Neurosciences最新文献_第10页

Diagnostic effectiveness of deep learning-based MRI in predicting multiple sclerosis: A meta-analysis. 基于深度学习的磁共振成像在预测多发性硬化症方面的诊断效果：荟萃分析

IF 1.2 4区医学

Neurosciences Pub Date : 2024-05-01 DOI: 10.17712/nsj.2024.2.20230103

Tareef S Daqqaq, Ayman S Alhasan, Hadeel A Ghunaim

{"title":"Diagnostic effectiveness of deep learning-based MRI in predicting multiple sclerosis: A meta-analysis.","authors":"Tareef S Daqqaq, Ayman S Alhasan, Hadeel A Ghunaim","doi":"10.17712/nsj.2024.2.20230103","DOIUrl":"10.17712/nsj.2024.2.20230103","url":null,"abstract":"Objectives: The brain and spinal cord, constituting the central nervous system (CNS), could be impacted by an inflammatory disease known as multiple sclerosis (MS). The convolutional neural networks (CNN), a machine learning method, can detect lesions early by learning patterns on brain magnetic resonance image (MRI). We performed this study to investigate the diagnostic performance of CNN based MRI in the identification, classification, and segmentation of MS lesions.Methods: PubMed, Web of Science, Embase, the Cochrane Library, CINAHL, and Google Scholar were used to retrieve papers reporting the use of CNN based MRI in MS diagnosis. The accuracy, the specificity, the sensitivity, and the Dice Similarity Coefficient (DSC) were evaluated in this study.Results: In total, 2174 studies were identified and only 15 articles met the inclusion criteria. The 2D-3D CNN presented a high accuracy (98.81, 95% CI: 98.50-99.13), sensitivity (98.76, 95% CI: 98.42-99.10), and specificity (98.67, 95% CI: 98.22-99.12) in the identification of MS lesions. Regarding classification, the overall accuracy rate was significantly high (91.38, 95% CI: 83.23-99.54). A DSC rate of 63.78 (95% CI: 58.29-69.27) showed that 2D-3D CNN-based MRI performed highly in the segmentation of MS lesions. Sensitivity analysis showed that the results are consistent, indicating that this study is robust.Conclusion: This metanalysis revealed that 2D-3D CNN based MRI is an automated system that has high diagnostic performance and can promptly and effectively predict the disease.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 2","pages":"77-89"},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11305363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PSYCHEDELIC PSILOCYBIN-ASSISTED THERAPY REDUCES DEPRESSIVE SYMPTOMS IN ADULTS WITH CANCER AND DEPRESSION. 迷幻药迷幻药辅助疗法可减轻癌症和抑郁症成人患者的抑郁症状。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-05-01

引用次数: 0

A review of the gastrointestinal, olfactory, and skin abnormalities in patients with Parkinson's disease. 回顾帕金森病患者的胃肠道、嗅觉和皮肤异常。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-01-01 DOI: 10.17712/nsj.2024.1.20230062

Mohannad A Almikhlafi

引用次数: 0

Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population. 评估土耳其人群中精神分裂症患者的白细胞介素（IL）-2 和 IL-2RA 基因多态性之间的基因-基因相互作用。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-01-01 DOI: 10.17712/nsj.2024.1.20230075

Kursat Ozdilli, Hasan Mervan Aytac, Fatima Ceren Tuncel, Yasemin Oyaci, Mustafa Pehlivan, Sacide Pehlivan

{"title":"Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population.","authors":"Kursat Ozdilli, Hasan Mervan Aytac, Fatima Ceren Tuncel, Yasemin Oyaci, Mustafa Pehlivan, Sacide Pehlivan","doi":"10.17712/nsj.2024.1.20230075","DOIUrl":"10.17712/nsj.2024.1.20230075","url":null,"abstract":"Objectives: To evaluate the genetic polymorphisms in IL-2 and IL-2RA genes in schizophrenia (SCZ) patients by comparing them with healthy controls.Methods: A sample of 127 patients with SCZ and 100 healthy volunteers were included in the case-control study. These individuals were consecutively selected from the Malazgirt State Hospital Psychiatry Outpatient Clinic in Mus, Turkey, over the three months from October 2020 to December 2020. The Structured Clinical Interview for DSM-5 Disorders, Clinician Version (SCID-5-CV) was used to confirm the diagnosis according to the DSM-5 criteria. In addition, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine gene polymorphisms from DNA material.Results: Our findings indicated significant differences in the IL-2 genotype and allele frequencies between SCZ patients and the healthy control group. Specifically, the frequency of the homozygous GG genotype was notably higher in SCZ patients compared to the control group. Conversely, when comparing the IL-2RA genotype and allele frequencies of SCZ patients with the control group, no statistically significant differences were observed between the 2 groups. When compared to individuals with other genotypes, interaction analysis indicated that carriers of the GG/AG (IL-2/IL-2RA) genotype demonstrated a significantly increased risk of SCZ.Conclusion: In light of the analyses, our study indicates that while the IL-2 genotype polymorphism may be considered a risk factor for developing SCZ, the IL-2RA variant was not associated with SCZ among Turkish patients.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 1","pages":"51-56"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of radiology modalities in diagnosing and characterizing brain disorders. 放射学模式在诊断和描述脑部疾病方面的有效性。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-01-01 DOI: 10.17712/nsj.2024.1.20230048

