Neurosciences最新文献

COULD BOTOX MAKE WALKING EASIER IN CHILDREN WITH CEREBRAL PALSY? 肉毒素能让脑瘫儿童更容易行走吗？

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01

引用次数: 0

Hearing loss in patients with dementia in Saudi Arabia. 沙特阿拉伯痴呆症患者的听力损失。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01 DOI: 10.17712/nsj.2024.4.20240030

Laila Alqahtani, Lena Alotaibi, Jullanar Alkhunein, Reema Alduaiji, Reema Alqadiri, Fawaz Alibrahim, Salih binSalih, Hashim Balubaid

{"title":"Hearing loss in patients with dementia in Saudi Arabia.","authors":"Laila Alqahtani, Lena Alotaibi, Jullanar Alkhunein, Reema Alduaiji, Reema Alqadiri, Fawaz Alibrahim, Salih binSalih, Hashim Balubaid","doi":"10.17712/nsj.2024.4.20240030","DOIUrl":"10.17712/nsj.2024.4.20240030","url":null,"abstract":"Objectives: To determine the prevalence of hearing loss in patients with dementia, examine the use of hearing aids in those with hearing loss, and ascertain if the cause of hearing loss is central or peripheral in origin.Methods: A retrospective cohort study involving 143 patients with dementia which was conducted in Saudi Arabia from 2020 to 2023 in King Abdulaziz Medical City, Riyadh, Saudi Arabia, to determine hearing loss. The study included patients aged ≥60 years who had dementia, hearing loss, and neurological diseases. Those with Parkinson's disease and secondary epilepsy were excluded. Data was analyzed for its demographics, clinical features, predisposing factors, treatment, dementia duration and progression, and hearing loss outcomes. All statistical analyses were performed using IBM's SPSS software, version 29.0.0. Statistical significance was established at a p-value of ≤0.05 and a confidence interval of 95%.Results: The findings indicated that 88.8% of the 143 patients exhibited dementia, with Alzheimer's disease being the most prevalent type. Moreover, 18.2% had hearing issues, and 11.2% had other complaints. Audiometry was performed in 15.4% of the cases. Hearing loss was present in 14.7% of the patients, being primarily bilateral, ranging from mild to severe.Conclusion: This study has clarified the link between hearing loss and dementia onset and has emphasized the need for early evaluation and intervention for individuals with hearing impairment.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 4","pages":"262-269"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of all-trans-retinoic acid are mediated via downregulation of TLR4/NF-κB signaling in a rat model of middle cerebral artery occlusion. 在大鼠大脑中动脉闭塞模型中，全反式维甲酸通过下调TLR4/NF-κB信号传导发挥神经保护作用。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01 DOI: 10.17712/nsj.2024.4.20240010

Lixi Tan, Qian Liu, Songfa Chen, Rongjiao You, Xinyue Li, Tao Wen, Zhongxing Peng

{"title":"Neuroprotective effects of all-trans-retinoic acid are mediated via downregulation of TLR4/NF-κB signaling in a rat model of middle cerebral artery occlusion.","authors":"Lixi Tan, Qian Liu, Songfa Chen, Rongjiao You, Xinyue Li, Tao Wen, Zhongxing Peng","doi":"10.17712/nsj.2024.4.20240010","DOIUrl":"10.17712/nsj.2024.4.20240010","url":null,"abstract":"Objectives: To determine the effects of all-trans-retinoic acid (ATRA) on the post-stroke inflammatory response and elucidate the underlying molecular mechanisms.Methods: This animal experiment was conducted at Central Laboratory, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China during 2020-2022. Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 1.5 h, and treated with ATRA at 2 and 24 h after reperfusion. Neurological deficit scores on behavioral tests, and cerebral infarct volume, microglial polarization, and the expression levels of inflammatory cytokines and proteins associated with TLR4/NF-κB signaling were assessed.Results: The ATRA administration reduced cerebral infarct volume and ameliorated neurological deficit scores in MCAO rats. Additionally, ATRA relieved cerebral edema and downregulated the secretion of proinflammatory cytokines after stroke. Finally, ATRA attenuated the polarization of the microglia toward the M1 phenotype and promoted the activation of the beneficial M2 phenotype; the underlying mechanism potentially involved the suppression of the TLR4/NF-κB signaling pathway.Conclusion: The ATRA treatment promoted functional recovery in an experimental model of ischemic stroke by attenuating neural inflammation. ATRA potentially modulated microglia-mediated neuroinflammation via the downregulation of the TLR4/NF-κB signaling pathway, which makes it a candidate treatment for post-stroke neuroinflammation.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 4","pages":"276-283"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do dieticians have weight biases towards themselves and others? 营养师对自己和他人的体重是否有偏见？

