Neurosciences最新文献

DOES WORK-RELATED STRESS COMPROMISE CARDIOVASCULAR HEALTH? 工作压力会损害心血管健康吗？

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01

引用次数: 0

Marchiafava-Bignami disease post-bariatric surgery: A case report and review of similar cases. 减肥手术后Marchiafava-Bignami病1例报告及类似病例回顾

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240036

Sohaila A Alshimemeri, Abdulaziz M Alshoumar, Abdullah Y Alfaifi, Abdulaziz I Almohanna

{"title":"Marchiafava-Bignami disease post-bariatric surgery: A case report and review of similar cases.","authors":"Sohaila A Alshimemeri, Abdulaziz M Alshoumar, Abdullah Y Alfaifi, Abdulaziz I Almohanna","doi":"10.17712/nsj.2025.1.20240036","DOIUrl":"10.17712/nsj.2025.1.20240036","url":null,"abstract":"Marchiafava-Bignami disease (MBD) is a rare neurological disorder typically occurring in alcoholic patients. The main disease mechanism is hypothesized to be vitamin B-complex deficiency due to malnutrition. In the literature, there have been few reported cases of the disease occurring in patients who have undergone bariatric surgery. This paper presents a case study of a 45-year-old non-alcoholic female who underwent a laparoscopic sleeve gastrectomy presenting with progressive worsening weakness of her lower limbs and slurred speech. Her condition continued to deteriorate, and she became mute and bedbound. The MRI revealed distinctive characteristics consistent with MBD. The diagnosis was confirmed following the exclusion of all other possible diagnoses. She was treated with multivitamins and had a significant improvement. Additionally, we conduct a review of similar cases of this condition occurring after bariatric surgery. This report sheds light on the occurrence of this uncommon condition after the bariatric procedures.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"64-69"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of key lncRNA related to Parkinson's disease based on gene co-expression weight networks. 基于基因共表达权重网络的帕金森病相关关键lncRNA分析

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20230112

Wenwen Liang, Wei Zhao, Binghan Li, Jiaying Luo, Xuemei Li, Weihua Jia

{"title":"Analysis of key lncRNA related to Parkinson's disease based on gene co-expression weight networks.","authors":"Wenwen Liang, Wei Zhao, Binghan Li, Jiaying Luo, Xuemei Li, Weihua Jia","doi":"10.17712/nsj.2025.1.20230112","DOIUrl":"10.17712/nsj.2025.1.20230112","url":null,"abstract":"Objectives: To identify a key Long chain non-coding RNAs (lncRNAs) related to PD and provide a new perspective on the role of LncRNAs in Parkinson's disease (PD) pathophysiology.Methods: Our study involved analyzing gene chips from the substantia nigra and white blood cells, both normal and PD-inclusive, in the Gene Expression Omnibus (GEO) database, utilizing a weighted gene co-expression network analysis (WGCNA). The technique of WGCNA facilitated the examination of differentially expressed genes (DEGs) in the substantia nigra and the white blood cells of individuals with PD. When merged with clinical data, gene modules containing crucial clinical details were chosen for network integration in GO and KEGG enrichment analysis.Results: A pair of LncRNA modules were identified. The crucial component in GSE7621 was the turquoise module. The DEGs were acquired using GSE133347. GO functions focused on phosphatidylinositol phosphate binding, inflammatory responses, and the regulation of nerves and synapses. KEGG analyses were largely enriched within the P13K-Akt, FaxO, mTOR, Oxytocin, and cGMP-PKG signaling pathways. A Venn diagram revealed that the two key LncRNA were CH17-189H20.1 and RP11-168O16.1.Conclusion: Using the WGCNA method, we obtained PD-related modules, identified biologically significant gene modules, obtained core LncRNAs, and found potential target genes for enrichment analysis. The objective of our research was to advance more detailed and efficient treatment methods for lncRNAs associated with PD.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"20-29"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-reactive protein-to-albumin ratio and systemic immune-inflammatory index as potential markers in distinguishing acute cerebellar infarction from benign paroxysmal positional vertigo. c反应蛋白与白蛋白比值和全身免疫炎症指数作为鉴别急性小脑梗死与良性阵发性位置性眩晕的潜在指标。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240084

Oruç Şahin, Muzaffer Güneş, Recep Dönmez

{"title":"C-reactive protein-to-albumin ratio and systemic immune-inflammatory index as potential markers in distinguishing acute cerebellar infarction from benign paroxysmal positional vertigo.","authors":"Oruç Şahin, Muzaffer Güneş, Recep Dönmez","doi":"10.17712/nsj.2025.1.20240084","DOIUrl":"10.17712/nsj.2025.1.20240084","url":null,"abstract":"Objectives: To investigate the potential utility of the C-reactive protein-to-albumin ratio (CAR) and the systemic immune-inflammatory index (SII) as a biomarker in distinguishing between BPPV and acute cerebellar infarction (ACI) due to posterior inferior cerebellar artery (PICA) involvement.Methods: The data of 2545 patients registered in our hospital database between 2017 and 2024 with a diagnosis of vertigo were retrospectively analyzed and 102 patients with benign paroxysmal positional vertigo (BPPV) and 100 patients with ACI were included in the study. Mann-Whitney U test, Chi-square test, or Fisher's exact test were used to compare variables between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to investigate the predictive value of the data.Results: The CAR and SII values were significantly higher in the ACI group compared to the BPPV group (p<0.001, p<0.001, respectively). The areas under the ROC curve (AUC) were as follows: CAR=0.768 (95% CI, 0.705-0.832), white blood cell count (WBC)=0.735 (95% CI, 0.667-0.802), monocytes=0.622 (95% CI, 0.544-0.699), red cell distribution width-standard deviation (RDW-SD)=0.600 (95% CI, 0.522-0.678), SII=0.674 (95% CI, 0.599-0.748), and neutrophil-to-lymphocyte ratio (NLR)=0.687 (95% CI, 0.613-0.761).Conclusion: CAR and SII could be useful biomarkers to differentiate between ACI and BPPV in vertigo patients, but further validation is needed in larger studies.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"30-35"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MEASLES CASES SURGE WORLDWIDE, INFECTING 10.3 MILLION PEOPLE IN 2023. 全球麻疹病例激增，2023年感染1030万人。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01

