{"title":"肌肉减少型肥胖与认知功能障碍的关联：一项系统综述和荟萃分析。","authors":"Qi Wu, Siye Xie, Jinhong Ying","doi":"10.17712/nsj.2025.3.20240131","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the association between sarcopenic obesity and cognitive dysfunction. Changes in human body composition may be linked to the development of cognitive dysfunction. Sarcopenic obesity, characterized by excessive fat accumulation and reduced muscle mass, is implicated in various adverse health outcomes.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis. PubMed, Cochrane Library, Web of Science, Embase, CINAHL, CNKI, Sinomed, Wanfang, and VIP databases were searched for studies examining the link between sarcopenic obesity and cognitive dysfunction. The process adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.</p><p><strong>Results: </strong>Eight studies, comprising 87,520 participants (5 cohort and 3 cross-sectional studies) were included. Meta-analysis using a random effects model addressed high heterogeneity (<i>p</i>=0.020, I<sup>2</sup>=50.1%) and demonstrated a statistically significant association between sarcopenic obesity and cognitive dysfunction (odds ratio=1.77, 95% confidence interval 1.48-2.12, <i>p</i><0.001). Sensitivity analysis confirmed the robustness of these findings, although funnel plots indicated some dispersion bias. Subgroup analyses based on varying diagnostic criteria for sarcopenic obesity and cognitive dysfunction revealed consistent associations.</p><p><strong>Conclusion: </strong>Sarcopenic obesity is associated with cognitive dysfunction. However, further research utilizing standardized diagnostic criteria and methodologies is essential to corroborate these findings.</p>","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":"30 3","pages":"177-188"},"PeriodicalIF":1.3000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279332/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of sarcopenic obesity with cognitive dysfunction: A systematic review and meta-analysis.\",\"authors\":\"Qi Wu, Siye Xie, Jinhong Ying\",\"doi\":\"10.17712/nsj.2025.3.20240131\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To evaluate the association between sarcopenic obesity and cognitive dysfunction. Changes in human body composition may be linked to the development of cognitive dysfunction. Sarcopenic obesity, characterized by excessive fat accumulation and reduced muscle mass, is implicated in various adverse health outcomes.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis. PubMed, Cochrane Library, Web of Science, Embase, CINAHL, CNKI, Sinomed, Wanfang, and VIP databases were searched for studies examining the link between sarcopenic obesity and cognitive dysfunction. The process adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.</p><p><strong>Results: </strong>Eight studies, comprising 87,520 participants (5 cohort and 3 cross-sectional studies) were included. Meta-analysis using a random effects model addressed high heterogeneity (<i>p</i>=0.020, I<sup>2</sup>=50.1%) and demonstrated a statistically significant association between sarcopenic obesity and cognitive dysfunction (odds ratio=1.77, 95% confidence interval 1.48-2.12, <i>p</i><0.001). Sensitivity analysis confirmed the robustness of these findings, although funnel plots indicated some dispersion bias. Subgroup analyses based on varying diagnostic criteria for sarcopenic obesity and cognitive dysfunction revealed consistent associations.</p><p><strong>Conclusion: </strong>Sarcopenic obesity is associated with cognitive dysfunction. 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引用次数: 0
摘要
目的：探讨肌肉减少型肥胖与认知功能障碍的关系。人体成分的变化可能与认知功能障碍的发展有关。肌肉减少型肥胖，其特征是过度脂肪积累和肌肉量减少，与各种不良健康结果有关。方法：我们进行了系统综述和荟萃分析。检索PubMed、Cochrane Library、Web of Science、Embase、CINAHL、中国知网、中国医学信息网、万方和VIP数据库，寻找肌减少型肥胖与认知功能障碍之间关系的研究。该过程遵循系统评价和荟萃分析（PRISMA）指南的首选报告项目。结果：纳入8项研究，共87,520名受试者（5项队列研究和3项横断面研究）。采用随机效应模型进行meta分析，发现高异质性（p=0.020, I2=50.1%），并显示肌肉减少性肥胖与认知功能障碍之间存在统计学意义上的关联（优势比=1.77,95%置信区间1.48-2.12,p）。结论：肌肉减少性肥胖与认知功能障碍相关。然而，利用标准化诊断标准和方法的进一步研究对于证实这些发现至关重要。
Association of sarcopenic obesity with cognitive dysfunction: A systematic review and meta-analysis.
Objectives: To evaluate the association between sarcopenic obesity and cognitive dysfunction. Changes in human body composition may be linked to the development of cognitive dysfunction. Sarcopenic obesity, characterized by excessive fat accumulation and reduced muscle mass, is implicated in various adverse health outcomes.
Methods: We conducted a systematic review and meta-analysis. PubMed, Cochrane Library, Web of Science, Embase, CINAHL, CNKI, Sinomed, Wanfang, and VIP databases were searched for studies examining the link between sarcopenic obesity and cognitive dysfunction. The process adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Results: Eight studies, comprising 87,520 participants (5 cohort and 3 cross-sectional studies) were included. Meta-analysis using a random effects model addressed high heterogeneity (p=0.020, I2=50.1%) and demonstrated a statistically significant association between sarcopenic obesity and cognitive dysfunction (odds ratio=1.77, 95% confidence interval 1.48-2.12, p<0.001). Sensitivity analysis confirmed the robustness of these findings, although funnel plots indicated some dispersion bias. Subgroup analyses based on varying diagnostic criteria for sarcopenic obesity and cognitive dysfunction revealed consistent associations.
Conclusion: Sarcopenic obesity is associated with cognitive dysfunction. However, further research utilizing standardized diagnostic criteria and methodologies is essential to corroborate these findings.
期刊介绍：
Neurosciences is an open access, peer-reviewed, quarterly publication. Authors are invited to submit for publication articles reporting original work related to the nervous system, e.g., neurology, neurophysiology, neuroradiology, neurosurgery, neurorehabilitation, neurooncology, neuropsychiatry, and neurogenetics, etc. Basic research withclear clinical implications will also be considered. Review articles of current interest and high standard are welcomed for consideration. Prospective workshould not be backdated. There are also sections for Case Reports, Brief Communication, Correspondence, and medical news items. To promote continuous education, training, and learning, we include Clinical Images and MCQ’s. Highlights of international and regional meetings of interest, and specialized supplements will also be considered. All submissions must conform to the Uniform Requirements.
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