Neurotoxicology and teratology最新文献

{"title":"Critical considerations on the study “Adolescent exposure to bisphenol a antagonizes androgen regulation of social behavior in male mice” (Zhong et al., 2024): The importance of locomotor and anxiety assessments","authors":"Guilherme Malafaia","doi":"10.1016/j.ntt.2025.107443","DOIUrl":"10.1016/j.ntt.2025.107443","url":null,"abstract":"<div><div>This correspondence provides constructive feedback on the study “Adolescent Exposure to Bisphenol A Antagonizes Androgen Regulation of Social Behavior in Male Mice” by Zhong et al. (2024). While the study attributes reductions in social play, interactions, and aggression to the antagonism of androgen-regulated pathways, we emphasize that unassessed confounding factors—such as locomotor deficits and anxiety-like behavior—may influence these outcomes. Evidence from Wang et al. (2020), Beauty et al. (2025), and Ji et al. (2023) highlights the necessity of evaluating these variables. We suggest incorporating behavioral assessments to ensure a more robust interpretation of BPA's direct effects on neurobehavioral responses.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107443"},"PeriodicalIF":2.6,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene × environment interaction between heterozygous deletion of the ADHD risk gene latrophilin-3 (adgrl3) and developmental deltamethrin exposure in Sprague Dawley rats","authors":"Charles V. Vorhees,&nbsp;Adam L. Fritz,&nbsp;Brooke M. Gollaway,&nbsp;Michael T. Williams","doi":"10.1016/j.ntt.2025.107435","DOIUrl":"10.1016/j.ntt.2025.107435","url":null,"abstract":"<div><div>The prevalence of attention deficit hyperactivity disorder (ADHD) is 9.8 % in U.S. children. Several variants of <em>Latrophiln-3</em> (<em>LPHN-3</em>) are associated with ADHD. Using CRISPR/Cas9 we deleted exon 3 in rats to create a global <em>Lphn3</em> knockout. These rats are hyperactive, startle hyper-reactive, impulsive, and have impaired working, spatial, and egocentric learning and memory. Deltamethrin (DLM) is a widely used pyrethroid insecticide. Several epidemiological studies report an increase in ADHD prevalence in children exposed to pyrethroids. Developmental exposure to DLM in rats results in multiple behavioral deficits. The present experiment tested whether <em>Lphn3</em> disruption interacts with developmental DLM exposure. Because Lphn3^−/− rats are severely impaired, we used Lphn3^+/− (Hets) because they have an intermediate phenotype. Rats were treated by gavage once/day from postnatal day 6–20 with DLM resulting in four groups: <em>Lphn3</em>-Het + DLM (1.0 mg/kg), <em>Lphn3</em>-Het + Corn Oil (CO), <em>Lphn3</em>^+/+ (wildtype: WT) + DLM, and WT + CO. From 31 litters, 19–27 offspring per genotype per treatment per sex were obtained with not more than 1 rat of each group and sex used from any one litter. Adult offspring were tested for exploration (open-field), 72-h home-cage activity, startle, novel object recognition (NOR), radial water maze (RWM), Morris water maze (MWM), and Cincinnati water maze (CWM). On MWM acquisition trials and the reversal probe trial, <em>Lphn3</em>-Het-DLM rats performed worse than other groups. This group also was impaired learning the CWM. No interactions were found for open-field, home-cage, startle, NOR, or RWM. The results show that the ADHD risk gene <em>Lphn3</em> in combination with developmental DLM exposure has selective adverse effects compared with either factor alone.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"108 ","pages":"Article 107435"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substance use and mental health symptoms in adults with prenatal alcohol exposure","authors":"Kallio Hunnicutt-Ferguson ,&nbsp;Susan A. Stoner ,&nbsp;Julie A. Kable ,&nbsp;Therese M. Grant ,&nbsp;Claire D. Coles","doi":"10.1016/j.ntt.2025.107436","DOIUrl":"10.1016/j.ntt.2025.107436","url":null,"abstract":"<div><h3>Background</h3><div>Substance use and mental health problems have been documented in individuals with prenatal alcohol exposure (PAE) in young adulthood, but little is known about how these patterns progress over time into midlife. The current study examined rates of substance use in a sample of adults with PAE in mid-life compared to a demographically similar contrast group.</div></div><div><h3>Methods</h3><div>Participants (<em>n</em> = 233) were drawn from two longitudinal cohorts of individuals recruited prenatally and followed into adulthood. Measures of cognition, substance use, and self-reported mental health functioning were obtained.