Neuroreport最新文献_第3页

Corticospinal excitability is not facilitated by observation of asymmetric walking on a split-belt treadmill in humans. 皮质脊髓兴奋性不促进观察不对称行走在分裂带跑步机上的人。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2024-12-18 DOI: 10.1097/WNR.0000000000002129

Masaya Kitamura, Tadao Ishikura, Kiyotaka Kamibayashi

{"title":"Corticospinal excitability is not facilitated by observation of asymmetric walking on a split-belt treadmill in humans.","authors":"Masaya Kitamura, Tadao Ishikura, Kiyotaka Kamibayashi","doi":"10.1097/WNR.0000000000002129","DOIUrl":"10.1097/WNR.0000000000002129","url":null,"abstract":"The present study aimed to investigate changes in corticospinal excitability (CSE) by observing unnatural walking patterns on a treadmill with different left and right belt speeds. Fifteen healthy adults watched video clips (10 s each) of walking under the tied condition (left and right treadmill belt speeds are the same), walking during the initial and late periods under the split-belt condition (left and right treadmill belt speeds are different), and the static fixation cross (control condition) in random order. The step lengths of the actor in the walking clips were almost symmetric under the tied condition and during the late period under the split-belt condition but largely asymmetric during the initial period under the split-belt condition. We recorded the motor-evoked potential (MEP) of the left tibialis anterior muscle during the observation of video clips by delivering transcranial magnetic stimulation to the right primary motor cortex. The MEP amplitude was significantly higher when observing walking under the tied condition and walking during the late period under the split-belt condition than the control condition. However, the MEP amplitudes during the observation of walking during the initial period under the split-belt condition and the control condition were not significantly different. These results indicate that observation of symmetric walking, even under the split-belt condition, facilitates CSE, whereas observation of unnatural asymmetric walking does not. Therefore, it is suggested that familiarity with observed movements affects CSE even in the observation of semi-automatic movements such as walking.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"140-144"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and clinical significance of 25-hydroxyvitamin D, insulin-like growth factor 1, and beta-2 microglobulin in cognitive dysfunction after ischemic stroke in the elderly. 25-羟基维生素D、胰岛素样生长因子1、β -2微球蛋白在老年人缺血性脑卒中后认知功能障碍中的表达及临床意义

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-06 DOI: 10.1097/WNR.0000000000002128

Huarong Yang, Qinhua Wu, Jianghuan Zheng

{"title":"Expression and clinical significance of 25-hydroxyvitamin D, insulin-like growth factor 1, and beta-2 microglobulin in cognitive dysfunction after ischemic stroke in the elderly.","authors":"Huarong Yang, Qinhua Wu, Jianghuan Zheng","doi":"10.1097/WNR.0000000000002128","DOIUrl":"10.1097/WNR.0000000000002128","url":null,"abstract":"We aimed to unveil the clinical significance of serum 25-hydroxyvitamin D (25-OH-VD), insulin-like growth factor 1 (IGF-1), and beta-2 microglobulin (β2-MG) levels in cognitive dysfunction after ischemic stroke (IS) in the elderly. A total of 160 geriatric IS patients admitted to our hospital were retrospectively collected. The patients' serum 25-OH-VD, IGF-1, and β2-MG levels were detected, and the correlation between the three levels and the patients' National Institutes of Health Stroke Scale (NIHSS) and Montreal Cognitive Assessment (MoCA) scores was tested by the Pearson test. The diagnostic values of 25-OH-VD, IGF-1, and β2-MG for cognitive dysfunction and risk factors inducing cognitive dysfunction in the elderly after IS were evaluated. NIHSS score was negatively correlated with serum 25-OH-VD and IGF-1 levels, and positively correlated with serum β2-MG levels; MoCA score exhibited an inverse correlation. Diabetes, years of education <12 years, age, and serum high-sensitive C-reactive protein, cystatin C, 25-OH-VD, IGF-1, and β2-MG levels were independent factors for the development of cognitive dysfunction after IS in the elderly. The detection of 25-OH-VD, IGF-1, and β2-MG may be important for assessing the occurrence of cognitive dysfunction and the severity of the disease in patients.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"127-134"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroacupuncture alleviates motor dysfunction after intracerebral hemorrhage via the PPARγ-EAAT2 pathway.

