Neurosciences最新文献

{"title":"Efficacy and Safety of Plasma Exchange and Immunoadsorption for Acute Optic Neuritis in Patients with Demyelinating Diseases: A Systematic Review and Meta-Analysis.","authors":"Mehenaz A Hanbazazh, Mohammed Ridha Algethami, Abdulwahhab Omar AnbarSerry, Ruba Mohammed Alghanmi, Lama Nawaf Alanazi, Ahmed Ayed N Alanazi, Bashaier Gubran AlQahtani, Mohammed Abdullah Alamri","doi":"10.17712/1658-3183.2798","DOIUrl":"10.17712/1658-3183.2798","url":null,"abstract":"<p><strong>Background: </strong>Optic neuritis (ON), a common manifestation of demyelinating disorders such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), often leads to significant visual impairment. Although high-dose corticosteroids are a first-line therapy, many patients experience incomplete recovery. Apheresis therapies, including plasma exchange (PLEX) and immunoadsorption (IA), are being increasingly used as rescue treatments, but their efficacy and safety are debated.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis of studies evaluating PLEX and IA for acute ON in patients with demyelinating diseases. Four databases were searched up to January 2025. The included studies reported visual or neurological outcomes in patients with MS, NMOSD, MOGAD, or idiopathic ON. The primary outcomes were treatment response and visual acuity changes (logMAR). The study quality was assessed using RoB 2, ROBINS-I, or JBI tools. Random effects models were employed for the meta-analysis.</p><p><strong>Results: </strong>Twelve studies (800+ ON attacks) were analyzed. Both PLEX and IA demonstrated significant visual improvement, with a pooled mean logMAR reduction of -1.11 (95% CI: -1.70 to -0.53). Early intervention correlated with better outcomes. MOGAD-ON patients showed the highest response rates, while delayed treatment in NMOSD-ON patients was linked to poorer vision. Adverse events were rare and mild.</p><p><strong>Conclusion: </strong>PLEX and IA are effective and safe second-line therapies for steroid-refractory ON, particularly when initiated early. These findings support the prompt use of apheresis in eligible patients to optimize visual recovery.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"220-229"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiseizure Drug Adherence in Pediatric Patients With Epilepsy and the Associated Factors in Saudi Arabia.","authors":"Ola A Shawky, Shaima A Althoubaiti, Reham M Alkahtani, Amirah S Alharthi","doi":"10.17712/1658-3183.2806","DOIUrl":"10.17712/1658-3183.2806","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the prevalence of adherence to antiseizure medications and related factors in Saudi Arabia. Pediatric epilepsy presents significant challenges to the well-being and quality of life of children. Adherence to antiseizure medication is associated with better outcomes.</p><p><strong>Methods: </strong>This study was carried out using a cross-sectional methodology to determine the prevalence of antiseizure medication adherence among children with epilepsy aged ≤17 years in Saudi Arabia. Data were collected between July and September 2024 via an online self-administered questionnaire, using convenience sampling through social platforms (Telegram and WhatsApp). Medication adherence was assessed using the MMAS-8 and categorized as high (score = 8), medium (6-7), or low (<6); for analysis, scores ≥6 were considered adherent.</p><p><strong>Results: </strong>A total of 231 responses were analyzed. In terms of medication adherence, 42.0% of the participants were adherent (35.9% medium adherence and 6.1% high adherence), and 58% were non-adherent. Parents' and caregivers' knowledge was classified as good in 63.6% and poor in 36.4% of the participants, respectively. The result showed a statistically significant association between knowledge levels and adherence to antiseizure medication. Factors significantly associated with medication adherence included mothers as caregivers, taking medication once daily, no emergency room visits, and the use of other medications.</p><p><strong>Conclusion: </strong>Adherence to medications among pediatric patients with epilepsy remains suboptimal. The key factors associated with better adherence included mothers as primary caregivers, good caregiver knowledge, taking medication once daily, and less frequent emergency room visits. This study highlights the importance of increased awareness and education to improve healthcare delivery and enhance knowledge and attitudes toward epilepsy management.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"280-288"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Activation Measures Among Individuals With Epilepsy: A Cross-Sectional Study of an Arabic-Speaking Population.","authors":"Ghada M Abbas, Abeer A Khoja, Haythum O Tayeb, Nagham S Alsolaimani, Ibrahim M Aldurayhim, Saher F Alqarni","doi":"10.17712/1658-3183.2805","DOIUrl":"10.17712/1658-3183.2805","url":null,"abstract":"<p><strong>Objectives: </strong>To examine patient activation levels among Arabic-speaking adults with epilepsy and to explore their associations with selected clinical and sociodemographic variables.