IF 1.6 4区医学

Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-10-11 DOI: 10.1097/WNR.0000000000002106

Xiaopeng Sun, Shugang Xu, Jingjing Wang, Xiaohong Li, Hongtao Sun, Wanyong Zhao

{"title":"Long-term hypothermia amplified neuroprotection by antagonizing intracranial pressure rebound after severe traumatic brain injury in rats.","authors":"Xiaopeng Sun, Shugang Xu, Jingjing Wang, Xiaohong Li, Hongtao Sun, Wanyong Zhao","doi":"10.1097/WNR.0000000000002106","DOIUrl":"10.1097/WNR.0000000000002106","url":null,"abstract":"Long-term hypothermia has been reported to prevent intracranial pressure (ICP) rebound in clinical patients, but the duration for hypothermia and the corresponding ICP data are not available. This study investigated the optimal duration of long-term hypothermia in traumatic brain injury (TBI) rats, and observed the effect on ICP and neurological function. In this study, we established a rat severe TBI model with electronic Controlled Cortical Injury device, and implemented hypothermia (33 °C) for different durations. The motor function of the rats in each group was evaluated by beam walking test and inclined-grid climbing test, brain water content was calculated by the wet-dry weight method, Evan's blue staining was used to measure the blood-brain barrier (BBB) permeability, the change of hippocampal neurons was observed by Nissl staining, the expressions of BrdU, NeuN, and CD86 positive cells were detected by immunofluorescence staining, and the expressions of Bcl-2, Bax, iNOS, IL-10, and Arg-1 were detected by Western blot. We found that therapeutic hypothermia improved neurological recovery after TBI with declining ICP, reducing brain edema, decreasing BBB permeability, promoting neurogenesis, inhibiting apoptosis, and regulating inflammation. Moreover, 48 h hypothermia amplified the neuroprotective effect after injury on the basis of 4 or 24 h hypothermic treatment. Both 4 and 24 h hypothermia led to ICP rebound during or after rewarming, whereas 48 h hypothermia completely abolished ICP rebound. Our study suggests that long-term hypothermia amplifies neuroprotection after TBI by antagonizing ICP rebound.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of apelin-13 in a mouse model of post-traumatic stress disorder. apelin-13 在创伤后应激障碍小鼠模型中的作用。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-09-30 DOI: 10.1097/WNR.0000000000002104

Yang Zhou, Zijun Meng, Yuqing Han, Xiaofang Yang, Jinxia Kuai, Haijun Bao

{"title":"The effects of apelin-13 in a mouse model of post-traumatic stress disorder.","authors":"Yang Zhou, Zijun Meng, Yuqing Han, Xiaofang Yang, Jinxia Kuai, Haijun Bao","doi":"10.1097/WNR.0000000000002104","DOIUrl":"10.1097/WNR.0000000000002104","url":null,"abstract":"The objective is to investigate the effects of apelin-13 in models of post-traumatic stress disorder (PTSD). Mature male CD1 mice were subjected to the single prolonged stress method to induce PTSD-related behaviors. These behaviors were then evaluated using the elevated plus maze test, Morris water maze test, and open field test. Hippocampal neural cell death was assessed using propidium iodide labeling. The expression of hippocampal autophagy pathway-associated proteins was determined through immunoblotting analysis, and LC3 levels were also measured via quantitative real-time reverse transcription-PCR. The results demonstrate that administration of apelin-13 suppressed PTSD-induced hippocampal neural cell death and alleviated PTSD-related behaviors in mice. Additionally, PTSD led to an up-regulation of LC3 and FoxO3a, and down-regulation of P62, p-PI3K, p-Akt, and p-FoxO3a in the hippocampus. However, these changes were reversed by apelin-13 treatment. These findings support the hypothesis that apelin-13 prevents the development of PTSD-like behavior and inhibits autophagy of neuronal cells in a mouse model of PTSD. Apelin-13 may hold potential as a therapeutic agent for PTSD in clinical applications.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium valproate ablates ferroptosis in kainic acid-induced epileptic seizure via suppressing lysyl oxidase. 丙戊酸钠通过抑制赖氨酰氧化酶消减凯尼酸诱导的癫痫发作中的铁突变。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-09-30 DOI: 10.1097/WNR.0000000000002103

