Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"Distinct patterns of metabolic motor cortex activity for phantom and residual limb pain in people with amputations: A functional near-infrared spectroscopy study","authors":"Marcel Simis , Lucas Murrins Marques , Sara Pinto Barbosa , André Tadeu Sugawara , João Ricardo Sato , Kevin Pacheco-Barrios , Linamara Rizzo Battistella , Felipe Fregni","doi":"10.1016/j.neucli.2023.102939","DOIUrl":"https://doi.org/10.1016/j.neucli.2023.102939","url":null,"abstract":"<div><h3>Background</h3><p>Phantom pain limb (PLP) has gained more attention due to the large number of people with amputations around the world and growing knowledge of the pain process, although its mechanisms are not completely understood.</p></div><div><h3>Objectives</h3><p>The aim of this study was to understand, in patients with amputations, the association between PLP and residual limb pain (RLP), and the brain metabolic response in cortical motor circuits, using functional near-infrared spectroscopy (fNIRS).</p></div><div><h3>Methods</h3><p>Sixty participants were recruited from the rehabilitation program in São Paulo, Brazil. Included patients were aged over 18 years, with traumatic unilateral lower-limb amputation, with PLP for at least 3 months after full recovery from amputation surgery. PLP and RLP levels were measured using visual analogue scales. fNIRS was performed during motor execution and motor mirror tasks for 20 s. In order to highlight possible variables related to variation in pain measures, univariate linear regression analyses were performed for both experimental conditions, resulting in four fNIRS variables (two hemispheres x two experimental conditions). Later, in order to test the topographic specificity of the models, eight multivariate regression analyses were performed (two pain scales x two experimental conditions x two hemispheres), including the primary motor cortex (PMC) related channel as an independent variable as well as five other channels related to the premotor area, supplementary area, and somatosensory cortex. All models were controlled for age, sex, ethnicity, and education.</p></div><div><h3>Results</h3><p>We found that: i) there is an asymmetric metabolic activation during motor execution and mirror task between hemispheres (with a predominance that is ipsilateral to the amputated limb), ii) increased metabolic response in the PMC ipsilateral to the amputation is associated with increased PLP (during both experimental tasks), while increased metabolic response in the contralateral PMC is associated with increased RLP (during the mirror motor task only); ii) increased metabolic activity of the ipsilateral premotor region is associated with increased PLP during the motor mirror task; iii) RLP was only associated with higher metabolic activity in the contralateral PMC and lower metabolic activity in the ipsilateral inferior frontal region during motor mirror task, but PLP was associated with higher metabolic activity during both tasks.</p></div><div><h3>Conclusion</h3><p>These results suggest there is both task and region specificity for the association between the brain metabolic response and the two different types of post-amputation pain. The metabolic predominance that is ipsilateral to the amputated limb during both tasks was associated with higher levels of PLP, suggesting a cortical motor network activity imbalance due to potential interhemispheric compensatory mechanisms. The present work contrib","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 1","pages":"Article 102939"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of textured surfaces on the orthostatic balance of patients with multiple sclerosis","authors":"Nathalie Bonardet ,&nbsp;Benjamin Bardel ,&nbsp;Jean-Pascal Lefaucheur ,&nbsp;Marc Sorel ,&nbsp;Alain Créange","doi":"10.1016/j.neucli.2023.102941","DOIUrl":"https://doi.org/10.1016/j.neucli.2023.102941","url":null,"abstract":"<div><h3>Objective</h3><p>To perform posturographic measurements with eyes open or closed using floor coverings with different textured surfaces to study postural control in patients with multiple sclerosis (MS).</p></div><div><h3>Methods</h3><p>Static posturographic recordings were performed with eyes open and eyes closed on a forceplate with no covering (control condition) or covered by a textured mat with small pimples (height 2 mm) or large pimples (height 7 mm). Several posturographic variables were measured, focusing on displacements of the center of pressure (CoP) including the average velocity (V_av), the total length (L) of all displacements, and the surface (S) of the confidence ellipse. The recordings made with the textured mats were compared to the control condition with eyes open or closed. Then, the differences between the recordings made with large vs. small pimples on the one hand, and with eyes closed vs. open were calculated to assess the impact of pimple height or eye closure on posturographic measurements. Clinical assessment was based on the Expanded Disability Status Scale (EDSS) and its functional system (FS) subscores, the Modified Fatigue Impact Scale (MFIS), the Unipodal Stance test (UST), and the Timed Up-and-Go test (TUG).