Nicotine & Tobacco Research最新文献

{"title":"E-cigarette Retail Outlets in Mexico: A Country That Bans the Sale.","authors":"David Zepeta Hernández, Angelica Susana López Arellano, Erika Mayte Del Angel Salazar, Nazaria Martínez Díaz","doi":"10.1093/ntr/ntae246","DOIUrl":"10.1093/ntr/ntae246","url":null,"abstract":"<p><strong>Introduction: </strong>Restrictive e-cigarette policies have not allowed for the characterization of the sale of these tobacco products in the countries where they are implemented. This is because it is believed that there are no stores. However, the use of e-cigarettes persists in these countries.</p><p><strong>Aims and methods: </strong>A content analysis of electronic cigarette points of sale through the Internet in Mexico was conducted. Cross-sectional study. Structured searches were performed in the Google Maps search engine with the terms \"electronic cigarette store\" and \"vape store\" in combination with the name of each state of Mexico, in the period from October 2021 to February 2022.</p><p><strong>Results: </strong>A total of 695 e-cigarette stores were located, of which 481 (69.2%) were physical stores, 207 hybrid stores (29.8%), 4 online stores (0.6%), and 3 (0.4%) vending machines. A total of 316 e-cigarette brands and 578 vape liquid brands were identified. The sales attraction strategy they used the most was free shipping of products (85.8%). Stores used WhatsApp (92.5%), Facebook (86.3%), and Instagram (74.4%) to promote their products. Only 35.1% of stores checked the age of their customers, of which, 95.9% asked if the customer was of legal age and 4.1% asked for the date of birth. In addition, 25.6% of the stores warned about nicotine addiction and 24.2% specifically about the ingredients of the liquids.</p><p><strong>Conclusions: </strong>E-cigarettes are widely available and marketed in a variety of retail outlets in Mexico. The high number of stores, brands of liquids, and e-cigarettes indicates noncompliance with existing regulations.</p><p><strong>Implications: </strong>E-cigarette consumption has increased globally, even in countries with restrictive regulations. However, there is limited data on the density and characteristics of vape stores in low- and middle-income countries with restrictive regulations. This study found no significant differences in e-cigarette sales between countries with permissive and restrictive regulations. Therefore, it is suggested that, in addition to establishing restrictive policies on the sale of e-cigarettes, their enforcement should also be monitored. Countries with restrictive measures should regulate Internet sales and promotion of e-cigarettes with greater emphasis.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"652-657"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsubstantiated Claims by the Hookah Tobacco Industry to Exempt Flavored Hookah Tobacco Products From Flavor Bans.","authors":"Mary Rezk-Hanna, Wasim Maziak","doi":"10.1093/ntr/ntae114","DOIUrl":"10.1093/ntr/ntae114","url":null,"abstract":"","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"773-776"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of e-Cigarette Packaging as a Health Communications Tool: A Focus Group Study With Adolescents and Adults in England and Scotland.","authors":"Daniel Jones, Amber Morgan, Crawford Moodie, Georgia Alexandrou, Allison Ford, Danielle Mitchell","doi":"10.1093/ntr/ntae107","DOIUrl":"10.1093/ntr/ntae107","url":null,"abstract":"<p><strong>Introduction: </strong>In the United Kingdom, e-cigarette and refill packaging must display a nicotine addiction warning. This study explored how this message is perceived, responses to alternative on-pack messages, and other options for using e-cigarette packaging to discourage youth and people who neither smoke nor use e-cigarettes while encouraging smokers to switch.</p><p><strong>Aims and methods: </strong>Between August and September 2022, 16 focus groups (n = 70) were conducted to explore these topics with adolescents (n = 31, aged 11-17 years) and adults (n = 39, nonsmokers, smokers that use e-cigarettes, smokers that do not use e-cigarettes) in England and Scotland.</p><p><strong>Results: </strong>While several participants thought the current nicotine addiction warning could help increase awareness of nicotine addiction, most reported that it failed to capture attention and was not a deterrent. Alternative messages shown on packs (about harm, toxicity, wellness, litter, or relative risk) received mixed responses. Relative risk messages were perceived as most beneficial for smokers switching but also thought to potentially encourage uptake among nonsmokers. Some participants considered certain harm and toxicity messages to potentially dissuade uptake. Participants proposed several ideas to reduce the appeal of e-cigarette packaging and devices to deter youth uptake, including more prominent warnings, standardized packaging, and devices that are plain or include health messages.