引用次数: 0

Structural and functional changes in the hippocampus induced by environmental exposures. 环境暴露引起的海马体结构和功能变化。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240052

Emad A Albadawi

引用次数: 0

Prevalence and factors influencing eating disorders among post-bariatric surgery patients in Saudi Arabia: A cross-sectional study. 沙特阿拉伯减肥手术后患者饮食失调患病率及影响因素：一项横断面研究

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240023

Saleh A Alghamdi, Mohammed A Al Jaffer, Renad A Almesned, Sadeem D Alanazi, Alanoud W Alhnake, Shahad M Alkhammash, Nuran M Baabbad

{"title":"Prevalence and factors influencing eating disorders among post-bariatric surgery patients in Saudi Arabia: A cross-sectional study.","authors":"Saleh A Alghamdi, Mohammed A Al Jaffer, Renad A Almesned, Sadeem D Alanazi, Alanoud W Alhnake, Shahad M Alkhammash, Nuran M Baabbad","doi":"10.17712/nsj.2025.1.20240023","DOIUrl":"10.17712/nsj.2025.1.20240023","url":null,"abstract":"Objectives: To examine the occurrence and contributing factors of disordered eating patterns in individuals post-bariatric surgery. It also investigated the impact of these patterns on weight loss outcomes and long-term weight management, focusing on psychological and emotional factors. Additionally, the relationship between body image dissatisfaction and disordered eating patterns was explored.Methods: A cross-sectional study was conducted across multiple medical centers in Saudi Arabia, using self-administered questionnaires to evaluate the prevalence of eating disorders and self-esteem among patients who underwent bariatric surgery in the past five years. Out of 557 respondents, 452 met the inclusion criteria.Results: The study found that 21.5% of participants experienced psychological disorders post-surgery. Notably, there was a significant improvement in mean self-esteem scores after surgery. Depression was the most frequently reported disorder (12.4%), followed by Generalized Anxiety Disorder (9.3%) and Eating Disorders (4.6%). The mean Rosenberg Self-esteem Scale score increased significantly from 28.17±6.2 pre-surgery to 31.7±5.3 post-surgery (p<0.001).Conclusion: The findings highlight a notable prevalence of psychological disorders among post-bariatric surgery patients, with depression being the most common. Despite this, significant improvements in self-esteem were observed. Understanding the psychological and emotional factors contributing to disordered eating patterns and body image dissatisfaction is crucial for improving long-term weight management and patient outcomes post-surgery.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"36-43"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the stroke burden in Saudi Arabia: Trends from 1990 to 2019 and forecasting through time series analysis. 了解沙特阿拉伯的中风负担：1990年至2019年的趋势以及通过时间序列分析进行预测。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240092

Ahmed A Mahfouz, Shaimaa A Abdelmoneim, Shymaa M M Abdu, Hoda A A Shiba, Asmaa M AboElela, Ramy M Ghazy, Adel A Alhazzani

{"title":"Understanding the stroke burden in Saudi Arabia: Trends from 1990 to 2019 and forecasting through time series analysis.","authors":"Ahmed A Mahfouz, Shaimaa A Abdelmoneim, Shymaa M M Abdu, Hoda A A Shiba, Asmaa M AboElela, Ramy M Ghazy, Adel A Alhazzani","doi":"10.17712/nsj.2025.1.20240092","DOIUrl":"10.17712/nsj.2025.1.20240092","url":null,"abstract":"Objectives: To describe age-standardized incidence and disability-adjusted life years (DALYs) of ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in the Kingdom of Saudi Arabia (KSA) from 1990 to 2019 and forecast these variables using the Global Burden of Diseases (GBD) data over the next years (2020-2030).Methods: Poisson regression models were employed to identify significant changes in incidence rate ratios (IRRs) and DALY rates for different stroke types. For time series models, the autoregressive integrated moving average (ARIMA) and exponential smoothing state space (ETS) models were used for forecasting.Results: The study demonstrated an increasing trend in the age-standardized incidence rate per 100,000 different types of strokes over the last 30 years, with a slight decrease in ICH and SAH types in 2015, followed by a continued increase. The prediction models indicated a sustained increase in the 3 types of strokes, accompanied by a decrease in DALYs. As regards DALYs, the trend for IS and ICH has been slowly and steadily increasing; however, there will be a modest decrease in DALYs rates for SAH during the next decade.Conclusion: Stroke rates in KSA have increased over 3 decades, mainly among women and older individuals, and have a slow sustained increase over the forecasted period (2020-2030); thus, proactive strategies and healthcare interventions are required.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"49-58"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: When assessing the risk of cerebral edema after aneurysm clipping, all contributing factors must be taken into account. 点评：在评估动脉瘤夹闭后脑水肿的风险时，必须考虑所有因素。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240107

引用次数: 0

WHO ADDS LC16M8 MPOX VACCINE TO EMERGENCY USE LISTING. Who将lc16m8 m痘疫苗添加到紧急使用清单中。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01

引用次数: 0