Nicotine & Tobacco Research最新文献

{"title":"Effectiveness of Nicotine Replacement Therapy and Behavioral Intervention in Tobacco Cessation-A Tertiary Hospital-Based Randomized Controlled Trial.","authors":"Utkal Keshari Mohanty, Kuldeep Kumar, Gaurav Sharma, Swapna Sarit, Hemamalini Rath","doi":"10.1093/ntr/ntaf091","DOIUrl":"https://doi.org/10.1093/ntr/ntaf091","url":null,"abstract":"<p><strong>Introduction: </strong>The effectiveness of nicotine replacement therapy (NRT) on smokeless tobacco (SLT) users is underexplored in India, with prior research primarily focusing on smokers. This study assessed and compared the effectiveness of combining behavioral intervention (BI) and NRT with BI alone on smoking and SLT cessation.</p><p><strong>Methods: </strong>This 1.5-year prospective, open-label, three-arm parallel-group randomized controlled trial was conducted at the Tobacco Cessation Clinic, SCB Dental College and Hospital, Odisha, India. The three intervention groups-BI, BI+nicotine patch, and BI+nicotine gum-were assessed using a prevalidated proforma on sociodemographics, relevant medical and dental history, oral hygiene practices, and previous tobacco use patterns.</p><p><strong>Results: </strong>The study enrolled 130 participants. At 26 weeks, 63.3% (19/30) in the BI+patch and 52.9% (18/34) in the BI+gum achieved abstinence, compared to 24.1% (7/29) in the BI group. The odds ratio (OR), 95% confidence interval (CI); p-value of abstinence was 6.03 (1.90-19.15; p=0.003) for BI + patch, and 3.25 (1.08-9.78; p=0.035) for BI+gum. Among SLT users, abstinence was achieved in 70.59% (12/17) with BI+patch (OR 6.40, 95% CI: 1.57-26.03; p =0.010) and 53.85% (14/26) with BI+gum (OR 3.11, 95% CI: 0.92-10.47; p=0.067) versus 27.27% (6/22) with BI alone. Both intervention groups demonstrated significantly reduced relapse risk versus BI alone (Hazard ratio [HR] 0.45, 95% CI: 0.24-0.83; p=0.011) for BI+patch and HR 0.40, 95% CI: 0.22-0.74; p=0.003 for BI+gum.</p><p><strong>Conclusion: </strong>Combination therapy (BI+NRT) is more effective than BI alone. The BI+patch combination is more effective than BI+gum and BI alone. The NRT intervention groups had higher abstinence rates and reduced relapses than the standard BI group. Further studies are required to validate these findings.</p><p><strong>Implications: </strong>This study portrays the effectiveness of combining behavioral intervention (BI) with nicotine replacement therapy (NRT) in promoting cessation of tobacco use in smokeless tobacco (SLT) users and reducing relapse rates. The findings highlight the superiority of BI+NRT over BI alone as they demonstrate notable efficacy, higher odds of abstinence, and lower relapse rates in the BI+patch and BI+gum group as compared to the BI group. The study underscores the significance of integrating NRT into cessation programs to enhance long-term outcomes by emphasizing the need for comprehensive approaches and tailored interventions to address the challenges of addiction with a focus on SLT users.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Women's National Basketball Association (WNBA) Star Athlete Kelsey Plum gets Signature Premium Cigar Amidst Record-Breaking WNBA Viewership.","authors":"Ollie Ganz, Cristine D Delnevo, Andrea C Villanti, Kevin R J Schroth, Jennifer Cornacchione Ross","doi":"10.1093/ntr/ntaf094","DOIUrl":"https://doi.org/10.1093/ntr/ntaf094","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Science, Improving Health, and Saving Lives in an Evolving Research Landscape.","authors":"Mariel S Bello, Brandon Henderson, Megan Passey, Bruce Wheeler, Eric C Donny, Christie D Fowler","doi":"10.1093/ntr/ntaf093","DOIUrl":"https://doi.org/10.1093/ntr/ntaf093","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Note on Ordinal Modeling of Smoking Rate Data.","authors":"Donald Hedeker, Robin J Mermelstein, Juned Siddique","doi":"10.1093/ntr/ntaf087","DOIUrl":"https://doi.org/10.1093/ntr/ntaf087","url":null,"abstract":"<p><strong>Introduction: </strong>This paper discusses statistical models for ordinal data that may be more appropriate for smoking rate outcomes than are models that assume continuous measurement and normality. Smoking rate outcomes often have distributions that make them inappropriate for many popular statistical models that assume normality, and are more appropriately considered ordinal outcomes. This article describes how the ordinal logistic regression model can be used to obtain estimates of means, and comparisons of means, for smoking rate outcomes.