</p><p><strong>Conclusions: </strong>Packaging can play a crucial role in communicating product and health messages to different consumer groups. Further consideration of how packaging and labeling can meet the needs of non-nicotine users while simultaneously reaching those who may benefit from using e-cigarettes to stop smoking is warranted.</p><p><strong>Implications: </strong>While some viewed the nicotine addiction warning required on e-cigarettes and refill packaging in the United Kingdom as helpful in raising awareness of nicotine addiction, it did not resonate with most of our sample of adolescents and adults. The findings suggest that e-cigarette packaging could be better used to encourage smokers to switch to a less harmful alternative, with relative risk messages showing promise. Furthermore, strengthening on-pack messaging (eg increasing salience and rotating messages) and reducing the appeal of packaging (eg drab colors) and devices (eg including warnings) may help increase awareness of e-cigarette harms while deterring use among adolescents and nonsmokers.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":"705-713"},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Extent of Illicit Tobacco Trade in Low and Middle-Income Countries (LMICs) - a Systematic Review and Meta-Analysis.","authors":"S M Abdullah, Zakariya Siddiqi, Rumana Huque, Mona Kanaan, Kamran Siddiqi","doi":"10.1093/ntr/ntaf070","DOIUrl":"https://doi.org/10.1093/ntr/ntaf070","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about the extent of the illicit tobacco trade in low- and middle-income countries (LMICs) where more than 80% of tobacco users now live. We systematically reviewed literature from LMICs to investigate the share of illicit tobacco and the methods studies applied.</p><p><strong>Methods: </strong>We searched nine electronic databases, three websites, and grey literature published in English from January, 2012 to July, 2023. Studies assessing the extent of illicit tobacco trade within LMICs were included. Two independent reviewers screened titles, abstracts, and full-text manuscripts' and extracted the data from those eligible. Studies were critically appraised using a bespoke framework. We conducted meta-analysis of the share of illicit tobacco and pooled the results with random effects. Analysis was stratified by type of tobacco and funding source. Based on the estimation methods for illicit tobacco, sub-group analysis was conducted. The review was registered in PROSPERO (CRD42023450354).</p><p><strong>Results: </strong>Among 48 eligible studies from 39 LMICs, 41 disclosed independent (non-industry) funding sources. Only two studies estimated the share of illicit smokeless tobacco. Studies used three estimation methods: i) pack analysis (n=33), ii) gap analysis (n=13), and iii) trade monitoring (n=2). The pooled share of illicit smoking and smokeless tobacco was 14.4% (95%CI: 10.5-18.9) and 86.9% (95%CI: 51.1-100.0) respectively.</p><p><strong>Conclusions: </strong>Approximately one in every seven cigarette packs is likely to be illicit in LMICs. The share of illicit smokeless tobacco may be a lot higher, but the estimates were uncertain due to very few studies.</p><p><strong>Implications: </strong>Since the inception of WHO FCTC Illicit Tobacco Trade Protocol (ITP) in 2012 this review is the first attempt to systematically investigate the share of illicit tobacco in LMICs. We found that the evidence is lacking in many LMICs, even among ITP signatories. The share of illicit smokeless tobacco is considerably higher than the smoking tobacco. Given that there is no fiscal marking (e.g. tax stamp) on the packs, studies in LMICs mainly relied on packaging compliance to detect illicit tobacco products. The findings highlight the lack of evidence in LMICs and the importance of robust estimation of the share of illicit tobacco where the evidence is lacking.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco Assessment in Actively Accruing National Cancer Institute Clinical Trials Network Trials.","authors":"Sarah N Price, Stephanie R Land, Kinsey Pebley, Margaret C Fahey, Amanda M Palmer, Marcia H McCall, Pamela J Raper, Alana M Rojewski, Ivana T Croghan, Lynne I Wagner, Benjamin A Toll","doi":"10.1093/ntr/ntaf071","DOIUrl":"https://doi.org/10.1093/ntr/ntaf071","url":null,"abstract":"<p><strong>Introduction: </strong>Tobacco use can adversely affect cancer treatment outcomes, yet routine assessment has not been fully incorporated into oncology clinical trials. In 2012, rates of tobacco use assessment in actively accruing National Cancer Institute (NCI) trials were <30% at enrollment and <5% during follow-up, prompting efforts by the NCI and major oncology associations to promote and standardize tobacco assessment in oncology research and practice (including development of the Cancer Patient Tobacco Use Questionnaire [C-TUQ]). This study was conducted to re-examine assessment patterns in 2022 (including utilization of the C-TUQ) and evaluate progress.