Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"Posterior insula repetitive transcranial magnetic stimulation for chronic pain in patients with Parkinson disease – pain type matters: A double-blinded randomized sham-controlled trial","authors":"Victor Rossetto Barboza ,&nbsp;Gabriel Taricani Kubota ,&nbsp;Valquíria Aparecida da Silva ,&nbsp;Luciana Mendonça Barbosa ,&nbsp;Debora Arnaut ,&nbsp;Antônia Lilian de Lima Rodrigues ,&nbsp;Ricardo Galhardoni ,&nbsp;Egberto Reis Barbosa ,&nbsp;Andre Russowsky Brunoni ,&nbsp;Manoel Jacobsen Teixeira ,&nbsp;Rubens Gisbert Cury ,&nbsp;Daniel Ciampi de Andrade","doi":"10.1016/j.neucli.2024.102994","DOIUrl":"10.1016/j.neucli.2024.102994","url":null,"abstract":"<div><h3>Objectives</h3><p>Altered somatosensory processing in the posterior insula may play a role in chronic pain development and contribute to Parkinson disease (PD)-related pain. Posterior-superior insula (PSI) repetitive transcranial magnetic stimulation (rTMS) has been demonstrated to have analgesic effects among patients with some chronic pain conditions. This study aimed at assessing the efficacy of PSI-rTMS for treating PD-related pain.</p></div><div><h3>Methods</h3><p>This was a double-blinded, randomized, sham-controlled, parallel-arm trial (NCT03504748). People with PD (PwP)-related chronic pain underwent five daily PSI-rTMS sessions for a week, followed by once weekly maintenance stimulations for seven weeks. rTMS was delivered at 10 Hz and 80% of the resting motor threshold. The primary outcome was <em>a</em> ≥ 30% pain intensity reduction at 8 weeks compared to baseline. Functionality, mood, cognitive, motor status, and somatosensory thresholds were also assessed.</p></div><div><h3>Results</h3><p>Twenty-five patients were enrolled. Mean age was 55.2 ± 9.5 years-old, and 56% were female. Nociceptive pain accounted for 60%, and neuropathic and nociplastic for 20% each. No significant difference was found for 30% pain reduction response rates between active (42.7%) and sham groups (14.6%, <em>p</em> = 0.26). Secondary clinical outcomes and sensory thresholds also did not differ significantly. In a <em>post hoc</em> analysis, PwP with nociceptive pain sub-type experienced more pain relief after active (85.7%) compared to sham PSI-rTMS (25%, <em>p</em> = 0.032).</p></div><div><h3>Conclusion</h3><p>Our preliminary results suggest that different types of PD-related pain may respond differently to treatment, and therefore people with PD may benefit from having PD-related pain well characterized in research trials and in clinical practice.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 5","pages":"Article 102994"},"PeriodicalIF":2.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705324000522/pdfft?md5=b333cbe05876b0562fd69818141dbb1d&pid=1-s2.0-S0987705324000522-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141637283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial fibrillation radiofrequency ablation in a patient with vagus nerve stimulation","authors":"Jeanne Benoit ,&nbsp;Fabien Squara ,&nbsp;Véronique Bourg ,&nbsp;Pierre Thomas","doi":"10.1016/j.neucli.2024.102996","DOIUrl":"10.1016/j.neucli.2024.102996","url":null,"abstract":"<div><p>Vagus nerve stimulation (VNS) is an effective neuromodulatory treatment for patients with drug resistant epilepsy who cannot undergo curative surgical resection. Safety information states that the use of radiofrequency ablation devices may damage the VNS generator and leads. However, documented cases are scarce. This 62-year-old patient with bitemporal lobe epilepsy treated with VNS underwent radiofrequency ablation of an atrial fibrillation without any perioperative or postoperative complications.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 5","pages":"Article 102996"},"PeriodicalIF":2.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705324000546/pdfft?md5=6712a2a29f767f2209ebd981e91394a4&pid=1-s2.0-S0987705324000546-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of home-based EEG neurofeedback training as a non-pharmacological intervention for Parkinson's disease","authors":"Andrew Cooke ,&nbsp;John Hindle ,&nbsp;Catherine Lawrence ,&nbsp;Eduardo Bellomo ,&nbsp;Aaron W. Pritchard ,&nbsp;Catherine A. MacLeod ,&nbsp;Pam Martin-Forbes ,&nbsp;Sally Jones ,&nbsp;Martyn Bracewell ,&nbsp;David E.J. Linden ,&nbsp;David M.A. Mehler","doi":"10.1016/j.neucli.2024.102997","DOIUrl":"10.1016/j.neucli.2024.102997","url":null,"abstract":"<div><h3>Objectives</h3><p>Aberrant movement-related cortical activity has been linked to impaired motor function in Parkinson's disease (PD). Dopaminergic drug treatment can restore these, but dosages and long-term treatment are limited by adverse side-effects. Effective non-pharmacological treatments could help reduce reliance on drugs. This experiment reports the first study of home-based electroencephalographic (EEG) neurofeedback training as a non-pharmacological candidate treatment for PD. Our primary aim was to test the feasibility of our EEG neurofeedback intervention in a home setting.