Qin Li, Yu-Han Huang, Qiu-Qi Li, Ji-Ning Jia, Zhao-Qian Liu, Hong-Hao Zhou, Xin-Yu Zhou, Wei-Lin Jin, Xiao-Yuan Mao

{"title":"Sodium valproate ablates ferroptosis in kainic acid-induced epileptic seizure via suppressing lysyl oxidase.","authors":"Qin Li, Yu-Han Huang, Qiu-Qi Li, Ji-Ning Jia, Zhao-Qian Liu, Hong-Hao Zhou, Xin-Yu Zhou, Wei-Lin Jin, Xiao-Yuan Mao","doi":"10.1097/WNR.0000000000002103","DOIUrl":"10.1097/WNR.0000000000002103","url":null,"abstract":"The objective of this study is to explore whether sodium valproate (VPA) alleviates epileptic seizures via suppressing lysyl oxidase (Lox)-mediated ferroptosis. Epileptic seizure mouse model was prepared via intrahippocampal injection of kainic acid (250 ng/μl). After treatment with kainic acid, VPA was injected intraperitoneally by the dose of 250 mg/kg twice daily for 4 days. Ferroptosis-associated indices including lipid peroxides (LPO) level and Ptgs2 mRNA in hippocampal tissue samples were detected. Additionally, effects of VPA on Lox mRNA and enzymatic activity were assessed by quantitative real-time PCR and a commercial kit, respectively. Neuronal survival was assessed by Nissl staining. In kainic acid-induced epileptic seizure mouse model, VPA significantly suppressed LPO level and Ptgs2 mRNA and the suppression of ferroptosis was positively correlated with its anti-seizure effect. Lox mRNA and enzymatic activity were also found to decrease in hippocampus of epileptic seizure mice after VPA treatment. Furthermore, overexpression of Lox via adeno-associated virus infection remarkably abrogated the inhibitory effect of VPA on ferroptosis and neuronal impairment together with its anti-seizure effect. VPA suppresses Lox-mediated ferroptosis process, which can provide the explanation for its anti-seizure property.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disrupted functional connectivity of bilateral nucleus accumbens in major depressive disorder with and without melancholic features. 伴有或不伴有忧郁症特征的重度抑郁障碍患者双侧伏隔核的功能连接紊乱

IF 1.6 4区医学

Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-09-18 DOI: 10.1097/WNR.0000000000002097

Hezhi Yan, Zhaosong Chu, Zonglin Shen, Lijin Yuan, Yanru Wu, Yi Lu, Hongyan Jiang, Xiufeng Xu

{"title":"Disrupted functional connectivity of bilateral nucleus accumbens in major depressive disorder with and without melancholic features.","authors":"Hezhi Yan, Zhaosong Chu, Zonglin Shen, Lijin Yuan, Yanru Wu, Yi Lu, Hongyan Jiang, Xiufeng Xu","doi":"10.1097/WNR.0000000000002097","DOIUrl":"10.1097/WNR.0000000000002097","url":null,"abstract":"Our study aims to explore the differences in functional connectivity in the nucleus accumbens (NAc) between patients with melancholic depression and non-melancholic depression (NMD) and their relation to melancholic depression's pathogenesis. We recruited 60 melancholic depression, 58 NMD, and 80 healthy controls, all matched for gender, age, and education. Functional connectivity analysis focused on bilateral NAc as the region of interest, comparing it with the whole brain and correlating significant differences with clinical scores. Melancholic depression patients showed reduced functional connectivity between the left NAc and anterior brain regions, and between the right NAc and temporal and frontal areas, compared to healthy controls. In contrast, NMD patients displayed reduced functional connectivity only between the left NAc and the posterior cingulate cortex. Melancholic depression patients also exhibited increased functional connectivity between the right NAc and the middle frontal gyrus, unlike NMD patients. The findings suggest that melancholic depression patients exhibit unique NAc functional connectivity patterns, particularly with the default mode network and prefrontal areas, suggesting atypical reward-circuitry interactions. The right NAc's connection to the prefrontal gyrus may distinguish melancholic depression from NMD.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting the effectiveness of binaural beats on working memory. 预测双耳节拍对工作记忆的影响