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 109 adult patients with confirmed epilepsy between December 2023 and October 2025. Data were collected during outpatient clinic visits, with additional information obtained through telephone contact when necessary. A sample size estimate indicated that at least 96 participants were required to achieve 80% statistical power. Patient activation was assessed using the validated Arabic version of the 13-item Patient Activation Measure (PAM-13). The variables examined included seizure type, medication regimen (monotherapy versus polytherapy), employment status, and medication adherence. Self-reported adherence was categorized as high or low based on patient responses regarding medication-taking behavior. Statistical analyses were performed using SPSS version 27. PAM scores were compared across relevant groups using appropriate bivariate statistical tests, and a <i>p</i> value <0.05 was considered to indicate statistical significance.</p><p><strong>Results: </strong>The mean PAM score was 66.2 ± 17.6, corresponding to a moderate level of activation. Most participants (86.2%) demonstrated activation levels of 3 or 4. Focal epilepsy was more common (62.4%) than generalized epilepsy was (37.6%). Monotherapy was used by 51.4% of the participants, and 77.1% reported high medication adherence. Compared with unemployed or retired participants, employed individuals had significantly higher PAM scores (72.0 vs. 60.0, <i>p<</i>0.01). Greater adherence was also associated with greater activation (<i>p<</i>0.01). No significant associations were observed between PAM scores and seizure types or treatment regimens.</p><p><strong>Conclusion: </strong>Most patients demonstrated moderate to high activation levels. Employment status and medication adherence were positively associated with activation, suggesting potential targets for interventions aimed at improving self-management among individuals with epilepsy.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"272-279"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Comparative Review of Antipsychotic Efficacy and Safety in the Treatment of Hiccups.","authors":"Omar Alshargi, Samah Alzaid, Zainab Albahouth, Muradi Hassan Albanji, Hala Makki, Rawan F Alboqami, Maram Al Shammari, Huda Alruwaili, Fawaz Alruwaili, Rahmah Ali Algarni, Omar Ibrahim Albahouth","doi":"10.17712/1658-3183.2801","DOIUrl":"10.17712/1658-3183.2801","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and compare the safety and effectiveness of antipsychotic medications for the treatment of hiccups, thereby guiding clinicians toward evidence-based treatment guidelines. Hiccups are often benign and self-limiting; however, they can become persistent and intractable, adversely affecting the quality of life. Antipsychotics have been identified as a therapeutic option for the management of hiccups; however, the available evidence supporting their safety and efficacy has not been synthesized.</p><p><strong>Methods: </strong>This review utilized the revised Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Cochrane Risk of Bias Assessment Tool was modified to evaluate the quality of the selected studies. The search strategy included terms related to or describing hiccups and antipsychotics. Research articles in English published between 1974 and March 2024 were searched in different databases. Duplicates and eligibility criteria were used to screen articles.</p><p><strong>Results: </strong>A search of Medline, Scopus, and Web of Science yielded 1537 articles, of which 1042 were retained after removing duplicates, and 16 met the inclusion criteria. The studies that met the inclusion criteria were all case reports, case series, or retrospective studies, with no randomized trials. A few antipsychotics have been shown to totally or partially alleviate hiccups. Nine studies reported that hiccups were completely resolved in patients treated with 10-25 mg oral and intramuscular chlorpromazine, 1-2 mg oral and intramuscular haloperidol, 2.5-10 mg oral olanzapine, 25-150 mg tetrabenazine, and 3 mg oral risperidone. Adverse events were documented in 7 of the studies.</p><p><strong>Conclusion: </strong>Chlorpromazine and olanzapine are effective antipsychotics for hiccup treatment. However, more evidence-based studies and controlled clinical trials are needed to confirm the efficacy and minimize the side effects.</p><p><strong>Prospero registration: </strong>(CRD42024511626).</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"230-243"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Patent Foramen Ovale-Migraine Link in Southern Saudi Arabia.","authors":"Al-Amir Bassiouny Mohamed, Maeed Alkathiri, Saad Mushabab Ali Alqahtani, Naif H Ali, Saima Kashif, Saad A Alshahrani, Mohammed S Alqahtani, Mohamed Gaber Mahmoud Gabr, Eltohami Zydan Dafalla, Basharat Hameed Zargar, Wael Qenawi, Ali Mohammed A Alshehri, Fatimah Asiri, Ahmed Borai","doi":"10.17712/1658-3183.2809","DOIUrl":"10.17712/1658-3183.2809","url":null,"abstract":"<p><strong>Objective: </strong>Migraine is a highly disabling neurological condition, and increasing attention has focused on a possible connection with patent foramen ovale (PFO).