Neurotoxicology and teratology最新文献

{"title":"Introduction to “Effects of stress exposure during development on neurobehavioral and neuroendocrine function”","authors":"Jerrold S. Meyer , Sonya Sobrian , Gregg D. Stanwood","doi":"10.1016/j.ntt.2025.107520","DOIUrl":"10.1016/j.ntt.2025.107520","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"110 ","pages":"Article 107520"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal exposure in Brazilian children of waste pickers from the largest open garbage dump in Latin America: Use of deciduous teeth as biomarker","authors":"Andrea M. Dantas ,&nbsp;Eliude B. Gomes ,&nbsp;Raquel F. Gerlach ,&nbsp;Airton C. Martins ,&nbsp;Tara R. Zolnikov ,&nbsp;Aline M. Susuki ,&nbsp;Ana C.B. Bezerra ,&nbsp;Fernando Barbosa Jr ,&nbsp;Michael Aschner ,&nbsp;Mariana R. Urbano ,&nbsp;Monica M.B. Paoliello ,&nbsp;Vanessa R.N. Cruvinel","doi":"10.1016/j.ntt.2025.107516","DOIUrl":"10.1016/j.ntt.2025.107516","url":null,"abstract":"<div><div>Environmental exposures to metals is a concern for public health, due to their association with various adverse health outcomes, especially in children. The aim of this study was to analyze 21 metals (V, Cr, Mn, Co, Ni, Cu, Zn, As, Se, Rb, Ag, Cd, Ba, Ti, Pb, U, Sn, Mo, Ce, La, and Th) in deciduous teeth of waste pickers' children from an open garbage dump region (<em>Estrutural</em> region- Group 1), and compare them with children living in two other regions in Brasilia (<em>Ceilandia</em> – Group 2, and <em>Plano Piloto</em> – Group 3). Three hundred and two children participated in the study, and a single deciduous whole tooth (dentine plus enamel) was analyzed from each child. Socio-demographic variables, breastfeeding time, visits to the dentist, drinking water consumption, among others, were obtained through a questionnaire provided to the parents or guardians of the children. Metal analyses were performed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Significantly higher concentrations of V, Co, Cu, and As were found in children from G1, where most parents were waste pickers, compared to the other two regions (<em>p</em> &lt; 0.01). Pb and Cd concentrations were significantly higher in children from G2 and G3 compared with G1 (p &lt; 0.01). Significantly higher levels of Cr, Mn, Zn and Se were found in children from G2 (p &lt; 0.01), where residents also have very low income, analogous to G1. We found a trend towards an increase in metal concentrations in incisor compared to canine and molar teeth of children in all three groups. This study provides novel data and reinforces the use of deciduous teeth as potential matrix for biomonitoring children's metal exposures.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"110 ","pages":"Article 107516"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of bisphenol-a on vasopressin regulating synaptic plasticity of hippocampus","authors":"Xiaohong Xu,&nbsp;Jinshan Wang,&nbsp;Yani Yang","doi":"10.1016/j.ntt.2025.107531","DOIUrl":"10.1016/j.ntt.2025.107531","url":null,"abstract":"<div><div>The neuropeptide arginine vasopressin (AVP) plays an important role in the hippocampus by regulating neuronal excitability, synaptic plasticity, and other processes. Activity of AVP is regulated by sex hormones. The present study investigated the effects of bisphenol-A (BPA), a environmental endocrine disruptor, on AVP regulating synaptic plasticity of hippocamus. AVP at 10–100 nM significantly increased the dendrite complexity and dendrite spine density of hippocampal neurons in vitro<em>,</em> which was partially eliminated by AVP receptor 1a (V1aR) antagonist (RG7713) or oxytocin receptor (OTR) antagonist (L368–899). BPA at 10 nM increased neuronal dendritic complexity and spine density, which was partially eliminated by estrogen receptor (ERs) antagonist (ICI182,780) but completely abolished by antagonist of both ERs and ERRγ (Tamoxifen). BPA at 10 nM did not affect the effect of AVP (100 nM) on the dendrite complexity and spine density, but eliminated the promoting effects of DHT + AVP on the dendritic complexity. BPA at 1000 nM not only inhibited the dendritic complexity but also eliminated the promoting effects of AVP, 17β-estradiol (17β-E₂) + AVP, and 11-ketodihydrotestosterone (DHT) + AVP on the dendritic complexity. In addition, BPA at 1000 nM down-regulated the levels of V1aR and OTR protein expressions. Meanwhile, BPA at 10 nM promoted the maintenance of LTP of CA2 in the hippocampal slices, but co-treatment of BPA eliminated the effect of 17β-E₂ or DHT on LTP. BPA (10 nM) did not affect the promotion of long-term potentiation (LTP) by AVP, but eliminated the promotion of LTP by DHT + AVP. These results suggest that BPA at nanomoles levels affected AVP regulating modification of dendrite morphology and synaptic plasticity of hippocampus mainly by disrupting the effects of 17β-E₂ and/or DHT on AVP activity.