Neurosciences最新文献_第3页

Epilepsy and Cluster C Personality Disorders: A Saudi Cross-Sectional Study. 癫痫和C类人格障碍：沙特横断面研究。

IF 2.3 4区医学

Neurosciences Pub Date : 2026-02-01 Epub Date: 2026-04-30 DOI: 10.17712/1658-3183.2794

Mohammed A Aljaffer, Ahmad H Almadani, Ayedh H Alghamdi, Mohammad N Aljarba, Azzam A Alotaibi, Mohammed A Alorayyidh, Abdulaziz M Alawwad, Rakan S Alromayan, Faisal M Alkhunein, Sohaila A Alshimemeri, Bandar N Aljafen

{"title":"Epilepsy and Cluster C Personality Disorders: A Saudi Cross-Sectional Study.","authors":"Mohammed A Aljaffer, Ahmad H Almadani, Ayedh H Alghamdi, Mohammad N Aljarba, Azzam A Alotaibi, Mohammed A Alorayyidh, Abdulaziz M Alawwad, Rakan S Alromayan, Faisal M Alkhunein, Sohaila A Alshimemeri, Bandar N Aljafen","doi":"10.17712/1658-3183.2794","DOIUrl":"10.17712/1658-3183.2794","url":null,"abstract":"Objective: Epilepsy is a neurological disorder with profound impacts on various aspects of life. It may lead to significant medical and psychiatric comorbidities, one of which is personality disorders (PDs). This study aims to assess the prevalence of Cluster C PDs among adult patients with epilepsy (PWE) at a tertiary care hospital in Riyadh, Saudi Arabia.Method: This cross-sectional study, conducted between January 2024 and April 2025, enroled 360 adult PWE using convenience sampling. The study tool included the Structured Clinical Interview for DSM Disorders criteria, along with additional demographic and epilepsy-related questions developed by the research team.Results: Cluster C PDs were identified in 30. 6% of the participants. Obsessive-compulsive PD was the most prevalent (17. 8%), followed by avoidant PD (9.7%). No significant gender difference was found in the prevalence of PDs (p > 0.05). Educational level and employment status were significantly associated with PDs (p=0.036 and 0.014, respectively). Participants with PDs had a longer mean epilepsy duration than those without PDs (p < 0.05).Conclusion: Cluster C PDs are prevalent among PWE, with lower educational levels, longer epilepsy duration, and unemployment being significantly associated with a higher prevalence. Screening for PDs among PWE is therefore warranted to enable earlier detection and intervention.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 2","pages":"174-180"},"PeriodicalIF":2.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Epileptic Seizures From EEG Signals Using Machine Learning. 利用机器学习从脑电图信号预测癫痫发作。

IF 2.3 4区医学

Neurosciences Pub Date : 2026-02-01 Epub Date: 2026-04-30 DOI: 10.17712/1658-3183.2789

Hamzah Luqman, Galal M BinMakhashen, Hanan AlAli, Marwa AlSleebi, Hamdi A Al-Jamimi, Motaz Alfarraj, Shahid Bashir, Brent Hedgcock, Ali Mir, Raidah AlBaradie

{"title":"Predicting Epileptic Seizures From EEG Signals Using Machine Learning.","authors":"Hamzah Luqman, Galal M BinMakhashen, Hanan AlAli, Marwa AlSleebi, Hamdi A Al-Jamimi, Motaz Alfarraj, Shahid Bashir, Brent Hedgcock, Ali Mir, Raidah AlBaradie","doi":"10.17712/1658-3183.2789","DOIUrl":"10.17712/1658-3183.2789","url":null,"abstract":"Objective: To develop a machine learning-based model for predicting epileptic seizures by analyzing electroencephalogram (EEG) signals and classifying the interictal and preictal phases.Methods: The EEG signals were analyzed in both the time and frequency domains using advanced feature extraction techniques. Three different machine learning approaches were employed, with special focus on long short-term memory (LSTM) networks. Features were extracted and classified to differentiate between seizure and non-seizure phases. The proposed models were evaluated using the publicly available CHB-MIT EEG dataset. The study was conducted between September 2022 and September 2024.Results: Among the tested models, the LSTM-based approach using the full-feature extraction pipeline achieved the highest prediction accuracy of 97.73%. This performance demonstrates strong potential for real-time seizure forecasting.Conclusion: Machine learning, particularly LSTM models, can accurately predict epileptic seizures by analyzing EEG signal patterns. These findings support the development of automated seizure prediction systems that could significantly improve the quality of life for epilepsy patients.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 2","pages":"133-139"},"PeriodicalIF":2.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Bevacizumab in Multiple Glioblastomas: A Retrospective Single-Center Analysis. 贝伐单抗在多发性胶质母细胞瘤中的作用：回顾性单中心分析