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01

引用次数: 0

Median nerve conduction study findings in various arm positions. 不同手臂姿势下的正中神经传导研究结果。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01 DOI: 10.17712/nsj.2024.4.20240034

Halit Fidancı, Halil C Alaydın

{"title":"Median nerve conduction study findings in various arm positions.","authors":"Halit Fidancı, Halil C Alaydın","doi":"10.17712/nsj.2024.4.20240034","DOIUrl":"10.17712/nsj.2024.4.20240034","url":null,"abstract":"Objectives: To investigate the effects of various arm positions on median nerve conduction studies (NCSs).Methods: This prospective cohort study, conducted at Adana City Training and Research Hospital between January and July 2023, included 20 healthy participants. Median NCSs were performed on the participants in three different standing positions with the elbow as the stimulation point: 1) with the arm adducted (P1), 2) with the arm anteflexed (P2), and 3) with the arm raised upwards (P3). We obtained median nerve compound muscle action potential (CMAP) latency, duration, peak-to-peak (PP) amplitude, onset-to-negative peak (OP) amplitude, negative area/duration. Three CMAPs were obtained in each position, and the mean and minimum/maximum values at each position were analyzed.Results: The mean age (minimum-maximum) of the participants (11 male, 9 female) was 28.5±6.5 (20-42) years. Median nerve CMAP means (median) of latency/negative duration in the P1, P2, and P3 positions were 6.82±0.59 (6.83)/5.50±0.76 (5.39) ms, 6.99±0.56 (7.02)/5.72±0.73 (5.73) ms, and 7.03±0.58 (7.12)/5.79±0.80 (5.83) ms. Median nerve CMAP mean/minimum latency and negative duration were lowest in the P1 position (p<0.05). The mean median nerve CMAP OP amplitude was highest in P3 than P1 or P2 (p=0.042 and p=0.048).Conclusion: Median NCS results differed based on the position of the arm.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 4","pages":"270-275"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative and postoperative effects of hydrostatic pressure applied to the dura mater on central nervous system in unilateral biportal endoscopic spine surgery. 在单侧双侧内窥镜脊柱手术中，对硬脑膜施加静水压对中枢神经系统的围手术期和术后影响。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01 DOI: 10.17712/nsj.2024.4.20230123

Eralp Çevikkalp, Hayati Aygün, Kadri Yıldız, Esra Mercanoğlu Efe

{"title":"Perioperative and postoperative effects of hydrostatic pressure applied to the dura mater on central nervous system in unilateral biportal endoscopic spine surgery.","authors":"Eralp Çevikkalp, Hayati Aygün, Kadri Yıldız, Esra Mercanoğlu Efe","doi":"10.17712/nsj.2024.4.20230123","DOIUrl":"10.17712/nsj.2024.4.20230123","url":null,"abstract":"Objectives: To evaluate the changes in optic nerve sheath diameter (ONSD) caused by this pressure applied to the dura mater and postoperative complications.Methods: The study was conducted between 01.01.2022 and 01.06.2022 at Private Medicabil Hospital. The ONSD was measured 3 mm behind the eyeball using US at 5 time points: T1 (in the supine position after anesthesia induction), T2 (after conversion to the prone position), T3 (in the prone position after applying pressure to the dura mater), T4 (in the prone position after the discontinuation of applying pressure to the dura mater), T5 (after conversion to the supine position). Postoperative complications were recorded.Results: The ONSD at T3 was higher than those at all time points. For an ONSD value >5.3 mm, the sensitivity, specificity, positive predictive, and negative predictive values were 87.5%, 71.9%, 50.9%, and 94.5%, respectively (Area under the curve 0.830, 95% Confidence Interval: 0.761-0.899, p<0.001) CONCLUSION: We think that the hydrostatic pressure applied to the dura mater in unilateral biportal endoscopic (UBE) surgeries causes changes in the ONSD sheath diameter and that monitoring ONSD with peroperative USG can reduce the possible complications in order to reduce the effects of this pressure on the central nervous system.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 4","pages":"239-245"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological changes among weight loss injection users compared with bariatric surgery patients in Saudi Arabia. 沙特阿拉伯减肥注射剂使用者与减肥手术患者的心理变化比较。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01 DOI: 10.17712/nsj.2024.4.20230112

