Neurosciences最新文献_第3页

Analysis of key lncRNA related to Parkinson's disease based on gene co-expression weight networks. 基于基因共表达权重网络的帕金森病相关关键lncRNA分析

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20230112

Wenwen Liang, Wei Zhao, Binghan Li, Jiaying Luo, Xuemei Li, Weihua Jia

{"title":"Analysis of key lncRNA related to Parkinson's disease based on gene co-expression weight networks.","authors":"Wenwen Liang, Wei Zhao, Binghan Li, Jiaying Luo, Xuemei Li, Weihua Jia","doi":"10.17712/nsj.2025.1.20230112","DOIUrl":"10.17712/nsj.2025.1.20230112","url":null,"abstract":"Objectives: To identify a key Long chain non-coding RNAs (lncRNAs) related to PD and provide a new perspective on the role of LncRNAs in Parkinson's disease (PD) pathophysiology.Methods: Our study involved analyzing gene chips from the substantia nigra and white blood cells, both normal and PD-inclusive, in the Gene Expression Omnibus (GEO) database, utilizing a weighted gene co-expression network analysis (WGCNA). The technique of WGCNA facilitated the examination of differentially expressed genes (DEGs) in the substantia nigra and the white blood cells of individuals with PD. When merged with clinical data, gene modules containing crucial clinical details were chosen for network integration in GO and KEGG enrichment analysis.Results: A pair of LncRNA modules were identified. The crucial component in GSE7621 was the turquoise module. The DEGs were acquired using GSE133347. GO functions focused on phosphatidylinositol phosphate binding, inflammatory responses, and the regulation of nerves and synapses. KEGG analyses were largely enriched within the P13K-Akt, FaxO, mTOR, Oxytocin, and cGMP-PKG signaling pathways. A Venn diagram revealed that the two key LncRNA were CH17-189H20.1 and RP11-168O16.1.Conclusion: Using the WGCNA method, we obtained PD-related modules, identified biologically significant gene modules, obtained core LncRNAs, and found potential target genes for enrichment analysis. The objective of our research was to advance more detailed and efficient treatment methods for lncRNAs associated with PD.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"20-29"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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MEASLES CASES SURGE WORLDWIDE, INFECTING 10.3 MILLION PEOPLE IN 2023. 全球麻疹病例激增，2023年感染1030万人。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01

引用次数: 0

Structural and functional changes in the hippocampus induced by environmental exposures. 环境暴露引起的海马体结构和功能变化。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240052

Emad A Albadawi

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Comment on: When assessing the risk of cerebral edema after aneurysm clipping, all contributing factors must be taken into account. 点评：在评估动脉瘤夹闭后脑水肿的风险时，必须考虑所有因素。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240107

引用次数: 0

Understanding the stroke burden in Saudi Arabia: Trends from 1990 to 2019 and forecasting through time series analysis. 了解沙特阿拉伯的中风负担：1990年至2019年的趋势以及通过时间序列分析进行预测。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240092

Ahmed A Mahfouz, Shaimaa A Abdelmoneim, Shymaa M M Abdu, Hoda A A Shiba, Asmaa M AboElela, Ramy M Ghazy, Adel A Alhazzani

{"title":"Understanding the stroke burden in Saudi Arabia: Trends from 1990 to 2019 and forecasting through time series analysis.","authors":"Ahmed A Mahfouz, Shaimaa A Abdelmoneim, Shymaa M M Abdu, Hoda A A Shiba, Asmaa M AboElela, Ramy M Ghazy, Adel A Alhazzani","doi":"10.17712/nsj.2025.1.20240092","DOIUrl":"10.17712/nsj.2025.1.20240092","url":null,"abstract":"Objectives: To describe age-standardized incidence and disability-adjusted life years (DALYs) of ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in the Kingdom of Saudi Arabia (KSA) from 1990 to 2019 and forecast these variables using the Global Burden of Diseases (GBD) data over the next years (2020-2030).Methods: Poisson regression models were employed to identify significant changes in incidence rate ratios (IRRs) and DALY rates for different stroke types. For time series models, the autoregressive integrated moving average (ARIMA) and exponential smoothing state space (ETS) models were used for forecasting.Results: The study demonstrated an increasing trend in the age-standardized incidence rate per 100,000 different types of strokes over the last 30 years, with a slight decrease in ICH and SAH types in 2015, followed by a continued increase. The prediction models indicated a sustained increase in the 3 types of strokes, accompanied by a decrease in DALYs. As regards DALYs, the trend for IS and ICH has been slowly and steadily increasing; however, there will be a modest decrease in DALYs rates for SAH during the next decade.Conclusion: Stroke rates in KSA have increased over 3 decades, mainly among women and older individuals, and have a slow sustained increase over the forecasted period (2020-2030); thus, proactive strategies and healthcare interventions are required.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"49-58"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Prevalence and factors influencing eating disorders among post-bariatric surgery patients in Saudi Arabia: A cross-sectional study. 沙特阿拉伯减肥手术后患者饮食失调患病率及影响因素：一项横断面研究

