.20241751","url":null,"abstract":"","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"164"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking the mimic: Leprosy neuropathy misdiagnosed as chronic inflammatory demyelinating polyneuropathy: A case report from Saudi Arabia.","authors":"Muteb K AlOtaibi, Bashaier G AlQahtani, Raniah M AlQawahmed","doi":"10.17712/nsj.2025.2.20240057","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20240057","url":null,"abstract":"<p><p>Leprosy neuropathy can mimic chronic inflammatory demyelinating polyneuropathy (CIDP), especially in non-endemic areas. We report a 72-year-old Saudi woman initially misdiagnosed with CIDP based on nerve conduction studies. The patient presented with widespread pruritus, erythematous cutaneous lesions, and progressive sensorimotor symptoms. Despite treatment with intravenous immunoglobulin, her condition worsened. Subsequent sural nerve and skin biopsies revealed acid-fast bacilli, confirming leprosy. This case highlights the importance of considering leprosy in the differential diagnosis of neuropathies, even in regions where it is rare. Nerve ultrasound, a valuable diagnostic tool in differentiating leprosy from CIDP, should be incorporated into the diagnostic workup of atypical neuropathies.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"157-161"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring physiotherapist's ability to identify cauda equina syndrome early.","authors":"Khalid F Althobaiti, Joshua R Zadro, Fahad A Alzhrani, Hosam A Alzahrani","doi":"10.17712/nsj.2025.2.20240035","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20240035","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the ability of physiotherapists in Saudi Arabia to identify cauda equina syndrome (CES) in a timely manner, and to identify the methods used by physiotherapists to manage patients with suspected CES.</p><p><strong>Methods: </strong>This study utilized a cross-sectional research design and was conducted in the period May-October 2023. It included licensed physiotherapists working in Saudi Arabia. The data was collected using a survey that aimed to assess physiotherapists' ability to identify CES early, using 12 statements. Based on the participants response to these statements, all responders were categorized into the following groups based on their ability to identify and manage CES early: proficient (10-12 points); good ability (7-9); fair ability (5-6); and poor ability (<=4). Consensus to a statement was reached when more than 70% of participants agreed or disagreed with the statement.</p><p><strong>Results: </strong>This study included 401 physiotherapists (mean age=29.51 (SD 5.54); 53.4% female). Most participants (63.6%) have a proficient-good ability to identify and manage CES early, while 36.4% were categorized as having fair-poor ability Consensus for the CES statements was achieved for 8 statements [1, 2, 3, 4, 5, 8, 9, 12] out of 12. Among these statements, most participants agreed that a patient should be suspected to have CES when they exhibited urinary difficulties of neurogenic origin (88.3%) and/or bilateral radiculopathy (85.5%); and 88.0% of them agreed that an MRI should be requested urgently when managing a patient with CES. Conversely, consensus was not achieved on statements, concerning communication with patients, patient instructions, and management decisions for suspected CES cases.</p><p><strong>Conclusion: </strong>Most physiotherapists had a proficient-good ability to identify and manage CES early. The study's findings can aid in the creation or improvement of clinical standards and protocols pertaining to physiotherapists' roles in the early identification of CES.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"101-107"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for unexplained early neurological deterioration after intravenous thrombolysis: a meta-analysis.","authors":"J Li, C L Zhu, C Y Zhang, L M Li, R Liu, S Zhang, M L He","doi":"10.17712/nsj.2025.2.20230105","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20230105","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the risk factors of unexplained early neurological dererioration (END) after IVT, and explore the underlying mechanisms by which these factors contribute to END onset and progression.</p><p><strong>Methods: </strong>We performed a systematic literature search in accordance with PRISMA guidelines, utilizing PubMed, WOS, and EMBASE databases to identify all relevant studies investigating END in AIS patients who received IVT within 4.5 hours of symptom onset.</p><p><strong>Results: </strong>Out of 2,613 reviewed records, 16 were included in this meta-analysis. The quantitative synthesis of data regarding the incidence of END in acute ischemic stroke (AIS) patients with IVT was 12% (95% confidence interval [CI], 10%-15%). Several factors were identified as significantly associated with post-IVT END, including demographic characteristics (age, male sex), comorbidities (hypertension, diabetes mellitus, atrial fibrillation), medications (antihypertensives, antiplatelets), admission parameters (hyperglycemia, elevated white blood cell count, cholesterol levels, blood pressure readings), timing of treatment, and the presence of large artery atherosclerosis (LAA).</p><p><strong>Conclusion: </strong>Understanding and monitoring multiple factors associated with END, including other comorbidities, may achieve satisfactory results. The investigation of white blood cells' involvement in END following AIS merits particular attention, as it may guide the development of targeted preventive medications.