Neurotoxicology and teratology最新文献

{"title":"Impact of early-life lead exposure on adult delta-9-tetrahydrocannabinol sensitivity in male and female C57BL6/J mice","authors":"Daniel Garcy,&nbsp;Stephen L. Boehm II","doi":"10.1016/j.ntt.2023.107290","DOIUrl":"10.1016/j.ntt.2023.107290","url":null,"abstract":"<div><p>Environmental exposure to lead (Pb) and cannabis use are two of the largest public health issues facing modern society in the United States and around the world. Exposure to Pb in early life has been unequivocally shown to have negative impacts on development, and recent research is mounting showing that it may also predispose individuals for risk of developing substance use disorders (SUD). At the same time, societal and legal attitudes towards cannabis (the main psychoactive component of which is delta-9-tetrahydrocannabinol) have been shifting, and many American states have legalized the recreational use of cannabis. It is also the 3rd most widely used drug of abuse in the US, and rates of cannabis use disorder are on the rise. Here we establish a link between early life Pb exposure and later THC-related behavior in C57BL6/J mice, as has been demonstrated for other drugs of abuse. The study seeks to answer whether Pb exposure affects physiological/behavioral THC sensitivity (as measured by the cannabinoid-induced tetrad). It was hypothesized that Pb exposure would decrease THC sensitivity and that sex-dependent effects of Pb-exposure and THC would be observed. Interestingly, results showed that THC sensitivity was increased by Pb exposure, but only in female mice. Future research will fully explore the implications of these findings, namely how these effects impact THC self-administration and the mechanism(s) by which developmental Pb exposure produces these effects.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"100 ","pages":"Article 107290"},"PeriodicalIF":2.9,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10256631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between fluoride exposure in drinking water and cognitive deficits in children: A pilot study","authors":"Tewodros Rango Godebo ,&nbsp;Marc Jeuland ,&nbsp;Redda Tekle-Haimanot ,&nbsp;Biniyam Alemayehu ,&nbsp;Arti Shankar ,&nbsp;Amy Wolfe ,&nbsp;Nati Phan","doi":"10.1016/j.ntt.2023.107293","DOIUrl":"10.1016/j.ntt.2023.107293","url":null,"abstract":"<div><p>Fluoride (F^<img>) exposure in drinking water may lead to reduced cognitive function among children; however, findings largely remain inconclusive. In this pilot study, we examined associations between a range of chronic F^<img> exposures (low to high: 0.4 to 15.5 mg/L) in drinking water and cognition in school-aged children (5–14 years, n = 74) in rural Ethiopia. Fluoride exposure was determined from samples of community-based drinking water wells and urine. Cognitive performance was measured using: 1) assessments of ability to draw familiar objects (donkey, house, and person), and 2) a validated Cambridge Neuropsychological Test Automated Battery's (CANTAB) Paired Associate Learning (PAL), which examines memory and new learning and is closely associated with hippocampus function of the brain. Associations between F^<img> and cognitive outcomes were evaluated using regression analysis, adjusting for demographic, health status, and other covariates. The median (range) of water and urine F^<img> levels was 7.6 (0.4–15.5 mg/L) and 6.3 (0.5–15.7 mg/L), respectively; these measures were strongly correlated (<em>r</em> = 0.74), indicating that water is the primary source of F^<img> exposure. Fluoride in drinking water was negatively associated with cognitive function, measured by both drawing and CANTAB test performance. Inverse relationships were also found between F^<img> and drawing objects task scores, after adjusting for covariates (<em>p</em> &lt; 0.05). Further analysis using CANTAB PAL tasks in the children confirmed that F^<img> level in drinking water was positively associated with the number of errors made by children (<em>p</em> &lt; 0.01), also after adjusting for covariates (<em>p</em> &lt; 0.05). This association between water F^<img> and total errors made became markedly stronger as PAL task difficulty increased. Fluoride exposure was also inversely associated with other PAL tasks<img>the number of patterns reached, first attempt memory score and mean errors to success. These findings provide supportive evidence that high F^<img> exposures may be associated with cognitive deficits in children. Additional well-designed studies are critically needed to establish the neurotoxicity of F^<img> in children and adults exposed to both low levels known to protect dental caries, as well as excess F^<img> levels in drinking water.