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-29 DOI: 10.1097/WNR.0000000000002134

Hequn Chen, Huiling Ren, Xudong Lu, Guosheng Shi, Qinglin Zhao, Dawei Zhao, Wei Bu

{"title":"Electroacupuncture alleviates motor dysfunction after intracerebral hemorrhage via the PPARγ-EAAT2 pathway.","authors":"Hequn Chen, Huiling Ren, Xudong Lu, Guosheng Shi, Qinglin Zhao, Dawei Zhao, Wei Bu","doi":"10.1097/WNR.0000000000002134","DOIUrl":"10.1097/WNR.0000000000002134","url":null,"abstract":"Nowadays, intracerebral hemorrhage (ICH) is the main cause of death and disability, and motor impairment is a common sequel to ICH. Electroacupuncture (EA) has been widely used for functional recovery after ICH. However, its role and associated regulatory mechanisms in rehabilitation after ICH remain poorly understood. This study investigated whether EA can have a neuroprotective effect in motor function after ICH by inhibiting glutamate-mediated excitotoxicity on the primary motor cortex. The model was established using autologous tail artery blood, followed by administration of EA at Quchi (LI11) and Zusanli (ST36) for 3 or 7 consecutive days. The rats' behavior was examined by modified neurological severity score (mNSS) and open-field test (OFT). Nissl staining, immunofluorescence detection, and transmission electron microscopy were used to observe the degree of neuron damage. The level of the cortical glutamate was detected by the ELISA. Peroxisome proliferator-activated receptor gamma (PPARγ) expression was detected by immunohistochemistry and western blot. The protein and mRNA expression of excitatory amino acid transporter 2 (EAAT2) was detected by western blot and quantitative real-time PCR. Our data demonstrated that EA significantly reduces glutamate levels, alleviates neuronal damage, and promotes motor function recovery in rats after ICH. In addition, EA upregulates PPARγ and EAAT2 expression. However, the protective effect of EA on motor function and EAAT2 expression are partially abolished by T0070907, an antagonist of PPARγ. EA at LI11 and ST36 improved glutamate excitotoxicity and promoted motor function recovery after ICH by activating the PPARγ-EAAT2 pathway and reducing the glutamate level.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"169-178"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plateau hypoxia-induced upregulation of reticulon 4 pathway mediates altered autophagic flux involved in blood-brain barrier disruption after traumatic brain injury. 高原缺氧诱导的网状4通路上调介导的自噬通量改变参与创伤性脑损伤后血脑屏障的破坏。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2024-12-02 DOI: 10.1097/WNR.0000000000002122

Xinning Dong, Jing Xu, Kejun Du, Xin Chen, Haifeng Shu, Sixun Yu

{"title":"Plateau hypoxia-induced upregulation of reticulon 4 pathway mediates altered autophagic flux involved in blood-brain barrier disruption after traumatic brain injury.","authors":"Xinning Dong, Jing Xu, Kejun Du, Xin Chen, Haifeng Shu, Sixun Yu","doi":"10.1097/WNR.0000000000002122","DOIUrl":"10.1097/WNR.0000000000002122","url":null,"abstract":"This study aimed to examine reticulon 4 (RTN4), neurite outgrowth inhibitor protein expression that changes in high-altitude traumatic brain injury (HA-TBI) and affects on blood-brain barrier's (BBB) function. C57BL/6J 6-8-week-old male mice were used for TBI model induction and randomized into the normal altitude group and the 5000-m high-altitude (HA) group, each group was divided into control (C) and 8h/12h/24h/48h-TBI according to different times post-TBI. Brain water content (BWC) and modified Neurological Severity Score were measured, RTN4 and autophagy-related indexes (Beclin1, LC3B, and SQSTM1/p62) were detected by western blot, immunofluorescence technique, and PCR in peri-injury cortical tissues. The expression of NgR1, Lingo-1, TROY, P75, PirB, S1PR2, and RhoA receptors' downstream of RTN4 was detected by PCR. HA-TBI caused increased neurological deficits including motor, sensory, balance and reflex deficits, increased BWC, earlier peak RTN4 expression and a longer duration of high expression in peri-injury cortical tissues, and enhanced levels of Beclin1, LC3B, and SQSTM1/p62 to varying degrees. Concurrently, the transcription of S1PR2 and PirB, the main signaling molecules downstream of RTN4, was significantly increased. In HA-TBI's early stages, the increased RTN4 may regulate enhanced autophagic initiation and impaired autolysosome degradation in vascular endothelial cells via S1PR2 receptor activation, thereby reducing BBB function. This suggests that autophagy could be a new target using RTN4 intervention as a clinical HA-TBI mechanism.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"81-92"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes obtained from human adipose-derived stem cells alleviate epileptogenesis in the pentylenetetrazol model of epilepsy.

