Neurotoxicology and teratology最新文献

{"title":"The effect of maternal and offspring exercise in mitigating motor deficits following exposure to developmental benzo[a]pyrene exposure","authors":"Alexandria Easton, Mackenzie Feltner, Christina Gogzheyan, Deaysha Fox, Leah Bishop, LeaAnn King, Annika White, Christine Curran","doi":"10.1016/j.ntt.2025.107499","DOIUrl":"10.1016/j.ntt.2025.107499","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107499"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid hormone insufficiency alters the pattern of expression of the Ca2+-binding proteins calbindin and parvalbumin in the rat neonatal cortex","authors":"MaryAnn Hawks , Ryne Thomas , Mary Gilbert","doi":"10.1016/j.ntt.2025.107479","DOIUrl":"10.1016/j.ntt.2025.107479","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107479"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of early-life nicotine exposure on striatal GABA interneurons and motivated behavior","authors":"Mia Trupiano, Deirdre McCarthy, Devon Graham, Gregg Stanwood, Pradeep Bhide","doi":"10.1016/j.ntt.2025.107480","DOIUrl":"10.1016/j.ntt.2025.107480","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107480"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights into choline and methyl donor nutrients: Mitigating inflammation during pregnancy","authors":"Elisabeth Larson , Laura Smith , Karen Switkowski , Wei Perng , Sheryl Rifas-Shiman , Emily Oken","doi":"10.1016/j.ntt.2025.107491","DOIUrl":"10.1016/j.ntt.2025.107491","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107491"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using systematic evidence mapping to explore lead exposure and antisocial behavior outcomes in toxicology studies","authors":"Laura Carlson , Kirstin Hester , Parker Duffney , Ellen Kirraine , Rachel Shaffer","doi":"10.1016/j.ntt.2025.107467","DOIUrl":"10.1016/j.ntt.2025.107467","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107467"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficulties in assessing risks of neurotoxic metal contamination through community-engaged toxicology research","authors":"Christine Curran, Nirmal Pandit, Abilene Morgan","doi":"10.1016/j.ntt.2025.107468","DOIUrl":"10.1016/j.ntt.2025.107468","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107468"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral toxicity of PFAS: Mixture effects and interactions with immunogens in developing artemia","authors":"Andrew Hawkey, Desiree Batangan, Melissa Haque, Matthew Pytynia, Vaibhav Tiwari","doi":"10.1016/j.ntt.2025.107465","DOIUrl":"10.1016/j.ntt.2025.107465","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107465"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal fentanyl disrupts long-term social dominance behaviors and gene expression patterns","authors":"Devon Graham, Chioma Uchegbu, Trinity Nguyen, Inayat Sood, Kimberly Blankenship, Huan He, Gregg Stanwood, Cynthia Vied","doi":"10.1016/j.ntt.2025.107481","DOIUrl":"10.1016/j.ntt.2025.107481","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107481"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre maternal dietary inulin and psyllium increase serum BDNF levels and reduce anxious behaviors in maternally separated and control juvenile rat offspring","authors":"Lori Driscoll, Matthew Viozzi, Rocky Sui","doi":"10.1016/j.ntt.2025.107493","DOIUrl":"10.1016/j.ntt.2025.107493","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107493"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral and neurochemical alterations in female mice following pregestational exposure to SARS-CoV-2 lysate protein","authors":"Bárbara Beatriz da Silva Nunes ,&nbsp;Juliana dos Santos Mendonça ,&nbsp;Stênio Gonçalves da Silva Matos ,&nbsp;Aline Sueli de Lima Rodrigues ,&nbsp;Bruno da Cruz Pádua ,&nbsp;Thiarlen Marinho da Luz ,&nbsp;Guilherme Malafaia","doi":"10.1016/j.ntt.2025.107451","DOIUrl":"10.1016/j.ntt.2025.107451","url":null,"abstract":"<div><div>The rapid introduction of new environmental contaminants, including viral agents like SARS-CoV-2, has raised concerns about their indirect effects on non-target terrestrial organisms, especially through contaminated water sources. In this study, we investigated the potential neurotoxic effects of pre-mating and gestational exposure to SARS-CoV-2 lysate protein. Female C57Bl/6 J mice were exposed to a concentration of 20 μg/L for 30 days via drinking water. No significant effects were observed on gestational duration, litter size, or offspring biomass, suggesting no direct impact on reproductive performance. However, exposed females exhibited marked neurobehavioral alterations, including increased anxiety-like behavior in the open field test and altered maternal care dynamics, characterized by hyper-responsiveness and increased nest attendance duration. These behavioral changes were strongly correlated with neurochemical imbalances, including elevated dopamine levels in the olfactory bulb, brain, and hypothalamic-pituitary region. Additionally, cholinesterase activity was significantly altered, with increased acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in the olfactory bulb and brain, but decreased AChE activity in the hypothalamus-pituitary region, suggesting disrupted cholinergic signaling. Furthermore, oxidative and nitrosative stress markers (ROS and NO) were significantly elevated in mammary and ovarian tissues, indicating a persistent inflammatory response even after exposure cessation. These findings highlight long-term neurochemical and behavioral disruptions following environmentally relevant exposure to SARS-CoV-2 lysate protein, which could compromise neurophysiological homeostasis, stress regulation, and maternal investment in non-target mammals. In natural environments, such alterations may reduce individual fitness and population resilience, emphasizing the need to further investigate the ecotoxicological consequences of viral pollutants on terrestrial organisms.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107451"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}