</div></div><div><h3>Results</h3><div>Differences among groups (PAE no dysmorphology, PAE with dysmorphology, No PAE contrast group) were examined on demographic variables of interest and substance use outcomes. Both PAE groups experienced higher levels of Adverse Childhood Experiences (ACEs) compared to the contrast group. We also observed higher rates of current tobacco use in those with PAE; those with PAE and no dysmorphology had almost twice the rate of current tobacco use as the nonexposed contrast group. We observed similar rates of high risk drinking on the Alcohol Use Identification Test (AUDIT) in all groups. Individuals with PAE also showed high rates of cannabis use compared to national averages. Generalized linear regressions examining predictive effects of PAE on substance use outcomes did not show significant results, though female sex at birth was predictive of current cannabis use. Current alcohol use predicted depression and PTSD symptoms, and significant interactions were observed between PAE group and ACEs on depression, PTSD, anxiety, and psychotic symptoms.</div></div><div><h3>Conclusion</h3><div>This is one of the only studies to examine rates of alcohol and other substance use among adults in mid-life with PAE. Results suggest that relationships between PAE, substance use, and mental health symptoms are complex, and it will be important for future studies to examine factors associated with high-risk substance use among this vulnerable population.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107436"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dl-3-n-butylphthalein inhibits neuronal apoptosis and ferroptosis after cerebral ischemia-reperfusion injury in rats by regulating CXCR4","authors":"Sifan Xu ,&nbsp;Qi Wang ,&nbsp;Yu Qin,&nbsp;Qian Yang,&nbsp;Yang Xu,&nbsp;Zhiming Zhou","doi":"10.1016/j.ntt.2025.107434","DOIUrl":"10.1016/j.ntt.2025.107434","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the anti-apoptosis and anti-ferroptosis effects of dl-3-n-butylphthalide (dl-NBP) on cerebral ischemia-reperfusion injury (CIRI) in rats, and the potential involvement of cysteine-X-cysteine chemokine receptor 4 (CXCR4).</div></div><div><h3>Methods</h3><div>The differentially expressed genes between healthy people and stroke patients were screened by GEO database. A transient middle cerebral artery occlusion rat model was used to induce CIRI in vivo. Rats were randomly divided into sham group, tMCAO group, and dl-NBP + tMCAO group. The therapeutic effect of dl-NBP in vivo and its effect on apoptosis and ferroptosis in brain tissues were evaluated. An in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model was established to simulate CIRI in cultured PC12 cells, and the effects of dl-NBP on apoptosis and ferroptosis were examined. In this model, CXCR4 expression was assessed by western blotting and its involvement in dl-NBP-mediated protection assessed by inhibition with AMD3100.</div></div><div><h3>Results</h3><div>In the stroke-related GSE22255 and GSE66724 datasets, a total of six genes with increased co-expression were found, including CXCR4. Dl-NBP treatment significantly reduced both the volume of cerebral infarction and the degree of cerebral edema, and improved neurological function in rats. dl-NBP reduced the degree of apoptosis and ferroptosis and alleviated CIRI both in vivo and in vitro. The pro-survival effects of dl-NBP were significantly reversed after CXCR4 inhibition with AMD3100.</div></div><div><h3>Conclusion</h3><div>Dl-NBP has anti-apoptotic and anti-ferroptotic effects on CIRI both in vivo and in vitro, and this effect is mediated by CXCR4.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"108 ","pages":"Article 107434"},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabinoids in hair and their prospective association with mental and physical health outcomes in adolescents","authors":"Isabel R. Aks ,&nbsp;Herry Patel ,&nbsp;William E. Pelham III ,&nbsp;Marilyn A. Huestis ,&nbsp;Natasha E. Wade","doi":"10.1016/j.ntt.2025.107433","DOIUrl":"10.1016/j.ntt.2025.107433","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Cannabis is one of the most widely used drugs in early adolescence, a crucial time for development. Cannabinoids within the cannabis plant (e.g., delta-9-tetrahydrocannabinol [THC], and cannabidiol [CBD]) are suggested to have a range of health implications. These may differ by sex, given sex differences in the endocannabinoid system (ECS). Yet, how aspects of mental and physical health are related to cannabis use as measured by hair concentrations, both within early adolescence and across sexes, is so far inconclusive.