IF 2.3 4区医学

Neurosciences Pub Date : 2026-02-01 Epub Date: 2026-04-30 DOI: 10.17712/1658-3183.2795

Yongrui Zhao, Yidong Chen, Leiming Wang, Ye Cheng, Feng Yan, Jiankun Xu

{"title":"Role of Bevacizumab in Multiple Glioblastomas: A Retrospective Single-Center Analysis.","authors":"Yongrui Zhao, Yidong Chen, Leiming Wang, Ye Cheng, Feng Yan, Jiankun Xu","doi":"10.17712/1658-3183.2795","DOIUrl":"10.17712/1658-3183.2795","url":null,"abstract":"Objective: To explore the prognostic factors of multiple glioblastomas (M-GBMs) and the role of bevacizumab (BEV) in M-GBMs.Methods: 162 patients treated for primary glioblastoma (GBM) from 2020 to 2024 were retrospectively reviewed. Kaplan-Meier analysis was performed to compare progression-free survival (PFS) and overall survival (OS) between the single glioblastoma (S-GBM) group and the M-GBMs group. Independent predictors of OS among M-GBMs patients were evaluated via multivariable Cox regression analysis.Results: 116 patients had S-GBM, and 46 had M-GBMs. Compared with S-GBM patients, M-GBMs patients had poorer PFS (6.5 vs. 11 months, p<0.001) and OS (15.5 vs. 21 months, p=0.005). In the M-GBMs group, based on the RANO resection criteria, both univariable analysis and multivariable Cox models confirmed that the extent of resection, use of radiotherapy and chemotherapy, p53 overexpression, and use of BEV were all factors that significantly influenced OS. Specifically, the use of BEV prolonged OS from 12 months to 19.5 months (p = 0.017). From the initiation of BEV therapy, the median PFS was 5.5 months (95% CI 4.45-6.56 months), and the median survival was significantly longer than in those who did not received BEV (10 vs. 3 months, p = 0.021).Conclusion: The extent of resection, radiotherapy/chemotherapy, p53 overexpression and BEV use emerged as independent prognostic factors in the M-GBMs cohort. BEV is effective as a salvage treatment against M-GBMs.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 2","pages":"181-188"},"PeriodicalIF":2.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Intake in Children with Cerebral Palsy: A Narrative Review Highlighting the Implications of Protein Intake on Muscle Mass, Growth, and Overall Nutritional Status. 脑性麻痹儿童的蛋白质摄入：一项强调蛋白质摄入对肌肉质量、生长和整体营养状况影响的叙述性综述。

IF 2.3 4区医学

Neurosciences Pub Date : 2026-02-01 Epub Date: 2026-04-30 DOI: 10.17712/1658-3183.2788

