Nicotine & Tobacco Research最新文献

{"title":"Exposure to Nicotine and Withdrawal in Wistar Rats: An Electrophysiological Study.","authors":"Allan Carlos da SilvaTiago, Suzane Maia da Fonseca, Esther Padilha da Silveira, Vitoria Corrêa Santos, Fernanda Myllena Sousa Campos, Danielma Carvalho de Lima, Mariana Kondo Obara, Rafaella Marques Ribeiro, João Cleiton Martins Rodrigues, Marcos Vinícius Cardoso Reis, Maria Klara Otake Hamoy, Josuelem Portela Castro, Walace Gomes Leal, Dielly Catrina Favacho Lopes, Moisés Hamoy","doi":"10.1093/ntr/ntae240","DOIUrl":"10.1093/ntr/ntae240","url":null,"abstract":"<p><strong>Introduction: </strong>Throughout the world, smoking is one of the principal causes of preventable death. Nicotine, the primary active component of tobacco, acts as a psychostimulant, and modulates the electrical activity of a number of the areas of the brain involved in addiction. Abstinence from nicotine will also impact the functional state of the brain, which is reflected in symptoms of craving and susceptibility to relapse. In addition, given the increase in the sympathetic tone of the heart and pulse rate promoted by nicotine, its consumption can contribute to tachyarrhythmia.</p><p><strong>Methods: </strong>The present study investigated the electroencephalographic (EEG) and electrocardiographic (ECG) patterns of Wistar rats submitted to acute or chronic exposure to nicotine, followed by withdrawal for 24 or 48 h, and the re-administration (or not) of nicotine, to simulate episodes of relapse.</p><p><strong>Results: </strong>The EEG data revealed an increase in all types of brainwaves, with emphasis on high-frequency (alpha, beta, and gamma) brain oscillations following both acute and chronic exposure to nicotine (14 days), whereas in withdrawal, there was a predominancy of delta waves. When exposure to nicotine was reinstated after withdrawal, the observed EEG profile was similar to that found in chronic exposure. The electrocardiogram reads showed that both acute and chronic exposure to nicotine caused abnormalities in the atrioventricular conduction and that, while these changes improve with substance withdrawal, relapse can worsen these parameters.</p><p><strong>Conclusions: </strong>The results of this study indicate that high-frequency brainwaves are correlated with nicotine dependence, while slow brain oscillations are consistent with drug craving, and episodes of nicotine relapse can reproduce brain activity patterns linked to dependence. Finally, exposure to nicotine predisposes the individual to heart rhythm abnormalities, which are attenuated by withdrawal, but may nevertheless be restored rapidly with re-exposure to the substance.</p><p><strong>Implications: </strong>This study demonstrated that nicotine increases high-frequency brain oscillations, which is associated with addiction, whereas withdrawal elevates the delta wave power, suggesting craving. Re-exposure to nicotine following withdrawal restores rapidly the EEG profile of chronic dependence. In addition, nicotine has deleterious impacts on cardiac activity, which are linked to fatal arrhythmias. This implies that stopping smoking is beneficial for the amelioration of the alterations in heart rhythm caused by nicotine addiction. This study elucidates the functional states of the brain and heart during both sporadic and chronic nicotine use, and the electrophysiological explanation for substance dependence and drug relapse after craving episodes.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1025-1034"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Analysis and Flavor Distribution of Electronic Cigarettes in Australian Schools.","authors":"Caitlin Jenkins, Fraser Powrie, Celine Kelso, Jody Morgan","doi":"10.1093/ntr/ntae262","DOIUrl":"10.1093/ntr/ntae262","url":null,"abstract":"<p><strong>Introduction: </strong>Adolescent usage of electronic cigarettes has increased globally. Inconsistent, or absent, labeling of nicotine and other ingredients requires chemical analysis to accurately determine the chemical composition of these products.</p><p><strong>Aims and methods: </strong>Electronic cigarettes confiscated from public and private high school students (N = 598) were provided for analysis from three regions in New South Wales, Australia. The products were examined for brand, model, and flavor and a subset was further analyzed for chemical composition (n = 410) quantifying nicotine, synthetic cooling agents, flavoring chemicals, and prohibited ingredients by gas chromatography-mass spectrometry (GC-MS).</p><p><strong>Results: </strong>The majority of samples provided were fruit-flavored disposable e-cigarettes across three main brands (IGET, HQD, and Gunnpod). Nicotine was quantified in 97.3% of disposable samples with an average concentration of 40.0 mg/mL, while one refill e-liquid was found to contain nicotine at a low concentration. Almost all samples contained the coolant WS-23 in relatively high concentrations compared to other flavoring chemicals present. Chemicals prohibited under the TGO110 (Australian e-cigarette product standard) were identified in 3.4% of the samples which were chemically analyzed. This included the presence of ethylene glycol in moderately high concentrations (up to 13.2 mg/mL).