Neuroreport最新文献_第5页

Dynamic and static brain functional abnormalities in autism patients at different developmental stages. 不同发育阶段自闭症患者动态和静态脑功能异常。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-03-05 Epub Date: 2025-02-12 DOI: 10.1097/WNR.0000000000002139

Haonan Li, Mingxing Han, Shaoting Tang, Yaqian Yang

{"title":"Dynamic and static brain functional abnormalities in autism patients at different developmental stages.","authors":"Haonan Li, Mingxing Han, Shaoting Tang, Yaqian Yang","doi":"10.1097/WNR.0000000000002139","DOIUrl":"10.1097/WNR.0000000000002139","url":null,"abstract":"To date, most studies on autism spectrum disorder (ASD) have focused on specific age ranges, while the mechanisms underlying the entire developmental process of autism patients remain unclear. The aim of this study was to investigate the alterations in brain function in autistic individuals at different developmental stages by resting-state functional MRI (rs-fMRI). We obtained rs-fMRI data from 173 ASD and 178 typical development (TD) individuals in Autism Brain Imaging Data Exchange, spanning child, adolescent, and adult groups. We characterized local brain activity using the amplitude of low-frequency fluctuations (ALFFs), regional homogeneity (ReHo), dynamic ALFF (dALFF), and dynamic ReHo (dReHo) metrics. Pearson correlation analyses were conducted on relationships between Autism Diagnostic Observation Schedule scores and activity measures in abnormal brain regions. We found abnormal ALFF values in the medial and lateral orbitofrontal gyrus and right insula cortex with ASD compared with the TD group. In addition, compared with adolescents with ASD, we found that adults with ASD exhibited an increase in dReHo values in the posterior lateral frontal lobe. We also found that changes in ALFF were associated with the severity of autism. We found abnormal activity in multiple brain regions in individuals with autism and correlated it with clinical characteristics. Our results may provide some help for further exploring the age-related neurobiological mechanisms of ASD patients.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"202-210"},"PeriodicalIF":1.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-course changes in videofluoroscopic findings during developmental and aging stages in mice. 小鼠发育和衰老阶段影像透视结果的时间变化。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-03-05 Epub Date: 2025-02-12 DOI: 10.1097/WNR.0000000000002140

Hiyori Takahashi, Jun Suzuki, Ryoukichi Ikeda, Takuma Hisaoka, Yasutoshi Koshiba, Jun Ohta, Ai Hirano-Kawamoto, Yukio Katori

{"title":"Time-course changes in videofluoroscopic findings during developmental and aging stages in mice.","authors":"Hiyori Takahashi, Jun Suzuki, Ryoukichi Ikeda, Takuma Hisaoka, Yasutoshi Koshiba, Jun Ohta, Ai Hirano-Kawamoto, Yukio Katori","doi":"10.1097/WNR.0000000000002140","DOIUrl":"10.1097/WNR.0000000000002140","url":null,"abstract":"Videofluoroscopic swallow study methodology in mice has recently been established; however, details of developmental and age-related changes remain unclear. This study aimed to reveal the changes in swallowing associated with the entire lifespan of mice using the videofluoroscopic swallow study methodology. We tested six age groups of male C57BL/6J mice (4, 8, 16, 54, 77, and 104 weeks old; n = 5 for each group, respectively). The videofluoroscopic swallow study analyzed the bolus area, pharyngeal transit time, interswallow interval, lick-swallow ratio, and lick rate. Significant age differences were found in the bolus area and lick rate. The bolus area increased significantly as the mice grew older. There was a significant increase in the lick rate from 4 to 8 weeks ( P < 0.001) and then a significant decrease from 8 to 104 weeks ( P < 0.01). No significant difference was observed between the various stages in the lick-swallow ratio, interswallow interval, or pharyngeal transit time. There was a significant positive correlation between the body weight and bolus area. This study revealed the detailed changes in swallowing at each life stage from swallowing maturation to old age in the mice. Our research may serve as a guide for future studies on swallowing in humans.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"211-216"},"PeriodicalIF":1.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of test on associative memory depend on semantic relevancy levels: evidence of event-related potentials. 测验对联想记忆的影响取决于语义关联水平：事件相关电位的证据。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-03-05 Epub Date: 2025-02-12 DOI: 10.1097/WNR.0000000000002143

