Neurotoxicology and teratology最新文献

{"title":"Spatiotemporal protein dynamics during early organogenesis in mouse conceptuses treated with valproic acid","authors":"Samantha Lapehn,&nbsp;Justin A. Colacino,&nbsp;Craig Harris","doi":"10.1016/j.ntt.2023.107286","DOIUrl":"10.1016/j.ntt.2023.107286","url":null,"abstract":"<div><p><span>Valproic acid (VPA) is an anti-epileptic medication that increases the risk of </span>neural tube<span><span><span> defect (NTD) outcomes in infants exposed during gestation. Previous studies into VPA's mechanism of action have focused on alterations in gene expression and metabolism but have failed to consider how exposure changes the abundance of critical developmental proteins over time. This study evaluates the effects of VPA on protein abundance in the developmentally distinct tissues of the mouse visceral yolk sac (VYS) and embryo proper (EMB) using mouse whole embryo culture. Embryos were exposed to 600 μM VPA at 2 h intervals over 10 h during early organogenesis with the aim of identifying protein pathways relevant to VPA's mechanism of action in failed NTC. Protein abundance was measured through tandem mass tag (TMT) labeling followed by liquid chromatography and </span>mass spectrometry<span><span><span>. Overall, there were over 1500 proteins with altered abundance after VPA exposure in the EMB or VYS with 428 of these proteins showing previous gene expression associations with VPA exposure. Limited overlap of significant proteins between tissues supported the conclusion of independent roles for the VYS and EMB in response to VPA. Pathway analysis of proteins with increased or decreased abundance identified multiple pathways with mechanistic relevance to NTC and </span>embryonic development including convergent extension, Wnt Signaling/planar </span>cell polarity, cellular migration, </span></span>cellular proliferation, cell death, and cytoskeletal organization processes as targets of VPA. Clustering of co-regulated proteins to identify shared patterns of protein abundance over time highlighted 4 h and 6/10 h as periods of divergent protein abundance between control and VPA-treated samples in the VYS and EMB, respectively. Overall, this study demonstrated that VPA temporally alters protein content in critical developmental pathways in the VYS and the EMB during early organogenesis in mice.</span></p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"99 ","pages":"Article 107286"},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10238806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in marijuana use from adolescence to young adulthood and its relation to gestational alcohol and marijuana exposure","authors":"Lidush Goldschmidt ,&nbsp;Gale A. Richardson ,&nbsp;Nancy L. Day ,&nbsp;Natacha M. De Genna","doi":"10.1016/j.ntt.2023.107287","DOIUrl":"10.1016/j.ntt.2023.107287","url":null,"abstract":"<div><h3>Introduction</h3><p>Many studies have examined changes in marijuana use across adolescence, but few have examined factors associated with transitions from adolescence to young adulthood. We examined prenatal exposures to alcohol and marijuana and adolescent risk and protective factors that best distinguished among abstinence, continuity, or cessation of marijuana use from 16 to 22 years.</p></div><div><h3>Method</h3><p><span><span>Data were from the Maternal Health Practices and Child Development Project at the prenatal and 16- and 22-year follow-up phases. The offspring were of lower socioeconomic status with an average of 12.8 years of education at 22 years. Participants' frequency and quantity of marijuana use over the past year were used to determine change in use. A </span>discriminant analysis was applied to distinguish among the identified groups. The risk factors considered included prenatal substance exposures and age 16 demographics, </span>behavior, and home environment.</p></div><div><h3>Result</h3><p>Four categories of transitions were defined based on marijuana use from 16 to 22 years: non-users (<em>n</em> = 193), stop/decrease (<em>n</em> = 81), continue at same level/increase (<em>n</em> = 125), and initiation after the 16-year phase (<em>n</em> = 122). The factors that best distinguished among these groups were peers' marijuana use, delinquency, caregivers' financial strain, prenatal exposure to alcohol and marijuana, and race.</p></div><div><h3>Conclusion</h3><p>Prenatal alcohol and marijuana exposure were significantly related to transitions of marijuana use from adolescence to young adulthood, controlling for peers' use, behavior problems, and home environment. While gestational marijuana exposure was associated with early initiation/increasing use, alcohol exposure was related to later initiation. The findings emphasize the long-term effects of prenatal exposure to alcohol and marijuana.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"99 ","pages":"Article 107287"},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10236977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NSAIDs exposure during late pregnancy: Trends in prescriptions and reporting fetal adverse effects","authors":"Fatiha Karam ,&nbsp;Sara Miranda ,&nbsp;Laurent Chouchana ,&nbsp;Tessa Pietri ,&nbsp;Isabelle Lacroix ,&nbsp;Judith Cottin ,&nbsp;Jérôme Drouin ,&nbsp;Mehdi Benkebil ,&nbsp;Emilie Vittaz ,&nbsp;Thierry Vial","doi":"10.1016/j.ntt.2023.107224","DOIUrl":"10.1016/j.ntt.2023.107224","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107224"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45689682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal cocaine exposure and self-reported behavioral adjustments from ages 12 to 21: Environmental pathways","authors":"Meeyoung Min ,&nbsp;Jeffrey Albert ,&nbsp;Sonia Minnes ,&nbsp;June-Yung Kim ,&nbsp;Sun-Kyung Kim ,&nbsp;Gregory Powers ,&nbsp;Lynn Singer","doi":"10.1016/j.ntt.2023.107275","DOIUrl":"10.1016/j.ntt.2023.107275","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107275"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48957374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort","authors":"Carly V. Goodman ,&nbsp;Christine Till ,&nbsp;Rivka Green ,&nbsp;Jana El-Sabbagh ,&nbsp;Tye E. Arbuckle ,&nbsp;Richard Hornung ,&nbsp;Bruce Lanphear ,&nbsp;Jean R. Seguin ,&nbsp;Linda Booij ,&nbsp;Mandy Fisher ,&nbsp;Gina Muckle ,&nbsp;Maryse F. Bouchard ,&nbsp;Jillian Ashley-Martin","doi":"10.1016/j.ntt.2023.107181","DOIUrl":"10.1016/j.ntt.2023.107181","url":null,"abstract":"<div><h3>Background</h3><p>Exposure to perfluoroalkyl substances (PFAS) has been shown to be neurotoxic in experimental studies, but epidemiological evidence linking prenatal PFAS exposure to child neurodevelopment is equivocal and scarce.