Manar Waleed Simbawa, Sheikha Nasser AlQahtnai

{"title":"Protein Intake in Children with Cerebral Palsy: A Narrative Review Highlighting the Implications of Protein Intake on Muscle Mass, Growth, and Overall Nutritional Status.","authors":"Manar Waleed Simbawa, Sheikha Nasser AlQahtnai","doi":"10.17712/1658-3183.2788","DOIUrl":"10.17712/1658-3183.2788","url":null,"abstract":"Children with cerebral palsy experience nutritional challenges that affect protein intake and may contribute to poor muscle mass and growth faltering. Since protein plays a major role in preserving muscle mass and supporting growth, ensuring adequate intake is critical. A comprehensive literature search was conducted for observational studies published between 2006 and 2025. The reviewed studies results were grouped into: [1] Protein intake, with values ranging from 0.66 to 4.1 g/kg/day, with higher intake observed among ambulatory or orally fed children, [2] Nutritional Status and Body Composition, as reduced muscle was reported in children with severe motor impairment, and [3] functional performance, as children with lower GMFCS levels had better protein intake and anthropometric measures. While current evidence suggests that protein intake may enhance body composition and support growth, there are still literature gaps regarding tailored protein needs. This review summarizes protein intake and its outcomes in CP.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 2","pages":"127-132"},"PeriodicalIF":2.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing Matters: Optimizing Oncology Involvement in Pediatric Neuro-Oncology Pathways in Saudi Arabia. 时机问题：优化肿瘤学参与儿童神经肿瘤学途径在沙特阿拉伯。

IF 2.3 4区医学

Neurosciences Pub Date : 2026-02-01 Epub Date: 2026-04-30 DOI: 10.17712/1658-3183.2792

Ali H Algiraigri, Mohammed Basamh, Ghadeer Alobaid, Lama M Alsulami, Razan A Almutairi, Zahraa S Alsultan, Rawan M Hammad

{"title":"Timing Matters: Optimizing Oncology Involvement in Pediatric Neuro-Oncology Pathways in Saudi Arabia.","authors":"Ali H Algiraigri, Mohammed Basamh, Ghadeer Alobaid, Lama M Alsulami, Razan A Almutairi, Zahraa S Alsultan, Rawan M Hammad","doi":"10.17712/1658-3183.2792","DOIUrl":"10.17712/1658-3183.2792","url":null,"abstract":"Objective: To explore current practices and barriers in pediatric neuro-oncology care coordination, and to identify opportunities to optimize care pathways. Timely coordination between pediatric neurosurgery and oncology is critical for optimal outcomes in children with central nervous system (CNS) tumors. However, in many centers, pediatric oncologists are not involved until after surgery, which contributes to treatment delays and repeated procedures.Methods: A cross-sectional survey was conducted among neurosurgeons and pediatric oncologists in Saudi Arabia. The questionnaire addressed the timing of oncological involvement, neuroimaging practices, cerebrospinal fluid (CSF) cytology collection, and opinions on care coordination solutions.Results: A total of 62 responses were obtained. Only 29% of the participants reported presurgical oncology involvement in their typical practice, whereas 58% indicated that involvement occurred only after the final pathology results were obtained. Neuroimaging protocols varied: only 56.5% always performed dedicated CNS tumor magnetic resonance imaging (MRI) protocols before surgery, and spinal MRI was often delayed. CSF cytology practices were inconsistent, and major barriers included the lack of multidisciplinary tumor boards and the belief that oncology input before pathology is unnecessary. Over 88% of the respondents supported the use of presurgical tumor boards as a solution.Conclusion: There is substantial heterogeneity in pediatric neuro-oncology coordination practices. Efforts to promote early oncology consultations, standardized imaging protocols, and integrated care discussions may bridge critical gaps in care delivery.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 2","pages":"158-163"},"PeriodicalIF":2.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Calculate the Nationwide Incidence/Prevalence Figures for Charcot-Marie-Tooth Disease, the Entire Population Must be Screened. 为了计算全国腓骨肌萎缩症的发病率/患病率，必须对整个人口进行筛查。

IF 2.3 4区医学

Neurosciences Pub Date : 2026-02-01 Epub Date: 2026-04-30 DOI: 10.17712/1658-3183.2796

Sinda Zarrouk, Josef Finsterer

引用次数: 0

Identifying Risk Factors for the Rising Prevalence of Multiple Sclerosis in Saudi Arabia: A case-control analysis. 确定沙特阿拉伯多发性硬化患病率上升的危险因素：一项病例对照分析。

IF 2.3 4区医学

Neurosciences Pub Date : 2026-01-01 Epub Date: 2026-03-27 DOI: 10.17712/1658-3183.1002