Wenting Geng, Yan Wang, Xintong Liu, Chunping Yan, Yunbing Zhang, Tian Gao

{"title":"The effects of test on associative memory depend on semantic relevancy levels: evidence of event-related potentials.","authors":"Wenting Geng, Yan Wang, Xintong Liu, Chunping Yan, Yunbing Zhang, Tian Gao","doi":"10.1097/WNR.0000000000002143","DOIUrl":"10.1097/WNR.0000000000002143","url":null,"abstract":"This study aims to investigate how the level of semantic relevance influences the effects of test on associative memory through bottom-up cognitive processes. This study manipulated the levels of semantic relevancy using synonym and nonsynonym pairs in a three-phase testing effect paradigm (an initial encoding phase, a cued-recall test as retrieval practice, and a final test phase) to explore the effects of testing effect and semantic relevancy on associative recognition by bottom-up processes using the event-related potential (ERP). The behavioral results suggested that the test practice (relative to the restudy) significantly facilitated memory retrieval in high semantic relevancy pairs during the final test phase. The ERP results showed that the testing effect tended toward right laterality over time in the retrieval practice phase. Moreover, test practice (relative to the restudy) significantly enhanced FN400 for high semantic relevancy and intact pairs and significantly enhanced FN400 and late positive complex for high semantic relevancy and rearranged pairs in the final test phase. These results suggest that the test practice provided a greater boost in memory encoding and retrieval for high semantic relevancy items. Specifically, the effects of test on associative memory is modulated by the level of semantic relevancy.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"217-222"},"PeriodicalIF":1.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes may contribute to cognitive impairment in Parkinson's disease via damaging white matter tracts. 糖尿病可能通过破坏白质束导致帕金森病的认知障碍。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2024-12-02 DOI: 10.1097/WNR.0000000000002123

Zhihui Liu, Jiahao Wei, Huahua Su, Yuchen She, Junyi Wang, Ying Liu, Lijuan Mo, Changhong Tan, Xi Liu, Lifen Chen

{"title":"Diabetes may contribute to cognitive impairment in Parkinson's disease via damaging white matter tracts.","authors":"Zhihui Liu, Jiahao Wei, Huahua Su, Yuchen She, Junyi Wang, Ying Liu, Lijuan Mo, Changhong Tan, Xi Liu, Lifen Chen","doi":"10.1097/WNR.0000000000002123","DOIUrl":"10.1097/WNR.0000000000002123","url":null,"abstract":"Parkinson's disease with dementia (PDD) severely affects the quality of life of patients with Parkinson's disease (PD) in the later stages. Recently, PD patients with diabetes were found to have a higher risk of cognitive decline and developing dementia with a faster progression, but the underlying mechanism remains unclear. Diabetes-related white matter damage may partially explain the mechanism by which diabetes participates in PDD. Seventy PD patients were included. PD patients underwent diffusion tensor imaging from The Second Affiliated Hospital of Chongqing Medical University were collected and were divided into four groups: PD with diabetes without dementia, PD with dementia without diabetes, PD without dementia and diabetes. Tract-based spatial statistics analysis and region-of-interest-based analysis were performed. Factorial analysis with diabetes and dementia taken as the main effects was performed, and the differences between the white matter fibers of PD patients from the four groups were also analyzed. The interaction between diabetes and dementia in the damage of white matter in PD patients was also analyzed. We found that both diabetes and dementia were found to be related to the damage in internal capsule, corona radiata, and thalamic radiation of the PD patients. There is an interaction between diabetes and dementia in the white matter damage of PD patients. Both diabetes and dementia were found to be related to the damage in internal capsule, corona radiata, and thalamic radiation of the PD patients. Diabetes may participate in cognitive decline in PD patients via damaging cognition-related white matter tracts.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"71-80"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRIM37 exacerbates cerebral ischemic injury by regulating the PPARγ/NF-κB pathway. TRIM37通过调控PPARγ/NF-κB通路加重脑缺血损伤。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2024-12-06 DOI: 10.1097/WNR.0000000000002126

