Vandana Esht , Mohammed M Alshehri , Karthick Balasubramanian , Ramya R Sanjeevi , Mohammed A Shaphe , Ahmed Alhowimel , Aqeel M Alenazi , Bader A Alqahtani , Norah Alhwoaimel
{"title":"Transcranial direct current stimulation (tDCS) for neurological disability among subacute stroke survivors to improve multiple domains in health-related quality of life: Randomized controlled trial protocol","authors":"Vandana Esht , Mohammed M Alshehri , Karthick Balasubramanian , Ramya R Sanjeevi , Mohammed A Shaphe , Ahmed Alhowimel , Aqeel M Alenazi , Bader A Alqahtani , Norah Alhwoaimel","doi":"10.1016/j.neucli.2024.102976","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102976","url":null,"abstract":"<div><h3>Objectives</h3><p>The primary goal of the current proposal is to fill the gaps in the literature by studying the effectiveness of transcranial direct current stimulation (tDCS) on lifestyle parameters, and physical, behavioral, and cognitive functions among stroke survivors, and understanding the factors that mediate the effects of various domains related to Health-related Quality of life (HRQoL) improvements.</p></div><div><h3>Methods</h3><p>Anticipated 64 volunteer subacute stroke survivors (>7 days to 3 months post stroke) aged 40–75 years with National Institutes of Health stroke scale (NIHSS) score of >10 and Mini-Mental State Examination (MMSE) score between 18 and 23 will be randomly assigned at a ratio of 1:1 to receive either: (1) 20 sessions of anodal tDCS or (2) sham tDCS in addition to conventional rehabilitation. Battery driven tDCS will be applied at 2 mA intensity to the dorsolateral prefrontal cortex and primary motor cortex for 20 minutes. The primary endpoints of study will be 36-Item Short Form Survey (SF-36) post intervention at 4 weeks. The secondary outcomes will include Stroke Specific Quality of Life Scale (SS_QOL), Montreal cognitive assessment (MCA), Beck Anxiety Inventory (BAI), Fugl-Meyer Assessment (FMA), 10 m walk test and Modified Barthel Activities of daily living (ADL) Index. At 0.05 level of significance, data normality, within group and between group actual differences will be analyzed with a moderate scope software.</p></div><div><h3>Discussion</h3><p>Our knowledge of this technique and its use is expanding daily as tDCS motor recovery studies—mostly single-center studies—in either single session or many sessions have been completed and shown positive results. The field is prepared for a multi-center, carefully planned, sham-controlled, double-blinded tDCS study to comprehensively examine its feasibility and effectiveness in enhancing outcomes in stroke population.</p></div><div><h3>Conclusion</h3><p>The function of Transcranial Direct Current Stimulation in aiding stroke recuperation will be ascertained.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 3","pages":"Article 102976"},"PeriodicalIF":3.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of transcranial direct current stimulation of the left primary motor cortex area on hand grip strength and dexterity in healthy individuals: A double-blind randomized sham-controlled trial","authors":"Sharareh Roshanzamir , Tayebeh Sadat Salehi Rihani , Afsaneh Dadarkhah","doi":"10.1016/j.neucli.2024.102959","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102959","url":null,"abstract":"<div><h3>Background and objective</h3><p>Motor function plays a critical role in everyday activities, from basic self-care tasks to complex activities that require precision and dexterity. This study was conducted to investigate the effects of transcranial direct current stimulation (tDCS) on grip strength and hand dexterity in healthy individuals.</p></div><div><h3>Method</h3><p>We conducted a double-blind randomized clinical trial with two groups of sham and active tDCS. The anode was fixed over the primary motor cortex area M1 on the C3 point. The primary outcome was hand grip strength measured by a dynamometer and the secondary outcomes were hand dexterity and assembly assessed by the Purdue Pegboard test. The tDCS program was administered at rest three and two times for the first and second week for a total of five sessions of 20 min each.