Non-Coding RNA最新文献_第7页

Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review. 硫化氢在肿瘤和非肿瘤疾病中的作用及其受非编码 RNAs 的调控：全面综述》。

IF 4.3

Non-Coding RNA Pub Date : 2024-01-18 DOI: 10.3390/ncrna10010007

Rana A Youness, Danira Ashraf Habashy, Nour Khater, Kareem Elsayed, Alyaa Dawoud, Sousanna Hakim, Heba Nafea, Carole Bourquin, Reham M Abdel-Kader, Mohamed Z Gad

{"title":"Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review.","authors":"Rana A Youness, Danira Ashraf Habashy, Nour Khater, Kareem Elsayed, Alyaa Dawoud, Sousanna Hakim, Heba Nafea, Carole Bourquin, Reham M Abdel-Kader, Mohamed Z Gad","doi":"10.3390/ncrna10010007","DOIUrl":"10.3390/ncrna10010007","url":null,"abstract":"Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a \"Maestro\" role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possible therapeutic targets. Although a significant amount of work has been conducted on the role of nitric oxide (NO) and carbon monoxide (CO) and their inter-relationship in the field of oncology, research about hydrogen sulfide (H2S) remains in its infancy. Recently, non-coding RNAs (ncRNAs) have been reported to play a dominating role in the regulation of the endogenous machinery system of H2S in several pathological contexts. A growing list of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are leading the way as upstream regulators for H2S biosynthesis in different mammalian cells during the development and progression of human diseases; therefore, their targeting can be of great therapeutic benefit. In the current review, the authors shed the light onto the biosynthetic pathways of H2S and their regulation by miRNAs and lncRNAs in various oncological and non-oncological disorders.","PeriodicalId":19271,"journal":{"name":"Non-Coding RNA","volume":"10 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10801522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

sRNAflow: A Tool for the Analysis of Small RNA-Seq Data. sRNAflow：用于分析小 RNA-Seq 数据的工具。

IF 3.6

Non-Coding RNA Pub Date : 2024-01-17 DOI: 10.3390/ncrna10010006

Pawel Zayakin

{"title":"sRNAflow: A Tool for the Analysis of Small RNA-Seq Data.","authors":"Pawel Zayakin","doi":"10.3390/ncrna10010006","DOIUrl":"10.3390/ncrna10010006","url":null,"abstract":"The analysis of small RNA sequencing data across a range of biofluids is a significant research area, given the diversity of RNA types that hold potential diagnostic, prognostic, and predictive value. The intricate task of segregating the complex mixture of small RNAs from both human and other species, including bacteria, fungi, and viruses, poses one of the most formidable challenges in the analysis of small RNA sequencing data, currently lacking satisfactory solutions. This study introduces sRNAflow, a user-friendly bioinformatic tool with a web interface designed for the analysis of small RNAs obtained from biological fluids. Tailored to the unique requirements of such samples, the proposed pipeline addresses various challenges, including filtering potential RNAs from reagents and environment, classifying small RNA types, managing small RNA annotation overlap, conducting differential expression assays, analysing isomiRs, and presenting an approach to identify the sources of small RNAs within samples. sRNAflow also encompasses an alternative alignment-free analysis of RNA-seq data, featuring clustering and initial RNA source identification using BLAST. This comprehensive approach facilitates meaningful comparisons of results between different analytical methods.","PeriodicalId":19271,"journal":{"name":"Non-Coding RNA","volume":"10 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10801628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional Stress Induces the Generation of DoGs in Cancer Cells. 转录压力诱导癌细胞产生 DoGs。

IF 3.6

Non-Coding RNA Pub Date : 2024-01-10 DOI: 10.3390/ncrna10010005

Francisco Rios, Maritere Uriostegui-Arcos, Mario Zurita

引用次数: 0

Genetic Loss of miR-205 Causes Increased Mammary Gland Development 基因缺失 miR-205 会导致乳腺发育加快

IF 4.3

Non-Coding RNA Pub Date : 2023-12-31 DOI: 10.3390/ncrna10010004

A. Cataldo, Douglas G. Cheung, John Hagan, Matteo Fassan, Sukhinder Sandhu-Deol, Carlo M. Croce, Gianpiero di Leva, M. Iorio

引用次数: 0

Long Non-Coding RNAs (lncRNAs) in Heart Failure: A Comprehensive Review 心力衰竭中的长非编码 RNA（lncRNA）：全面综述

IF 4.3

Non-Coding RNA Pub Date : 2023-12-28 DOI: 10.3390/ncrna10010003

Shambhavi Jha, Vasanth Kanth Thasma Loganathbabu, Kasinathan Kumaran, Gopinath Krishnasamy, Kandasamy Nagarajan Aruljothi