Guixin Shi, Linyan Fu, Hua Xiao, Fang Cao

{"title":"TRIM37 exacerbates cerebral ischemic injury by regulating the PPARγ/NF-κB pathway.","authors":"Guixin Shi, Linyan Fu, Hua Xiao, Fang Cao","doi":"10.1097/WNR.0000000000002126","DOIUrl":"10.1097/WNR.0000000000002126","url":null,"abstract":"Ischemic stroke is the primary cause of mortality for individuals with disability worldwide. Tripartite motif 37 (TRIM37) plays multiple regulatory roles in various cellular processes. Our research aimed to investigate the effects of TRIM37 on the progression of ischemic stroke and its related mechanisms. Primary rat brain microvascular endothelial cells (BMECs) were treated with oxygen-glucose deprivation and reoxygenation (OGD/R) and then transduced with pShuttle-H1-TRIM37 shRNA plasmid, pShuttle-CMV-TRIM37 plasmid, or corresponding negative controls. The effects of TRIM37 were also explored in middle cerebral artery occlusion surgery-induced rat brain damage in vivo . Factor VIII staining showed the successful isolation of the primary BMECs. The OGD/R procedure significantly inhibited the cell viability and upregulated the TRIM37 expression in a time-dependent manner. In addition, OGD/R evidently increased the cell permeability, elevated the tumor necrosis factor alpha and intercellular adhesion molecule 1 levels, and upregulated the nuclear expression of nuclear factor (NF)-κB, but downregulated the peroxisome proliferator-activated receptors γ (PPARγ), zonula occludens-1, and cytoplasmic NF-κB expressions, which were reversed by TRIM37 knockdown. Furthermore, TRIM37 interacted with PPARγ and promoted its ubiquitination. The effects on cell permeability and inflammation induced by TRIM37 overexpression were reversed by PPARγ agonist. TRIM37 knockdown also inhibited middle cerebral artery occlusion-induced rat brain damage in vitro . TRIM37 may be a potential therapeutic target for ischemic stroke, and the knockdown of TRIM37 may improve brain injury by regulating the PPARγ/NF-κB pathway to modulate the inflammatory response.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"105-115"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and clinical significance of 25-hydroxyvitamin D, insulin-like growth factor 1, and beta-2 microglobulin in cognitive dysfunction after ischemic stroke in the elderly. 25-羟基维生素D、胰岛素样生长因子1、β -2微球蛋白在老年人缺血性脑卒中后认知功能障碍中的表达及临床意义

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-06 DOI: 10.1097/WNR.0000000000002128

Huarong Yang, Qinhua Wu, Jianghuan Zheng

{"title":"Expression and clinical significance of 25-hydroxyvitamin D, insulin-like growth factor 1, and beta-2 microglobulin in cognitive dysfunction after ischemic stroke in the elderly.","authors":"Huarong Yang, Qinhua Wu, Jianghuan Zheng","doi":"10.1097/WNR.0000000000002128","DOIUrl":"10.1097/WNR.0000000000002128","url":null,"abstract":"We aimed to unveil the clinical significance of serum 25-hydroxyvitamin D (25-OH-VD), insulin-like growth factor 1 (IGF-1), and beta-2 microglobulin (β2-MG) levels in cognitive dysfunction after ischemic stroke (IS) in the elderly. A total of 160 geriatric IS patients admitted to our hospital were retrospectively collected. The patients' serum 25-OH-VD, IGF-1, and β2-MG levels were detected, and the correlation between the three levels and the patients' National Institutes of Health Stroke Scale (NIHSS) and Montreal Cognitive Assessment (MoCA) scores was tested by the Pearson test. The diagnostic values of 25-OH-VD, IGF-1, and β2-MG for cognitive dysfunction and risk factors inducing cognitive dysfunction in the elderly after IS were evaluated. NIHSS score was negatively correlated with serum 25-OH-VD and IGF-1 levels, and positively correlated with serum β2-MG levels; MoCA score exhibited an inverse correlation. Diabetes, years of education <12 years, age, and serum high-sensitive C-reactive protein, cystatin C, 25-OH-VD, IGF-1, and β2-MG levels were independent factors for the development of cognitive dysfunction after IS in the elderly. The detection of 25-OH-VD, IGF-1, and β2-MG may be important for assessing the occurrence of cognitive dysfunction and the severity of the disease in patients.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"127-134"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticospinal excitability is not facilitated by observation of asymmetric walking on a split-belt treadmill in humans. 皮质脊髓兴奋性不促进观察不对称行走在分裂带跑步机上的人。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2024-12-18 DOI: 10.1097/WNR.0000000000002129