</p></div><div><h3>Methods</h3><p>Sixteen people with PD received six home visits comprising symptomology self-reports, a standardised motor assessment, and a precision handgrip force production task while EEG was recorded (visits 1, 2 and 6); and 3 × 1-hr EEG neurofeedback training sessions to supress the EEG mu rhythm before initiating handgrip movements (visits 3 to 5).</p></div><div><h3>Results</h3><p>Participants successfully learned to self-regulate mu activity, and this appeared to expedite the initiation of precision movements (i.e., time to reach target handgrip force off-medication pre-intervention = 628 ms, off-medication post-intervention = 564 ms). There was no evidence of wider symptomology reduction (e.g., Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III Motor Examination, off-medication pre-intervention = 29.00, off-medication post intervention = 30.07). Interviews indicated that the intervention was well-received.</p></div><div><h3>Conclusion</h3><p>Based on the significant effect of neurofeedback on movement-related cortical activity, positive qualitative reports from participants, and a suggestive benefit to movement initiation, we conclude that home-based neurofeedback for people with PD is a feasible and promising non-pharmacological treatment that warrants further research.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 5","pages":"Article 102997"},"PeriodicalIF":2.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0987705324000558/pdfft?md5=a54a1cff70101c4c167721783828485b&pid=1-s2.0-S0987705324000558-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the effect of the nerve conduction distance on the MScanFit method ofmotor unit number estimation (MUNE)","authors":"H.Evren Boran ,&nbsp;Halil Can Alaydin ,&nbsp;Ilker Arslan ,&nbsp;Ozlem Kurtkaya Kocak ,&nbsp;Hasan Kılınc ,&nbsp;Bulent Cengiz","doi":"10.1016/j.neucli.2024.102991","DOIUrl":"10.1016/j.neucli.2024.102991","url":null,"abstract":"<div><h3>Objective</h3><p>MScanFit motor unit number estimation (MUNE) is a sensitive method for detecting motor unit loss and has demonstrated high reproducibility in various settings. In this study, our aim was to assess the outputs of this method when the nerve conduction distance is increased.</p></div><div><h3>Methods</h3><p>MScanFit recordings were obtained from the abductor digiti minimi muscle of 20 healthy volunteers. To evaluate the effect of nerve conduction distance, the ulnar nerve was stimulated from the wrist and elbow respectively. Reproducibility of MUNE, compound muscle action potential (CMAP), and other motor unit parameters were assessed using intraclass correlation coefficients (ICCs).</p></div><div><h3>Results</h3><p>Motor unit numbers obtained from stimulation at the wrist and elbow did not significantly differ and exhibited strong consistency in the ICC test (120.3 ± 23.7 vs. 118.5 ± 27.9, <em>p</em> &gt; 0.05, ICC: 0.88). Similar repeatability values were noted for other parameters. However, the Largest Unit (%) displayed notable variability between the two regions and exhibited a negative correlation with nerve conduction distance.</p></div><div><h3>Conclusion</h3><p>Our findings indicate that MScanFit can consistently calculate motor unit numbers and most of its outputs without substantial influence from nerve conduction distance. Exploring MScanFit's capabilities in various settings could enhance our understanding of its strengths and limitations for extensive use in clinical practice.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 5","pages":"Article 102991"},"PeriodicalIF":2.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A neural signature for brain compensation in stroke with EEG and TMS: Insights from the DEFINE cohort study","authors":"Guilherme JM Lacerda ,&nbsp;Kevin Pacheco-Barrios ,&nbsp;Sara Pinto Barbosa ,&nbsp;Lucas M Marques ,&nbsp;Linamara Battistella ,&nbsp;Felipe Fregni","doi":"10.1016/j.neucli.2024.102985","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102985","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to explore the relationships between potential neurophysiological biomarkers and upper limb motor function recovery in stroke patients, specifically focusing on combining two neurophysiological markers: electroencephalography (EEG) and transcranial magnetic stimulation (TMS).