</p></div><div><h3>Results</h3><p>There was no significant improvement in the mean difference in grip strength between the sham (<em>N</em> = 27) and active (<em>N</em> = 27) tDCS groups (1.7 vs. 2.3, Mann-Whitney <em>U</em> test, <em>P</em> = 0.869, <em>d</em> = 0.02). Participants who received active tDCS showed subtle improvements in right-hand dexterity (0.6 vs. 1.3, <em>U</em> test <em>P</em> = 0.017, <em>d</em> = 0.33) and overall manual dexterity (1.4 vs. 3.2, <em>U</em> test <em>P</em> = 0.023, <em>d</em> = 0.31) compared with the sham group. Other comparisons for hand dexterity and assembly (motor coordination and fine skills during the manipulation of small objects) between the two groups were not significant. We did not find any adverse effects of sham or active tDCS.</p></div><div><h3>Conclusion</h3><p>Our study showed a potential for clinical improvement in hand dexterity after five sessions of tDCS in healthy individuals.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 4","pages":"Article 102959"},"PeriodicalIF":3.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140309766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Celeste Bonacci , Ilaria Sammarra , Maria Eugenia Caligiuri , Miriam Sturniolo , Iolanda Martino , Patrizia Vizza , Pierangelo Veltri , Antonio Gambardella
{"title":"Quantitative analysis of visually normal EEG reveals spectral power abnormalities in temporal lobe epilepsy","authors":"Maria Celeste Bonacci , Ilaria Sammarra , Maria Eugenia Caligiuri , Miriam Sturniolo , Iolanda Martino , Patrizia Vizza , Pierangelo Veltri , Antonio Gambardella","doi":"10.1016/j.neucli.2024.102951","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102951","url":null,"abstract":"<div><h3>Objective</h3><p>To compare quantitative spectral parameters of visually-normal EEG between Mesial Temporal Lobe Epilepsy (MTLE) patients and healthy controls (HC).</p></div><div><h3>Method</h3><p>We enrolled 26 MTLE patients and 26 HC. From each recording we calculated total power of all frequency bands and determined alpha-theta (ATR) and alpha-delta (ADR) power ratios in different brain regions. Group-wise differences between spectral parameters were investigated (<em>p</em> < 0.05). To test for associations between spectral-power and cognitive status, we evaluated correlations between neuropsychological tests and quantitative EEG (qEEG) metrics.</p></div><div><h3>Results</h3><p>In all comparisons, ATR and ADR were significantly decreased in MTLE patients compared to HC, particularly over the hemisphere ipsilateral to epileptic activity. A positive correlation was seen in MTLE patients between ATR in ipsilateral temporal lobe, and results of neuropsychological tests of auditory verbal learning (RAVLT and RAVLT-D), short term verbal memory (Digit span backwards), and executive function (Weigl's sorting test). ADR values in the contralateral posterior region correlated positively with RAVLT-D and Digit span backwards tests.</p></div><div><h3>Discussion</h3><p>Results confirmed that the power spectrum of qEEG is shifted towards lower frequencies in MTLE patients compared to HC.</p></div><div><h3>Conclusion</h3><p>Of note, our results were found in visually-normal recordings, providing further evidence of the value of qEEG for longitudinal monitoring of MTLE patients over time. Exploratory analysis of associations between qEEG and neuropsychological data suggest this could be useful for investigating effects of antiseizure medications on cognitive integrity in patients.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 3","pages":"Article 102951"},"PeriodicalIF":3.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705324000091/pdfft?md5=b589ca6fe7764618de2c54b3659eee78&pid=1-s2.0-S0987705324000091-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140321444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Test-retest reliability of corticokinematic coherence in young children with cerebral palsy: An observational longitudinal study","authors":"Josselin Démas , Mathieu Bourguignon , Rodolphe Bailly , Sandra Bouvier , Sylvain Brochard , Mickael Dinomais , Patrick Van Bogaert","doi":"10.1016/j.neucli.2024.102965","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102965","url":null,"abstract":"<div><h3>Objectives</h3><p>To assess the test-retest reliability of the corticokinematic coherence (CKC), an electrophysiological marker of proprioception, in children with cerebral palsy (CP).