</p><p><strong>Conclusions: </strong>Australian students' preferences for fruity, disposable e-cigarettes were identified regardless of region with the vast majority containing high concentrations of nicotine. WS-23 was found in most disposable e-cigarettes, potentially to reduce throat irritation from nicotine and other flavoring chemicals. The inhalational safety of the samples is of concern due to health risks associated with detected prohibited compounds, particularly ethylene glycol.</p><p><strong>Implications: </strong>This is the first study to quantify nicotine, coolants, and flavoring chemicals in e-cigarette products seized from Australian high school students and has significant implications for future policy development. Students appear to be almost exclusively using disposable e-cigarettes with high nicotine concentrations and predominately fruity flavors. WS-23 may potentially be added to disposable e-cigarettes to facilitate the uptake of these products by adolescents unaccustomed to the throat irritation from nicotine and intense flavors. The e-cigarette coils were found to have degraded over time, potentially affecting the composition of the aerosol and leaching of metals.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"997-1005"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Social Support and Trying Smoking Among Rural Adolescents in Rural Western China: The Intermediary Role of Mental Health Problems and Life Satisfaction.","authors":"Ji Yuanyi, Cheng Yongzhong, Yang Ting, Zhang Jing, Liu Qiaolan","doi":"10.1093/ntr/ntae211","DOIUrl":"10.1093/ntr/ntae211","url":null,"abstract":"<p><strong>Introduction: </strong>Most adult smokers develop their addiction by trying smoking during adolescence. Elucidation of the psychosocial mechanisms underlying smoking initiation may be crucial for the prevention of adolescent tobacco use. The study aimed to identify key psychosocial factors to provide a scientific basis for preventing and reducing the occurrence of initial smoking behavior among adolescents.</p><p><strong>Methods: </strong>A total of 2671 students from rural middle schools in western China were surveyed three times as part of a 2-year longitudinal study. The adolescent health questionnaire included the Global Youth Tobacco Survey, the Mental Health Inventory of Middle School Students, the Social Support Rating Scale, and the Adolescent Life Satisfaction Scale. Structural equation modeling was used to analyze the direct or indirect relationships between smoking initiation and psychosocial factors.</p><p><strong>Results: </strong>The prevalence of trying smoking among adolescents was 28.3%, with boys (38.3%) having a higher rate than girls (19.7%; p < .05). Mental health problems were positively associated with trying smoking (β = 0.112, p < .05). Greater life satisfaction had a negative direct effect on trying smoking (β = -0.125, p < .05) and also played a mediating role in the relationship between mental health problems and trying smoking (β = 0.016, 95% CI = 0.008 to 0.025), accounting for 20.7% of the total effect. Social support had a full mediating effect on smoking initiation through both mental health problems and life satisfaction (β = -0.022, 95% CI = -0.028 to -0.016).</p><p><strong>Conclusions: </strong>The behavior of young people who try smoking is associated with complex psychosocial factors. Interventions aimed at preventing adolescent tobacco use should prioritize the provision of social support and the promotion of life satisfaction.</p><p><strong>Implications: </strong>The study elucidated the direct and indirect relationships between psychosocial factors and trying smoking behavior. To prevent adolescents from trying smoking, it is essential to intervene through external social support and internal development of mental health and well-being to improve adolescents' social support, increase their life satisfaction, and maintain their mental health.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1109-1115"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of Smoking Stigma Among African Americans: A Qualitative Study.","authors":"Denine R Crittendon, Alison C Brecher, Samantha Okere, Richard Hass, Rosemary Frasso, Rickie Brawer, Charnita Zeigler-Johnson","doi":"10.1093/ntr/ntae127","DOIUrl":"10.1093/ntr/ntae127","url":null,"abstract":"<p><strong>Introduction: </strong>African Americans/Blacks (AAB) are at increased risk for morbidity and mortality from smoking-related diseases including lung cancer (LC). Smoking stigma is believed to be a primary barrier to health care-seeking for people who smoke. Previous studies illustrate that perceptions of smoking vary across populations. However, little is known about the prevalence of smoking stigmas among AAB. The purpose of this study was to increase understanding of the perception of cigarette smoking by AAB.