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"110 ","pages":"Article 107531"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro(nano)plastics in the brain: Epigenetic perturbations in progression to neurodegenerative diseases","authors":"Mou Mondal ,&nbsp;Apoorva Chouksey ,&nbsp;Vikas Gurjar ,&nbsp;Rajnarayan Tiwari ,&nbsp;Rupesh K. Srivasatava ,&nbsp;Pradyumna Kumar Mishra","doi":"10.1016/j.ntt.2025.107521","DOIUrl":"10.1016/j.ntt.2025.107521","url":null,"abstract":"<div><div>As global plastic production escalates, micro(nano)plastics (MNPs) have become pressing ecological and biomedical concerns. These pollutants are increasingly implicated in the pathogenesis of neurodegenerative diseases. Due to their nanoscale size and surface reactivity, MNPs can cross the blood-brain barrier, accumulating in neural tissues. Once internalized, they disrupt neuronal homeostasis by inducing oxidative stress, mitochondrial dysfunction, and chronic neuroinflammation, key processes in neurodegenerative progression. Mitochondria, central to neuronal energy and redox regulation, are particularly vulnerable, leading to impaired ATP production, elevated ROS, and pro-apoptotic signaling. Recent studies reveal that MNPs also induce epigenetic changes, including aberrant DNA methylation, histone modifications, and dysregulation of non-coding RNAs. These alterations can result in synaptic instability, persistent transcriptional reprogramming, and heightened susceptibility to diseases like Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis. The mitochondrial epigenome is a vital target of MNP-induced disruption, offering potential biomarkers like methylated mtDNA and microRNAs for early diagnosis and prognosis. Understanding the molecular mechanisms behind these epigenetic alterations is essential for developing practical diagnostic tools and therapies. This review provides a comprehensive overview of MNP-induced neurodegeneration, focusing on mitochondrial and epigenetic disruptions. Moreover, it explores emerging biosensing technologies for detecting MNP-induced epigenetic alterations, highlighting the urgent need for further investigation to fully understand the neurotoxic potential of MNPs and develop preventive and therapeutic strategies for mitigating their effects on brain health.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"110 ","pages":"Article 107521"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The East Palestine train derailment: A complex environmental disaster","authors":"Lynn T. Singer ,&nbsp;Fredrick Schumacher ,&nbsp;James Fabisiak ,&nbsp;Laura J. Dietz ,&nbsp;Timothy Ciesielski","doi":"10.1016/j.ntt.2025.107522","DOIUrl":"10.1016/j.ntt.2025.107522","url":null,"abstract":"<div><div>This symposium, <em>The East Palestine Train Derailment: A Complex Environmental Disaster</em>, brought together scientists whose research represented initial scientific responses to the community health impacts of the chemical exposures incurred from a disastrous train derailment and subsequent combustion in East Palestine, Ohio in February, 2023. This derailment and burn led to multiple complex toxic exposures to air, soil and water, including vinyl chloride and butyl acrylate. Presenters described the multi-university consortium formed to assist with developing and communicating data-informed summaries to the affected community. Presenters also reported on the immediate health sequelae experienced by the community and the stress and uncertainty regarding long term effects. Plans were reported for several pilot studies funded by the National Institute on Environmental Health Sciences in immediate response to the