引用次数: 0

MiR-4646-5p Acts as a Tumor-Suppressive Factor in Triple Negative Breast Cancer and Targets the Cholesterol Transport Protein GRAMD1B MiR-4646-5p 是三阴性乳腺癌的肿瘤抑制因子，靶向胆固醇转运蛋白 GRAMD1B

IF 4.3

Non-Coding RNA Pub Date : 2023-12-26 DOI: 10.3390/ncrna10010002

Katharina Jonas, Felix Prinz, Manuela Ferracin, Katarina Krajina, Alexander Deutsch, Tobias Madl, B. Rinner, O. Slaby, Christiane Klec, Martin Pichler

{"title":"MiR-4646-5p Acts as a Tumor-Suppressive Factor in Triple Negative Breast Cancer and Targets the Cholesterol Transport Protein GRAMD1B","authors":"Katharina Jonas, Felix Prinz, Manuela Ferracin, Katarina Krajina, Alexander Deutsch, Tobias Madl, B. Rinner, O. Slaby, Christiane Klec, Martin Pichler","doi":"10.3390/ncrna10010002","DOIUrl":"https://doi.org/10.3390/ncrna10010002","url":null,"abstract":"MicroRNAs (miRNAs) are crucial post-transcriptional regulators of gene expression, and their deregulation contributes to many aspects of cancer development and progression. Thus, miRNAs provide insight into oncogenic mechanisms and represent promising targets for new therapeutic approaches. A type of cancer that is still in urgent need of improved treatment options is triple negative breast cancer (TNBC). Therefore, we aimed to characterize a novel miRNA with a potential role in TNBC. Based on a previous study, we selected miR-4646-5p, a miRNA with a still unknown function in breast cancer. We discovered that higher expression of miR-4646-5p in TNBC patients is associated with better survival. In vitro assays showed that miR-4646-5p overexpression reduces growth, proliferation, and migration of TNBC cell lines, whereas inhibition had the opposite effect. Furthermore, we found that miR-4646-5p inhibits the tube formation ability of endothelial cells, which may indicate anti-angiogenic properties. By whole transcriptome analysis, we not only observed that miR-4646-5p downregulates many oncogenic factors, like tumor-promoting cytokines and migration- and invasion-related genes, but were also able to identify a direct target, the GRAM domain-containing protein 1B (GRAMD1B). GRAMD1B is involved in cellular cholesterol transport and its knockdown phenocopied the growth-reducing effects of miR-4646-5p. We thus conclude that GRAMD1B may partly contribute to the diverse tumor-suppressive effects of miR-4646-5p in TNBC.","PeriodicalId":19271,"journal":{"name":"Non-Coding RNA","volume":"26 2","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequencing Reveals miRNAs Enriched in the Developing Mouse Enteric Nervous System 测序揭示发育中小鼠肠神经系统中丰富的 miRNAs

IF 4.3

Non-Coding RNA Pub Date : 2023-12-22 DOI: 10.3390/ncrna10010001

Christopher Pai, Rajarshi Sengupta, R. Heuckeroth

{"title":"Sequencing Reveals miRNAs Enriched in the Developing Mouse Enteric Nervous System","authors":"Christopher Pai, Rajarshi Sengupta, R. Heuckeroth","doi":"10.3390/ncrna10010001","DOIUrl":"https://doi.org/10.3390/ncrna10010001","url":null,"abstract":"The enteric nervous system (ENS) is an essential network of neurons and glia in the bowel wall. Defects in ENS development can result in Hirschsprung disease (HSCR), a life-threatening condition characterized by severe constipation, abdominal distention, bilious vomiting, and failure to thrive. A growing body of literature connects HSCR to alterations in miRNA expression, but there are limited data on the normal miRNA landscape in the developing ENS. We sequenced small RNAs (smRNA-seq) and messenger RNAs (mRNA-seq) from ENS precursor cells of mid-gestation Ednrb-EGFP mice and compared them to aggregated RNA from all other cells in the developing bowel. Our smRNA-seq results identified 73 miRNAs that were significantly enriched and highly expressed in the developing ENS, with miR-9, miR-27b, miR-124, miR-137, and miR-488 as our top 5 miRNAs that are conserved in humans. However, contrary to prior reports, our follow-up analyses of miR-137 showed that loss of Mir137 in Nestin-cre, Wnt1-cre, Sox10-cre, or Baf53b-cre lineage cells had no effect on mouse survival or ENS development. Our data provide important context for future studies of miRNAs in HSCR and other ENS diseases and highlight open questions about facility-specific factors in development.","PeriodicalId":19271,"journal":{"name":"Non-Coding RNA","volume":"53 8","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Non-Coding RNA Journal Club: Highlights on Recent Papers-13. 非编码 RNA 期刊俱乐部：近期论文集锦-13。