</p></div><div><h3>Results</h3><p>Forty-six MS patients (mean EDSS score: 3.6) completed the study. Several posturographic variables, including V_av and L, deteriorated when measured on a textured mat, especially with large pimples and in eyes open condition. In contrast, no difference was found with small pimples and eyes closed, as compared to the control condition (no covering). The deleterious impact of pimple height on posturography correlated positively with the alteration of balance and gait clinically assessed by the UST and the TUG, and also with the MFIS physical and cerebral EDSS-FS subscores, and negatively with the cerebellar and brainstem subscores. On the other hand, the impact of eye closure on posturography was negatively correlated with the visual EDSS-FS subscore.</p></div><div><h3>Discussion</h3><p>Static posturographic measurements made with different textured surfaces and visual conditions can be considered as a sensitive tool to measure \"proprioceptive reserves\". Actually, when cerebellar, brainstem, or visual functions are impaired, the resources of the sensory (proprioceptive) system, if preserved, can be recruited at a higher level and compensate for dysfunctions of other postural controls to maintain a satisfactory balance. In addition, this procedure of static posturographic examination can provide objective measurements correlated with clinical testing of balance and gait and could usefully complement EDSS scoring to assess disability affecting postural control and the risk of falling in MS patients.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 1","pages":"Article 102941"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139915191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of transcranial direct current stimulation in the treatment of fibromyalgia: A systematic review and meta-analysis","authors":"Chun-Lan Yang ,&nbsp;Yun Qu ,&nbsp;Jia-Peng Huang ,&nbsp;Ting-Ting Wang ,&nbsp;Han Zhang ,&nbsp;Yin Chen ,&nbsp;Ying-Chao Tan","doi":"10.1016/j.neucli.2024.102944","DOIUrl":"10.1016/j.neucli.2024.102944","url":null,"abstract":"<div><h3>Objectives</h3><p>To update a systematic review of the efficacy and safety of transcranial direct current stimulation (tDCS) for analgesia, for antidepressant effects, and to reduce the impact of fibromyalgia (FM), looking for optimal areas of stimulation.</p></div><div><h3>Methods</h3><p>We searched five databases to identify randomized controlled trials comparing active and sham tDCS for FM. The primary outcome was pain intensity, and secondary outcome measures included FM Impact Questionnaire (FIQ) and depression score. Meta-analysis was conducted using standardized mean difference (SMD). Subgroup analysis was performed to determine the effects of different regional stimulation, over the primary motor cortex (M1), dorsolateral prefrontal cortex (DLPFC), opercular-insular cortex (OIC), and occipital nerve (ON) regions. We analyzed the minimal clinically important difference (MCID) by the value of the mean difference (MD) for an 11-point scale for pain, the Beck Depressive Inventory-II (BDI-II), and the Fibromyalgia Impact Questionnaire (FIQ) score. We described the certainty of the evidence (COE) using the tool <em>GRADE profile.</em></p></div><div><h3>Results</h3><p>Twenty studies were included in the analysis. Active tDCS had a positive effect on pain (SMD= -1.04; 95 % CI -1.38 to -0.69), depression (SMD= -0.46; 95 % CI -0.64 to -0.29), FIQ (SMD= -0.73; 95 % CI -1.09 to –0.36), COE is moderate. Only group M1 (SD=-1.57) and DLPFC (SD=-1.44) could achieve MCID for analgesia; For BDI-II, only group DLPFC (SD=-5.36) could achieve an MCID change. Adverse events were mild.</p></div><div><h3>Conclusion</h3><p>tDCS is a safe intervention that relieves pain intensity, reduces depression, and reduces the impact of FM on life. Achieving an MCID is related to the stimulation site and the target symptom.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 1","pages":"Article 102944"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705324000029/pdfft?md5=bb20761e234970c2f17d77b6b91d83d4&pid=1-s2.0-S0987705324000029-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139925223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can epilepsy affect normal EEG variants? A comparative study between subjects with and without epilepsy","authors":"Greta Macorig ,&nbsp;Arielle Crespel ,&nbsp;Annacarmen Nilo ,&nbsp;Ngoc Phuong Loc Tang ,&nbsp;Gian Luigi Gigli ,&nbsp;Philippe Gélisse","doi":"10.1016/j.neucli.2023.102935","DOIUrl":"https://doi.org/10.1016/j.neucli.2023.102935","url":null,"abstract":"<div><h3>Objectives</h3><p>To compare the prevalence of benign EEG variants (BEVs) between epileptic and non-epileptic subjects.