</p><p><strong>Methods: </strong>This single-center observational study enrolled 45 individuals from January to April 2024: 30 migraine patients with PFO (Group 1) and 15 migraine patients without PFO serving as controls (Group 2). All subjects underwent transthoracic echocardiography and completed standardized instruments including the Migraine Disability Assessment (MIDAS), Headache Impact Test (HIT-6), Migraine Symptom Severity Scale (MSSS), Allodynia Symptom Checklist (ASC-12), Visual Aura Rating Scale (VARS), and Migraine Treatment Optimization Questionnaire (mTOQ-6).</p><p><strong>Results: </strong>The participant's mean age was 37.3 ± 9 years. More than half experienced migraine with aura, a proportion notably greater among those with PFO. A positive family history, suboptimal response to therapy, and positional exacerbation were significantly associated with the PFO group. Fibrinogen concentrations and several migraine-related scores including MIDAS, HIT-6, MSSS, ASC-12, and mTOQ-6 differed significantly between groups.</p><p><strong>Conclusion: </strong>Migraine linked to PFO are more likely to have an aura, a stronger family patterns, worsening symptoms based on position, and overall, greater disability and increased severity of symptoms. These findings support an association between PFO and migraine characteristics and may have implications for clinical management.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"304-314"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Top 50 Cited Articles in Pediatric Neurology: A Bibliometric Analysis.","authors":"Anas Alyazidi, Osama Muthaffar, Ahmed Bamaga, Hebah Qashqari, Abdulmalek Alhithlool, Ahmad Alanezi, Sameer Almehmadi, Mohamed Babiker, Fahad Bashiri","doi":"10.17712/1658-3183.2810","DOIUrl":"10.17712/1658-3183.2810","url":null,"abstract":"<p><strong>Objectives: </strong>To identify and analyze the most influential articles within the field of pediatric neurology through a bibliometric lens. As pediatric neurology continues to expand across subspecialties, identifying landmark studies is critical for understanding clinical and research priorities. Bibliometric analysis enables the evaluation of citation trends to highlight impactful contributions that have shaped the field.</p><p><strong>Method: </strong>A bibliometric analysis of the 50 most-cited pediatric neurology articles was conducted. Articles were assessed by citation metrics, study design, subspecialty, journal impact factor (JIF), and funding status. Correlation and regression analyses evaluated associations between variables.</p><p><strong>Results: </strong>Citation counts ranged from 185 to 1,440 (median: 332). Epilepsy accounted for the largest proportion of studies (26%) but showed lower citation density (31.5 cites/year) compared with subspecialties such as neuroimmunology (45 cites/year). International collaboration was the strongest predictor of citation impact; each additional collaborating country increased total citations (β = 48.9, <i>p</i> = 0.002) and citation density (β = 5.3, <i>p</i> < 0.001), resulting in a 42% higher citation density than single-nation studies. While publication year negatively affected total citations (β = -22.4, <i>p</i> < 0.001), newer studies demonstrated faster citation accrual. Funding modestly increased citation count (β = 135.3, <i>p</i> = 0.026), whereas JIF showed no significant effect (<i>p</i> = 0.846). Neurodevelopmental topics had the highest mean citations, and open-access articles exhibited 38% greater citation density than paywalled publications.</p><p><strong>Conclusion: </strong>The most influential studies were collaborative, funded, and open access. Recent works, especially in neurogenetics and neurocritical care, are gaining rapid traction. International collaboration and topic selection drive scholarly impact. Future research should focus on high-impact and underrepresented specialties.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"315-323"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between the Corpus Callosum Index and Current Blood Parameters and Temporal Changes in these Parameters in Patients with Multiple Sclerosis.","authors":"Oruç Şahin, Muzaffer Güneş","doi":"10.17712/1658-3183.2807","DOIUrl":"10.17712/1658-3183.2807","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate changes in blood parameters and examine the relationships among the corpus callosum index (CCI), plaque characteristics, and blood parameters in multiple sclerosis (MS) patients. In MS, the CCI is associated with brain atrophy and disease progression.</p><p><strong>Methods: </strong>In this retrospective, cross-sectional study, demographic data from 103 MS patients (38 males), along with blood parameters obtained five years earlier and current values, were analyzed in relation to magnetic resonance imaging (MRI) findings. The CCI calculated from MRI scans was assessed in relation to plaque distribution and number. Statistical analyses included paired sample t tests, Wilcoxon tests, and Spearman correlation analysis.