Neurotoxicology and teratology最新文献_第8页

Pregnancy and infancy as sensitive periods for prevention and interventions: Leveraging cross-species and randomized clinical trial approaches 妊娠期和婴儿期作为预防和干预的敏感期：利用跨物种和随机临床试验方法

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107469

Elysia Davis

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Critical windows of susceptibility for the effects of prenatal exposure to heat and heat variability on gestational growth 产前热暴露和热变异性对妊娠生长影响的敏感性关键窗口

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107454

Jeffrey Carlson

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Co-occurring substance use and mental health symptoms among prenatally substance-exposed emerging adults 在产前物质暴露的新生成人中共同发生的物质使用和精神健康症状

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107498

June-Yung Kim , Sonia Minnes , Meeyoung O. Min , Liat R. Johnson , Lynn T. Singer

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Neurobehavioral assessments in preterm pigs 早产儿神经行为评估

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107489

Helen J.K. Sable

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Regulatory aspects of neurobehavioral testing in alternate animal models 在替代动物模型中神经行为测试的调节方面

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107490

Elizabeth Green

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A new ethical paradigm challenged: Reproductive research in the post-Dobbs era 挑战新的伦理范式：后多布斯时代的生殖研究

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107477

Anne D. Lyerly

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Evaluating neurobehavioral outcomes after exposure 评估暴露后的神经行为结果

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107460

Claire Coles

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A longitudinal study comparing the impact of pesticide exposure on cognitive abilities of Latinx children from rural farmworker and urban non-farmworker families 一项比较农药暴露对农村农场工人和城市非农场工人家庭拉丁裔儿童认知能力影响的纵向研究

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-04-13 DOI: 10.1016/j.ntt.2025.107450

Monica Soni , Haiying Chen , Milton J. Cepeda , Lesley Berenson , Sydney Smith , Kim A. Anderson , Sara A. Quandt , Thomas A. Arcury , Paul J. Laurienti , Jonathan H. Burdette

{"title":"A longitudinal study comparing the impact of pesticide exposure on cognitive abilities of Latinx children from rural farmworker and urban non-farmworker families","authors":"Monica Soni , Haiying Chen , Milton J. Cepeda , Lesley Berenson , Sydney Smith , Kim A. Anderson , Sara A. Quandt , Thomas A. Arcury , Paul J. Laurienti , Jonathan H. Burdette","doi":"10.1016/j.ntt.2025.107450","DOIUrl":"10.1016/j.ntt.2025.107450","url":null,"abstract":"<div><div>Growing evidence shows that pesticide exposure contributes to numerous adverse health effects. Pesticide exposure can be especially problematic for vulnerable populations, and even more so for children in vulnerable populations who are still developing, such as Latinx children. Several studies have demonstrated the negative cognitive effects of prenatal exposure to pesticides, particularly organophosphates (OPs). We previously reported the results from a baseline study (Dobbins et al., 2022) designed to compare the cognitive abilities of 8-year-old children from rural, farmworking families and urban, non-farmworking families. We found that the children from both populations have considerable pesticide exposure, but to different chemicals. The children of farmworkers had greater exposure to OPs, while the children of non-farmworkers had greater exposure to organochlorines (OCs) and pyrethroids. Using the Weschler Intelligence Scale for Children–Fifth Edition (WISC-V), baseline analyses determined that children of non-farmworkers exhibited lower cognitive scores, specifically on the VSI (visual spatial) and VCI (verbal comprehension) indices. The current study examined the longitudinal significance of these findings in the same participants over a 2–3-year period. We present evidence that children from non-farmworking families exhibited significant declines on the FRI (fluid reasoning index) of the WISC-V. The children from farmworker families did not decline, and this longitudinal difference between the groups was significant. Our findings further suggest that these declines in FRI scores are likely due to greater cumulative OC exposure over the entire longitudinal period.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107450"},"PeriodicalIF":2.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans 三氯醇致人神经毒性机制的计算机分析

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-03-30 DOI: 10.1016/j.ntt.2025.107447