</p><p><strong>Methods: </strong>Protocols and forms from 144 actively accruing (as of December 2022) NCI National Clinical Trials Network (NCTN) trials were evaluated using a standardized coding instrument.</p><p><strong>Results: </strong>Of 144 trials, 49.3% assessed tobacco use at enrollment (43.8% measured cigarettes, 14.8% e-cigarettes, and <12.5% other tobacco products). Approximately 20.8% used at least one C-TUQ question, but only 3.5% used all four core items. Few measured secondhand smoke exposure (3.5%) or quit interest (2.8%). At follow-up, 8.3% assessed any form of tobacco use. Assessment rates were higher in smoking-related cancer trials.</p><p><strong>Conclusion: </strong>Almost half of accruing trials did not measure any tobacco use and fewer used the C-TUQ. There was a >70% increase in tobacco use assessment at enrollment and follow-up compared to 2012, an improvement with room for further enhancement. Standardized tobacco use information enhances investigators' ability to estimate cancer treatment efficacy, offer equitable cessation support, and accurately understand the impact of tobacco use on treatment outcomes.</p><p><strong>Implications: </strong>In 2012, few (<30%) cancer clinical trials evaluated tobacco use at enrollment and <5% did so during follow-up, prompting efforts to promote and standardize tobacco assessment in oncology research and practice (including development of the Cancer Patient Tobacco Use Questionnaire [C-TUQ]). The present study builds on this foundational paper and finds an overall increase in tobacco use assessment with room for improvement: 49.3% of trials in 2022 assessed tobacco use at enrollment and 8.3% did so during follow-up. About 20.8% used at least one C-TUQ question, highlighting that tobacco use assessment is not yet fully incorporated into oncology clinical trials.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American Indian Persons' Perspectives on Various Smoking Cessation Aids and Approaches: A Community-Engaged Qualitative Research Study.","authors":"Dana Mowls Carroll, Julie Ntegeye, Lou Moerner, Claradina Soto, Dorothy Hatsukami, Antony Stately, Dylan Jennings, Wyatt Pickner","doi":"10.1093/ntr/ntaf032","DOIUrl":"10.1093/ntr/ntaf032","url":null,"abstract":"<p><strong>Introduction: </strong>Increasing smoking cessation among American Indian (AI) persons is a critical equity goal.</p><p><strong>Aims and methods: </strong>During 2022, AI persons (N = 46) were interviewed on perceptions of existing and novel cessation approaches. Intention to use each approach was assessed and questions started with \"cold turkey\" and then queried about the following: nicotine patches, gum, lozenges (NRT); prescription medications; plant-based medications; personalized medicine; e-cigarettes; and nicotine reduction standard (NRS).</p><p><strong>Results: </strong>Perspectives informed the identification of six crosscutting themes which were (a) environmental constraints, (b) addictiveness and side effects, (c) effectiveness of approach, (d) interpersonal influence, (e) duration or requirements of approach, and (f) novelty. Plant-based medications were viewed as natural, less likely to cause side effects, and aligned with AI cultures. Regarding NRT, many participants talked about positive word-of-mouth but noted concerns about effectiveness, side effects, and price. Regarding personalized medicine, many indicated curiosity, but some noted it would delay treatment and was too extreme to share a sample. Common perspectives for cold turkey were its drug-free nature and cost savings, but some noted it does not address cravings. Regarding the NRS, many were supportive, although some were concerned with compensatory smoking and what else remains in the cigarettes.</p><p><strong>Conclusions: </strong>Themes translated to the greatest proportion of participants stating they would use plant-based medications followed by NRT and personalized medicine. Fewer participants reported intent to use prescription medications and e-cigarettes which reflect greater concerns with these approaches.</p><p><strong>Implications: </strong>Results can inform tribal and other public health programming and communication efforts to increase smoking cessation among AI persons and help drive down disparities.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking Cessation in Black Adults: Differences by Sex and Age.","authors":"Ryan A Park, Alicia M Allen, Devashri Prabhudesai, Emmery E Kelly, Janet L Rothers, Nikki Nollen","doi":"10.1093/ntr/ntaf058","DOIUrl":"https://doi.org/10.1093/ntr/ntaf058","url":null,"abstract":"<p><strong>Introduction: </strong>Females have poorer smoking cessation outcomes than males, especially with nicotine replacement therapy (NRT) aided attempts, perhaps due to ovarian hormones. Additionally, Black adults experience higher rates of tobacco-related mortality and also experience important ovarian hormone differences. This is the first study to examine sex, age, and menopause differences in NRT-aided smoking cessation outcomes in an all-Black sample.