</p><p><strong>Methods: </strong>Analyses of the daily smoking rate of a sample of 383 subjects are presented using linear regression and ordinal logistic regression. From the latter, we derive regression estimates (intercepts and slopes) in terms of the mean response without having to assume any distributional form for the smoking rate outcome variable. Regressors considered are the subject's gender and their level of dependency as assessed by the nicotine dependence symptom scale (NDSS).</p><p><strong>Results: </strong>Estimated regression coefficients were similar, but the linear regression model indicated a significant gender effect, such that females had a higher smoking rate than males. Though similar, this effect was not quite significant (at the 0.05 level) in the ordinal model. The effect of dependency was significant in both models, with more dependent smokers having a higher smoking rate.</p><p><strong>Conclusions: </strong>Results and conclusions can depend on the assumptions of a statistical model. Methods relaxing the assumption of normality are useful to examine how robust effects are to this common assumption.</p><p><strong>Implications: </strong>Modeling of smoking rate outcomes can be performed without having to rely on methods that assume a normal distribution. The ordinal model can provide estimates relating to mean differences in smoking rate for the effects of regressors.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Low-Dose Computed Tomography Findings on Cigarette Smoking Cessation Among High-Risk Adults Participating in Lung Cancer Screening.","authors":"Evangelos Katsampouris, Amyn Bhamani, Fanta Bojang, Jennifer L Dickson, Helen Hall, Carolyn Horst, Priyam Verghese, Andrew Creamer, Ruth Prendecki, Chuen Khaw, Sophie Tisi, John McCabe, Kylie Gyertson, Anne-Marie Hacker, Laura Farrelly, Neal Navani, Allan Hackshaw, Sam M Janes, Samantha L Quaife","doi":"10.1093/ntr/ntaf010","DOIUrl":"https://doi.org/10.1093/ntr/ntaf010","url":null,"abstract":"<p><strong>Introduction: </strong>Integrating effective smoking cessation strategies for individuals undergoing lung cancer screening stands to significantly increase the impact of lung screening programmes. We assessed the impact of low-dose computed tomography (LDCT) findings on smoking cessation among high-risk adults who currently smoked.</p><p><strong>Aims and methods: </strong>13 035 individuals, aged 55-77 years, attended a lung health check appointment, as part of a prospective observational cohort study (the SUMMIT Study), prior to undergoing a baseline LDCT scan. Logistic regressions examined the likelihood of smoking cessation at a 1-year follow-up appointment and its association with LDCT findings.</p><p><strong>Results: </strong>12.6% (n = 647/5135) of individuals self-reported smoking cessation at 1-year follow-up. Higher odds of quitting were found in those receiving indeterminate pulmonary nodule findings requiring a 3-month interval LDCT (aOR = 1.27; 1.01, 1.61), those with urgent findings requiring referral to secondary care (aOR = 1.55; 1.05, 2.32), and those with a possible new chronic obstructive pulmonary disease diagnosis (aOR = 1.60; 1.23, 2.06), compared to those receiving no actionable LDCT findings. Older age, Asian ethnic background, current high smoking intensity, motivation and number of quit attempts, and low nicotine dependence were associated with increased odds of quitting.</p><p><strong>Conclusions: </strong>Individuals currently smoking, at high lung cancer risk, participating in LDCT screening, and receiving incidental findings requiring a 1-year interval LDCT or primary care follow-up might therefore need additional behavioral support to quit. Tailored communication strategies depending on the severity of the LDCT findings, including additional behavioral support for those with less clinical concerning or negative findings, could increase quit rates and reduce smoking-related morbidity.</p><p><strong>Implications: </strong>This study reports high odds of self-reported complete smoking cessation in adults who currently smoked after receiving their LDCT findings. Though the impact of specific types of LDCT findings on smoking cessation was positive for high lung cancer risk individuals, reception of incidental findings could potentially be perceived as less severe to encourage individuals who currently smoked to quit. Clearly communicating the severity of LDCT findings along with the delivery of behavioral smoking cessation support targeted to high-risk individuals may increase their chances of complete smoking cessation and reduce lung cancer mortality.