</p><p><strong>Aims and methods: </strong>We conducted free-listing interviews in which individuals listed all-thoughts and feelings regarding smoking and health-related questions with a convenience sample of eligible AAB adults (n = 58) in the Philadelphia region. Additionally, we collected participant self-reported demographic data. Data were cleaned and the salience of each term was computed using Anthropac. Graphical methods were then used to determine salient responses across groups stratified by gender, age, education, and smoking status.</p><p><strong>Results: </strong>The sample had a median age of 51 years and was 67.2% female. Most participants had completed college (58.6%) and had never smoked (74.1%). Regarding their perceptions of people who smoke cigarettes, results showed that \"smelly,\" \"health hazard,\" and \"judgment\" were the most salient terms among all-participants. Overall, \"smelly\" and \"unhealthy\" were salient for both males and females. However, \"dental,\" \"dirty,\" \"addictive,\" and \"habit\" were also salient among males. Phrases such as \"unhealthy\" and \"addictive\" were primarily salient for older participants (>51 years) versus \"smelly\" for younger participants. The term \"smelly\" was salient among all-education levels. However, \"unhealthy\" was also salient among those with less than a 4-year college degree. Moreover, the terms \"smelly\" and \"annoying\" were most common among people who smoke as opposed to \"health hazard\" among people who don't smoke.</p><p><strong>Conclusions: </strong>We observed that the most stigmatizing language was primarily associated with perceptions of negative social interactions, social judgment, and health-related concerns. Future studies are needed to explore how smoking-related stigmas impact patient adherence to smoking cessation programs and LC screening protocols.</p><p><strong>Implications: </strong>Little is known about the prevalence of smoking stigmas among AAB. This study explores the AAB perspective of cigarette smoking and related stigmas. Among AAB, smoking is represented by stigmatizing language across gender, age groups, and smoking history. It is primarily associated with negative social interactions, social judgement, and health-related concerns indicating that smoking stigma is a concern for AAB individuals who smoke. Further research is warranted.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1073-1082"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Content Analysis of Illicit Tobacco-Related Crimes Reported in Australian Media.","authors":"Isabel Meciar, Cheneal Puljević, Alice Holland, Coral Gartner","doi":"10.1093/ntr/ntae254","DOIUrl":"10.1093/ntr/ntae254","url":null,"abstract":"<p><strong>Introduction: </strong>Australian survey and seizure data suggest a growing illicit tobacco market. As an illicit product, accurately tracking trends in illicit tobacco growing, manufacture, and sales is challenging. We examined trends in Australian illicit tobacco-related crimes using a content analysis of news articles.</p><p><strong>Aims and methods: </strong>We analyzed Australian news articles identified in the Factiva database and government press releases describing Australian illicit tobacco-related crimes reported between January 2000 and December 2023. Sources were coded for crime type, location, product type, dollar value of seized products, methods of distribution or storage, agencies involved, and other crimes involved.</p><p><strong>Results: </strong>We identified 447 crimes reported in 389 sources. The number of illicit tobacco-related crimes reported increased between 2000 and 2023. The most common crimes were possession of illicit tobacco (n = 196/43.7%) and smuggling (n = 187/41.8%), and the most common product type was \"illicit cigarettes\" (n = 197/44.1%). The most common distribution/storage method reported was via residential premises (n = 98/21.9%). One-hundred and twenty incidents involved other crimes such as financial crimes involving money laundering (n = 59/13.2%). Across all included news articles, the quantity of seized products totaled 827 529 307 cigarette sticks, 76 185 cartons, 668 687 packs, 239 hectares (of land growing tobacco plants), and 2 149 000 plants of illicit tobacco between 2000 and 2023. The median value (worth; AUD) of each seizure was $1 500 000 (range $43 to $67 000 000).</p><p><strong>Conclusions: </strong>Australian media reporting on illicit tobacco-related crimes increased over the past two decades, particularly since 2018. These findings highlight a need for improved border detection measures, investment in enforcement, and other deterrent activities.