</p><p><strong>Methods: </strong>A secondary-data analysis conducted on non-Hispanic Black adults aged 18+ who smoked 5-30 cigarettes/day for at least 6 months. Participants were categorized by sex assigned at birth (female versus male) and age (<45 versus ≥45 years) with females in the ≥45 age group restricted to those who were postmenopausal (defined as one year post menses per self-report). Smoking status two weeks post-quit date was assessed by cessation attempts, expired carbon monoxide-verified abstinence, and reduction in daily cigarettes. Statistical analyses utilized Mann-Whitney rank-sum tests, chi-square tests, and regression models controlling for baseline cigarettes/day.</p><p><strong>Results: </strong>Participants (n=340; 55.9% female) were, on average 53.4 (standard deviation: ±11.6) years old. At baseline, males smoked significantly more cigarettes/day than females (13.9±7.7 versus 11.9±6.3, respectively; p-value=0.031). Among those <45 years of age, males (n=30) had a greater reduction in cigarettes/day two weeks post cessation than females (n=52; 11.3±6.1 versus 7.9±5.3, respectively; p-value=0.008), but this difference became null after adjusting for baseline cigarettes/day (p-value=0.989). No other significant differences were identified.</p><p><strong>Conclusions: </strong>After adjusting for baseline differences in smoking rate, no significant sex differences in smoking cessation outcomes were observed in this all-Black sample. Additional research is needed to replicate this observation.</p><p><strong>Implications: </strong>Despite known racial disparities and sex-based differences in nicotine replacement therapy (NRT) efficacy, little is known about sex differences in cessation among Black people who smoke. While we did not observe any differences by sex in smoking cessation outcomes within this all-Black sample, our results suggest that sex differences in baseline level of cigarettes/day may play a critical role in cessation outcomes. Further research should replicate these observations and examine potential implications for cessation among Black people who smoke.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors.","authors":"Deniz Bagdas, Jennifer Sedaille, Mariam Khan, Nnedinma Okpala, Nii A Addy","doi":"10.1093/ntr/ntaf037","DOIUrl":"https://doi.org/10.1093/ntr/ntaf037","url":null,"abstract":"<p><strong>Introduction: </strong>Oral nicotine products (ONPs) are emerging as a new nicotine delivery method, with varied types and flavors such as sweeteners and cinnamon. This study evaluates how sucrose, saccharin, and cinnamaldehyde influence nicotine preference, shedding light on the potential appeal of ONPs and how they may impact on harm reduction.</p><p><strong>Methods: </strong>For oral choice behavior studies, we utilized a four-bottle choice (BC) test in male and female adult Sprague-Dawley rats. We first examined most common sucrose (1%) and saccharin (0.32%) concentrations as sweet solutions, and quinine (0.01%) as a bitter solution, to determine 4BC sensitivity and ability to distinguish between sweet and bitter tastes. We then performed dose-response analyses with sucrose (0.01%, 0.1%, and 1%), saccharin (0.032%, 0.1%, and 0.32%), and cinnamaldehyde (0.0005%, 0.005%, and 0.05%), in comparison to water in 4BC. Lastly, we tested nicotine (10 µg/mL) choice behaviors in the presence of sweeteners and/or cinnamaldehyde.</p><p><strong>Results: </strong>Female and male rats significantly preferred sucrose (1%) and saccharin (0.1% and 0.32%) but not cinnamaldehyde. Moreover, rats differentiated sweet and bitter solutions with the highest preference for saccharin. Sucrose increased nicotine preference in females, but cinnamaldehyde increased nicotine preference in males. Saccharin increased nicotine preference in females, but not in males. Additionally, the combination of cinnamaldehyde and saccharin increased nicotine preference in females.</p><p><strong>Conclusions: </strong>We found differential preferences among the test solution concentrations with the highest sweetener concentrations being most preferred. Sweetness value of the nicotine solution played a major role on nicotine preference in females but not in males.</p><p><strong>Implications: </strong>Understanding how sweeteners and flavor additives affect oral nicotine choice behavior and nicotine preference in ONPs can guide the development of targeted harm reduction strategies and regulatory policies. By identifying which additives enhance product appeal and potentially influence addiction, this research can inform the creation of safer ONP formulations. This research also supports the utility of evidence-based guidelines for ONP use.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network dynamics of social influence on e-cigarette use among an ethnically diverse adolescent cohort.","authors":"Sarah E Piombo, Kayla de la Haye, Thomas W Valente","doi":"10.1093/ntr/ntaf065","DOIUrl":"https://doi.org/10.1093/ntr/ntaf065","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study was to examine the mechanisms of social influence driving e-cigarette use in adolescent social networks and differentiate between the effects of exposure to friend behavior and social norms on individual use.