</p></div><div><h3>Methods</h3><p>A prospective, observational EEG study of 1,163 consecutive patients, using the 10–20 international system with systematically two additional anterior/inferior temporal electrodes. The video-EEG monitoring duration was between 24 h and eight days.</p></div><div><h3>Results</h3><p>We identified 917 (78.9%) epileptic patients (mean age: 33.42 ± 15.5 years; females: 53.4%) and 246 (21.2%) non-epileptic patients (mean age: 35.6 ± 18.75 years; females: 54.9%). Despite a shorter mean duration of the EEG recordings, the prevalence of BEVs was higher in non-epileptic vs. epileptic patients (73.2% vs. 57.8%, <em>p</em> = 0.000011). This statistical difference was confirmed for lambda waves (23.6% in the non-epilepsy group vs. 14.8% in the epilepsy group, <em>p</em> = 0.001), POSTs (50.8% vs. 32.5%, <em>p</em> &lt; 0.000001), wicket spikes (20.3% vs. 13.6%, <em>p</em> = 0.009) in particular in NREM and REM sleep, and 14- and 6-Hz positive bursts (13% vs. 7.1% <em>p</em> = 0.003). Mu rhythm was observed at the same frequency in both groups (21.1% in the non-epilepsy group vs. 22.7% in the epilepsy group). There was no difference between the two groups for rarer rhythms, such as rhythmic mid-temporal theta burst of drowsiness, small sharp spikes, and midline theta rhythm.</p></div><div><h3>Conclusions</h3><p>There was no increase in any of the BEVs in the epilepsy group. On the contrary, BEVs were more frequent and diversified in the non-epilepsy group. Epilepsy may negatively affect the occurrence of the most common BEVs, with the exception of the mu rhythm, which is present in about one-fifth of the population with or without epilepsy.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 1","pages":"Article 102935"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705323000928/pdfft?md5=c2d64820738e2040286d91b616a0da68&pid=1-s2.0-S0987705323000928-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139935832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suboptimal postnatal function of brainstem auditory pathway in late preterm infants who do not have major perinatal and postnatal complications","authors":"Cui Wang,&nbsp;James K. Jiang,&nbsp;Rong Yin,&nbsp;Ze D. Jiang","doi":"10.1016/j.neucli.2023.102919","DOIUrl":"https://doi.org/10.1016/j.neucli.2023.102919","url":null,"abstract":"<div><h3>Objectives</h3><p>To examine postnatal functional status of the brainstem auditory pathway in late preterm infants and detect any postnatal auditory abnormality.</p></div><div><h3>Methods</h3><p>Thirty preterm infants born at 33–36 weeks gestation were studied three months after term. None had major perinatal and postnatal complications to minimize confounding effects. Brainstem auditory evoked responses were recorded with 21–91/s clicks.</p></div><div><h3>Results</h3><p>Compared with postnatal age-matched normal term infants, the late preterm infants did not manifest any major abnormalities in brainstem auditory evoked responses at conventionally used 21/s clicks. At higher click rates, however, the late preterm infants manifested a moderate prolongation in BAER wave V latency. All interpeak intervals tended to be prolonged at higher click rates. The I-V interval was significantly prolonged at 51/s and particularly at 91/s clicks. Both the I-III and III-V intervals were significantly prolonged at 91/s. The late preterm infants also manifested reduced amplitudes of BAER waves III and V at most click rates.</p></div><div><h3>Conclusion</h3><p>The central components of the brainstem auditory evoked responses were abnormal at higher click rates three months after term in the late preterm infants. Postnatal brainstem auditory function is suboptimal in late preterm infants without major complications. This suboptimal brainstem auditory function may not be clearly shown at term or an earlier stage, but can be shown later. Late preterm infants, although they may not have major complications, should be followed for later auditory development, providing valuable information for improving postnatal care.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102919"},"PeriodicalIF":3.