Neurotoxicology and teratology最新文献

{"title":"Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort","authors":"Carly V. Goodman ,&nbsp;Christine Till ,&nbsp;Rivka Green ,&nbsp;Jana El-Sabbagh ,&nbsp;Tye E. Arbuckle ,&nbsp;Richard Hornung ,&nbsp;Bruce Lanphear ,&nbsp;Jean R. Seguin ,&nbsp;Linda Booij ,&nbsp;Mandy Fisher ,&nbsp;Gina Muckle ,&nbsp;Maryse F. Bouchard ,&nbsp;Jillian Ashley-Martin","doi":"10.1016/j.ntt.2023.107181","DOIUrl":"10.1016/j.ntt.2023.107181","url":null,"abstract":"<div><h3>Background</h3><p>Exposure to perfluoroalkyl substances (PFAS) has been shown to be neurotoxic in experimental studies, but epidemiological evidence linking prenatal PFAS exposure to child neurodevelopment is equivocal and scarce.</p></div><div><h3>Objective</h3><p>To quantify associations between prenatal exposure to legacy PFAS and children's intelligence (IQ) and executive functioning (EF) in a Canadian pregnancy and birth cohort and to determine if these associations differ by child sex.</p></div><div><h3>Methods</h3><p>We measured first-trimester plasma concentrations of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) in the Maternal-Infant Research on Environmental Chemicals (MIREC) study and assessed children's full-scale (<em>n</em> = 522), performance (<em>n</em> = 517), and verbal (<em>n</em> = 519) IQ using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III). Children's working memory (<em>n =</em> 513) and ability to plan and organize (<em>n</em> = 514) were assessed using a parent-reported questionnaire, the Behavior Rating Inventory of Executive Function - Preschool Version (BRIEF-P). We quantified associations between individual log2-transformed PFAS exposure and children's IQ and EF using multiple linear regression analyses and evaluated effect modification by child sex. We also used Repeated Holdout Weighted Quantile Sum (WQS) regression models with effect modification by child sex to quantify the effect of combined exposure to all three PFAS chemicals on IQ and EF. All models were adjusted for key sociodemographic characteristics.</p></div><div><h3>Results</h3><p>Geometric mean plasma concentrations (IQR) for PFOA, PFOS and PFHxS were 1.68 (1.10–2.50), 4.97 (3.20–6.20) and 1.09 (0.67–1.60) μg/L respectively. We found evidence of effect modification by child sex in all models examining performance IQ (<em>p</em> &lt; .01). Specifically, every doubling of PFOA, PFOS, and or PFHxS was inversely associated with performance IQ, but only in males (PFOA: <em>B</em> = −2.80, 95% CI: −4.92, −0.68; PFOS: <em>B</em> = −2.64, 95% CI: −4.77, −0.52; PFHxS: <em>B</em> = −2.92, 95% CI: −4.72, −1.12). Similarly, every quartile increase in the WQS index was associated with poorer performance IQ in males (<em>B</em> = −3.16, 95% CI: −4.90, −1.43), with PFHxS contributing the largest weight to the index. In contrast, no significant association was found for females (<em>B</em> = 0.63, 95% CI: −0.99, 2.26). No significant associations were found for EF in either males or females.</p></div><div><h3>Conclusions</h3><p>Higher prenatal PFAS exposure was associated with lower performance IQ in males, suggesting that this association may be sex- and domain-specific.</p></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107181"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10151722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotretinoin cases in the Finnish TIS database","authors":"Maria Ellfolk ,&nbsp;Melinda Gonzalez ,&nbsp;Julia Reponen ,&nbsp;Heli Malm","doi":"10.1016/j.ntt.2023.107231","DOIUrl":"10.1016/j.ntt.2023.107231","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107231"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47756376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes following maternal favipiravir exposure: A case series","authors":"Baris Karadas ,&nbsp;Nusret Uysal ,&nbsp;Secil Karaca Kurtulmus ,&nbsp;Merve Tor ,&nbsp;Ismail Yilmaz ,&nbsp;Nihal Olgac Dundar ,&nbsp;Yusuf Cem Kaplan","doi":"10.1016/j.ntt.2023.107213","DOIUrl":"10.1016/j.ntt.2023.107213","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107213"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48622929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do infant behaviors mediate the relationship of prenatal cocaine exposure (PCE) to adult perceptual reasoning deficits?","authors":"Lynn Singer ,&nbsp;Jeffrey Albert ,&nbsp;Sun-kyung Kim ,&nbsp;Sonia Minnes ,&nbsp;Meeyoung Min ,&nbsp;June-yung Kim ,&nbsp;Gregory Powers","doi":"10.1016/j.ntt.2023.107266","DOIUrl":"10.1016/j.ntt.2023.107266","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107266"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49453350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monotherapy treatment of epilepsy in pregnancy: Congenital malformation outcomes in the child","authors":"Sonia Khanom ,&nbsp;Naghme Adab ,&nbsp;Matthew Bluett-Duncan ,&nbsp;Jill Clayton-Smith ,&nbsp;Jakob Christensen ,&nbsp;Katherine Edwards ,&nbsp;Janette Greenhalgh ,&nbsp;Ruaraidh Hill ,&nbsp;Cerian Jackson ,&nbsp;Anthony Marson ,&nbsp;Ronan McGinty ,&nbsp;Catrin Tudur-Smith ,&nbsp;Jennifer Weston ,&nbsp;Rebecca Bromley","doi":"10.1016/j.ntt.2023.107243","DOIUrl":"https://doi.org/10.1016/j.ntt.2023.107243","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107243"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50168697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying safety concerns related to antiseizure medication use in breastfeeding women with epilepsy by reviewing questions to the Norwegian drug information and pharmacovigilance centres","authors":"Sunniva Reitan Riibe ,&nbsp;Kristine Heitmann ,&nbsp;Jan Schjøtt ,&nbsp;Bettina Riedel","doi":"10.1016/j.ntt.2023.107220","DOIUrl":"https://doi.org/10.1016/j.ntt.2023.107220","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107220"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50169929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quetiapine intake and milk ejection reflex in a breastfeeding woman: A case report","authors":"Anneke Passier ,&nbsp;Maaike Lamers ,&nbsp;Karen van den Berg ,&nbsp;Michael Ceulemans","doi":"10.1016/j.ntt.2023.107238","DOIUrl":"10.1016/j.ntt.2023.107238","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107238"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46304858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of latrophilin-3, an ADHD risk gene, and deltamethrin in Sprague Dawley rats on learning and memory","authors":"Charles Vorhees,&nbsp;Adam Fritz,&nbsp;Brooke Gollaway,&nbsp;Michael Williams","doi":"10.1016/j.ntt.2023.107271","DOIUrl":"10.1016/j.ntt.2023.107271","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107271"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42377503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lasting impact of maternal immune activation during gestation on neurodevelopment","authors":"Judy Van de Water,&nbsp;Melissa Bauman","doi":"10.1016/j.ntt.2023.107253","DOIUrl":"10.1016/j.ntt.2023.107253","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107253"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45884730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of miscarriage or preterm labor after COVID-19 vaccination before and during pregnancy","authors":"Maud de Feijter ,&nbsp;Marleen M.H.J. van Gelder ,&nbsp;Lieke C.M. Vissers ,&nbsp;Agnes C. Kant ,&nbsp;Petra J. Woestenberg","doi":"10.1016/j.ntt.2023.107234","DOIUrl":"10.1016/j.ntt.2023.107234","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"98 ","pages":"Article 107234"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43035280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}