</p></div><div><h3>Methods</h3><p>This cross-sectional study analyzed neurophysiological, clinical, and demographical data from 102 stroke patients from the DEFINE cohort. We searched for correlations of EEG and TMS measurements combined to build a prediction model for upper limb motor functionality, assessed by five outcomes, across five assessments: Fugl-Meyer Assessment (FMA), Handgrip Strength Test (HST), Finger Tapping Test (FTT), Nine-Hole Peg Test (9HPT), and Pinch Strength Test (PST).</p></div><div><h3>Results</h3><p>Our multivariate models agreed on a specific neural signature: higher EEG Theta/Alpha ratio in the frontal region of the lesioned hemisphere is associated with poorer motor outcomes, while increased MEP amplitude in the non-lesioned hemisphere correlates with improved motor function. These relationships are held across all five motor assessments, suggesting the potential of these neurophysiological measures as recovery biomarkers.</p></div><div><h3>Conclusion</h3><p>Our findings indicate a potential neural signature of brain compensation in which lower frequencies of EEG power are increased in the lesioned hemisphere, and lower corticospinal excitability is also increased in the non-lesioned hemisphere. We discuss the meaning of these findings in the context of motor recovery in stroke.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 5","pages":"Article 102985"},"PeriodicalIF":2.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative versus quantitative assessment of electroencephalography in cognitive decline: Comparison in a clinical population","authors":"Jordan Labidi ,&nbsp;Aude Warniez ,&nbsp;Philippe Derambure ,&nbsp;Thibaud Lebouvier ,&nbsp;Florence Pasquier ,&nbsp;Arnaud Delval ,&nbsp;Nacim Betrouni","doi":"10.1016/j.neucli.2024.102995","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102995","url":null,"abstract":"<div><p>This study aimed to compare the diagnostic performance of visual assessment of electroencephalography (EEG) using the Grand Total EEG (GTE) score and quantitative EEG (QEEG) using spectral analysis in the context of cognitive impairment.</p><p>This was a retrospective study of patients with mild cognitive impairment, with (MCI+V) or without (MCI) vascular dysfunction, and patients with dementia including Alzheimer's disease, Lewy Body Dementia and vascular dementia.</p><p>The results showed that the GTE is a simple scoring system with some potential applications, but limited ability to distinguish between dementia subtypes, while spectral analysis appeared to be a powerful tool, but its clinical development requires the use of artificial intelligence tools.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 5","pages":"Article 102995"},"PeriodicalIF":3.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence (AI): Why does it matter for clinical neurophysiology?","authors":"A McGonigal ,&nbsp;H Tankisi","doi":"10.1016/j.neucli.2024.102993","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102993","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 4","pages":"Article 102993"},"PeriodicalIF":3.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141323992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal artificial intelligence-based deep learning models for diagnosis and prediction of the future occurrence of polyneuropathy in diabetes and prediabetes","authors":"Yun-Ru Lai ,&nbsp;Wen-Chan Chiu ,&nbsp;Chih-Cheng Huang ,&nbsp;Ben-Chung Cheng ,&nbsp;Chia-Te Kung ,&nbsp;Ting Yin Lin ,&nbsp;Hui Ching Chiang ,&nbsp;Chia-Jung Tsai ,&nbsp;Chien-Feng Kung ,&nbsp;Cheng-Hsien Lu","doi":"10.1016/j.neucli.2024.102982","DOIUrl":"10.1016/j.neucli.2024.102982","url":null,"abstract":"<div><h3>Objective</h3><p>The objective of this study was to develop artificial intelligence-based deep learning models and assess their potential utility and accuracy in diagnosing and predicting the future occurrence of diabetic distal sensorimotor polyneuropathy (DSPN) among individuals with type 2 diabetes mellitus (T2DM) and prediabetes.</p></div><div><h3>Methods</h3><p>In 394 patients (T2DM=300, Prediabetes=94), we developed a DSPN diagnostic and predictive model using Random Forest (RF)-based variable selection techniques, specifically incorporating the combined capabilities of the Clinical Toronto Neuropathy Score (TCNS) and nerve conduction study (NCS) to identify relevant variables. These important variables were then integrated into a deep learning framework comprising Convolutional Neural Networks (CNNs) and Long Short-Term Memory (LSTM) networks. To evaluate temporal predictive efficacy, patients were assessed at enrollment and one-year follow-up.