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Implications of abortion legislation on birth defects surveillance 堕胎法对出生缺陷监测的影响
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI: 10.1016/j.ntt.2025.107475
Amanda L. Elmore
{"title":"Implications of abortion legislation on birth defects surveillance","authors":"Amanda L. Elmore","doi":"10.1016/j.ntt.2025.107475","DOIUrl":"10.1016/j.ntt.2025.107475","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107475"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reverse translation in animals and cell models: Methods to accelerate therapeutic development and mechanisms 动物和细胞模型中的反翻译：加速治疗发展的方法和机制
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI: 10.1016/j.ntt.2025.107461
Gregg Stanwood
{"title":"Reverse translation in animals and cell models: Methods to accelerate therapeutic development and mechanisms","authors":"Gregg Stanwood","doi":"10.1016/j.ntt.2025.107461","DOIUrl":"10.1016/j.ntt.2025.107461","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107461"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Constellation of traits of disorders? Challenging our definition of autism as an adverse outcome 疾病特征的星座？挑战了我们对自闭症的定义
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI: 10.1016/j.ntt.2025.107463
Sura Alwan
{"title":"Constellation of traits of disorders? Challenging our definition of autism as an adverse outcome","authors":"Sura Alwan","doi":"10.1016/j.ntt.2025.107463","DOIUrl":"10.1016/j.ntt.2025.107463","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107463"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Work & family: How a social scientist thinks about chemical and non-chemical toxicants 工作与家庭：社会科学家如何看待化学和非化学毒物
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI: 10.1016/j.ntt.2025.107464
Joseph Grzywacz
{"title":"Work & family: How a social scientist thinks about chemical and non-chemical toxicants","authors":"Joseph Grzywacz","doi":"10.1016/j.ntt.2025.107464","DOIUrl":"10.1016/j.ntt.2025.107464","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107464"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applying cumulative risk methods to evaluate prenatal phthalate and stress exposures on adverse antiandrogenic health effects 应用累积风险方法评估产前邻苯二甲酸盐和应激暴露对抗雄激素健康的不良影响
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI: 10.1016/j.ntt.2025.107456
Catherine Genevieve Corey , Paul Turner , Devon Payne-Sturges
{"title":"Applying cumulative risk methods to evaluate prenatal phthalate and stress exposures on adverse antiandrogenic health effects","authors":"Catherine Genevieve Corey , Paul Turner , Devon Payne-Sturges","doi":"10.1016/j.ntt.2025.107456","DOIUrl":"10.1016/j.ntt.2025.107456","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107456"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High times: The effects of prenatal cannabis exposure and next steps 高峰时期：产前大麻暴露的影响和下一步
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI: 10.1016/j.ntt.2025.107458
Natacha M. De Genna
{"title":"High times: The effects of prenatal cannabis exposure and next steps","authors":"Natacha M. De Genna","doi":"10.1016/j.ntt.2025.107458","DOIUrl":"10.1016/j.ntt.2025.107458","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107458"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene x environment interaction between heterozygous deletion of the ADHD risk gene latrophilin-3 (Lphn3) and developmental deltamethrin exposure in Sprague Dawley rats Sprague Dawley大鼠ADHD风险基因latrophilin-3 （Lphn3）杂合缺失与发育期溴氰菊酯暴露之间的基因x环境相互作用
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI: 10.1016/j.ntt.2025.107492
Charles Vorhees, Adam Fritz, Brooke Gollaway, Michael Williams
{"title":"Gene x environment interaction between heterozygous deletion of the ADHD risk gene latrophilin-3 (Lphn3) and developmental deltamethrin exposure in Sprague Dawley rats","authors":"Charles Vorhees, Adam Fritz, Brooke Gollaway, Michael Williams","doi":"10.1016/j.ntt.2025.107492","DOIUrl":"10.1016/j.ntt.2025.107492","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107492"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans 三氯醇致人神经毒性机制的计算机分析
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-03-30 DOI: 10.1016/j.ntt.2025.107447
Fuat Karakuş , Burak Kuzu
{"title":"An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans","authors":"Fuat Karakuş ,&nbsp;Burak Kuzu","doi":"10.1016/j.ntt.2025.107447","DOIUrl":"10.1016/j.ntt.2025.107447","url":null,"abstract":"<div><div>Dicofol (DCF) is an organochlorine pesticide that has recently been recognized as a persistent organic pollutant. This study begins by investigating the neurotoxicity of DCF and its metabolites through <em>in silico</em> tools. It subsequently explores the molecular mechanisms and key targets associated with DCF-induced neurotoxicity in humans by employing network toxicology, multi-level bioinformatics approaches, and molecular docking analyses. The prediction results indicate that both DCF and its metabolites can traverse the blood-brain barrier, penetrating the central nervous system, and inducing neurotoxicity. A thorough analysis has identified 56 potential targets linked to DCF-induced neurotoxicity. Gene Ontology enrichment analysis revealed significant associations with pathways related to sodium ion transmembrane transport, sodium/potassium-exchanging ATPase complexes, and P-type calcium transporter activity. Pathway enrichment analysis suggests that DCF-induced neurotoxicity arises from disruptions in ion transport <em>via</em> P-type ATPases. Further examination of gene-gene and protein-protein interactions, along with centrality analysis, identified 11 hub targets, including ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, and MAPK1, as key players. Notably, six of these targets are subunits of the Na<sup>+</sup>/K<sup>+</sup>-ATPase, a P-type ATPase. Molecular docking results demonstrated that DCF binds more effectively to the ATP1A3-ATP1B1 protein complex than to its natural ligand, ATP. These findings suggest that DCF may inhibit Na<sup>+</sup>/K<sup>+</sup>-ATPase through ATP1A3, resulting in an imbalance of sodium and potassium gradients and ultimately leading to neurotoxicity.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107447"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond birth: The potential socioeconomic influences on NAS outcomes 超越出生：对NAS结果的潜在社会经济影响
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI: 10.1016/j.ntt.2025.107473
Ginger Cameron
{"title":"Beyond birth: The potential socioeconomic influences on NAS outcomes","authors":"Ginger Cameron","doi":"10.1016/j.ntt.2025.107473","DOIUrl":"10.1016/j.ntt.2025.107473","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107473"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the impact of air pollution on birth defects and potential for modification by residential built food environment 评估空气污染对出生缺陷的影响以及住宅建筑食品环境的潜在改变
IF 2.6 3区 医学
Neurotoxicology and teratology Pub Date : 2025-05-01 Epub Date: 2025-06-17 DOI: 10.1016/j.ntt.2025.107455
Adiba Gaffar , Nichole Kulikowski , Alison Krajewski , Maxwell Hatala , Archana Lamicchane
{"title":"Assessing the impact of air pollution on birth defects and potential for modification by residential built food environment","authors":"Adiba Gaffar ,&nbsp;Nichole Kulikowski ,&nbsp;Alison Krajewski ,&nbsp;Maxwell Hatala ,&nbsp;Archana Lamicchane","doi":"10.1016/j.ntt.2025.107455","DOIUrl":"10.1016/j.ntt.2025.107455","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107455"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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