</p><p><strong>Implications: </strong>This media analysis complements trends identified in national survey data that indicate a growing illicit tobacco market in Australia since 2013 with a marked increase since 2018. While survey data suggests that the Australian tobacco tax policy, which has included regular large tax increases since 2010, has decreased consumer demand for tobacco overall, it may have also incentivized criminal networks to supply illicit tobacco products due to it being a \"low risk\" and \"high reward\" activity. Controlling the Australian illicit tobacco market should be a policy priority.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"980-987"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do-It-Yourself Flavored Capsule Cigarettes: Exploiting Potential Regulatory Loopholes?","authors":"Page D Dobbs, Eric K Soule, Margaret Mahoney, Mufazzela Tabassum, Nia Burgess, Lisa Henriksen","doi":"10.1093/ntr/ntae258","DOIUrl":"10.1093/ntr/ntae258","url":null,"abstract":"<p><strong>Introduction: </strong>Capsule cigarettes allow users to crush liquid-filled capsules to release flavors into cigarettes' filters. New devices are emerging across the globe that allow people who smoke to circumvent tobacco flavor restrictions via injectable capsules. This study examined TikTok videos marketing flavored capsule injector devices.</p><p><strong>Methods: </strong>TikTok videos (n = 832) posted worldwide between July 6, 2021, and December 28, 2023, that used hashtags #injectorflavor, #flavourclickball, #flavorball, and #injectorballcigarette were collected using a TikTok application programing interface. A codebook was developed using a systematic iterative approach, identifying six codes: flavor capsules, promotes flavors (i.e., fruit, mint or menthol flavors, nonalcoholic drinks, alcoholic drinks), demonstrates how to use or refill large injector devices, demonstrates how to use small convenient devices, includes music (any or English language). Two independent coders annotated all videos.</p><p><strong>Results: </strong>Overall, 88.3% (n = 735) of the videos displayed flavor capsules and had been viewed more than 72 million times. Half (51.6%) of the videos demonstrated how to use large box-shaped devices to inject capsules into the filter of a cigarette, and 15.0% of the videos showed how to do this with smaller, more convenient devices. Flavors including fruit (35.5%), menthol/mint (27.8%), nonalcoholic drinks (21.9%), and alcoholic drinks (11.6%) were used to promote these capsules. Most videos (85.6%) were uploaded by sellers on \"TikTok shop.\"</p><p><strong>Discussion: </strong>TikTok accounts are promoting injectable capsule devices that circumvent flavored tobacco sales restrictions. Policy makers, tobacco control advocates, and public health practitioners should be aware of such marketing to inform regulation and develop prevention strategies.</p><p><strong>Implications: </strong>Our findings identified an emerging product that can encourage circumvention of flavor restriction policies. Regulators, policy makers, public health practitioners, researchers, and advocates should be aware of such products to inform regulation and develop prevention strategies. Given the potential for these products to reduce the intended effects of flavored tobacco sales restrictions, policy makers must be poised to address materials that consumers use to create their own flavored tobacco products, including flavor capsules designed to be inserted into cigarettes.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1142-1146"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Snus and Cardiometabolic Health Markers Among Swedish Young Adults.","authors":"Anna Zettergren, Niklas Andersson, Göran Pershagen, Christian Lindh, Antonios Georgelis, Inger Kull, Erik Melén, Sandra Ekström, Petter Ljungman, Anna Bergström","doi":"10.1093/ntr/ntae267","DOIUrl":"10.1093/ntr/ntae267","url":null,"abstract":"<p><strong>Introduction: </strong>Snus is suggested as a risk factor for cardiometabolic disease, but little is known about health effects in young populations, particularly in women. We aimed to investigate associations between snus and cardiometabolic health markers among young men and women.</p><p><strong>Aims and methods: </strong>This study was conducted within the BAMSE (Swedish acronym for Children, Allergy, Environment, Stockholm, Epidemiology) birth cohort and included participants followed up around 24 years (n = 2256) and 26 years (n = 1011). Snus use was assessed at 24 years by questionnaires. Cardiometabolic health markers were recorded at clinical examinations at 24 and 26 years. Associations between snus use and cardiometabolic markers were assessed by multivariable linear regression.