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136697199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis","authors":"Thusharika Dissanayaka ,&nbsp;Piumi Nakandala ,&nbsp;Kavinda Malwanage ,&nbsp;Aron T. Hill ,&nbsp;Deborah N. Ashthree ,&nbsp;Melissa M. Lane ,&nbsp;Nikolaj Travicia ,&nbsp;Elizabeth Gamage ,&nbsp;Wolfgang Marx ,&nbsp;Shapour Jaberzadeh","doi":"10.1016/j.neucli.2023.102921","DOIUrl":"https://doi.org/10.1016/j.neucli.2023.102921","url":null,"abstract":"<div><h3>Objectives</h3><p>To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA).</p></div><div><h3>Methods</h3><p>The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement.</p></div><div><h3>Results</h3><p>Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) −0.52; 95% CI, −0.78 to −0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD −1.23; 95% CI, −1.59 to −0.88; P&lt;0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision.</p></div><div><h3>Discussion and Conclusion</h3><p>A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings.</p></div><div><h3>Significance</h3><p>A-tDCS can be used as a standalone and adjunct treatment for KOA.</p></div><div><h3>Study registration</h3><p>PROSPERO number CRD42021255114</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102921"},"PeriodicalIF":3.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705323000783/pdfft?md5=d74ed43e772b7e90a1592563c166f12a&pid=1-s2.0-S0987705323000783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136697371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"tDCS for pain management in knee osteoarthritis: A plea for noninvasive brain stimulation techniques in neuromusculoskeletal rehabilitation","authors":"Samira Cutts ,&nbsp;Alexander T. Sack","doi":"10.1016/j.neucli.2023.102922","DOIUrl":"https://doi.org/10.1016/j.neucli.2023.102922","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102922"},"PeriodicalIF":3.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705323000795/pdfft?md5=a637d6b3850efe77dda9185b7794d84b&pid=1-s2.0-S0987705323000795-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134657297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of transcranial direct current stimulation in patients with knee osteoarthritis: A systematic review","authors":"Fatemeh Rahimi ,&nbsp;Meissam Sadeghisani ,&nbsp;Atefeh Karimzadeh","doi":"10.1016/j.neucli.2023.102918","DOIUrl":"10.1016/j.neucli.2023.102918","url":null,"abstract":"<div><h3>Objective</h3><p>Transcranial direct current stimulation (tDCS) has demonstrated its efficacy in alleviating pain among individuals with musculoskeletal disorders. This review focuses on the application of tDCS as a therapeutic intervention for managing knee osteoarthritis (OA), a prevalent musculoskeletal condition. The primary objective is to assess the effectiveness of tDCS(add-on tDCS and /or stand-alone tDCS), whether as an add-on to existing treatments or as a standalone therapy, in reducing pain and enhancing functional capacity in patients with knee OA.</p></div><div><h3>Methods</h3><p>A comprehensive search was conducted across multiple databases, including PubMed, Science Direct, OVID, MEDLINE, CINAHL, EMBASE, ProQuest, and Google Scholar, and Web of Science. The search terms employed were \"Transcranial direct current stimulation\" or \"tDCS\" in combination with \"Osteoarthritis\" or \"OA\" and \"knee.\" After eliminating duplicates and studies that did not meet the inclusion criteria, a total of 14 relevant articles were identified for review.</p></div><div><h3>Results</h3><p>Among the included studies, twelve reported statistically significant improvements in pain levels when comparing the active tDCS group to the sham tDCS group. Only two studies reported no significant difference in pain intensity between the active tDCS and sham tDCS groups. Findings regarding functional abilities were diverse, with some studies demonstrating a significant enhancement in functional outcomes in the active tDCS group, while others observed no statistically significant differences.</p></div><div><h3>Conclusion</h3><p>The results of this review suggest that tDCS holds promise as a pain management intervention for individuals with knee OA. Notably, anodal tDCS applied over the primary motor cortex (M1) appears to be particularly effective in alleviating pain in patients with knee OA. However, the impact of tDCS on functional performance appears to be limited.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102918"},"PeriodicalIF":3.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OPRM1 and BDNF polymorphisms associated with a compensatory neurophysiologic signature in knee osteoarthritis patients","authors":"Fernanda de Toledo Gonçalves ,&nbsp;Lucas Murrins Marques ,&nbsp;Anne Victório Pessotto ,&nbsp;Sara Pinto Barbosa ,&nbsp;Marta Imamura ,&nbsp;Marcel Simis ,&nbsp;Felipe Fregni ,&nbsp;Linamara Battistella","doi":"10.1016/j.neucli.2023.102917","DOIUrl":"10.1016/j.neucli.2023.102917","url":null,"abstract":"<div><h3>Objective</h3><p>The present study investigated the relationship between three genetic polymorphisms of <em>OPRM1</em> (rs1799971 - A118G and rs1799972 - C17T) and <em>BDNF</em> (rs6265 - C196T) and EEG-measured brain oscillations in Knee Osteoarthritis (KOA) patients.