</p></div><div><h3>Objective</h3><p>To quantify associations between prenatal exposure to legacy PFAS and children's intelligence (IQ) and executive functioning (EF) in a Canadian pregnancy and birth cohort and to determine if these associations differ by child sex.</p></div><div><h3>Methods</h3><p>We measured first-trimester plasma concentrations of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) in the Maternal-Infant Research on Environmental Chemicals (MIREC) study and assessed children's full-scale (<em>n</em> = 522), performance (<em>n</em> = 517), and verbal (<em>n</em> = 519) IQ using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III). Children's working memory (<em>n =</em> 513) and ability to plan and organize (<em>n</em> = 514) were assessed using a parent-reported questionnaire, the Behavior Rating Inventory of Executive Function - Preschool Version (BRIEF-P). We quantified associations between individual log2-transformed PFAS exposure and children's IQ and EF using multiple linear regression analyses and evaluated effect modification by child sex. We also used Repeated Holdout Weighted Quantile Sum (WQS) regression models with effect modification by child sex to quantify the effect of combined exposure to all three PFAS chemicals on IQ and EF. All models were adjusted for key sociodemographic characteristics.</p></div><div><h3>Results</h3><p>Geometric mean plasma concentrations (IQR) for PFOA, PFOS and PFHxS were 1.68 (1.10–2.50), 4.97 (3.20–6.20) and 1.09 (0.67–1.60) μg/L respectively. We found evidence of effect modification by child sex in all models examining performance IQ (<em>p</em> &lt; .01). Specifically, every doubling of PFOA, PFOS, and or PFHxS was inversely associated with performance IQ, but only in males (PFOA: <em>B</em> = −2.80, 95% CI: −4.92, −0.68; PFOS: <em>B</em> = −2.64, 95% CI: −4.77, −0.52; PFHxS: <em>B</em> = −2.92, 95% CI: −4.72, −1.12). Similarly, every quartile increase in the WQS index was associated with poorer performance IQ in males (<em>B</em> = −3.16, 95% CI: −4.90, −1.43), with PFHxS contributing the largest weight to the index. In contrast, no significant association was found for females (<em>B</em> = 0.63, 95% CI: −0.99, 2.26). No significant associations were found for EF in either males or females.</p></div><div><h3>Conclusions</h3><p>Higher prenatal PFAS exposure was associated with lower performance IQ in males, suggesting that this association may be sex- and domain-specific.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107181"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10151722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotretinoin cases in the Finnish TIS database","authors":"Maria Ellfolk ,&nbsp;Melinda Gonzalez ,&nbsp;Julia Reponen ,&nbsp;Heli Malm","doi":"10.1016/j.ntt.2023.107231","DOIUrl":"10.1016/j.ntt.2023.107231","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107231"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47756376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes following maternal favipiravir exposure: A case series","authors":"Baris Karadas ,&nbsp;Nusret Uysal ,&nbsp;Secil Karaca Kurtulmus ,&nbsp;Merve Tor ,&nbsp;Ismail Yilmaz ,&nbsp;Nihal Olgac Dundar ,&nbsp;Yusuf Cem Kaplan","doi":"10.1016/j.ntt.2023.107213","DOIUrl":"10.1016/j.ntt.2023.107213","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107213"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48622929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do infant behaviors mediate the relationship of prenatal cocaine exposure (PCE) to adult perceptual reasoning deficits?","authors":"Lynn Singer ,&nbsp;Jeffrey Albert ,&nbsp;Sun-kyung Kim ,&nbsp;Sonia Minnes ,&nbsp;Meeyoung Min ,&nbsp;June-yung Kim ,&nbsp;Gregory Powers","doi":"10.1016/j.ntt.2023.107266","DOIUrl":"10.1016/j.ntt.2023.107266","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107266"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49453350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monotherapy treatment of epilepsy in pregnancy: Congenital malformation outcomes in the child","authors":"Sonia Khanom ,&nbsp;Naghme Adab ,&nbsp;Matthew Bluett-Duncan ,&nbsp;Jill Clayton-Smith ,&nbsp;Jakob Christensen ,&nbsp;Katherine Edwards ,&nbsp;Janette Greenhalgh ,&nbsp;Ruaraidh Hill ,&nbsp;Cerian Jackson ,&nbsp;Anthony Marson ,&nbsp;Ronan McGinty ,&nbsp;Catrin Tudur-Smith ,&nbsp;Jennifer Weston ,&nbsp;Rebecca Bromley","doi":"10.1016/j.ntt.2023.107243","DOIUrl":"https://doi.org/10.1016/j.ntt.2023.107243","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107243"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50168697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying safety concerns related to antiseizure medication use in breastfeeding women with epilepsy by reviewing questions to the Norwegian drug information and pharmacovigilance centres","authors":"Sunniva Reitan Riibe ,&nbsp;Kristine Heitmann ,&nbsp;Jan Schjøtt ,&nbsp;Bettina Riedel","doi":"10.1016/j.ntt.2023.107220","DOIUrl":"https://doi.org/10.1016/j.ntt.2023.107220","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107220"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50169929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}