IF 1.6 4区医学

Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-09-30 DOI: 10.1097/WNR.0000000000002101

Ahmad Zahid Rao, Muhammad Danish Mujib, Saad Ahmed Qazi, Ahmad O Alokaily, Ayesha Ikhlaq, Eraj Humayun Mirza, Ahmed Ali Aldohbeyb, Muhammad Abul Hasan

{"title":"Predicting the effectiveness of binaural beats on working memory.","authors":"Ahmad Zahid Rao, Muhammad Danish Mujib, Saad Ahmed Qazi, Ahmad O Alokaily, Ayesha Ikhlaq, Eraj Humayun Mirza, Ahmed Ali Aldohbeyb, Muhammad Abul Hasan","doi":"10.1097/WNR.0000000000002101","DOIUrl":"10.1097/WNR.0000000000002101","url":null,"abstract":"Working memory is vital for short-term information processing. Binaural beats can enhance working memory by improving attention and memory consolidation through neural synchronization. However, individual differences in cognitive and neuronal functioning affect effectiveness of binaural beats, necessitating personalized approaches. This study aimed to develop a machine learning model to predict binaural beats's effectiveness on working memory using electroencephalography. Sixty healthy participants underwent a 5-min electroencephalography recording, an initial working memory evaluation, 15 min of binaural beats stimulation, and a subsequent working memory evaluation using digit span tests of increasing difficulty. Recall accuracy and response times were measured. Differential scores from pre-evaluation and post-evaluation labeled participants as active or inactive to binaural beats stimulation. electroencephalography data, recorded using 14 electrodes, provided brain activity estimates across theta, alpha, beta, and gamma frequency bands, resulting in 56 features (14 channels × 4 bands) for the machine learning model. Several classifiers were tested to identify the most effective model. The weighted K-nearest neighbors model achieved the highest accuracy (90.0%) and area under the receiver operating characteristic curve (92.24%). Frontal and parietal electroencephalography channels in theta and alpha bands were crucial for classification. This study's findings offer significant clinical insights, enabling informed interventions and preventing resource inefficiency.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gray matter volume differences based on sex in first-episode drug-naive patients with major depressive disorder and its molecular analysis. 基于性别的重度抑郁障碍首发药物依赖者灰质体积差异及其分子分析。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-10-10 DOI: 10.1097/WNR.0000000000002107