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We analyzed hair toxicology data from three cannabinoid analytes (THC, CBD, and 11-nor-9-carboxy-THC [THCCOOH]) and multiple mental and physical health measures in 9–15 year-old youth (49 % female) from the Adolescent Brain Cognitive Development (ABCD) Study (&lt;em&gt;N&lt;/em&gt; = 2262). Two-part linear regression models were fit to assess the effects of cannabis constituent presence, concentrations, and THC concentrations + CBD presence on externalizing and internalizing symptoms, physical and strengthening exercise, asthma presence, and sleep duration. Secondary analyses fit the same models but stratified by sex. Finally, to further characterize these relationships, we conducted two exploratory analyses: we assessed health variables prospectively and concurrently predicting cannabinoid concentrations. False discovery rate corrections were employed for all analyses.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;In the full sample, greater THC concentrations predicted more frequent strength exercise one year later; greater CBD concentrations predicted fewer strength exercise days; and greater THCCOOH concentrations predicted shorter sleep duration. Among males, cannabinoids differentially predicted exercise days; greater THC and THCCOOH concentrations predicted shorter sleep duration. Among females, greater THC and THCCOOH concentrations predicted strength exercise frequency, and THC concentrations predicted shorter sleep duration. In exploratory models, asthma presence predicted THCCOOH concentration one year later. Concurrently, THC concentration alone and in the presence of CBD predicted both sleep duration and lower exercise days, while THCCOOH concentration predicted lower exercise days, less asthma presence, as well as greater internalizing and externalizing symptoms.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;In a nationwide study of youth ages 9–15 years old, we found cannabinoid hair concentrations predicted differences in health outcomes a year later, suggesting potential differential mechanisms for THC and CBD effects on health. Furthermore, sex-specific observations in these prospective associations emphasize the importance of considering sex assigned at birth when investigating correlates of cannabis use. Analysis of cannabinoid hair concentrations can reveal key links to mental health, physical activity, and sleep, aiding understanding of complex cannabis effects.&lt;/div&gt;&lt;/d","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"108 ","pages":"Article 107433"},"PeriodicalIF":2.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricresylphosphate isomers: A review of toxicity pathways","authors":"Marta Tkachuk,&nbsp;Nataliya Matiytsiv","doi":"10.1016/j.ntt.2025.107432","DOIUrl":"10.1016/j.ntt.2025.107432","url":null,"abstract":"<div><div>Synthetiс organophosphates are a large group of chemicals, annually produced by an industry with their further application as oil additives, flame retardants, plasticizers, warfare agents and insecticides for domestic use and in the control of vector-borne diseases. Consequently, organophosphates are often detected in the environment and human samples, which can have adverse effects on ecosystems and human health. This review aimed to summarize recent findings about different aspects of tricresyl phosphate mixture and separate isomers toxicity, including their impact on nervous, endocrine, and reproductive systems studied in animal models or <em>in vitro</em>. We also discuss the underlying molecular and cellular mechanisms involved in these processes, which comprise inhibition of neuropathy target esterase (NTE), overactivation of neuregulin1/ErbB and MAPK signaling pathways, impairment of glutamate signaling as well as interaction with nuclear hormone. Finally, we outline potential therapeutic targets and promising agents as important directions for future research.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"108 ","pages":"Article 107432"},"PeriodicalIF":2.