</p><p><strong>Results: </strong>Current lymphocyte, platelet, and monocyte levels were significantly lower than those measured five years earlier (<i>p</i><0.001; <i>p</i>=0.026; <i>p</i><0.001), whereas the systemic immune-inflammation index (SII) significantly increased (<i>p</i>=0.035). The CCI was positively correlated with the monocyte/neutrophil ratio (MNR) (<i>p</i>=0.011, <i>r</i> = 0.251) and negatively correlated with the SII (<i>p</i>=0.048, <i>r</i>=-0.196). Additionally, the CCI was significantly negatively correlated with periventricular and juxtacortical plaque number, the Expanded Disability Status Scale (EDSS), and MS attack frequency.</p><p><strong>Conclusion: </strong>In MS patients, the CCI is negatively associated with the SII, plaque distribution, and plaque number and positively associated with the MNR. A decreased MNR and increased SII are linked to corpus callosum atrophy.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"289-296"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrovascular and Bleeding Outcomes of Warfarin versus Direct Oral Anticoagulants Therapy for Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Abeer A Alomairi, Rana Alduhaysh, Alaa Samandar, Abeer Alshehri, Ghada AlAbdullah, Saud Almutairi, Faisal Althekair","doi":"10.17712/1658-3183.2800","DOIUrl":"10.17712/1658-3183.2800","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the effects on cerebral health in atrial fibrillation patients receiving either warfarin or direct oral anticoagulants (DOACs). Atrial fibrillation is linked to a higher likelihood of both stroke and cognitive impairment. While warfarin has historically served as the leading anticoagulant treatment, DOACs are now more frequently viewed as alternatives with an improved safety profile.</p><p><strong>Methods: </strong>The methodology involved an extensive search of multiple databases, completed up to June 2024. This search yielded randomized controlled trials, which together enrolled over 60,000 participants between the ages of 70 and 84. The DOACs studied were dabigatran, rivaroxaban, apixaban, and edoxaban, given in various dosages. Warfarin was administered with dose adjustments to keep the international normalized ratio within a target range of 2.0 to 3.0.</p><p><strong>Results: </strong>With a relative risk of 0.81 (95% CI, p < 0.00001; I² = 19%), the results showed that 20 high-dose DOACs considerably decreased the risk of stroke when compared to warfarin. However, there were no discernible variations for major bleeding (relative risk 0.89), moderate bleeding (relative risk 0.92), or cardiovascular events (relative risk 0.96).</p><p><strong>Conclusion: </strong>The DOACs are frequently more efficacious than warfarin in avoiding stroke and systemic embolism in patients with non-valvular atrial fibrillation. A significant decline in hemorrhagic stroke was the main cause of the pooled data's 19% relative risk reduction in stroke or systemic embolism. While bleeding outcomes varied among the individual DOACs, the overall findings support their favorable risk-benefit profile. Compared to warfarin, DOACs consistently showed fewer intracranial hemorrhages and a more favorable bleeding profile. These results support prioritizing DOACs in clinical practice, given their enhanced safety and reduced mortality rates. However, due to differences in bleeding risks among DOACs, treatment decisions should be tailored to individual patient factors.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"193-206"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue and Depression in Epilepsy Patients May Not be Solely Related to the Epilepsy Itself.","authors":"Sounira Mehri, Josef Finsterer","doi":"10.17712/1658-3183.2811","DOIUrl":"10.17712/1658-3183.2811","url":null,"abstract":"","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"324-325"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable Sensor Technology and Biomechanical Gait Analysis in Post-Stroke Rehabilitation: A Review with Implications for the Saudi Healthcare System.","authors":"Abdullah H Alzahrani","doi":"10.17712/1658-3183.2802","DOIUrl":"10.17712/1658-3183.2802","url":null,"abstract":"<p><p>Stroke remains a major cause of disability worldwide, with gait impairment affecting up to 80% of survivors and contributing to long-term dependence, fall risk, and reduced quality of life. In Saudi Arabia, stroke incidence is rising, with a significant burden on younger populations and disparities in access to post-stroke rehabilitation services. Conventional gait analysis tools rely on expensive, specialized laboratory equipment, which limits their availability in low-resource and rural settings. Recent advances in wearable sensor technologies, including inertial measurement units, pressure insoles, and electromyography systems, offer portable, scalable, and cost-efficient options for assessing gait in real-world environments. These systems can offer continuous monitoring, tele-rehabilitation, and personalized feedback, aligning with global shifts toward digital health oversight. This review explores the application of wearable sensor-based gait analysis in post-stroke rehabilitation, highlighting sensor modalities, clinical utility, implementation challenges, and opportunities, particularly in Saudi Arabia, to strengthen rehabilitation services and optimize patient outcomes.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 3","pages":"244-254"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}