Sadeem Aljahdali, Ghofran Azim, Waad Zabani, Saeed Bafaraj, Jaber Alyami, Ahmed Abduljabbar

{"title":"Effectiveness of radiology modalities in diagnosing and characterizing brain disorders.","authors":"Sadeem Aljahdali, Ghofran Azim, Waad Zabani, Saeed Bafaraj, Jaber Alyami, Ahmed Abduljabbar","doi":"10.17712/nsj.2024.1.20230048","DOIUrl":"10.17712/nsj.2024.1.20230048","url":null,"abstract":"Objectives: To observe the accuracy of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) scans in evaluating neurological disorders.Methods: This retrospective research used CT or MRI to diagnose and characterize brain disorders. Patients' records suffering from neurological disorders were considered eligible for inclusion, regardless of the time of appearance of symptoms, the severity of their symptoms, or their final clinical diagnosis. The exclusion criteria for this study involved patients who did not undergo either a CT or MRI scan. A chi-square test was performed to observe the association between the study variables. A total of 3155 cases were analyzed.Results: The most prevalent comorbid was dyslipidemia 670 (21.6%) followed by hypertension 548 (17.6%). Overall brain disorders were confirmed in 2426 (77%) patients. It was observed that half of the patients 1543 (48.9%) were diagnosed with stroke. It was found that the accuracy of CT and MRI was 78% and 74% respectively. The association of modalities, patient type, and gender with the confirmation of diseases was not found significant (p=>0.05).Conclusion: Our study revealed that CT and MRI were accurate by more than 75% and no difference was between both techniques to detect neurological disorders.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 1","pages":"37-43"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Working under the sun causes 1 in 3 deaths from non-melanoma skin cancer, say WHO AND ILO. 世界卫生组织和国际劳工组织表示，在阳光下工作导致每 3 人中就有 1 人死于非黑色素瘤皮肤癌。

IF 0.9 4区医学

Neurosciences Pub Date : 2024-01-01

引用次数: 0

Vagus nerve stimulation in medically refractory epilepsy: Adverse effects and clinical correlates. 迷走神经刺激治疗药物难治性癫痫：不良反应和临床相关性。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-01-01 DOI: 10.17712/nsj.2024.1.20230006

Khaled A Alshehri, Shaima H Abuhulayqah, Mohammed A Asiry, Suad A Alyamani

{"title":"Vagus nerve stimulation in medically refractory epilepsy: Adverse effects and clinical correlates.","authors":"Khaled A Alshehri, Shaima H Abuhulayqah, Mohammed A Asiry, Suad A Alyamani","doi":"10.17712/nsj.2024.1.20230006","DOIUrl":"10.17712/nsj.2024.1.20230006","url":null,"abstract":"Objectives: To assess the frequency of adverse effects among pediatric and adult patients and the clinical variables associated with a higher probability of developing side effects.Methods: This retrospective study enrolled pediatric and adult patients who underwent Vagus nerve stimulation (VNS) implantation at our institution and had documented follow-up during clinic visits for at least 6 months after implantation. Data collected included demographic information, epilepsy diagnosis, and device data.Results: A total of 43 patients with drug-resistant epilepsy who received a VNS device at our institution were enrolled. The median follow-up period was 12 months. Fourteen patients (32.55%) reported no side effects from VNS therapy. Side effects ranged from mild to severe, with significant side effects observed in 8 patients. Data on therapy efficacy were collected, and 10 patients (23.26%) reported no change in seizure frequency following device implantation.Conclusion: This study demonstrates that VNS is an important adjunct treatment option for epilepsy patients. Dysphagia and dyspnea can be significant adverse effects leading to treatment discontinuation, aspiration pneumonia, intensive care unit (ICU) admission, and prolonged hospital stay. These effects are more frequent in patients with symptomatic generalized epilepsy, global developmental delay at baseline, previous ICU admissions, abnormal brain magnetic resonance imaging findings, and seizures with multiple semiologies.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"29 1","pages":"10-17"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: A relapse of Guillain-Barre syndrome caused by SARS-CoV-2 is not uncommon. 评论由 SARS-CoV-2 引起的格林-巴利综合征复发并不少见。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-01-01 DOI: 10.17712/nsj.2024.1.20230104

Sounira Mehri, Josef Finsterer, Vladimir S Jankovic

引用次数: 0

Comment on: Hydrodiscectomy is not indicated in patients with chronic radicular pain as long as all differentials have been ruled out. 评论：只要排除了所有鉴别因素，慢性根性疼痛患者就不适合进行水动力切除术。

IF 1.2 4区医学

Neurosciences Pub Date : 2024-01-01 DOI: 10.17712/nsj.2024.1.20230101

Josef Finsterer, Mohamed A Elkhalifa

引用次数: 0

Do allergic conditions increase the risk of developing Long-COVID after SARS-CoV-2 infection? 过敏性疾病是否会增加感染 SARS-CoV-2 后患 Long-COVID 的风险？