Masaya Kitamura, Tadao Ishikura, Kiyotaka Kamibayashi

{"title":"Corticospinal excitability is not facilitated by observation of asymmetric walking on a split-belt treadmill in humans.","authors":"Masaya Kitamura, Tadao Ishikura, Kiyotaka Kamibayashi","doi":"10.1097/WNR.0000000000002129","DOIUrl":"10.1097/WNR.0000000000002129","url":null,"abstract":"The present study aimed to investigate changes in corticospinal excitability (CSE) by observing unnatural walking patterns on a treadmill with different left and right belt speeds. Fifteen healthy adults watched video clips (10 s each) of walking under the tied condition (left and right treadmill belt speeds are the same), walking during the initial and late periods under the split-belt condition (left and right treadmill belt speeds are different), and the static fixation cross (control condition) in random order. The step lengths of the actor in the walking clips were almost symmetric under the tied condition and during the late period under the split-belt condition but largely asymmetric during the initial period under the split-belt condition. We recorded the motor-evoked potential (MEP) of the left tibialis anterior muscle during the observation of video clips by delivering transcranial magnetic stimulation to the right primary motor cortex. The MEP amplitude was significantly higher when observing walking under the tied condition and walking during the late period under the split-belt condition than the control condition. However, the MEP amplitudes during the observation of walking during the initial period under the split-belt condition and the control condition were not significantly different. These results indicate that observation of symmetric walking, even under the split-belt condition, facilitates CSE, whereas observation of unnatural asymmetric walking does not. Therefore, it is suggested that familiarity with observed movements affects CSE even in the observation of semi-automatic movements such as walking.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"140-144"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroacupuncture alleviates motor dysfunction after intracerebral hemorrhage via the PPARγ-EAAT2 pathway. 电针通过PPARγ-EAAT2通路缓解脑出血后运动功能障碍。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-29 DOI: 10.1097/WNR.0000000000002134

Hequn Chen, Huiling Ren, Xudong Lu, Guosheng Shi, Qinglin Zhao, Dawei Zhao, Wei Bu

{"title":"Electroacupuncture alleviates motor dysfunction after intracerebral hemorrhage via the PPARγ-EAAT2 pathway.","authors":"Hequn Chen, Huiling Ren, Xudong Lu, Guosheng Shi, Qinglin Zhao, Dawei Zhao, Wei Bu","doi":"10.1097/WNR.0000000000002134","DOIUrl":"10.1097/WNR.0000000000002134","url":null,"abstract":"Nowadays, intracerebral hemorrhage (ICH) is the main cause of death and disability, and motor impairment is a common sequel to ICH. Electroacupuncture (EA) has been widely used for functional recovery after ICH. However, its role and associated regulatory mechanisms in rehabilitation after ICH remain poorly understood. This study investigated whether EA can have a neuroprotective effect in motor function after ICH by inhibiting glutamate-mediated excitotoxicity on the primary motor cortex. The model was established using autologous tail artery blood, followed by administration of EA at Quchi (LI11) and Zusanli (ST36) for 3 or 7 consecutive days. The rats' behavior was examined by modified neurological severity score (mNSS) and open-field test (OFT). Nissl staining, immunofluorescence detection, and transmission electron microscopy were used to observe the degree of neuron damage. The level of the cortical glutamate was detected by the ELISA. Peroxisome proliferator-activated receptor gamma (PPARγ) expression was detected by immunohistochemistry and western blot. The protein and mRNA expression of excitatory amino acid transporter 2 (EAAT2) was detected by western blot and quantitative real-time PCR. Our data demonstrated that EA significantly reduces glutamate levels, alleviates neuronal damage, and promotes motor function recovery in rats after ICH. In addition, EA upregulates PPARγ and EAAT2 expression. However, the protective effect of EA on motor function and EAAT2 expression are partially abolished by T0070907, an antagonist of PPARγ. EA at LI11 and ST36 improved glutamate excitotoxicity and promoted motor function recovery after ICH by activating the PPARγ-EAAT2 pathway and reducing the glutamate level.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"169-178"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plateau hypoxia-induced upregulation of reticulon 4 pathway mediates altered autophagic flux involved in blood-brain barrier disruption after traumatic brain injury. 高原缺氧诱导的网状4通路上调介导的自噬通量改变参与创伤性脑损伤后血脑屏障的破坏。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2024-12-02 DOI: 10.1097/WNR.0000000000002122