Duo Sun, Kang Xi, Runxu Yang, Jiangmin Chu, Mingjie Xu, Dafu Zhang, Yuqi Cheng

{"title":"Gray matter volume differences based on sex in first-episode drug-naive patients with major depressive disorder and its molecular analysis.","authors":"Duo Sun, Kang Xi, Runxu Yang, Jiangmin Chu, Mingjie Xu, Dafu Zhang, Yuqi Cheng","doi":"10.1097/WNR.0000000000002107","DOIUrl":"10.1097/WNR.0000000000002107","url":null,"abstract":"This study analyzed whether gray matter volume (GMV) differences exist between the sexes in patients with major depressive disorder (MDD) and explored the relationships between these differences and neurotransmitter systems. This study enrolled 190 first-episode drug-naive patients with MDD and 293 healthy controls. All participants underwent T1-weighted high-resolution MRI. The interaction between the diagnosis (healthy controls vs. MDD) and sex (male vs. female) regarding GMV alterations was analyzed. The JuSpace toolbox, which covers a wide range of neurotransmitter systems, was used to identify the relationship between MDD-induced and sex-induced GMV alterations and specific receptor/transporter proteins in the brain. Sex-specific GMV differences were observed in the healthy controls but not in MDD patients. Male healthy controls had a larger GMV in the bilateral parahippocampal, lingual, inferior occipital, fusiform, cerebellar subregions, and left inferior temporal than female healthy controls, but several subregions of the thalamus had a larger GMV in female healthy controls than in male healthy controls. Sex-induced GMV alterations were associated with 5-hydroxytryptamine receptor subtype 1a, cannabinoid receptor, and dopamine receptor ( P < 0.01, false discovery rate corrected). GMV differences were not detected in the main effect of diagnosis and the interaction of diagnosis and sex. Sex-specific GMV differences are associated with the spatial distribution of serotonin, dopamine, and cannabinoid neurotransmitter receptor systems. Sex-based physiological differences in the GMV may account for male and female susceptibility to and differences in the clinical symptoms of MDD.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant dynamic functional and effective connectivity changes of the primary visual cortex in patients with retinal detachment via machine learning. 通过机器学习研究视网膜脱离患者初级视觉皮层的动态功能和有效连接性异常变化。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-10-03 DOI: 10.1097/WNR.0000000000002100

Yu Ji, Yuan-Yuan Wang, Qi Cheng, Wen-Wen Fu, Ben-Liang Shu, Bin Wei, Qin-Yi Huang, Xiao-Rong Wu

{"title":"Aberrant dynamic functional and effective connectivity changes of the primary visual cortex in patients with retinal detachment via machine learning.","authors":"Yu Ji, Yuan-Yuan Wang, Qi Cheng, Wen-Wen Fu, Ben-Liang Shu, Bin Wei, Qin-Yi Huang, Xiao-Rong Wu","doi":"10.1097/WNR.0000000000002100","DOIUrl":"10.1097/WNR.0000000000002100","url":null,"abstract":"Objective: Previous neuroimaging studies have identified significant alterations in brain functional activity in retinal detachment (RD) patients, these investigations predominantly concentrated on local functional activity changes. The potential directional alterations in functional connectivity within the primary visual cortex (V1) in RD patients remain to be elucidated.Methods: In this study, we employed seed-based functional connectivity analysis along with Granger causality analysis to examine the directional alterations in dynamic functional connectivity (dFC) within the V1 region of patients diagnosed with RD. Finally, a support vector machine algorithm was utilized to classify patients with RD and healthy controls (HCs).Results: RD patients exhibited heightened dynamic functional connectivity (dFC) and dynamic effective connectivity (dEC) between the Visual Network (VN) and default mode network (DMN), as well as within the VN, compared to HCs. Conversely, dFC between VN and auditory network (AN) decreased, and dEC between VN and sensorimotor network (SMN) significantly reduced. In state 4, RD patients had higher frequency. Notably, variations in dFC originating from the left V1 region proved diagnostically effective, achieving an AUC of 0.786.Conclusion: This study reveals significant alterations in the connectivity between the VN and the default mode network in patients with RD. These changes may disrupt visual information processing and higher cognitive integration in RD patients. Additionally, alterations in the left V1 region and whole-brain dFC show promising potential in aiding the diagnosis of RD. These findings offer valuable insights into the neural mechanisms underlying visual and cognitive impairments associated with RD.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered static brain activity and functional connectivity after heat stroke. 中暑后大脑静态活动和功能连接的改变。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-11-06 Epub Date: 2024-09-19 DOI: 10.1097/WNR.0000000000002096

Ting Yang, Xinyu Hou, Xu Li, Xiaoxin Chen, Zhengwei Qu, Wenzheng Zhang, Maoyang Wang, Jun Li