</p></div><div><h3>Methods</h3><p>Electroencephalography (EEG) signals from 15 children with unilateral or bilateral CP aged 23 to 53 months were recorded in two sessions 3 months apart using 128-channel EEG caps. During each session, children's fingers were moved at 2 Hz by an experimenter, in separate recordings for the more-affected (MA) and less-affected (LA) hands. The CKC was computed at the electrode and source levels, at movement frequency F0 (2 Hz) and its first harmonic F1 (4 Hz). A two-way mixed-effects model intraclass-correlation coefficient (ICC) was computed for the maximum CKC strength across electrodes at F0 and F1 obtained during the two sessions.</p></div><div><h3>Results</h3><p>ICC of the CKC strength acquired from LA and MA hands pooled together were respectively 0.51 (95% CI: 0.30–0.68) at F0 and 0.96 (95% CI: 0.93–0.98) at F1. The mean distances separating the CKC peaks in the source space at the two evaluation times were in the order of a centimeter.</p></div><div><h3>Conclusion</h3><p>CKC is a robust electrophysiologic marker to study the longitudinal changes in cortical processing of proprioceptive afferences in young children with CP.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 4","pages":"Article 102965"},"PeriodicalIF":3.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140309744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabine Prud'hon , Hélène Amiel , Adrien Zanin , Eric Revue , Nathalie Kubis , Pierre Lozeron
{"title":"EEG and acute confusional state at the emergency department","authors":"Sabine Prud'hon , Hélène Amiel , Adrien Zanin , Eric Revue , Nathalie Kubis , Pierre Lozeron","doi":"10.1016/j.neucli.2024.102966","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102966","url":null,"abstract":"<div><h3>Objectives</h3><p>Acute confusional state (ACS) is a common cause of admission to the emergency department (ED). It can be related to numerous etiologies. Electroencephalography (EEG) can show specific abnormalities in cases of non-convulsive status epilepticus (NCSE), or metabolic or toxic encephalopathy. However, up to 80% of patients with a final diagnosis of NCSE have an ACS initially attributed to another cause. The exact place of EEG in the diagnostic work-up remains unclear.</p></div><div><h3>Methods</h3><p>Data of consecutive patients admitted to the ED for an ACS in a two-year period and who were referred for an EEG were collected. The initial working diagnosis was based on medical history, clinical, biological and imaging investigations allowing classification into four diagnostic categories. Comparison to the final diagnosis was performed after EEG recordings (and sometimes additional tests) were performed, which allowed the reclassification of some patients from one category to another.</p></div><div><h3>Results</h3><p>Seventy-five patients (mean age: 71.1 years) were included with the following suspected diagnoses: seizures for 8 (11%), encephalopathy for 14 (19%), other cause for 34 (45%) and unknown for 19 (25%). EEG was recorded after a mean of 1.5 days after symptom onset, and resulted in the reclassification of patients as follows: seizure for 15 (20%), encephalopathy for 15 (20%), other cause for 29 (39%) and unknown cause for 16 (21%). Moreover, ongoing epileptic activity (NCSE or seizure) and interictal epileptiform activity were found in eight (11%) patients initially diagnosed in another category.</p></div><div><h3>Discussion</h3><p>In our cohort, EEG was a key examination in the management strategy of ACS in 11% of patients admitted to the ED. It resulted in a diagnosis of epilepsy in these patients admitted with unusual confounding presentations.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 4","pages":"Article 102966"},"PeriodicalIF":3.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Focal to bilateral tonic-clonic seizure induced by high-frequency repetitive transcranial magnetic stimulation over the primary motor cortex in a woman with chronic low back pain: A case report","authors":"Philippe Patricio , Hugo Massé-Alarie","doi":"10.1016/j.neucli.2024.102967","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102967","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 4","pages":"Article 102967"},"PeriodicalIF":3.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140309683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}