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: Stepwise rather than linear trend in prevalence of secondhand tobacco exposure among children.","authors":"Yudai Tamada, Kenji Takeuchi, Takahiro Tabuchi","doi":"10.1093/ntr/ntaf090","DOIUrl":"https://doi.org/10.1093/ntr/ntaf090","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Electronic Nicotine Delivery Systems and Cigarette Use Among Texas College Students, 2015-2024.","authors":"Caroline North, Hien Nguyen, Xiaoyin Li, Alexandra Loukas","doi":"10.1093/ntr/ntaf086","DOIUrl":"https://doi.org/10.1093/ntr/ntaf086","url":null,"abstract":"<p><strong>Introduction: </strong>We examined trends in past 30-day electronic nicotine delivery systems (ENDS) and past 30-day cigarette use among Texas college students from 2015-2024. We hypothesized that ENDS use would a) decline from 2015-2017 similar to national surveillance research, b) increase from 2017-2019 after the surging popularity of JUUL and similar pod-vapes, and then c) decline again from 2019-2024 after the enactment of federal tobacco policies and the onset of the COVID-19 pandemic. We also hypothesized that cigarette smoking would decline steadily over the ten-year period.</p><p><strong>Methods: </strong>Participants were 45,129 18-25-year-old Texas college students who participated in at least one of ten repeated cross-sectional surveys from 2015-2024. Discontinuous growth curve models were used to analyze trends in past 30-day ENDS use and cigarette smoking across the 10-year period.</p><p><strong>Results: </strong>Results indicated that ENDS use decreased from 2015-2017 (AOR=0.88, 95%CI: 0.81, 0.96), increased from 2017-2019 (AOR=2.08, 95%CI: 1.96, 2.20), and then decreased from 2019-2024 (AOR=0.95, 95%CI: 0.93, 0.97). Past 30-day cigarette smoking decreased steadily across the ten-year study period (AOR = 0.82, 95%CI: 0.80, 0.83).</p><p><strong>Conclusions: </strong>Findings suggest that while cigarette use has declined over the past decade among Texas college students, there have been inconsistent changes in ENDS use. Although the present study cannot infer causaility, these changes align with the timing of tobacco legislation and FDA regulations. The sharp increase in ENDS between 2017-2019 highlights the need to remain vigilant about new products and marketing strategies from tobacco companies, as they may undermine the effectiveness of tobacco control efforts.</p><p><strong>Implications: </strong>The present study provides new information on trends in cigarette and ENDS use among college students in Texas, a state with minimal tobacco control efforts. While cigarette use has steadily decreased over the past decade, ENDS use has fluctuated, and remains high. Policy efforts made at the national level may aid in tobacco prevention and cessation efforts in states with minimal tobacco control efforts.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Stop-Smoking Strategy After Cervical Cancer Screening: Results of a Cluster-Randomized Controlled Trial in Dutch General Practice.","authors":"Marthe B L Mansour, Mathilde R Crone, Henk C van Weert, Niels H Chavannes, Kristel M van Asselt","doi":"10.1093/ntr/ntae285","DOIUrl":"10.1093/ntr/ntae285","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to assess whether brief stop-smoking advice given to women who smoke and visit their general practice for cervical cancer screening improves smoking cessation outcomes.</p><p><strong>Aims and methods: </strong>This two-arm cluster-randomized controlled trial was conducted in 75 Dutch general practices. Participants in the intervention group received brief stop-smoking advice based on the Ask-Advise-Connect method, delivered by a practice assistant. Patient-reported outcomes were measured at 6 months: undertaking a serious quit attempt of at least 24 hours during follow-up (primary outcome), 7-day point prevalence abstinence at 6 months, reduction in number of cigarettes smoked, increase in motivation to quit smoking, exposure to advice or support, and other psychological and behavioral measurements.