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of prenatal maternal psychosocial stress and depression with neurodevelopmental outcomes in 7.5-month-old infants in the ECHO.CA.IL prospective birth cohorts","authors":"Nicholas Cragoe ,&nbsp;Jenna Sprowles ,&nbsp;Stephanie M. Eick ,&nbsp;Lynn Harvey ,&nbsp;Xavier R. Ramirez ,&nbsp;Gloria Arroyo Sugg ,&nbsp;Rachel Morello-Frosch ,&nbsp;Tracey Woodruff ,&nbsp;Susan L. Schantz","doi":"10.1016/j.ntt.2025.107431","DOIUrl":"10.1016/j.ntt.2025.107431","url":null,"abstract":"<div><h3>Background</h3><div>Exposure to maternal stress and depression during pregnancy can have a marked impact on birth outcomes and child development, escalating the likelihood of preterm birth, lower birth weight, and various domains of physical and neurodevelopment.</div></div><div><h3>Methods</h3><div>The joint ECHO.CA.IL cohort is comprised of the Chemicals in Our Bodies (CIOB) and Illinois Kids Development Study (IKIDS) prospective cohorts, recruiting pregnant women in San Francisco, CA, and Urbana-Champaign, IL, respectively. Using a combined sample of 428 mother-infant dyads, we examined associations between two prenatal measures of maternal stress (perceived stress (PSS) and stressful events (SLE)), as well as maternal depression, and five domains of neurodevelopment via the Ages &amp; Stages Questionnaire (ASQ) administered at 7.5 months. Linear regression models were adjusted for relevant demographic characteristics and used to identify patterns of association.</div></div><div><h3>Results</h3><div>CIOB mothers were comparatively racially/ethnically diverse (52 % white, 28 % Asian American/Pacific Islander, 12 % Hispanic), while IKIDS mothers were disproportionately white (80 %). Both cohorts demonstrated high levels of maternal education and were similar in terms of other demographic characteristics. CIOB mothers reported higher levels of stress (e.g., SLE: 49.63 % report ≥1 event) compared to IKIDS mothers (e.g., SLE: 16.34 % report ≥1 event). In adjusted linear models, patterns of association were nearly uniformly negative between stress and ASQ measures, with associations between PSS and fine motor skills (β-0.26, CI = -0.52; 0.00) and SLEs and communication skills (β = −2.9245, CI = -6.1643; 0.3152) showing the strongest associations (<em>p</em> &lt; 0.1). Depression showed no significant or clear pattern of association with ASQ scores.</div></div><div><h3>Conclusion</h3><div>This study found negative associations between prenatal maternal stress and infant neurodevelopment in the combined ECHO.CA.IL cohort, suggesting that prenatal stress is associated with delayed development of motor and communication skills during infancy. The inconclusive links between maternal depression and ASQ outcomes leave open the question regarding the influence of prenatal depression on early child neurodevelopment.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"108 ","pages":"Article 107431"},"PeriodicalIF":2.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplacental signals involved in the programming effects of prenatal psychosocial stress on neurodevelopment","authors":"Sandra P. Zoubovsky ,&nbsp;Louis J. Muglia","doi":"10.1016/j.ntt.2025.107424","DOIUrl":"10.1016/j.ntt.2025.107424","url":null,"abstract":"<div><div>Exposure to psychosocial stress during pregnancy has been associated with the emergence of neurodevelopmental and neuropsychiatric disorders in offspring. The placenta is known to orchestrate various functions that are essential for normal fetal development, including the brain. It has therefore been postulated that alterations in such functions, and downstream signaling, have the potential to dramatically affect brain developmental trajectories and contribute to adverse neurodevelopmental outcomes. This review will focus on discussing various placental functions that have been proposed to be affected by exposure to prenatal psychosocial stress and the implications of such disruptions on long-term neurodevelopmental programming.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"107 ","pages":"Article 107424"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Earlier pubertal timing, not tempo, links time-limited early adversity with psychopathology","authors":"Mariann A. Howland ,&nbsp;Brie M. Reid ,&nbsp;Bonny Donzella ,&nbsp;Megan R. Gunnar","doi":"10.1016/j.ntt.2024.107420","DOIUrl":"10.1016/j.ntt.2024.107420","url":null,"abstract":"<div><div>Evolutionary-developmental theories propose that early adverse experiences adaptively shift the timing (i.e., onset) and tempo (i.e., rate) of pubertal maturation. Empirical evidence of links between early life adversity and pubertal maturation is mixed, potentially in part because isolating