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"92-100"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saudi clinical practice guidelines for the treatment and prevention of migraine headache.","authors":"Faisal A Al-Suwaidan, Hajer Y Almudaiheem, Haifa F Alotaibi, Waleed A Alhazzani, Khalid W Al-Quliti, Khalidah A Alenzi, Bedor A Al-Omari, Majed M Alabdali, Abubker W Omaer, Saleh M Alrajhi, Ali N Alshoaiby, Ahmed H Al-Jedai","doi":"10.17712/nsj.2025.2.20240097","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20240097","url":null,"abstract":"<p><strong>Objective: </strong>To develop clinical practice guidelines based on evidence based medicine on the use of abortive and preventive therapies for managing migraine headaches. We formulated these guidelines to offer evidence-based recommendations to improve the knowledge of physicians, healthcare professionals, and policymakers in migraine headache management.</p><p><strong>Method: </strong>A panel of 11 experts from different sectors in Saudi Arabia approved 26 questions on abortive and preventive therapies for migraines. To develop each question, we searched \"PubMed\" and \"Cochrane Library\" databases for recent relevant systematic reviews published between 2013 and 2024. We employed the Grading Recommendations, Assessment, Development, and Evaluation methodological approach to ensure the certainty of the collated evidence and to formulate the recommendations. The expert panel voted electronically on each recommendation, and a consensus was defined as >70% agreement.</p><p><strong>Results: </strong>We formulated a total of 26 recommendations. Of these, 14 are focused on abortive therapy for acute migraine attacks, whereas 12 are focused on the prevention of episodic or chronic migraines. These guidelines strongly recommend the use of paracetamol and ibuprofen as the first-line treatment for mild to moderate migraine. Furthermore, we concluded that propranolol should be considered as the first-line preventive intervention for migraine.</p><p><strong>Conclusion: </strong>The Saudi clinical practice guidelines offer systematically validated recommendations of migraine headaches in adults. The recommendations are potentially beneficial for all healthcare professionals managing patients with migraine headaches.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"77-91"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the severity of facet joint osteoarthritis affect facet medial branch radiofrequency thermocoagulation results?","authors":"Kaya S Sancar, Çelik Şeref, Göksu Hamit, Akçaboy E Yavuz, Şahin Şaziye","doi":"10.17712/nsj.2025.30.4.20240037","DOIUrl":"https://doi.org/10.17712/nsj.2025.30.4.20240037","url":null,"abstract":"<p><strong>Objectives: </strong>To assess how facet medial branch radiofrequency thermocoagulation (FMB-RFT) outcomes are affected by severe facet joint osteoarthritis (FJO).</p><p><strong>Methods: </strong>This retrospective study involved 91 individuals with lumbar facet joint disease-related chronic lower back pain (CLBP), all of whom underwent FMB-RFT. The patients were assigned to 3 groups using the Weishaupt facet grading system (WFGS). Pain scores were assessed prior to treatment, as well as at the 1-, 6-, and 12-month marks.</p><p><strong>Results: </strong>Based on the WFGS, 38 of the 91 patients were assigned a grade 1 FJO, 28 a grade 2 FJO, and 25 a grade 3 FJO. The percentage of patients in each group who saw a 50% or greater improvement in their pain scores at 1, 6, and 12 months did not differ significantly.</p><p><strong>Conclusion: </strong>For patients with CLBP, FMB-RFT has been shown to be safe and effective in both the short and long terms. The results from FMB-RFT do not seem to be affected by the severity of FJO.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"144-149"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Sleep patterns and quality depend not only on gender and the time of year, but also on a variety of other influencing factors.","authors":"","doi":"10.17712/nsj.2025.2.20240127","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20240127","url":null,"abstract":"","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"162-163"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors, clinical characteristics, and outcomes of perinatal stroke in a Tertiary University Hospital.","authors":"Shaden S Alfayez, Muddathir H Hamad, Amal Y Kentab, Ahmad A Alanezi, Daniah M Kurdi, Hanady A Almuhideb, Fahad A Bashiri","doi":"10.17712/nsj.2025.2.20240089","DOIUrl":"https://doi.org/10.17712/nsj.2025.2.20240089","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the risk factors, clinical characteristics, and neurodevelopmental outcomes associated with perinatal stroke, as well as to assess the risk of epilepsy, seizure control, and cognitive function in children with perinatal stroke.</p><p><strong>Methods: </strong>Data from 32 patients diagnosed with perinatal stroke between October 2007 and October 2020 were retrospectively reviewed.</p><p><strong>Results: </strong>Of 32 patients, 27 were born after normal pregnancies, and 20 (62.5%) had consanguineous parents. Family histories of stroke, haematological disease, and epilepsy were noted in 3.13%, 3.13%, and 21.88%, respectively. Initial symptoms included hemiparesis (56.25%), seizures (37.5%), respiratory distress (3.13%), and tiptoe walking (3.13%). Epilepsy was diagnosed in 22 patients, with 72.72% achieving seizure control. Among 12 patients who underwent IQ testing, 15.63% had borderline impairment, 9.37% average IQ, 3.13% below-average IQ, and 6.26% moderate-to-severe impairment.</p><p><strong>Conclusion: </strong>Hemiparesis was the most frequent presenting symptom, followed by seizures. Many patients developed epilepsy, with most achieving satisfactory seizure control. IQ testing revealed varying degrees of cognitive impairment, highlighting the complex neurodevelopmental effects of perinatal stroke.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"138-143"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DOES SLEEP APNEA TREATMENT INFLUENCE PATIENTS' RISK OF GETTING INTO CAR ACCIDENTS?","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"166"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHO PREQUALIFIES DIAGNOSTIC TEST TO SUPPORT SAFER ADMINISTRATION OF P. VIVAX MALARIA TREATMENTS.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 2","pages":"167-168"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}