</p></div><div><h3>Materials and Methods</h3><p>We performed a cross-sectional analysis of a cohort study (DEFINE cohort), KOA arm, with 66 patients, considering demographic (age, sex, and education), clinical (pain intensity and duration), <em>OPRM1</em> (rs1799971 - A118G and rs1799972 - C17T) and <em>BDNF</em> (rs6265 - C196T) genotypes, and electrophysiological measures. Brain oscillations relative power from Delta, Theta, Alpha, Low Alpha, High Alpha, Beta, Low Beta and High Beta oscillations were measured during resting state EEG. Multivariate regression models were used to explore the main brain oscillation predictors of the three genetic polymorphisms.</p></div><div><h3>Results</h3><p>Our findings demonstrate that Theta and Low Beta oscillations are associated with the variant allele of <em>OPRM1</em>-rs1799971 (A118G) on left frontal and left central regions, respectively, while Alpha brain oscillation is associated with variant genotypes (CT/TT) of <em>BDNF</em>-rs6265 on frontal (decrease of oscillation power) and left central (increase of oscillation power) regions. No significant model was found for <em>OPRM1</em>-rs1799972 (C17T) in addition to the inclusion of pain intensity as a significant predictor of this last model.</p></div><div><h3>Conclusion</h3><p>One potential interpretation for these findings is that polymorphisms of <em>OPRM1</em> – that is involved with endogenous pain control - lead to increased compensatory oscillatory mechanisms, characterized by increased theta oscillations. Along the same line, polymorphisms of the BDNF lead to decreased alpha oscillations in the frontal area, likely also reflecting the disruption of resting states to also compensate for the increased injury associated with knee OA. It is possible that these polymorphisms require additional brain adaption to the knee OA related injury.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102917"},"PeriodicalIF":3.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of clinical and tumor-specific factors on the resting motor threshold in navigated transcranial magnetic stimulation","authors":"Thomas Eibl ,&nbsp;Michael Schrey ,&nbsp;Adrian Liebert ,&nbsp;Leonard Ritter ,&nbsp;Rüdiger Lange ,&nbsp;Hans-Herbert Steiner ,&nbsp;Karl-Michael Schebesch","doi":"10.1016/j.neucli.2023.102920","DOIUrl":"10.1016/j.neucli.2023.102920","url":null,"abstract":"<div><h3>Objective</h3><p>Preoperative non-invasive mapping of motor function with navigated transcranial magnetic stimulation (nTMS) has become a widely used diagnostic procedure. Determination of the patient-individual resting motor threshold (rMT) is of great importance to achieve reliable results when conducting nTMS motor mapping. Factors which contribute to differences in rMT of brain tumor patients have not been fully investigated.</p></div><div><h3>Methods</h3><p>We included adult patients with all types of de novo and recurrent intracranial lesions, suspicious for intra-axial brain tumors. The outcome measure was the rMT of the upper extremity, defined as the stimulation intensity eliciting motor evoked potentials with amplitudes greater than 50µV in 50 % of applied stimulations.</p></div><div><h3>Results</h3><p>Eighty nTMS examinations in 75 patients (37.5 % female) aged 57.9 ± 14.9 years were evaluated. In non-parametric testing, rMT values were higher in patients with upper extremity paresis (<em>p</em> = 0.024) and lower in patients with high grade gliomas (HGG) (<em>p</em> = 0.001). rMT inversely correlated with patient age (<em>r_s</em>=-0.28, <em>p</em> = 0.013) and edema volume (<em>r_s</em>=-0.28, <em>p</em> = 0.012) In regression analysis, infiltration of the precentral gyrus (<em>p</em>&lt;0.001) increased rMT values. Values of rMT were reduced in high grade gliomas (<em>p</em>&lt;0.001), in patients taking Levetiracetam (<em>p</em> = 0.019) and if perilesional edema infiltrated motor eloquent brain (<em>p</em>&lt;0.001). Subgroup analyses of glioma patients revealed similar results. Values of rMT did not differ between hand and forearm muscles.</p></div><div><h3>Conclusion</h3><p>Most factors confounding rMT in our study were specific to the lesion. These factors contributed to the variability in cortical excitability and must be considered in clinical work with nTMS to achieve reliable results with nTMS motor mapping.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102920"},"PeriodicalIF":3.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705323000771/pdfft?md5=9e0442c54448837ca02c75117e323bf5&pid=1-s2.0-S0987705323000771-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}