the unique impacts of early environments is challenging. The current accelerated longitudinal study used a quasi-experimental design to examine pubertal maturation among 132 previously-institutionalized (PI), internationally adopted children who experienced a time-limited form of severe early life adversity, compared to 169 non-adopted (NA) children. Based on prior literature, we also assessed whether pubertal timing and/or tempo are pathways by which early adversity relates to later symptoms of psychopathology. At each of three annual sessions, Tanner pubertal staging was determined by nurse exam, and symptoms of psychopathology were captured in a composite of child self-reported internalizing and parent-reported externalizing symptoms. Findings revealed that, only among children at Tanner pubertal stages 3 or below, PI children were more likely to have reached stage 3 compared to NA children, reflective of earlier pubertal timing. No group differences were found for pubertal tempo. In the subsample of children at Tanner stage 3 or lower, earlier pubertal timing was an indirect pathway by which early adversity related to both higher levels and greater longitudinal declines in internalizing and externalizing symptoms of psychopathology, accounting for a small proportion of the total effect of early adversity on psychopathology. Results from this quasi-experimental study add to existing research on associations between early adversity, early pubertal timing, and psychopathology, further suggesting that links may be specific to timing but not tempo. While findings broadly align with recent calls to consider early pubertal maturation as a transdiagnostic risk marker with utility for identifying children who could benefit from early mental health intervention, they also suggest that pubertal timing is unlikely to be a robust target for reducing psychopathology risk in these children.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"107 ","pages":"Article 107420"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study","authors":"Hailey Modi ,&nbsp;David A.A. Baranger ,&nbsp;Sarah E. Paul ,&nbsp;Aaron J. Gorelik ,&nbsp;Alana Hornstein ,&nbsp;Jared V. Balbona ,&nbsp;Arpana Agrawal ,&nbsp;Janine D. Bijsterbosch ,&nbsp;Ryan Bogdan","doi":"10.1016/j.ntt.2024.107404","DOIUrl":"10.1016/j.ntt.2024.107404","url":null,"abstract":"<div><h3>Objective</h3><div>Though caffeine use during pregnancy is common, its longitudinal associations with child behavioral and physical health outcomes remain poorly understood. Here, we estimated associations between prenatal caffeine exposure, body mass index (BMI), and behavior as children enter adolescence.</div></div><div><h3>Method</h3><div>Longitudinal data and caregiver-reported prenatal caffeine exposure were obtained from the ongoing Adolescent Brain and Cognitive Development (ABCD)^SM Study, which recruited 11,875 children aged 9–11 years at baseline from 21 sites across the United States starting June 1, 2016. Prenatal caffeine exposure was analyzed as a 4-level categorical variable, and further group contrasts were used to characterize “any exposure” and “daily exposure” groups. Outcomes included psychopathology characteristics in children, sleep problems, and BMI. Potentially confounding covariates included familial (e.g., income, familial psychopathology), pregnancy (e.g., prenatal substance exposure), and child (e.g., caffeine use) variables.</div></div><div><h3>Results</h3><div>Among 10,873 children (5686 boys [52.3 %]; mean [SD] age, 9.9 [0.6] years) with nonmissing prenatal caffeine exposure data, 6560 (60 %) were exposed to caffeine prenatally. Relative to no exposure, daily caffeine exposure was associated with higher child BMI (β = 0.08; FDR-corrected <em>p</em> = 0.02), but was not associated with child behavior following correction for multiple testing. Those exposed to two or more cups of caffeine daily (<em>n</em> = 1028) had greater sleep problems than those with lower/no exposure (β &gt; 0.92; FDR-corrected <em>p</em> &lt; 0.04).</div></div><div><h3>Conclusion</h3><div>Daily prenatal caffeine exposure is associated with heightened childhood BMI, and when used multiple times a day greater sleep problems even after accounting for potential confounds. Whether this relationship is a consequence of prenatal caffeine exposure or its correlated factors remains unknown.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"107 ","pages":"Article 107404"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}