</p><p><strong>Methods: </strong>Surveys on health behaviors and friendship networks from nine high schools in Southern California (N = 2,245; 48% Hispanic) were collected at three time points from Spring 2021 of grade 9, Fall 2021, and Spring 2022 of grade 10. Stochastic actor-oriented models for the co-evolution of social networks and behavior dynamics tested for friendship network social influences on e-cigarette use. Two mechanisms of social influence were estimated, exposure to friend behavior (e-cigarette use among friends) and pro-e-cigarette social norms (perceived peer approval and use of e-cigarettes), while controlling for social selection, individual covariates, and endogenous network effects. Results from the nine schools were combined in a meta-analysis.</p><p><strong>Results: </strong>Findings revealed social influence effects through exposure to friend e-cigarette use and pro-e-cigarette social norms, which both had significant positive influences on individual e-cigarette initiation over time. Further, Hispanic/Latine individuals and females were more likely to initiate e-cigarette use compared to males and non-Hispanic/Latine students.</p><p><strong>Conclusions: </strong>The importance of these effects should be considered in tobacco prevention initiatives. Designing culturally tailored interventions that target youth social networks and e-cigarette social norms could be effective at curtailing adolescent use. Changing perceptions and social acceptability of e-cigarettes could be one way to slow or prevent the spread of e-cigarette use in adolescent networks.</p><p><strong>Implications: </strong>These findings demonstrate the role of social influence on adolescent e-cigarette use through two mechanisms, both friend behavior and social norms. A shift in prevention strategies toward addressing social dynamics and social norms rather than focusing solely on individual level factors may be effective in curtailing use. Changing social perceptions and reducing he social acceptability of e-cigarette use may help slow the spread in adolescent networks.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-cigarette Use and Incident Cardiometabolic Conditions in the All of Us Research Program.","authors":"John Erhabor, Zhiqi Yao, Erfan Tasdighi, Emelia J Benjamin, Aruni Bhatnagar, Michael J Blaha","doi":"10.1093/ntr/ntaf067","DOIUrl":"https://doi.org/10.1093/ntr/ntaf067","url":null,"abstract":"<p><strong>Introduction: </strong>Although several potential respiratory and cardiovascular health effects of e-cigarettes have been reported, their association with incident cardiometabolic conditions remains unclear.</p><p><strong>Methods: </strong>We used longitudinal data from the All of Us research program to investigate the association between current exclusive e-cigarette use (EE), exclusive combustible cigarette use (ECC), and dual use (DU) with incident cardiometabolic conditions, including hypertension, type 2 diabetes mellitus (T2DM), chronic obstructive pulmonary disease (COPD), heart failure (HF), and atherosclerotic cardiovascular disease (ASCVD), using Cox regression analyses adjusted for age, sex, race and ethnicity, and body mass index (BMI). ECC use was used as a positive control to validate our methodology/findings.</p><p><strong>Results: </strong>Among 249,190 individuals (67.2% female, 52.0% non-Hispanic White, 21.5% non-Hispanic Black) followed for 3.7-3.9 years, EE, compared with nonuse, was not significantly associated with hypertension (aHR 1.01[95%CI 0.83-1.23]), T2DM (0.88[0.66-1.16]), ASCVD (1.05[0.59-1.86]), or HF (0.82[0.47-1.41]), but was significantly associated with COPD (2.29[1.42-3.71]). Among individuals aged 30-70 years, EE was significantly associated with hypertension (1.39[1.09-1.77]). ECC and DU were strongly associated with all outcomes with DU having higher point estimates but overlapping confidence intervals for all outcomes except ASCVD (2.18[1.82-2.62]).</p><p><strong>Conclusion: </strong>We demonstrated significant longitudinal association between exclusive e-cigarette use and COPD, and hypertension only among individuals aged 30-70 years. ECC and DU were strongly associated with all conditions, with dual use potentially associated with higher ASCVD risk. These findings highlight some potential risks of e-cigarette use and provide context to inform advisories and regulatory policies on novel products on their health risks.</p><p><strong>Implication: </strong>These findings help to clarify the potential risks associated with e-cigarette use. Understanding these risks can aid the FDA in developing regulatory frameworks for tobacco products.</p>","PeriodicalId":19241,"journal":{"name":"Nicotine & Tobacco Research","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}