Omar Babateen, Jamil Adnan Samkari, Rewaa Abdulaziz Alkaki, Sadin Ayman Alamri, Manal Mutlaq Alzahrani, Mussaed Saleh Alharbi, Ali Abdulrazaq Alghamdi, Amwaj Sultan Aljurays, Amjad Faleh Aldosari, Seraj Makkawi

{"title":"Identifying Risk Factors for the Rising Prevalence of Multiple Sclerosis in Saudi Arabia: A case-control analysis.","authors":"Omar Babateen, Jamil Adnan Samkari, Rewaa Abdulaziz Alkaki, Sadin Ayman Alamri, Manal Mutlaq Alzahrani, Mussaed Saleh Alharbi, Ali Abdulrazaq Alghamdi, Amwaj Sultan Aljurays, Amjad Faleh Aldosari, Seraj Makkawi","doi":"10.17712/1658-3183.1002","DOIUrl":"10.17712/1658-3183.1002","url":null,"abstract":"Objective: This study aims to identify risk factors linked to the increasing prevalence of multiple sclerosis (MS) in Saudi Arabia. Multiple sclerosis is a chronic autoimmune condition affecting the central nervous system, marked by inflammation and damage to nerves and the myelin sheath.Method: A case-control study conducted from September 2022 to January 2024 included 832 participants-263 diagnosed with MS and 569 controls. Controls were matched by age, gender, residence, and employment status. Data was collected using a validated questionnaire, with written consent obtained from participants aged 18 and older. Logistic regression analysis was used to ascertain risk factors.Results: Out of 832 participants, 263 (31.6%) were diagnosed with MS. The greatest percentage of MS cases occurred in the 25-34 age range (37.7%). After adjusting for potential confounders, smoking was significantly associated with increased MS risk (AOR = 2.34, 95% CI: [1.22-4.48], p = 0.01), as were vitamin D deficiency (AOR = 1.97, 95% CI: [1.31-2.98], p<0.00), and a history of childhood sexual abuse (AOR = 1.96, 95% CI: [1.11-3.45], p = 0.02). Conversely, vitamin D supplementation was associated with a substantial reduction in MS risk (AOR = 0.17, 95% CI: [0.10-0.28], p < 0.001), as was coffee consumption (AOR = 0.53, 95% CI: [0.30-0.96], p < 0.04).Conclusion: Smoking, vitamin D deficiency, and a history of childhood sexual abuse increase MS risk, while vitamin D supplementation and coffee consumption reduce it. Further research is essential to confirm these findings.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"18-25"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Key Attributes of an Ideal Neurology Residency Candidate: Program Directors' Perspectives. 理想的神经内科住院医师候选人的关键属性：项目主管的观点。

IF 2.3 4区医学

Neurosciences Pub Date : 2026-01-01 Epub Date: 2026-03-27 DOI: 10.17712/1658-3183.1005

Bandar N Aljafen, Ruwa A Alneseyan, Rahmah M Alsawad, Mohamed Bahr

{"title":"Key Attributes of an Ideal Neurology Residency Candidate: Program Directors' Perspectives.","authors":"Bandar N Aljafen, Ruwa A Alneseyan, Rahmah M Alsawad, Mohamed Bahr","doi":"10.17712/1658-3183.1005","DOIUrl":"10.17712/1658-3183.1005","url":null,"abstract":"Objectives: To guide medical students and interns interested in neurology by identifying the key attributes of an ideal neurology candidate from the perspectives of neurology program directors (PDs).Methods: In this cross-sectional study, former and current neurology PDs were contacted across Saudi Arabia to complete a self-administered survey sent via email or text. The survey included seven questions: six on PD demographics and a seventh with 51 items evaluating candidate attributes on a 7-point Likert scale from disadvantage to advantage.Results: Thirty-two neurology PDs filled out the questionnaire. Among the key attributes PDs prioritized in a candidate is their letter of recommendation, preferably from a neurologist working at the same center where the candidate applied (mean = 2.44 ± 1.01); this was followed by the teamwork traits demonstrated by the candidate during their interview (mean = 2.34 ± 1.00) and, finally, clerkships completed as an intern in neurology at the same hospital where the candidate applied (mean = 2.28 ± 1.11). A significant regional difference was found regarding candidates who undertook international medical licensing examinations, which was observed as a disadvantage in the central region but as an advantage in the eastern and western regions (p = 0.002) of Saudi Arabia.Conclusion: The PDs prioritized candidates' skills, educational background, and genuine interest in neurology. Regional differences in the importance of international licensing exams reflect varied expectations. Future global studies could help refine and unify selection criteria for a fairer process.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"41-46"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights Into Stroke Risk and Prediction for Underweight Individuals. 对体重过轻个体的中风风险和预测的见解。

