Neurosciences最新文献

{"title":"The Incidence Rate of Post-Stroke Epilepsy: A Multi-Center, Retrospective Study in Taif City.","authors":"Adnan A Mubaraki, Shomoukh A Alhumyani, Arwa M Altowairqi, Liyan K Abu Rukbah, Hanouf H Alhamyani, Alhanouf A Alkhaldi, Mohammed S Alhamyani, Mohammed M Algethami","doi":"10.17712/1658-3183.1008","DOIUrl":"10.17712/1658-3183.1008","url":null,"abstract":"<p><strong>Background: </strong>The International League Against Epilepsy in 2014, defined epilepsy in any patient who has experienced one unprovoked seizure and has a probability of further seizures similar to the general recurrence risk (at least 60%) after 2 unprovoked seizures occurring over the next 10 years. Epilepsy patients are classified into 2 groups: early post-stroke seizures (EPSS), including patients who experience a seizure within 1 week of stroke onset, and late PSS (LPSS), including those who have a seizure more than 1 week after the stroke.</p><p><strong>Methods: </strong>This retrospective, record-based study was conducted between January 2021 and December 2024. A total of 486 stroke patients were screened. After excluding 241 patients with prior brain tumors, surgeries, or stroke events, 245 patients were included. Data were collected using a structured checklist covering demographic characteristics, seizure risk factors, stroke type and mechanism, seizure type, and timing of PSE diagnosis. Statistical analyses were performed using SPSS. Chi-square tests and logistic regression were used to evaluate the associations between risk factors and PSE development.</p><p><strong>Results: </strong>Of the 245 patients, 17 (6.9%) developed PSE. Among them, 41.2% were classified as having EPSS and 58.8% as having LPSE. Most PSE patients were men and married. Most seizures were of an unknown type. A statistically significant association was found between the mechanism of stroke and the development of PSE (p = 0.021), particularly cardioembolic and atherosclerotic (thrombotic) stroke. Other variables including age, sex, ICU admission, and comorbidities did not show statistically significant associations.</p><p><strong>Conclusion: </strong>The incidence of PSS in this study was 6.9%. LPSS was more common than EPSS. The development of PSE was significantly associated with stroke mechanisms, particularly cardioembolic and thrombotic stroke, whereas other risk factors showed no significant relationship.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"60-66"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Erenumab in Patients With Treatment-Resistant Chronic Migraine and Medication Overuse Headache.","authors":"Mohamed F Binfalah, Anwar A Alrayyes, Hussein H Alhafnawi, Moiz O Bakhiet","doi":"10.17712/1658-3183.1006","DOIUrl":"10.17712/1658-3183.1006","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of erenumab, a monoclonal antibody that targets the calcitonin gene-related peptide (CGRP) receptor, in patients with treatment-resistant chronic migraine and medication overuse headache.</p><p><strong>Methods: </strong>A single-center, retrospective observational study conducted at University Medical Center on 73 patients with both medication-overuse headache and treatment-resistant chronic migraine who failed at least three oral preventive medications and/or botulinum toxin injections. Clinical data were extracted from the medical records and patient interviews. The patients received monthly erenumab injections 70 mg. Key outcomes included monthly migraine days, headache severity (visual analog scale [VAS]), headache impact test (HIT-6), acute medication use, and global impression of change (PGIC) over a 3-month follow-up period.</p><p><strong>Results: </strong>Significant reductions were observed in monthly migraine days (mean: 12.3 days, p<0.001), HIT-6 scores (mean: 21 points, P <0.001), headache severity (VAS score reduction: 6.1, P <0.001), and acute medication use (mean: 14.8 days, P <0.001). Most patients reported a \"very good\" or \"good\" improvement with minimal side effects.</p><p><strong>Conclusion: </strong>Erenumab demonstrated substantial efficacy and safety in reducing the frequency and severity of chronic migraine with medication overuse, improving the quality of life, and decreasing acute medications use. These findings support its role as a valuable therapeutic option for this challenging condition.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"47-54"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel <i>ENPP</i>1 Gene Mutation Causing Generalized Arterial Calcification of Infancy: A case report.","authors":"Haifa M AlTurki, Haya S AlFaris, Mohammed A Al-Owain, Musaad F Abukhalid","doi":"10.17712/1658-3183.1011","DOIUrl":"10.17712/1658-3183.1011","url":null,"abstract":"<p><p>Generalized Arterial Calcification of Infancy (GACI), a complex disorder affecting multiple systems, stems from an autosomal recessive mutation in the <i>ENPP1</i> gene. This condition is marked by arterial stenosis and usually manifests prenatally or in the initial months following birth. High mortality rates characterize the first few months, a phase often termed the \"critical period.