IF 4.3

Non-Coding RNA Pub Date : 2023-12-14 DOI: 10.3390/ncrna9060076

Patrick K T Shiu, Johanna K DiStefano, Suresh K Alahari, Francisco J Enguita, Mark W Feinberg, Nikolaos Sideris, Salih Bayraktar, Leandro Castellano, Diana Luna Buitrago, Andrea Caporali, Alessandro Mannucci, Ajay Goel

引用次数: 0

Regulation of Macrophage Polarization in Allergy by Noncoding RNAs. 非编码 RNA 对过敏症中巨噬细胞极化的调控

IF 4.3

Non-Coding RNA Pub Date : 2023-12-11 DOI: 10.3390/ncrna9060075

Osamu Ishibashi, Stefan A Muljo, Zohirul Islam

{"title":"Regulation of Macrophage Polarization in Allergy by Noncoding RNAs.","authors":"Osamu Ishibashi, Stefan A Muljo, Zohirul Islam","doi":"10.3390/ncrna9060075","DOIUrl":"10.3390/ncrna9060075","url":null,"abstract":"Allergy is a type 2 immune reaction triggered by antigens known as allergens, including food and environmental substances such as peanuts, plant pollen, fungal spores, and the feces and debris of mites and insects. Macrophages are myeloid immune cells with phagocytic abilities that process exogenous and endogenous antigens. Upon activation, they can produce effector molecules such as cytokines as well as anti-inflammatory molecules. The dysregulation of macrophage function can lead to excessive type 1 inflammation as well as type 2 inflammation, which includes allergic reactions. Thus, it is important to better understand how macrophages are regulated in the pathogenesis of allergies. Emerging evidence highlights the role of noncoding RNAs (ncRNAs) in macrophage polarization, which in turn can modify the pathogenesis of various immune-mediated diseases, including allergies. This review summarizes the current knowledge regarding this topic and considers three classes of ncRNAs: microRNAs, long ncRNAs, and circular ncRNAs. Understanding the roles of these ncRNAs in macrophage polarization will provide new insights into the pathogenesis of allergies and identify potential novel therapeutic targets.","PeriodicalId":19271,"journal":{"name":"Non-Coding RNA","volume":"9 6","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10745746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age and 17β-Estradiol (E2) Facilitate Nuclear Export and Argonaute Loading of microRNAs in the Female Brain 年龄和 17β 雌二醇 (E2) 促进雌性大脑中 microRNA 的核输出和 Argonaute 装载

IF 4.3

Non-Coding RNA Pub Date : 2023-12-06 DOI: 10.3390/ncrna9060074

Megan L. Linscott, Yoldas Yildiz, Sarah Flury, Mikayla L. Newby, Toni R. Pak

{"title":"Age and 17β-Estradiol (E2) Facilitate Nuclear Export and Argonaute Loading of microRNAs in the Female Brain","authors":"Megan L. Linscott, Yoldas Yildiz, Sarah Flury, Mikayla L. Newby, Toni R. Pak","doi":"10.3390/ncrna9060074","DOIUrl":"https://doi.org/10.3390/ncrna9060074","url":null,"abstract":"Aging in women is accompanied by a dramatic change in circulating sex steroid hormones. Specifically, the primary circulating estrogen, 17β-estradiol (E2), is nearly undetectable in post-menopausal women. This decline is associated with a variety of cognitive and mood disorders, yet hormone replacement therapy is only effective within a narrow window of time surrounding the menopausal transition. Our previous work identified microRNAs as a potential molecular substrate underlying the change in E2 efficacy associated with menopause in advanced age. Specifically, we showed that E2 regulated a small subset of mature miRNAs in the aging female brain. In this study, we hypothesized that E2 regulates the stability of mature miRNAs by altering their subcellular localization and their association with argonaute proteins. We also tested the hypothesis that the RNA binding protein, hnRNP A1, was an important regulator of mature miR-9-5p expression in neuronal cells. Our results demonstrated that E2 treatment affected miRNA subcellular localization and its association with argonaute proteins differently, depending on the length of time following E2 deprivation (i.e., ovariectomy). We also provide strong evidence that hnRNP A1 regulates the transcription of pri-miR-9 and likely plays a posttranscriptional role in mature miR-9-5p turnover. Taken together, these data have important implications for considering the optimal timing for hormone replacement therapy, which might be less dependent on age and more related to how long treatment is delayed following menopause.","PeriodicalId":19271,"journal":{"name":"Non-Coding RNA","volume":"43 15","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138597548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0