</p></div><div><h3>Results</h3><p>RF-based variable selection identified key factors for diagnosing DSPN. Numbness scores, sensory test results (vibration), reflexes (knee, ankle), sural nerve attributes (sensory nerve action potential [SNAP] amplitude, nerve conduction velocity [NCV], latency), and peroneal/tibial motor NCV were candidate variables at baseline and over one year. Tibial compound motor action potential amplitudes were used for initial diagnosis, and ulnar SNAP amplitude for subsequent diagnoses. CNNs and LSTMs achieved impressive AUC values of 0.98 for DSPN diagnosis prediction, and 0.93 and 0.89 respectively for predicting the future occurrence of DSPN. RF techniques combined with two deep learning algorithms exhibited outstanding performance in diagnosing and predicting the future occurrence of DSPN. These algorithms have the potential to serve as surrogate measures, aiding clinicians in accurate diagnosis and future prediction of DSPN.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 4","pages":"Article 102982"},"PeriodicalIF":3.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological abnormalities of the neuromuscular transmission in two patients with botulism-like syndrome following Botulinum-A muscle injections","authors":"Julian Theuriet ,&nbsp;Laure Huchon ,&nbsp;Jacques Luaute ,&nbsp;Anne-Evelyne Vallet ,&nbsp;Françoise Bouhour ,&nbsp;Antoine Pegat","doi":"10.1016/j.neucli.2024.102984","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102984","url":null,"abstract":"<div><p>Botulinum neurotoxin serotype A (BoNT-A) has several therapeutic indications such as spasticity and dystonia. Although its use is generally considered safe, a systemic diffusion can lead to systemic complications, and a botulism-like syndrome can occur after intramuscular injections. Herein, two adult cases who developed general muscle weakness after a BoNT-A intramuscular injection are reported. Both presented with a progressive decrement on low-frequency (LF) repetitive nerve stimulation (RNS). It is suggested that a progressive decrement on LF-RNS in muscles distant from the injection site strongly supports the diagnosis of iatrogenic botulism.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 4","pages":"Article 102984"},"PeriodicalIF":3.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S098770532400042X/pdfft?md5=e10f627d148fa9d107b542b40cf1cdce&pid=1-s2.0-S098770532400042X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140952270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interhemispheric coherence of EEG rhythms in children: Maturation and differentiation in corpus callosum dysgenesis","authors":"J. Guillou ,&nbsp;J. Duprez ,&nbsp;R. Nabbout ,&nbsp;A. Kaminska ,&nbsp;S. Napuri ,&nbsp;C. Gomes ,&nbsp;M. Kuchenbuch ,&nbsp;P. Sauleau","doi":"10.1016/j.neucli.2024.102981","DOIUrl":"https://doi.org/10.1016/j.neucli.2024.102981","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate the evolution of interhemispheric coherences (ICo) in background and spindle frequency bands during childhood and use it to identify individuals with corpus callosum dysgenesis (CCd).</p></div><div><h3>Methods</h3><p>A monocentric cohort of children aged from 0.25 to 15 years old, consisting of 13 children with CCd and 164 without, was analyzed. The ICo of background activity (ICO_BckgrdA), sleep spindles (ICO_spindles), and their sum (_sICO) were calculated. The impact of age, gender, and CC status on the ICo was evaluated, and the _sICO was used to discriminate children with or without CCd.</p></div><div><h3>Results</h3><p>ICO_BckgrdA, ICO_spindles and sICO increased significantly with age without any effect of gender (<em>p</em> &lt; 10⁻⁴), in both groups. The regression equations of the different ICo were stronger, with adjusted R2 values of 0.54, 0.35, and 0.57, respectively. The ICo was lower in children with CCd compared to those without CCd (<em>p</em> &lt; 10⁻⁴ for all comparisons). The area under the precision recall curves for predicting CCd using _sICO was 0.992 with 98.9 % sensitivity and 87.5 % specificity.</p></div><div><h3>Discussion</h3><p>ICo of spindles and background activity evolve in parallel to brain maturation and depends on the integrity of the corpus callosum. sICO could be an effective diagnostic biomarker for screening children with interhemispheric dysfunction.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 3","pages":"Article 102981"},"PeriodicalIF":3.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}