\" The report presents a case study of a four-year-old female with a new mutation in the <i>ENPP1</i> gene, which broadens our understanding of this rare genetic disorder.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"80-84"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Aetiologies, and Disposition Outcomes of Patients Presenting with Altered Mental Status in an Academic Emergency Department.","authors":"Zohair A Al Aseri, Omar M Alotaibi, Ibrahim M A Albarrak, Saif A S Aljaghwani, Ahmed M A Alkhars, Marwan M Althubaiti, Abdulaziz A Alkathami, Abdullah R A Alanazi, Fahad I Abuguyan","doi":"10.17712/1658-3183.1009","DOIUrl":"10.17712/1658-3183.1009","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the clinical characteristics, aetiologies, and disposition outcomes of patients presenting with altered mental status (AMS) in an academic emergency department, as well as to explore factors associated with hospitalization, intubation, and mortality.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 142 AMS patients presenting to the Emergency Department of <b>(Blinded for Review)</b> between December 2019 and December 2022. Adults (≥18 years) with documented AMS were enrolled, excluding those who died upon arrival or with iatrogenic AMS. Demographic, clinical presentation, comorbidity, medication, aetiology, intervention, and disposition outcome data, were extracted from the electronic System for Integrated Health Information.</p><p><strong>Results: </strong>The cohort (N = 142, mean age of 44.7 ± 21.1 years) was predominantly male (58.5%), and 83.1% of patients developed symptoms within 1 hour. Chronic comorbidities included diabetes (28.9%) and hypertension (28.2%), with frequent use of antihypertensives (23.2%), insulin (17.6%), and anticonvulsants (18.3%). Aetiologies were neurological (24.6%), drug abuse (24.6%), cardiovascular (15.5%), and endocrine/metabolic (12.0%). Most patients were discharged (81.7%), but the mortality rate was 4.2%. Intubation rate was 5.6%, of which intubation was primarily for traumatic AMS patients (37.5%), and all the intubated patients were male (p = 0.021). Males accounted for 83.3% of fatalities.</p><p><strong>Conclusion: </strong>The present study identified key AMS patterns, including high-risk aetiologies (cardiovascular and traumatic) and male-dominated disparities (intubation and mortality). These findings advocate for aetiology-specific protocols and reassessment of potential sex biases in acute care.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"67-74"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Extracranial Artery Stenosis and Cerebral Small-Vessel Disease in Patients with Ischemic Stroke.","authors":"Ahmad Ghoochani-Khorasani, Seyed Hadi Aghili, Seyed Zakaria Hosseini, Seyed Amir Hasan Habibi, Mehri FarhangRanjbar, Mahdi Abdi","doi":"10.17712/1658-3183.1007","DOIUrl":"10.17712/1658-3183.1007","url":null,"abstract":"<p><strong>Objective: </strong>To review the relationship between extracranial artery stenosis (ECAS) severity and total cerebral small-vessel disease (CSVD) burden and evaluated 5-year mortality, disability, and stroke recurrence in ischemic stroke patients. Cerebral small-vessel disease and ECAS often share risk factors such as hypertension and atherosclerosis and coexist in ischemic stroke. Although ECAS affects large-artery disease, its impact on total CSVD burden on MRI and subsequent clinical outcomes is not well defined.</p><p><strong>Methods: </strong>We retrospectively reviewed the medical records of 348 patients older than 35 who had suffered acute ischemic stroke and were admitted to selected hospitals in Tehran, Iran from March 2018-March 2020. The patients were stratified into 4 ECAS groups, and brain MRIs were scored to yield a total CSVD burden score. Ordinal logistic regression was used to examine the association between ECAS category and CSVD score, adjusting for age, sex, hypertension, diabetes mellitus, and hyperlipidemia. Logistic regression assessed 5-year outcomes.</p><p><strong>Results: </strong>Of the 309 patients with complete imaging, increasing ECAS severity was independently associated with a higher CSVD burden (adjusted OR 1.86; 95% CI 1.56-2.22; p<0.001). Five-year mortality was 39.9%, and severe ECAS predicted lower survival rates (adjusted OR 2.43; 95% CI 1.02-5.78; p = 0.045). However, ECAS was not linked to disability (p = 0.077) or recurrence (p = 0.191).