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"100 ","pages":"Article 107293"},"PeriodicalIF":2.9,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10256633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic effects of exogenous retinoic acid on the neurodevelopment of zebrafish (Danio rerio) embryos","authors":"Xiaoxuan Wang ,&nbsp;Ting Ma ,&nbsp;Cizhao Wei ,&nbsp;Juan Liu ,&nbsp;Ting Yu ,&nbsp;Yu Zou ,&nbsp;Song Liu ,&nbsp;Zheqiong Yang ,&nbsp;Jinlei Xi","doi":"10.1016/j.ntt.2023.107291","DOIUrl":"10.1016/j.ntt.2023.107291","url":null,"abstract":"<div><p>Endogenous retinoic acid<span><span><span> (RA) is essential for embryonic development and maintaining adult physiological processes. Human-caused RA residues in the environment threaten the survival of organisms in the environment. We employed zebrafish as a model to explore the developmental impacts of excess RA. We used exogenous RA to raise the amount of RA signal in the embryos and looked at the effects of excess RA on embryonic morphological development. Upregulation of the RA signal significantly reduced embryo hatching and increased embryo </span>malformation. To further understand the neurotoxic impact of RA signaling on early </span>neurodevelopment<span><span>, we measured the expression of neurodevelopmental marker genes and cell death and proliferation markers in zebrafish embryos. Exogenous RA disrupted stem cell (SC) and neuron marker gene expression and exacerbated apoptosis in the embryos. Furthermore, we looked into the links between the transcriptional coactivator RBM14 and RA signaling to better understand the mechanism of RA neurotoxicity. There was a negative interaction between RA signaling and the transcription coactivator RBM14, and the morpholino-induced RBM14 down-regulation can partially block the effects of </span>RAR antagonist BMS493-induced RA signaling inhibition on embryonic malformation and cell apoptosis. In conclusion, exogenous RA causes neurodevelopmental toxicity, and RBM14 may be involved in this neurotoxic process.</span></span></p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"100 ","pages":"Article 107291"},"PeriodicalIF":2.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10246710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of the prospective T2 MRI biomarker of neurotoxicity in a trimethyltin model in rats at 7 T","authors":"Serguei Liachenko ,&nbsp;Jaivijay Ramu ,&nbsp;Merle G. Paule ,&nbsp;Joseph Hanig","doi":"10.1016/j.ntt.2023.107289","DOIUrl":"https://doi.org/10.1016/j.ntt.2023.107289","url":null,"abstract":"<div><p><span>The assessment of the sensitivity and specificity of any potential biomarker against the gold standard is an important step in the process of its qualification by regulatory authorities. Such qualification is an important step towards incorporating the biomarker into the panel of tools available for drug development. In the current study we analyzed the sensitivity and specificity of T</span>₂<span> MRI<span> relaxometry to detect trimethyltin-induced neurotoxicity in rats. Seventy-five male Sprague-Dawley rats were injected with a single intraperitoneal dose of either TMT (8, 10, 11, or 12 mg/kg) or saline (2 ml/kg) and imaged with 7 T MRI before and 3, 7, 14, and 21 days after injection using a quantitative T</span></span>₂ mapping. Neurohistopathology (the gold standard in the case of neurotoxicity) was performed at the end of the observation and used as an outcome qualifier in receiver-operator characteristic (ROC) curve analysis of T₂ changes as a predictor of neurotoxicity. TMT treatment led to a significant increase in T₂ values in many brain areas. The biggest changes in T₂<span> values were seen around the lateral ventricles, which was interpreted as ventricular dilation. The area under the ROC curve for the volume of the lateral ventricles was 0.878 with the optimal sensitivity/specificity of 0.805/0.933, respectively. T</span>₂<span> MRI is a promising method for generating a non-invasive biomarkers of neurotoxicity, which shows the dose-response behavior with substantial sensitivity and specificity. While its performance was strong in the TMT model, further characterization of the sensitivity and specificity of T</span>₂ MRI with other neurotoxicants is warranted.