{"title":"Altered static brain activity and functional connectivity after heat stroke.","authors":"Ting Yang, Xinyu Hou, Xu Li, Xiaoxin Chen, Zhengwei Qu, Wenzheng Zhang, Maoyang Wang, Jun Li","doi":"10.1097/WNR.0000000000002096","DOIUrl":"10.1097/WNR.0000000000002096","url":null,"abstract":"This study aimed to investigate the alteration of brain function based on resting-state functional MRI in patients after heat stroke. This study included 10 cases of patients after heat stroke and 10 cases of healthy controls. Abnormal brain function was calculated using amplitude of low-frequency fluctuations (ALFF) and degree centrality analysis, as well as functional connectivity analysis based on regions of interest (ROI). Correlation analyses were performed to evaluate the association between brain function changes and clinical scales. Combining ALFF and degree centrality results, the decreased brain regions included the left cuneus and the right angular gyrus, while the increased brain regions included the right cerebellar_Crus1. Using the left cuneus with significant differences in ALFF and degree centrality as ROI, the functional connectivity results revealed decreased brain regions including bilateral lingual gyrus, bilateral postcentral cingulate gyrus, and left precentral gyrus. The degree centrality value of the right cerebellar_Crus1 was positively correlated with glasgow coma scale (GCS) scores ( r = 0.726, P = 0.027), and the functional connectivity value of the right posterior cingulate gyrus was positively correlated with GCS scores ( r = 0.717, P = 0.030). Heat stroke patients exhibit abnormal activity in multiple brain regions, which has important clinical significance for evaluating the severity of the disease.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pRb phosphorylation regulates the proliferation of supporting cells in gentamicin-damaged neonatal avian utricle: Erratum. pRb磷酸化调控庆大霉素损伤的新生禽类胞器支持细胞的增殖勘误。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-11-06 Epub Date: 2024-09-25 DOI: 10.1097/WNR.0000000000002102

引用次数: 0

Adipose-derived stem cell transplantation enhances spinal cord regeneration by upregulating PGRN expression. 脂肪源性干细胞移植通过上调PGRN的表达增强脊髓再生。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-11-06 Epub Date: 2024-09-12 DOI: 10.1097/WNR.0000000000002091

Qiongchi Zhang, Jingtao Wu, Dong Guo, Ning Ji, Weidong Liu, Xinyu Li, Hao Liu, Chengyi Zhang, Minchao Zhao, Haopeng Li, Hongxu Jin, Su'e Chang, Dong Wang

{"title":"Adipose-derived stem cell transplantation enhances spinal cord regeneration by upregulating PGRN expression.","authors":"Qiongchi Zhang, Jingtao Wu, Dong Guo, Ning Ji, Weidong Liu, Xinyu Li, Hao Liu, Chengyi Zhang, Minchao Zhao, Haopeng Li, Hongxu Jin, Su'e Chang, Dong Wang","doi":"10.1097/WNR.0000000000002091","DOIUrl":"10.1097/WNR.0000000000002091","url":null,"abstract":"This study aims to investigate the effect of adipose-derived stem cells (ADSCs) transplantation on progranulin (PGRN) expression and functional recovery in rats with spinal cord injury (SCI). ADSCs were isolated from the inguinal adipose tissue of rats. A SCI model was created, and ADSCs were injected into the injured area. Various techniques were used to assess the effects of ADSCs transplantation, including hematoxylin-eosin staining, Masson staining, immunofluorescence staining, electron microscopy, MRI, and motor function assessment. The potential mechanisms of ADSC transplantation were investigated using gene expression analysis and protein analysis. Finally, the safety of this therapy was evaluated through hematoxylin-eosin staining and indicators of liver and kidney damage in serum. PGRN expression increased in the injured spinal cord, and ADSCs transplantation further enhanced PGRN levels. The group that received ADSCs transplantation showed reduced inflammation, decreased scar formation, increased nerve regeneration, and faster recovery of bladder function. Importantly, motor function significantly improved in the ADSC transplantation group. ADSCs transplantation enhances functional regeneration in SCI by upregulating PGRN expression, reducing inflammation and scar formation, and promoting nerve regeneration and myelin repair. These findings suggest that ADSC transplantation is a potential therapy for SCI.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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