</p><p><strong>Results: </strong>There was no significant difference in undertaking a serious quit attempt between the intervention (39.8% of n = 266) and control group (36.0% of n = 214), odds ratio 1.18 (95% confidence intervals: 0.80-1.72, p = .41). Neither did the point prevalence abstinence significantly differ between groups: 21.1% versus 16.3%, odds ratio 1.38 (95% confidence interval: 0.83-2.29, p = .21). Although nonsignificant, the direction of effects for the aforementioned outcomes was in favor of the intervention group. The reduction in the number of cigarettes smoked and increase in motivation to quit did not differ between groups. The uptake of cessation counseling was higher in the intervention (14.7%) than in the control group (2.8%).</p><p><strong>Conclusions: </strong>A brief stop-smoking strategy after the smear test for cervical screening might encourage women who smoke to attempt quitting and seek cessation counseling, but a significant effect could not be demonstrated in this trial.</p><p><strong>Implications: </strong>The results of this cluster-randomized trial suggest that brief advice to stop-smoking delivered by a practice assistant after routine cervical screening in general practice might encourage women who smoke to attempt quitting, but a significant effect could not be proven. Also, women who receive advice show a higher uptake of professional cessation counseling compared to their controls. Providing brief advice after the cervical smear might therefore be a useful opportunistic approach to stimulate cessation in women who smoke.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"805-814"},"PeriodicalIF":3.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Nicotine Pharmacokinetics of New-Generation Tobacco Products and Conventional Cigarettes: A Systematic Review and Meta-analysis.","authors":"Yue Cao, Xinru Liu, Zhongyi Hu, Jiaxuan Li, Xi Chen, Yuming Xiong, Fangzhen Zheng, Jianqiang Zhang, Lin Zhang, Xiaona Liu","doi":"10.1093/ntr/ntae199","DOIUrl":"10.1093/ntr/ntae199","url":null,"abstract":"<p><strong>Introduction: </strong>New-generation tobacco products (NGPs) hold promises as modified-risk alternatives to conventional cigarettes (CCs), given their comparable characteristics. This study investigated the nicotine pharmacokinetics (PK) of NGPs, encompassing closed pod systems, refillable e-cigarettes (ECs), and heated tobacco products (HTPs), in comparison to CCs through systematic review and meta-analysis.</p><p><strong>Aims and methods: </strong>A comprehensive search was conducted on PubMed, Embase, and Web of Science for articles published between January 2013 and July 2023. Maximum nicotine concentration (Cmax), time to peak concentration (Tmax), and total nicotine exposure (area under the concentration-time curve, AUC) were extracted to evaluate nicotine delivery PK. Random effects meta-analyses were performed to determine pooled standardized mean differences, facilitating a comparison of PK profiles between NGPs and CCs. Subgroup analyses exploring flavors and nicotine concentrations across NGPs, and CCs were also conducted.</p><p><strong>Results: </strong>The meta-analysis incorporated 30 articles with 2728 participants. Cmax and AUC were significantly lower for NGPs, while Tmax demonstrated statistical similarity compared to CCs. Among three NGPs, Cmax, and AUC were lower for closed pod systems and refillable ECs. In HTPs, Cmax was statistically similar while AUC was lower compared to CCs. Tmax was statistically similar in closed pod systems and HTPs compared to that of CCs. No significant difference was observed in the comparisons of PK between each type of NGPs versus CCs.</p><p><strong>Conclusions: </strong>NGPs delivered less nicotine than CCs but reached Cmax over a similar timeframe, indicating that NGPs may serve as modified-risk alternatives with lower nicotine delivery to CCs for craving relief and smoking cessation.</p><p><strong>Implications: </strong>This study suggested that NGPs, such as the closed pod systems, the refillable ECs, and the HTPs, delivered either lower or comparable nicotine levels and achieved peak nicotine concentration at a similar rate as CCs. Our findings carry implications that NGPs can serve as modified-risk nicotine alternatives to CCs in helping smokers manage cravings and potentially quit smoking, thereby highlighting their value in the field of tobacco harm reduction.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"783-793"},"PeriodicalIF":3.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarification on the National Institute of Public Health's Independence from the Tobacco Industry.","authors":"Tomofumi Sone","doi":"10.1093/ntr/ntae265","DOIUrl":"10.1093/ntr/ntae265","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"942"},"PeriodicalIF":3.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}