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"100 ","pages":"Article 107289"},"PeriodicalIF":2.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50170454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental outcomes in children and adults with Fetal Valproate Spectrum Disorder: A contribution from the ConcePTION project","authors":"M. Bluett-Duncan ,&nbsp;D. Astill ,&nbsp;R. Charbak ,&nbsp;J. Clayton-Smith ,&nbsp;S. Cole ,&nbsp;P.A. Cook ,&nbsp;J. Cozens ,&nbsp;K. Keely ,&nbsp;J. Morris ,&nbsp;R. Mukherjee ,&nbsp;E. Murphy ,&nbsp;P. Turnpenny ,&nbsp;J. Williams ,&nbsp;A.G. Wood ,&nbsp;L.M. Yates ,&nbsp;R.L. Bromley","doi":"10.1016/j.ntt.2023.107292","DOIUrl":"10.1016/j.ntt.2023.107292","url":null,"abstract":"<div><h3>Aim</h3><p>To describe the neurodevelopmental phenotype of older children and adults with a diagnosis of Fetal Valproate Spectrum Disorder (FVSD).</p></div><div><h3>Methods</h3><p>In this cross-sectional study, 90 caregivers were recruited and completed a series of questionnaires regarding the neurodevelopmental outcomes of 146 individuals aged 7–37 years (M = 18.1), including individuals with a formal diagnosis of FVSD (<em>n</em> = 99), individuals exposed to Valproate but without an FVSD diagnosis (<em>n</em> = 24), and individuals not exposed to Valproate (<em>N</em> = 23). The mean dose of valproate exposure for individuals with an FVSD diagnosis was 1470 mg/day.</p></div><div><h3>Results</h3><p>Individuals with a diagnosis of FVSD showed significantly higher levels of moderate (43.4%) and severe (14.4%) cognitive impairment than other groups (<em>p</em> = 0.003), high levels of required formal educational support (77.6%), and poorer academic competence than individuals not exposed to Valproate (<em>p</em> = 0.001). Overall psychosocial problems (<em>p =</em> 0.02), internalising problems (<em>p</em> = 0.05) and attention problems (<em>p</em> = 0.001), but not externalising problems, were elevated in individuals with a diagnosis of FVSD. Rates of neurodevelopmental disorders, particularly autistic spectrum disorders (62.9%) and sensory problems (80.6%) are particularly central to the FVSD phenotype. There was no evidence of a statistical dose-dependent effect, possibly due to the high mean dose of exposure having a uniformly negative impact across the sample. Individuals with FVSD had required a significant number of health and child development services.</p></div><div><h3>Interpretation</h3><p>Children and young adults with a diagnosis of FVSD are at an increased risk of a range of altered neurodevelopmental outcomes, highlighting the need for a multidisciplinary approach to clinical management across the lifespan.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"100 ","pages":"Article 107292"},"PeriodicalIF":2.9,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10188146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Region- and age-specific effects of perinatal phthalate exposure on developmental cell death and adult anatomy of dorsal and ventral hippocampus and associated cognitive behaviors","authors":"Elli P. Sellinger ,&nbsp;Amara S. Brinks ,&nbsp;Rajvi R. Javeri ,&nbsp;Savannah L. Theurer ,&nbsp;Ruibin Wang ,&nbsp;Janice M. Juraska","doi":"10.1016/j.ntt.2023.107288","DOIUrl":"10.1016/j.ntt.2023.107288","url":null,"abstract":"<div><p><span><span>Humans are exposed to phthalates, a class of endocrine-disrupting chemicals used in food packaging/processing, PVC plastics, and personal care products. Gestational exposure may lead to adverse neurodevelopmental outcomes. In a rat model, </span>perinatal exposure<span><span> to an environmentally relevant mixture and dose of phthalates leads to increased developmental apoptosis in the medial prefrontal cortex (mPFC) and a subsequent reduction in neurons and in cognitive flexibility measured in adults of both sexes (Sellinger et al., 2021b; Kougias et al., 2018b). However, whether these effects generalize to other cognitive regions, like the hippocampus, is less well understood as existing studies used single phthalates at large doses, unrepresentative of human exposure. In the current study, patterns of naturally occurring cell death were first established in the dorsal and ventral hippocampal subfields (CA3 and CA1). Both dorsal and ventral