IF 2.3 4区医学

Neurosciences Pub Date : 2026-01-01 Epub Date: 2026-03-27 DOI: 10.17712/1658-3183.1000

Saeed Awad M Alqahtani, Moutasem S Aboonq

{"title":"Insights Into Stroke Risk and Prediction for Underweight Individuals.","authors":"Saeed Awad M Alqahtani, Moutasem S Aboonq","doi":"10.17712/1658-3183.1000","DOIUrl":"10.17712/1658-3183.1000","url":null,"abstract":"This review explores the relationship between underweight status and stroke risk and outcomes. Although the impact of obesity on stroke is well-documented, the harmful effects of being underweight are often overlooked. Drawing on evidence from observational studies, case-control studies, and meta-analyses, this review highlights that underweight individuals face increased mortality, poorer functional recovery, and higher rates of major adverse cardiovascular events and recurrent strokes post-stroke. Challenges in stroke prediction for this population are examined, including the limited research focus, shortcomings of existing risk assessment tools such as the CHA2DS2-VASc score, and population-specific factors affecting underweight prevalence and outcomes. The review identifies key research gaps, emphasizing the need for longitudinal studies encompassing diverse populations to inform tailored preventive strategies and improve risk assessment. It concludes by advocating for individualized risk assessment approaches that integrate nutritional status and targeted interventions to reduce the elevated stroke risks associated with being underweight.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"1-8"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vagal Nerve Stimulation as Therapy for Drug-Resistant Epilepsy: A Tertiary Hospital Experience of Outcomes and Efficacy in King Abdullah Medical City. 迷走神经刺激治疗耐药癫痫：阿卜杜拉国王医疗城三级医院疗效观察

IF 2.3 4区医学

Neurosciences Pub Date : 2026-01-01 Epub Date: 2026-03-27 DOI: 10.17712/1658-3183.1012

Bassam G Sef, Abeer S AlBalawi, Ahmed M AlHajji, Muhammed M Irfan, Hanadi M Abu AlEla

{"title":"Vagal Nerve Stimulation as Therapy for Drug-Resistant Epilepsy: A Tertiary Hospital Experience of Outcomes and Efficacy in King Abdullah Medical City.","authors":"Bassam G Sef, Abeer S AlBalawi, Ahmed M AlHajji, Muhammed M Irfan, Hanadi M Abu AlEla","doi":"10.17712/1658-3183.1012","DOIUrl":"10.17712/1658-3183.1012","url":null,"abstract":"Objective: To determine the efficacy and safety of vagus nerve stimulation (VNS) for reducing the frequency of seizures and complications in drug-resistant epilepsy.Methods: This was a retrospective case series study conducted in King Abdullah Medical City from January 2015 to December 2021 hospital record. All patients undergoing VNS were enrolled according to inclusion and exclusion criteria. Patients were followed up for 12 months, and the seizure frequency and number of epileptic drugs used were evaluated. A paired sample t-test was applied to compare the outcome variables considering p-value < 0.05 as significant.Results: Among 9 enrolled patients, four were females, and five were males. The mean age of the patients was 23.9 ± 10.8 years. The average number of drugs used before VNS was 3, while it was 2 after VNS. However, a statistically significant (p = 0.08) reduction was not achieved. The mean seizure frequency before and after VNS was 14.4 ± 4.0 and 2.2 ± 3.2 at the 12-month follow-up visit (p < 0.05). The seizure frequency was statistically significantly reduced since the p-value was less than 0.05. No significant complications or death were observed.Conclusion: The VNS is a safe and effective adjuvant therapy for reducing the frequency of seizures in patients with drug-resistant epilepsy.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"85-88"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0