</p><p><strong>Results: </strong>Snus was used by 6.4% (n = 81) among women and 21.9% (n = 219) among men. Compared to no tobacco use, daily exclusive snus use among women at 24 years was associated with higher body mass index (BMI) (adjusted β: 1.93 kg/m2, 95% confidence interval [CI] = 0.54, 3.33) and waist circumference (WC) (aβ: 3.80 cm, 95% CI = 0.41, 7.18) at 24 years, and with higher BMI (aβ: 2.73 kg/m2, 95% CI = 0.53 to 4.93) at 26 years. Among men, using ≥4 cans/week was associated with increased BMI (aβ: 2.48 kg/m2, 95% CI = 0.73, 4.24) and a tendency toward increased body fat (aβ: 2.31%, 95% CI = -0.53, 5.14) at 26 years. Snus use was not associated with glycemic status or blood pressure.</p><p><strong>Conclusions: </strong>Our results suggest that snus is associated with increased BMI, and possibly other measures of adiposity, among young women and heavy-using young men. Given the cross-sectional study design, the results should be interpreted with caution.</p><p><strong>Implications: </strong>We found cross-sectional associations between snus use and measures of increased adiposity in a cohort of Swedish young adults, including BMI and WC among women and BMI among heavy snus-using men. We did not find associations between snus use and body fat %, glycemic status, or blood pressure. This is one of few studies to investigate the health effect of snus among both women and men as well as cardiometabolic health markers in young adults. Given the recent trends of increased snus use among young adults, our findings highlight the need for further research on snus on cardiometabolic health.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1098-1108"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"'Keep It a Secret': Leaked Documents Suggest Philip Morris International, and Its Japanese Affiliate, Continue to Exploit Science for Profit\".","authors":"Tomoyasu Hirano","doi":"10.1093/ntr/ntae287","DOIUrl":"10.1093/ntr/ntae287","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1151-1152"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of E-Cigarette Warning Labels About Mental Health Consequences of Nicotine Addiction Among Young Adults in the USA: Results From a Randomized Controlled Experiment.","authors":"Kristy L Marynak, Joanna E Cohen, Johannes Thrul, Ryan D Kennedy, Rupali Limaye, Meghan B Moran","doi":"10.1093/ntr/ntae298","DOIUrl":"10.1093/ntr/ntae298","url":null,"abstract":"<p><strong>Introduction: </strong>Since 2016, the US Food and Drug Administration (FDA) has required e-cigarette packaging and advertising to bear the warning: \"WARNING: THIS PRODUCT CONTAINS NICOTINE. NICOTINE IS AN ADDICTIVE CHEMICAL.\" Nicotine has numerous adverse consequences besides addiction, including increased anxiety and depression symptoms that arise from nicotine withdrawal. We tested the effects of exposure to text-only e-cigarette package labels about the psychological consequences of nicotine withdrawal.</p><p><strong>Aims and methods: </strong>We randomized 1919 US young adults aged 18-24 years to view one of four warning label conditions: a no-message control, the current FDA warning, a message that \"nicotine addiction can worsen depression and anxiety symptoms,\" and a message that \"nicotine addiction is a source of stress.\" We explored associations between condition and intentions to use or quit e-cigarettes and perceived message effectiveness.</p><p><strong>Results: </strong>Label condition was not associated with intentions to use or quit e-cigarettes. Intentions were equivalent among those who viewed the FDA label and those who viewed the no-message control. Compared with the FDA label, the depression/anxiety label and the stress label produced greater agreement among participants that the message \"makes me concerned about nicotine addiction\" after adjustment for sociodemographic characteristics; those who viewed the depression/anxiety label had greater agreement that the message \"discourages me from wanting to use nicotine.\"</p><p><strong>Conclusions: </strong>While brief exposure to the warnings tested may not impact young adults' intentions to use or quit vaping, messages about stress, depression, and anxiety arising from nicotine addiction had higher perceived effectiveness among young adults than the FDA's current message about addictiveness.</p><p><strong>Implications: </strong>Findings from this randomized controlled experiment among US young adults suggest that warnings about the mental health consequences of nicotine addiction might be one type of message to consider including in a suite of required e-cigarette warnings and as part of a comprehensive effort to educate the public about the risks of commercial tobacco products.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"1006-1015"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warnings and Other Communications to Promote Tobacco Cessation.","authors":"Amy Ferketich","doi":"10.1093/ntr/ntaf061","DOIUrl":"10.1093/ntr/ntaf061","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"949-950"},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}