CA3 reached high levels of cell death on P2 while levels in dorsal and ventral CA1 peaked on P5 in both sexes. Exposure to a phthalate mixture (0.2 and 1 mg/kg/day) throughout gestation through postnatal day 10 resulted in subtle age- and region-specific decreases in developmental cell death, however there were no significant changes in adult neuron number or associated </span>behaviors: the Morris </span></span>water maze and social recognition. Therefore, perinatal exposure to a low dose mixture of phthalates does not result in the dramatic structural and behavioral changes seen with high doses of single phthalates. This study also adds to our understanding of the distinct neurodevelopmental effects of phthalates on different brain regions.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"99 ","pages":"Article 107288"},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10239851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational paracetamol exposure induces core behaviors of neurodevelopmental disorders in infant rats and modifies response to a cannabinoid agonist in females","authors":"Rodrigo Moreno Klein ,&nbsp;Vanessa Nishikawa Motomura ,&nbsp;Juliana Diosti Debiasi ,&nbsp;Estefânia Gastaldello Moreira","doi":"10.1016/j.ntt.2023.107279","DOIUrl":"10.1016/j.ntt.2023.107279","url":null,"abstract":"<div><p><span><span>Paracetamol (PAR) is an over-the-counter analgesic/antipyretic used during pregnancy worldwide. Epidemiological studies have been associating gestational PAR exposure with neurobehavioral alterations in the </span>progeny<span><span> resembling autism spectrum disorders and attention-deficit hyperactivity disorder symptoms. The </span>endocannabinoid<span><span> (eCB) dysfunction was previously hypothesized as one of the modes of action by which PAR may harm the developing nervous system<span><span>. We aimed to evaluate possible effects of gestational exposure to PAR on male and female rat's offspring behavior and if an acute injection of WIN 55,212–2 (WIN, 0.3 mg/kg), a non-specific </span>cannabinoid agonist, prior to behavioral tests, would induce different effects in PAR exposed and non-exposed animals. Pregnant </span></span>Wistar rats were gavaged with PAR (350 mg/kg/day) or water from gestational day 6 until delivery. Nest-seeking, open field, apomorphine-induced stereotypy, marble burying and three-chamber tests were conducted in 10-, 24-, 25- or 30-days-old rats, respectively. PAR exposure resulted in increased apomorphine-induced stereotyped behavior and time spent in the central area of the open field in exposed female pups. Additionally, it induced hyperactivity in the open field and increased marble burying behavior in both male and female pups. WIN injection modified the behavioral response only in the nest seeking test, and opposite effects were observed in control and PAR-exposed </span></span></span>neonate females. Reported alterations are relevant for the neurodevelopmental disorders that have been associated with maternal PAR exposure and suggest that eCB dysfunction may play a role in the action by which PAR may harm the developing brain.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"99 ","pages":"Article 107279"},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10228305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal protein dynamics during early organogenesis in mouse conceptuses treated with valproic acid","authors":"Samantha Lapehn,&nbsp;Justin A. Colacino,&nbsp;Craig Harris","doi":"10.1016/j.ntt.2023.107286","DOIUrl":"10.1016/j.ntt.2023.107286","url":null,"abstract":"<div><p><span>Valproic acid (VPA) is an anti-epileptic medication that increases the risk of </span>neural tube<span><span><span> defect (NTD) outcomes in infants exposed during gestation. Previous studies into VPA's mechanism of action have focused on alterations in gene expression and metabolism but have failed to consider how exposure changes the abundance of critical developmental proteins over time. This study evaluates the effects of VPA on protein abundance in the developmentally distinct tissues of the mouse visceral yolk sac (VYS) and embryo proper (EMB) using mouse whole embryo culture. Embryos were exposed to 600 μM VPA at 2 h intervals over 10 h during early organogenesis with the aim of identifying protein pathways relevant to VPA's mechanism of action in failed NTC. Protein abundance was measured through tandem mass tag (TMT) labeling followed by liquid chromatography and </span>mass spectrometry<span><span><span>. Overall, there were over 1500 proteins with altered abundance after VPA exposure in the EMB or VYS with 428 of these proteins showing previous gene expression associations with VPA exposure. Limited overlap of significant proteins between tissues supported the conclusion of independent roles for the VYS and EMB in response to VPA. Pathway analysis of proteins with increased or decreased abundance identified multiple pathways with mechanistic relevance to NTC and </span>embryonic development including convergent extension, Wnt Signaling/planar </span>cell polarity, cellular migration, </span></span>cellular proliferation, cell death, and cytoskeletal organization processes as targets of VPA. Clustering of co-regulated proteins to identify shared patterns of protein abundance over time highlighted 4 h and 6/10 h as periods of divergent protein abundance between control and VPA-treated samples in the VYS and EMB, respectively. Overall, this study demonstrated that VPA temporally alters protein content in critical developmental pathways in the VYS and the EMB during early organogenesis in mice.</span></p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"99 ","pages":"Article 107286"},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10238806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in marijuana use from adolescence to young adulthood and its relation to gestational alcohol and marijuana exposure","authors":"Lidush Goldschmidt ,&nbsp;Gale A. Richardson ,&nbsp;Nancy L. Day ,&nbsp;Natacha M. De Genna","doi":"10.1016/j.ntt.2023.107287","DOIUrl":"10.1016/j.ntt.2023.107287","url":null,"abstract":"<div><h3>Introduction</h3><p>Many studies have examined changes in marijuana use across adolescence, but few have examined factors associated with transitions from adolescence to young adulthood. We examined prenatal exposures to alcohol and marijuana and adolescent risk and protective factors that best distinguished among abstinence, continuity, or cessation of marijuana use from 16 to 22 years.</p></div><div><h3>Method</h3><p><span><span>Data were from the Maternal Health Practices and Child Development Project at the prenatal and 16- and 22-year follow-up phases. The offspring were of lower socioeconomic status with an average of 12.8 years of education at 22 years. Participants' frequency and quantity of marijuana use over the past year were used to determine change in use. A </span>discriminant analysis was applied to distinguish among the identified groups. The risk factors considered included prenatal substance exposures and age 16 demographics, </span>behavior, and home environment.</p></div><div><h3>Result</h3><p>Four categories of transitions were defined based on marijuana use from 16 to 22 years: non-users (<em>n</em> = 193), stop/decrease (<em>n</em> = 81), continue at same level/increase (<em>n</em> = 125), and initiation after the 16-year phase (<em>n</em> = 122). The factors that best distinguished among these groups were peers' marijuana use, delinquency, caregivers' financial strain, prenatal exposure to alcohol and marijuana, and race.</p></div><div><h3>Conclusion</h3><p>Prenatal alcohol and marijuana exposure were significantly related to transitions of marijuana use from adolescence to young adulthood, controlling for peers' use, behavior problems, and home environment. While gestational marijuana exposure was associated with early initiation/increasing use, alcohol exposure was related to later initiation. The findings emphasize the long-term effects of prenatal exposure to alcohol and marijuana.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"99 ","pages":"Article 107287"},"PeriodicalIF":2.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10236977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NSAIDs exposure during late pregnancy: Trends in prescriptions and reporting fetal adverse effects","authors":"Fatiha Karam ,&nbsp;Sara Miranda ,&nbsp;Laurent Chouchana ,&nbsp;Tessa Pietri ,&nbsp;Isabelle Lacroix ,&nbsp;Judith Cottin ,&nbsp;Jérôme Drouin ,&nbsp;Mehdi Benkebil ,&nbsp;Emilie Vittaz ,&nbsp;Thierry Vial","doi":"10.1016/j.ntt.2023.107224","DOIUrl":"10.1016/j.ntt.2023.107224","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107224"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45689682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}