</p><p><strong>Conclusions: </strong>We found that ECAS severity correlated with greater CSVD burden and poorer long-term survival in ischemic stroke.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"55-59"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and Molecular Characterization of Infant-Type Hemispheric Glioma.","authors":"Murad A Alturkustani","doi":"10.17712/1658-3183.1001","DOIUrl":"10.17712/1658-3183.1001","url":null,"abstract":"<p><strong>Objectives: </strong>To characterize the clinical, histopathological, and molecular features of infant-type hemispheric glioma (IHG) and explore any overlaps it might have with other types of pediatric gliomas.</p><p><strong>Methods: </strong>Data from the Children's Brain Tumor Network (CBTN) were analyzed (last accessed in January 2025), with a focus on patients aged 0-4 years with gliomas, glioneuronal tumors, or ependymomas. This analysis encompassed the clinical, histological, and molecular profiles of the cases, including those with recurrent tumors. The study scrutinized the tumor circumscription, grading features, and molecular alterations, along with the Methylation Class, using methylation profiling via the Heidelberg v12.5 and v12.8 classifiers.</p><p><strong>Results: </strong>IHG is predominantly well-circumscribed, but recurrence may lead to infiltrative growth. Novel findings include the acquisition of additional genetic alterations in recurrent IHG, which alters prognosis. One case exhibited progression to a pleomorphic xanthoastrocytoma-like profile, while another acquired glioblastoma-like infiltrative pattern and <i>TP53</i> mutations, associated with a more aggressive course. Distinguishing IHG from desmoplastic infantile ganglioglioma/astrocytoma (DIG/A) and Pediatric High-Grade Gliomas (pHGG) remains challenging, particularly in the absence of molecular data.</p><p><strong>Conclusion: </strong>This study emphasizes the heterogeneity of IHG and underscores the necessity for molecular surveillance in recurrent instances. The findings aid in refining diagnostic criteria and understanding the prognostic implications of genetic alterations in IHG.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"9-17"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Burnout and Sleep Deprivation on the Clinical Performance of Neurology Residents: A Cross-Sectional Country Wide Study.","authors":"Bandar N Aljafen, Walaa S Alkhamis, Rahmah M Alsawad, Israa B Alhamoud, Zahra B Alamer, Waad A Alshanqiti, Rawan M Alenez","doi":"10.17712/1658-3183.1003","DOIUrl":"10.17712/1658-3183.1003","url":null,"abstract":"<p><strong>Objective: </strong>To assess burnout (BU) and sleep deprivation (SD) among neurology residents and their impact on clinical performance (CP). This study is based on a neurology residents from Saudi Arabia.</p><p><strong>Methods: </strong>This multi-centric, cross-sectional study invited 214 registered neurology residents in the country; 179 participated in the study. The Maslach Burnout Inventory (MBI), the Pittsburgh Sleep Quality Index (PSQI), and the Medical Council of Canada's Physicians' Self-Assessment Questionnaire (PSAQ) were used to evaluate burnout (BU) and sleep deprivation (SD) among neurology residents and their impact on clinical performance (CP).</p><p><strong>Results: </strong>Of the total 214 registered neurology residents, 179 participated in the study. About 50% reported irregularity in daily meals, while >50% failed to exercise due to time constraints. More than 80% of residents had moderate-to-high levels of emotional exhaustion (EE) and depersonalisation (DP), and 90% had low personal accomplishment (PA). The global PSQI score of 9.3 resulted from mediocre sleep quality, poor sleep duration, high sleep latency and daytime dysfunction. Moreover, 83.2% of residents complained of SD and opined that it affects their mental capability at work. Regarding residents' CP, 49.44% were high performers, while the proportion of low performers was marginally higher at 50.56%. The rampant prevalence of moderate-to-high EE and DP and poor PSQI scores had a significantly negative correlation with residents' CP (p= 0.0168, 0.0011 and 0.0441, respectively), CP correlated positively with PA levels (p=0.0045).</p><p><strong>Conclusion: </strong>Moderate to high levels of BU prevail among neurology residents in Saudi Arabia. A high number of neurology residents suffer from sleep disturbances. Both BU and SD exert a detrimental impact on neurology residents' CP, which adversely affects the quality of neurological care delivered by the burned-out and sleep-deprived residents.