Ahmed B Alasiri, Faisal S Alahmari, Sadeem D Alanazi, Alanoud W Alhnake, Abdullah H Alkahtani, Mohammed Abdullah Aljaffer

{"title":"Psychological changes among weight loss injection users compared with bariatric surgery patients in Saudi Arabia.","authors":"Ahmed B Alasiri, Faisal S Alahmari, Sadeem D Alanazi, Alanoud W Alhnake, Abdullah H Alkahtani, Mohammed Abdullah Aljaffer","doi":"10.17712/nsj.2024.4.20230112","DOIUrl":"10.17712/nsj.2024.4.20230112","url":null,"abstract":"Objectives: To assess and evaluate the mental health and psychological changes in weight loss injection users and bariatric surgery.Methods: A descriptive and analytical cross-sectional study was conducted from July 2022 to December 2022. A self-administered questionnaire was given among participants using social media platforms. The questionnaire included socio-demographic characteristics, weight-loss-related characteristics, General Anxiety Disorder (GAD-7) to measure anxiety, and Patient Health Questionnaire (PHQ-9) to measure depression experienced by the patients.Results: Of the 721 patients, 73.9% were females, and 30.1% were aged between 30 to 39 years old. The prevalence of patients who underwent weight loss by surgery and injection was 47.7% and 41.2%, respectively. Overall, symptoms of anxiety and depression were detected in 19.7% and 24%, respectively. Independent risk factor of anxiety and depression was the symptom of the psychiatric disorder prior to surgery, while the independent protective factor for anxiety and depression was older age. Depression was higher in weight loss injection users.Conclusion: Nearly one-quarter of the study population experienced anxiety or depression following weight loss treatment. Weight loss treatment by injections increases the risk of depression. However, improved self-confidence, mood, and relationships with family and friends were some of the positive changes exhibited by the patients after undergoing weight loss treatment. Appropriate psychiatric evaluation is necessary before and after weight loss intervention.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 4","pages":"215-223"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WHO PREQUALIFIES THE FIRST SELF-TEST FOR HEPATITIS C VIRUS. 谁通过了首次丙型肝炎病毒自我检测的资格预审。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01

引用次数: 0

Unusual association of cervical arachnoid cyst and idiopathic intracranial hypertension. 颈椎蛛网膜囊肿与特发性颅内高压症的不寻常关联。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01 DOI: 10.17712/nsj.2024.4.20240005

Shirin H Alokayli, Sarah A Maghrabi, Fawaz S Almotairi, Sherif M Elwatidy

引用次数: 0

Assessment of social stigma among multiple sclerosis patients in Saudi Arabia: A cross-sectional study. 沙特阿拉伯多发性硬化症患者的社会耻辱感评估：一项横断面研究。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-10-01 DOI: 10.17712/nsj.2024.4.20240011

Rami M Algahtani, Mohammad O Abu Zahirah, Zainab I Alsuni, Ajwaad S Alfahmi, Asim S Alfahmi, Najla A Kabli

{"title":"Assessment of social stigma among multiple sclerosis patients in Saudi Arabia: A cross-sectional study.","authors":"Rami M Algahtani, Mohammad O Abu Zahirah, Zainab I Alsuni, Ajwaad S Alfahmi, Asim S Alfahmi, Najla A Kabli","doi":"10.17712/nsj.2024.4.20240011","DOIUrl":"10.17712/nsj.2024.4.20240011","url":null,"abstract":"Objectives: To assess the social stigma towards multiple sclerosis in Saudi Arabia.Methods: A descriptive cross-sectional online survey study was done in Saudi Arabia. It targets social stigma among multiple sclerosis patients in Saudi Arabia. This questionnaire was filled out by patients using Google Forms, and the questionnaire was designed to measure the demographic data and social Stigma using a validated RSS-MS scale.Results: After we applied the exclusion criteria, we received 381 MS patients who completed the study questionnaire. The results of the study showed that there are regions in the Kingdom of Saudi Arabia where the societal stigma towards multiple sclerosis is high compared to other regions in the Northern region (25.5±10.0) and the lowest among Eastern region patients (17.3±7.2). The study also, showed that unmarried people have a higher stigma compared to married patients (21.0±8.3 vs. 18.9±8.0, respectively; p=.011).Conclusion: Our study showed the extent of societal stigma towards patients with multiple sclerosis in the Kingdom of Saudi Arabia. We recommend more psychological and social support for patients with multiple sclerosis and more volunteer campaigns for the disease.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 4","pages":"246-251"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0