Neurotoxicology and teratology最新文献

{"title":"Difficulties in assessing risks of neurotoxic metal contamination through community-engaged toxicology research","authors":"Christine Curran, Nirmal Pandit, Abilene Morgan","doi":"10.1016/j.ntt.2025.107468","DOIUrl":"10.1016/j.ntt.2025.107468","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107468"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal fentanyl disrupts long-term social dominance behaviors and gene expression patterns","authors":"Devon Graham, Chioma Uchegbu, Trinity Nguyen, Inayat Sood, Kimberly Blankenship, Huan He, Gregg Stanwood, Cynthia Vied","doi":"10.1016/j.ntt.2025.107481","DOIUrl":"10.1016/j.ntt.2025.107481","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107481"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral toxicity of PFAS: Mixture effects and interactions with immunogens in developing artemia","authors":"Andrew Hawkey, Desiree Batangan, Melissa Haque, Matthew Pytynia, Vaibhav Tiwari","doi":"10.1016/j.ntt.2025.107465","DOIUrl":"10.1016/j.ntt.2025.107465","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107465"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral and neurochemical alterations in female mice following pregestational exposure to SARS-CoV-2 lysate protein","authors":"Bárbara Beatriz da Silva Nunes ,&nbsp;Juliana dos Santos Mendonça ,&nbsp;Stênio Gonçalves da Silva Matos ,&nbsp;Aline Sueli de Lima Rodrigues ,&nbsp;Bruno da Cruz Pádua ,&nbsp;Thiarlen Marinho da Luz ,&nbsp;Guilherme Malafaia","doi":"10.1016/j.ntt.2025.107451","DOIUrl":"10.1016/j.ntt.2025.107451","url":null,"abstract":"<div><div>The rapid introduction of new environmental contaminants, including viral agents like SARS-CoV-2, has raised concerns about their indirect effects on non-target terrestrial organisms, especially through contaminated water sources. In this study, we investigated the potential neurotoxic effects of pre-mating and gestational exposure to SARS-CoV-2 lysate protein. Female C57Bl/6 J mice were exposed to a concentration of 20 μg/L for 30 days via drinking water. No significant effects were observed on gestational duration, litter size, or offspring biomass, suggesting no direct impact on reproductive performance. However, exposed females exhibited marked neurobehavioral alterations, including increased anxiety-like behavior in the open field test and altered maternal care dynamics, characterized by hyper-responsiveness and increased nest attendance duration. These behavioral changes were strongly correlated with neurochemical imbalances, including elevated dopamine levels in the olfactory bulb, brain, and hypothalamic-pituitary region. Additionally, cholinesterase activity was significantly altered, with increased acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in the olfactory bulb and brain, but decreased AChE activity in the hypothalamus-pituitary region, suggesting disrupted cholinergic signaling. Furthermore, oxidative and nitrosative stress markers (ROS and NO) were significantly elevated in mammary and ovarian tissues, indicating a persistent inflammatory response even after exposure cessation. These findings highlight long-term neurochemical and behavioral disruptions following environmentally relevant exposure to SARS-CoV-2 lysate protein, which could compromise neurophysiological homeostasis, stress regulation, and maternal investment in non-target mammals. In natural environments, such alterations may reduce individual fitness and population resilience, emphasizing the need to further investigate the ecotoxicological consequences of viral pollutants on terrestrial organisms.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107451"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and infancy as sensitive periods for prevention and interventions: Leveraging cross-species and randomized clinical trial approaches","authors":"Elysia Davis","doi":"10.1016/j.ntt.2025.107469","DOIUrl":"10.1016/j.ntt.2025.107469","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107469"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical windows of susceptibility for the effects of prenatal exposure to heat and heat variability on gestational growth","authors":"Jeffrey Carlson","doi":"10.1016/j.ntt.2025.107454","DOIUrl":"10.1016/j.ntt.2025.107454","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107454"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-occurring substance use and mental health symptoms among prenatally substance-exposed emerging adults","authors":"June-Yung Kim ,&nbsp;Sonia Minnes ,&nbsp;Meeyoung O. Min ,&nbsp;Liat R. Johnson ,&nbsp;Lynn T. Singer","doi":"10.1016/j.ntt.2025.107498","DOIUrl":"10.1016/j.ntt.2025.107498","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107498"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral assessments in preterm pigs","authors":"Helen J.K. Sable","doi":"10.1016/j.ntt.2025.107489","DOIUrl":"10.1016/j.ntt.2025.107489","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107489"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory aspects of neurobehavioral testing in alternate animal models","authors":"Elizabeth Green","doi":"10.1016/j.ntt.2025.107490","DOIUrl":"10.1016/j.ntt.2025.107490","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107490"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new ethical paradigm challenged: Reproductive research in the post-Dobbs era","authors":"Anne D. Lyerly","doi":"10.1016/j.ntt.2025.107477","DOIUrl":"10.1016/j.ntt.2025.107477","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107477"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}