Fuat Karakuş , Burak Kuzu

{"title":"An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans","authors":"Fuat Karakuş , Burak Kuzu","doi":"10.1016/j.ntt.2025.107447","DOIUrl":"10.1016/j.ntt.2025.107447","url":null,"abstract":"<div><div>Dicofol (DCF) is an organochlorine pesticide that has recently been recognized as a persistent organic pollutant. This study begins by investigating the neurotoxicity of DCF and its metabolites through <em>in silico</em> tools. It subsequently explores the molecular mechanisms and key targets associated with DCF-induced neurotoxicity in humans by employing network toxicology, multi-level bioinformatics approaches, and molecular docking analyses. The prediction results indicate that both DCF and its metabolites can traverse the blood-brain barrier, penetrating the central nervous system, and inducing neurotoxicity. A thorough analysis has identified 56 potential targets linked to DCF-induced neurotoxicity. Gene Ontology enrichment analysis revealed significant associations with pathways related to sodium ion transmembrane transport, sodium/potassium-exchanging ATPase complexes, and P-type calcium transporter activity. Pathway enrichment analysis suggests that DCF-induced neurotoxicity arises from disruptions in ion transport <em>via</em> P-type ATPases. Further examination of gene-gene and protein-protein interactions, along with centrality analysis, identified 11 hub targets, including ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, and MAPK1, as key players. Notably, six of these targets are subunits of the Na<sup>+</sup>/K<sup>+</sup>-ATPase, a P-type ATPase. Molecular docking results demonstrated that DCF binds more effectively to the ATP1A3-ATP1B1 protein complex than to its natural ligand, ATP. These findings suggest that DCF may inhibit Na<sup>+</sup>/K<sup>+</sup>-ATPase through ATP1A3, resulting in an imbalance of sodium and potassium gradients and ultimately leading to neurotoxicity.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107447"},"PeriodicalIF":2.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring how pregnant people in recovery from opioid use disorder describe their child during pregnancy 探索从阿片类药物使用障碍中恢复的孕妇如何在怀孕期间描述他们的孩子

IF 2.6 3区医学

Neurotoxicology and teratology Pub Date : 2025-03-27 DOI: 10.1016/j.ntt.2025.107449

Katherine L. Guyon-Harris , Regan Carell , Montia D. Brock , Kathryn L. Humphreys , Alissa C. Huth-Bocks

{"title":"Exploring how pregnant people in recovery from opioid use disorder describe their child during pregnancy","authors":"Katherine L. Guyon-Harris , Regan Carell , Montia D. Brock , Kathryn L. Humphreys , Alissa C. Huth-Bocks","doi":"10.1016/j.ntt.2025.107449","DOIUrl":"10.1016/j.ntt.2025.107449","url":null,"abstract":"<div><h3>Objective</h3><div>Understanding parenting strengths and challenges among pregnant people in recovery from opioid use disorder supports effective intervention delivery. How parents think and feel about their child prenatally has implications for postnatal parenting. In our past work, greater use of positive compared to negative or neutral prenatal descriptors of the child during pregnancy was associated with higher sensitivity, warmth, and engagement during caregiver–infant interactions 12-months postpartum. We analyzed descriptions of the child among pregnant people in recovery compared to a non-substance using sample to further our understanding of potential parenting strengths and risks for people in recovery.</div></div><div><h3>Method</h3><div>Participants included pregnant people (<em>N</em> = 18; M age = 30.06, SD = 3.33) recruited from an outpatient substance use treatment program providing buprenorphine (recovery sample) and a comparison sample of pregnant people (<em>N</em> = 120; M age = 26.16, SD = 5.71) reporting high rates of economic disadvantage and intimate partner violence, but not substance use. Through a semi-structured interview, participants described the personality of the child they were pregnant with in up to five words/phrases. Each description was coded as positive, neutral, or negative.</div></div><div><h3>Results</h3><div>Participants in the recovery sample used a greater number of positive words on average (M = 3.5, SD = 1.4) relative to the comparison sample (M = 2.7, SD = 1.5; Cohen's d = 0.56, 95 % confidence interval: LL = 0.06, UL = 1.06). Use of negative descriptors was similar across samples.</div></div><div><h3>Conclusions</h3><div>Assessing how pregnant people in recovery think and feel about their developing fetus is feasible and could create opportunities for engagement in preventive parenting interventions to support healthy conceptualizations of the child.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107449"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0