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240023

Saleh A Alghamdi, Mohammed A Al Jaffer, Renad A Almesned, Sadeem D Alanazi, Alanoud W Alhnake, Shahad M Alkhammash, Nuran M Baabbad

{"title":"Prevalence and factors influencing eating disorders among post-bariatric surgery patients in Saudi Arabia: A cross-sectional study.","authors":"Saleh A Alghamdi, Mohammed A Al Jaffer, Renad A Almesned, Sadeem D Alanazi, Alanoud W Alhnake, Shahad M Alkhammash, Nuran M Baabbad","doi":"10.17712/nsj.2025.1.20240023","DOIUrl":"10.17712/nsj.2025.1.20240023","url":null,"abstract":"Objectives: To examine the occurrence and contributing factors of disordered eating patterns in individuals post-bariatric surgery. It also investigated the impact of these patterns on weight loss outcomes and long-term weight management, focusing on psychological and emotional factors. Additionally, the relationship between body image dissatisfaction and disordered eating patterns was explored.Methods: A cross-sectional study was conducted across multiple medical centers in Saudi Arabia, using self-administered questionnaires to evaluate the prevalence of eating disorders and self-esteem among patients who underwent bariatric surgery in the past five years. Out of 557 respondents, 452 met the inclusion criteria.Results: The study found that 21.5% of participants experienced psychological disorders post-surgery. Notably, there was a significant improvement in mean self-esteem scores after surgery. Depression was the most frequently reported disorder (12.4%), followed by Generalized Anxiety Disorder (9.3%) and Eating Disorders (4.6%). The mean Rosenberg Self-esteem Scale score increased significantly from 28.17±6.2 pre-surgery to 31.7±5.3 post-surgery (p<0.001).Conclusion: The findings highlight a notable prevalence of psychological disorders among post-bariatric surgery patients, with depression being the most common. Despite this, significant improvements in self-esteem were observed. Understanding the psychological and emotional factors contributing to disordered eating patterns and body image dissatisfaction is crucial for improving long-term weight management and patient outcomes post-surgery.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"36-43"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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WHO ADDS LC16M8 MPOX VACCINE TO EMERGENCY USE LISTING. Who将lc16m8 m痘疫苗添加到紧急使用清单中。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01

引用次数: 0

Comparing the clinical efficacy of preganglionic and preganglionic plus ganglionic transforaminal epidural steroid injections for lumbosacral radicular pain. 节前与节前加节前经椎间孔硬膜外注射类固醇治疗腰骶神经根性疼痛的临床疗效比较。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2025.1.20240064

Hamit Göksu, Şeref Celik, Erkan Y Akcaboy, Şaziye Şahin, Müge Baran, Gökhan Yıldız, Samet S Kaya, Mustafa Y Ayhan

{"title":"Comparing the clinical efficacy of preganglionic and preganglionic plus ganglionic transforaminal epidural steroid injections for lumbosacral radicular pain.","authors":"Hamit Göksu, Şeref Celik, Erkan Y Akcaboy, Şaziye Şahin, Müge Baran, Gökhan Yıldız, Samet S Kaya, Mustafa Y Ayhan","doi":"10.17712/nsj.2025.1.20240064","DOIUrl":"10.17712/nsj.2025.1.20240064","url":null,"abstract":"Objectives: To compare the effectiveness of preganglionic transforaminal epidural steroid injection (TFESI) with preganglionic plus postganglionic TFESI.Methods: Patients with unilateral radicular pain and disc pathology were randomly assigned to either the preganglionic group or the preganglionic plus postganglionic group. All patients were evaluated using a numeric rating scale (NRS) and a patient satisfaction scale (PSS) at the third week and the third month after treatment.Results: There were significant differences between the patients' NRS scores after TFESI for both groups. In terms of >50% pain relief at three weeks and 3 months post-treatment, no significant differences were found between the groups (p>0.05). The PSS scores of the preganglionic plus postganglionic group were significantly lower at third month than at the third week (p=0.046). The PSS scores of the two groups were similar at third week and third month (p>0.05). A weak negative correlation was found between age and meaningful pain relief at the third month (Rho=.278, p=0.024). A moderate positive correlation was found between meaningful pain relief at the third week and meaningful pain relief the third month (Rho=.465, p<0.001). Male gender showed a weak positive correlation with meaningful pain relief at the third week (Rho=.281, p=0.022) and the third month (Rho=.256, p=0.038) CONCLUSION: The combined preganglionic plus postganglionic approach for TFESI did not affect the outcomes in patients with unilateral discogenic radicular pain. The preganglionic TFESI approach alone at the disc level was sufficient to achieve pain relief.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 1","pages":"44-48"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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STUDY REVEALS LINKS BETWEEN MANY PESTICIDES AND PROSTATE CANCER. 研究揭示了许多杀虫剂与前列腺癌之间的联系。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01

引用次数: 0

Editorial Message. 编辑信息。

IF 1.2 4区医学

Neurosciences Pub Date : 2025-01-01 DOI: 10.17712/nsj.2024.1.20241111

引用次数: 0