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"26-33"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Long-Term Outcome and Recurrence of Intramedullary Spinal Ependymomas: A multicenter study.","authors":"Reem Albuhairan, Laila Alqahtani, Ahmed Gamal Sayed, Ali Alkhaibary, Sami Khairy, Faisal Farash, Ali H Alassiri, Ahmed Alkhani","doi":"10.17712/1658-3183.1004","DOIUrl":"10.17712/1658-3183.1004","url":null,"abstract":"<p><strong>Objectives: </strong>To define prognostic factors that affect clinical outcome of patients after surgical resection of spinal intramedullary ependymoma.</p><p><strong>Methods: </strong>A retrospective multi-center study, including all cases operated on from 2007 through 2024 at 3 institutes. Data on surgical factors included: resection extent, intraoperative neurophysiology monitoring methods, and intraoperative/postoperative complications.</p><p><strong>Results: </strong>A total of 19 patients were included with a mean age of 37.8 years (SD = 13.2, range 8-57 years). The majority of ependymomas (n = 14, 73.7%) were in the cervical region. The most common presenting symptoms included pain in 14 patients (73.7%), sensory deficits in 11 patients (57.8%), and motor deficits 10 patients (52.6%). As per preoperative McCormick grading, 31.6%, 10.5%, and 31.6% were grade I, II, and III, respectively. Postoperatively, 57.9% of patients improved to McCormick grade I. Total gross tumor resection was achieved in 15 participants (78.9%). Syndromes, specifically neurofibromatosis type II, were significantly associated with a chance of recurrence (p = 0.004) and the need for a second surgery (p = 0.018).</p><p><strong>Conclusion: </strong>The preoperative neurological status correlates significantly with the postoperative outcome of the patient.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"34-40"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Routine, On-Demand Electroencephalograms for Seizure Detection in the Intensive Care Unit of a Major Saudi Tertiary Center.","authors":"Abdulrahman Yousef Aldayel, Homoud Alsahli, Rawabi Alhathlool, Afag Osman, Sonia Khan, Mohammed T Alshahrani","doi":"10.17712/1658-3183.1010","DOIUrl":"10.17712/1658-3183.1010","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the occurrence and characteristics of seizures using routine electroencephalograms (EEGs) in intensive care unit (ICU) patients.</p><p><strong>Methods: </strong>We conducted a retrospective analysis on routine, portable EEGs of 188 adult ICU patients (53% male) in a large tertiary hospital in Riyadh, Kingdom of Saudi Arabia. We compared variables of interest using a t-test and chi-squared analyses and explored significant associations using binary logistic regression analysis.</p><p><strong>Results: </strong>We found significant associations between the occurrence of seizures on EEGs and several variables, including patient age, ICU admission due to status epilepticus, history of epilepsy or previous neurosurgical procedure, coma state, and convulsions at the time of EEG (p < 0.05). Logistic regression analysis revealed that age, ICU admission due to status epilepticus, and a history of epilepsy were independently associated with the occurrence of seizures on EEG. Epileptiform abnormalities were observed in 14.9% of patients; periodic abnormalities were identified in 14.3%. Electrographic seizures were evident in 11.2% of patients, and 63 comatose patients did not exhibit any evidence of seizures in their EEGs.</p><p><strong>Conclusion: </strong>Routine EEGs play a vital role in investigating altered mental status in ICU patients, particularly for seizure evaluation. Age, ICU admission due to status epilepticus, and a history of epilepsy are significant factors associated with seizure occurrence on EEG. Future studies should validate these findings and explore the comparative effectiveness of routine and continuous EEGs in ICU settings.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"31 1","pages":"75-79"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabotropic glutamate receptors: Allosteric structural modulation and new treatments for anxiety disorders.","authors":"Madaniah O Zakari","doi":"10.17712/nsj.2025.4.20240062","DOIUrl":"10.17712/nsj.2025.4.20240062","url":null,"abstract":"<p><p>Anxiety disorders are psychiatric ailments that affect people throughout the world. Several studies have revealed that the development of anxiety is affected by changes in glutamatergic neurotransmission. Metabotropic glutamate receptors (mGluRs) can be allosterically modified, offering a new strategy for developing specific therapeutic agents that affect the cell membrane. Allosteric modulators have many advantages over other therapeutic options. In the field of stress treatment modulation, they can maintain the properties of natural glutamatergic neurotransmission. This review describes the design of allosteric modulators and the advantages of this class of compounds over current stress drugs.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 4","pages":"255-261"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}