F-waves responses derived from low-intensity electrical stimulation: A method to explore split-hand pathogenesis

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurophysiologie Clinique/Clinical Neurophysiology Pub Date : 2024-11-01 DOI:10.1016/j.neucli.2024.103018

Miguel Lopes , Michael Swash , Mamede de Carvalho

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引用次数: 0

Abstract

Objectives

The “split-hand syndrome” is a common clinical sign in amyotrophic lateral sclerosis (ALS), being characterized by more severe atrophy of the hand muscles on the radial side of the hand compared to the ulnar side. We aimed to investigate possible physiological differences between relevant hand muscles using low-intensity F-wave stimulation to assess spinal motoneuron excitability.

Methods

We recruited 36 healthy volunteers. F-waves were recorded from the abductor pollicis brevis (APB), first dorsal interosseous (FDI) and abductor digiti minimi (ADM), using 20 supramaximal stimuli followed by 20 stimuli at a low-intensity required to obtain M-waves with 10 % amplitude of maximal CMAP. We evaluated the following F-wave parameters: F-M latency, chronodispersion, persistence, amplitude, F/CMAP amplitude ratio and number of F-wave repeaters (with low-intensity). In 10 subjects, low-intensity stimulation F-waves were compared after 20 and 50 stimuli in each muscle.

Results

Low-intensity stimulation resulted in lower F-wave amplitude and persistence and higher F/CMAP amplitude ratios. There were no significant differences in F-wave latencies and chronodispersion. When comparing the three muscles, we found higher F-wave persistence and F/CMAP amplitude ratios when recording over the ADM and APB compared to the FDI. We also found a higher number of F-wave repeaters in the ADM with low-intensity stimulation. Results from 20 to 50 low-intensity stimuli were similar.

Discussion

A small number of low-intensity stimuli is appropriate to study F-wave latencies and chronodispersion. We found differences in some physiological properties of the ADM spinal motoneuron pool compared to other hand muscles.

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低强度电刺激产生的 F 波反应：探索分裂手发病机制的方法

研究目的分裂手综合征 "是肌萎缩性脊髓侧索硬化症（ALS）的一种常见临床表现，其特征是手部桡侧肌肉的萎缩程度比尺侧更严重。我们的目的是利用低强度 F 波刺激来评估脊髓运动神经元的兴奋性，从而研究相关手部肌肉之间可能存在的生理差异：我们招募了 36 名健康志愿者。方法：我们招募了 36 名健康志愿者，使用 20 次超大强度刺激，然后再使用 20 次低强度刺激，以获得振幅为最大 CMAP 的 10% 的 M 波，记录了来自拇趾外展肌（APB）、第一背侧骨间肌（FDI）和拇趾外展肌（ADM）的 F 波。我们评估了以下 F 波参数：F-M潜伏期、时间分散性、持续性、振幅、F/CMAP振幅比和F波重复次数（低强度）。在 10 名受试者中，对每块肌肉进行 20 次和 50 次刺激后的低强度刺激 F 波进行了比较：结果：低强度刺激导致较低的 F 波振幅和持续性，以及较高的 F/CMAP 振幅比。F 波潜伏期和时间分散性无明显差异。在比较三块肌肉时，我们发现在 ADM 和 APB 上记录的 F 波持续时间和 F/CMAP 振幅比高于 FDI。我们还发现，在低强度刺激下，ADM 的 F 波重复次数较多。20 至 50 次低强度刺激的结果相似：讨论：少量低强度刺激适用于研究 F 波潜伏期和时序分散。我们发现，与其他手部肌肉相比，ADM脊髓运动神经元池的某些生理特性存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurophysiologie Clinique/Clinical Neurophysiology 医学-临床神经学

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

60 days

期刊介绍： Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.