Xinning Dong, Jing Xu, Kejun Du, Xin Chen, Haifeng Shu, Sixun Yu

{"title":"Plateau hypoxia-induced upregulation of reticulon 4 pathway mediates altered autophagic flux involved in blood-brain barrier disruption after traumatic brain injury.","authors":"Xinning Dong, Jing Xu, Kejun Du, Xin Chen, Haifeng Shu, Sixun Yu","doi":"10.1097/WNR.0000000000002122","DOIUrl":"10.1097/WNR.0000000000002122","url":null,"abstract":"This study aimed to examine reticulon 4 (RTN4), neurite outgrowth inhibitor protein expression that changes in high-altitude traumatic brain injury (HA-TBI) and affects on blood-brain barrier's (BBB) function. C57BL/6J 6-8-week-old male mice were used for TBI model induction and randomized into the normal altitude group and the 5000-m high-altitude (HA) group, each group was divided into control (C) and 8h/12h/24h/48h-TBI according to different times post-TBI. Brain water content (BWC) and modified Neurological Severity Score were measured, RTN4 and autophagy-related indexes (Beclin1, LC3B, and SQSTM1/p62) were detected by western blot, immunofluorescence technique, and PCR in peri-injury cortical tissues. The expression of NgR1, Lingo-1, TROY, P75, PirB, S1PR2, and RhoA receptors' downstream of RTN4 was detected by PCR. HA-TBI caused increased neurological deficits including motor, sensory, balance and reflex deficits, increased BWC, earlier peak RTN4 expression and a longer duration of high expression in peri-injury cortical tissues, and enhanced levels of Beclin1, LC3B, and SQSTM1/p62 to varying degrees. Concurrently, the transcription of S1PR2 and PirB, the main signaling molecules downstream of RTN4, was significantly increased. In HA-TBI's early stages, the increased RTN4 may regulate enhanced autophagic initiation and impaired autolysosome degradation in vascular endothelial cells via S1PR2 receptor activation, thereby reducing BBB function. This suggests that autophagy could be a new target using RTN4 intervention as a clinical HA-TBI mechanism.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"81-92"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes obtained from human adipose-derived stem cells alleviate epileptogenesis in the pentylenetetrazol model of epilepsy. 从人脂肪来源的干细胞中获得的外泌体减轻戊四氮唑癫痫模型的癫痫发生。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-29 DOI: 10.1097/WNR.0000000000002133

Fateme Derisfard, Zahra Jafarinezhad, Negar Azarpira, Mohammad Reza Namavar, Hadi Aligholi

{"title":"Exosomes obtained from human adipose-derived stem cells alleviate epileptogenesis in the pentylenetetrazol model of epilepsy.","authors":"Fateme Derisfard, Zahra Jafarinezhad, Negar Azarpira, Mohammad Reza Namavar, Hadi Aligholi","doi":"10.1097/WNR.0000000000002133","DOIUrl":"10.1097/WNR.0000000000002133","url":null,"abstract":"As exosome therapy is a promising treatment in neurological disorders including epilepsy, the present study aimed to evaluate the effects of exosomes obtained from human adipose-derived stem cells (ADSCs) on pentylenetetrazol (PTZ) model of epilepsy in mice. Thirty adult mice were divided into PTZ, diazepam + PTZ, and exosome (5, 10, and 15 µg) + PTZ groups. The exosomes were administered intranasally 30 min before PTZ injection. The seizure latency, tonic-clonic onset, seizure duration, and mortality protection rate were monitored. Also, the level of hippocampal malondialdehyde (MDA), the oxidative stress marker, was evaluated. Exosomes in 5 and 15 µg concentration significantly increased seizure latency. Only 15 µg of exosomes induced a considerable delay in tonic-clonic onset. Seizure duration was significantly attenuated in the 5 µg exosome group. In addition, the 5-µg exosome indicated the highest mortality protection rate. Furthermore, the MDA level was significantly reduced in all animals treated by exosomes. Exosomes obtained from human ADSCs could alleviate epileptogenesis induced by PTZ maybe through reducing hippocampal oxidative stress.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":"36 3","pages":"161-168"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0