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-29 DOI: 10.1097/WNR.0000000000002133

Fateme Derisfard, Zahra Jafarinezhad, Negar Azarpira, Mohammad Reza Namavar, Hadi Aligholi

{"title":"Exosomes obtained from human adipose-derived stem cells alleviate epileptogenesis in the pentylenetetrazol model of epilepsy.","authors":"Fateme Derisfard, Zahra Jafarinezhad, Negar Azarpira, Mohammad Reza Namavar, Hadi Aligholi","doi":"10.1097/WNR.0000000000002133","DOIUrl":"10.1097/WNR.0000000000002133","url":null,"abstract":"As exosome therapy is a promising treatment in neurological disorders including epilepsy, the present study aimed to evaluate the effects of exosomes obtained from human adipose-derived stem cells (ADSCs) on pentylenetetrazol (PTZ) model of epilepsy in mice. Thirty adult mice were divided into PTZ, diazepam + PTZ, and exosome (5, 10, and 15 µg) + PTZ groups. The exosomes were administered intranasally 30 min before PTZ injection. The seizure latency, tonic-clonic onset, seizure duration, and mortality protection rate were monitored. Also, the level of hippocampal malondialdehyde (MDA), the oxidative stress marker, was evaluated. Exosomes in 5 and 15 µg concentration significantly increased seizure latency. Only 15 µg of exosomes induced a considerable delay in tonic-clonic onset. Seizure duration was significantly attenuated in the 5 µg exosome group. In addition, the 5-µg exosome indicated the highest mortality protection rate. Furthermore, the MDA level was significantly reduced in all animals treated by exosomes. Exosomes obtained from human ADSCs could alleviate epileptogenesis induced by PTZ maybe through reducing hippocampal oxidative stress.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":"36 3","pages":"161-168"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive effect of aminocaproic acid combined with nimodipine on short-term rebleeding in patients with aneurysmal subarachnoid hemorrhage. 氨基己酸联合尼莫地平对动脉瘤性蛛网膜下腔出血患者短期再出血的预防作用。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2024-12-06 DOI: 10.1097/WNR.0000000000002127

Qiong Zhao, Zhongyang Liu, Qingcheng Yang

{"title":"Preventive effect of aminocaproic acid combined with nimodipine on short-term rebleeding in patients with aneurysmal subarachnoid hemorrhage.","authors":"Qiong Zhao, Zhongyang Liu, Qingcheng Yang","doi":"10.1097/WNR.0000000000002127","DOIUrl":"10.1097/WNR.0000000000002127","url":null,"abstract":"Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening and life-limiting disease with high mortality and disability rates. Herein, we aim to explore the preventive effect of aminocaproic acid combined with nimodipine on short-term rebleeding in patients with aSAH. Retrospectively, the medical data of patients with aSAH ( n = 256) were collected. According to different treatment methods, patients were categorized into the aminocaproic acid + nimodipine group ( n = 152) and the nimodipine group ( n = 104), and were treated for 1 week. Baseline characteristics, incidence of rebleeding, average velocity of cerebral artery blood flow, cerebral vasospasm index, vascular endothelial function, complications, and adverse events were analyzed between the two groups. After 1-week treatment, compared to the nimodipine group, the aminocaproic acid + nimodipine group exhibited lower incidence of rebleeding, notable decreases in average velocity of cerebral artery blood flow and the cerebral vasospasm index, and downregulation of endothelin-1 and vascular endothelial growth factor ( P < 0.05). There were no significant differences about complications and adverse events between the two groups. Aminocaproic acid combined with nimodipine is superior to nimodipine alone in preventing the short-term rebleeding in patients with aSAH, and has good safety.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"99-104"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional imaging of time on task and habituation in passive exposure to faces with emotional expression.

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-29 DOI: 10.1097/WNR.0000000000002130

Karin Labek, Roberto Viviani

引用次数: 0

Artemisinin antagonizes cognitive disorder in hyperuricemia through glutamate receptor-interacting protein 1-suppressed pyroptosis.