disaster. Fredrick Schumacher, PhD outlined the aims of The <em>Healthy Futures Research Study</em>: <em>Linking Somatic Mutation Rate with Baseline Exposure in East Palestine</em> that plans to use somatic mutation rate (SMR) to measure the biological impact of environmental exposures based on proximity to the train derailment and residents’ clinical symptomatology. James Fabisiak, PhD shared plans for their study<em>, East Palestine Community-Engaged Environmental Exposure, Health Data, and Biospecimen Bank</em> that will measure chemical contaminants in indoor air and water in homes<strong>,</strong> monitor liver damage in residents and identify parents’ concerns about children’s health and development. As part of that study, Laura Dietz, PhD noted the major psychosocial stressors experienced by the community, particularly the psychological effects on children which the study will try to identify through parental report. Timothy Ciesielski, MD, PhD summarized the difficulties of drawing conclusions related to health and safety risk from the toxicants released through currently available government databases and his experience trying to provide the community with reliable and valid information in the context of working across state lines and multiple state and federal agencies.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"110 ","pages":"Article 107522"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying teratogens: Challenges and opportunities","authors":"Sonja A. Rasmussen","doi":"10.1016/j.ntt.2025.107453","DOIUrl":"10.1016/j.ntt.2025.107453","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107453"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays","authors":"Emily Pitzer","doi":"10.1016/j.ntt.2025.107459","DOIUrl":"10.1016/j.ntt.2025.107459","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107459"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic changes and pathway analysis of brain tissues following exposure to the glutamatergic excitotoxin, kainic acid in Long Evans rats","authors":"Emily Pitzer,&nbsp;Tracey Beasley,&nbsp;Garyn Jung,&nbsp;Kathy McDaniel,&nbsp;William Padgett,&nbsp;Witold Winnik,&nbsp;David Herr","doi":"10.1016/j.ntt.2025.107486","DOIUrl":"10.1016/j.ntt.2025.107486","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107486"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways from prenatal alcohol exposure to adult working memory deficit","authors":"Lynn Singer ,&nbsp;Elizabeth Schultheis ,&nbsp;Jeffrey Albert ,&nbsp;June-yung Kim ,&nbsp;Sonia Minnes ,&nbsp;Meeyoung Min","doi":"10.1016/j.ntt.2025.107483","DOIUrl":"10.1016/j.ntt.2025.107483","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107483"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental impacts of deprivation and threat on emotion recognition","authors":"Nicolas Murgueitio ,&nbsp;Margaret A. Sheridan ,&nbsp;Michelle Shipkova ,&nbsp;Amy G. Halberstadt ,&nbsp;Patricia T. Garrett-Peters ,&nbsp;Cathi B. Propper","doi":"10.1016/j.ntt.2025.107446","DOIUrl":"10.1016/j.ntt.2025.107446","url":null,"abstract":"<div><div>Dimensional models of early adversity propose developmental mechanisms by which threat and deprivation confer risk for psychopathology. Exposure to violent environments may influence social information processing biases, and limited access to complex learning environments might be associated with general challenges in emotion recognition. We examined associations of adversity measured early in development (6–36 months) and emotion recognition in early (72 months) and middle (96 months) childhood in a sample of 92 mother-child dyads. Low cognitive stimulation negatively predicted early childhood emotion recognition (β = −0.32, <em>p =</em> .01). Moreover, experiences of intimate-partner violence were associated with anger bias, but not global emotion recognition, in early (β = 0.24, <em>p =</em> .01), and middle (β = 0.18, <em>p =</em> .04) childhood. This pattern suggests that while the lack of exposure to complex learning experiences might impact children's conceptual knowledge of emotions, children who experience violence show biases that facilitate threat detection.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107446"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}