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-29 DOI: 10.1097/WNR.0000000000002131

Yanfang Chen, Shuangxi Chen, Huiqing Wang, Peng Cao

{"title":"Artemisinin antagonizes cognitive disorder in hyperuricemia through glutamate receptor-interacting protein 1-suppressed pyroptosis.","authors":"Yanfang Chen, Shuangxi Chen, Huiqing Wang, Peng Cao","doi":"10.1097/WNR.0000000000002131","DOIUrl":"10.1097/WNR.0000000000002131","url":null,"abstract":"The prevalence of hyperuricemia (HUA) is climbing worldwide and persistent elevation of serum uric acid impairs cognitive function. This study aimed to explore the mechanisms of Artemisinin (Art) antagonizing cognitive disorder in HUA by suppressing pyroptosis. A mouse model of HUA was established by intraperitoneal injection of 300 mg/kg potassium oxonate (PO) in C57BL/6 mice for 14 days. The mice were simultaneously treated with Art, an agonist of pyroptosis Polyphyllin VI (PPVI), or glutamate receptor-interacting protein 1 (GRIP1) knockdown lentiviral plasmid. After treatment, serum uric acid, IL-6, and TNF-ɑ levels were examined, as well as hippocampal IL-1β and IL-18 levels, and the cognitive function of mice was assessed by the Morris water maze test. Pathological changes in the CA1 of the hippocampus were observed. Cleave-caspase-1, GSDMD-N, and GRIP1 protein level in the hippocampus was quantified by western blot. After PO induction, the escape latency and the time spent in the target quadrant increased in mice, cell arrangement in CA1 hippocampus was loose and disorganized, with obvious inflammatory infiltration and serious damage being observed, and the mouse hippocampus had elevated cleaved-caspase-1, GSDMD-N, IL-1β, and IL-18. Art treatment reduced pyroptosis in the hippocampus and improved cognitive disorder in HUA mice. Administration of PPVI aggravated cognitive disorder in Art-treated HUA mice, and Art improved cognitive dysfunction in HUA mice by inhibiting pyroptosis through upregulation of GRIP1. Art blunts pyroptosis in the hippocampus of HUA mice suffering from cognitive disorder by upregulating GRIP1.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":"36 3","pages":"145-152"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of mitochondrially-targeted tetrapeptide in protecting against noise-induced hearing impairment. 线粒体靶向四肽对噪声性听力损伤的保护潜力。

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2024-12-02 DOI: 10.1097/WNR.0000000000002124

Niranj A Kumar, Azmi Marouf, Kumar N Alagramam, Ruben Stepanyan

{"title":"The potential of mitochondrially-targeted tetrapeptide in protecting against noise-induced hearing impairment.","authors":"Niranj A Kumar, Azmi Marouf, Kumar N Alagramam, Ruben Stepanyan","doi":"10.1097/WNR.0000000000002124","DOIUrl":"10.1097/WNR.0000000000002124","url":null,"abstract":"Noise-induced hearing loss (NIHL) constitutes a significant global health issue for which there is no effective treatment. The loss of cochlear hair cells and associated synaptopathy are common causes of hearing impairment. One primary mechanism implicated in NIHL is the accumulation of reactive oxygen species (ROS), which ultimately overwhelms cochlear cells. ROS are detected in the cochlea immediately after noise exposure and persist for at least a week. Within cells, ROS are primarily generated in mitochondria as byproducts of cellular metabolism. Elamipretide is a synthetic tetrapeptide known to concentrate in mitochondria, improving mitochondrial function and reducing ROS production. To test the hypothesis that elamipretide treatment mitigates NIHL, 16-week-old male and female CBA/J mice were exposed to 8-16 kHz octave-band noise (OBN) at 98 dB SPL for 2 hours. Elamipretide was administered intraperitoneally immediately after noise exposure and continued for 2 weeks. Efficacy was evaluated based on auditory brainstem response (ABR) thresholds, wave amplitudes, and wave latencies in treated and control groups. Results showed that OBN-exposed mice exhibited an elevation in ABR thresholds at 16 and 32 kHz and a reduction in ABR wave-I amplitude at 32 kHz, although wave-I latencies were not affected at 16 or 32 kHz. Elamipretide treatment prevented the OBN-induced elevation of ABR thresholds and the attenuation of wave-I amplitude. These findings provide proof of concept that mitochondrial-targeted elamipretide can prevent NIHL in a mammalian model and highlight its potential to protect against NIHL in humans.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"93-98"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A finite set of content-free pointers in visual working memory: magnetoencephalography (MEG) evidence.

IF 1.6 4区医学

Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-29 DOI: 10.1097/WNR.0000000000002132

Xinchi Yu, Ellen Lau

引用次数: 0