Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"Repurposing neurophysiological techniques.","authors":"Kristian Bernhard Nilsen","doi":"10.1016/j.neucli.2026.103199","DOIUrl":"https://doi.org/10.1016/j.neucli.2026.103199","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 5","pages":"103199"},"PeriodicalIF":3.0,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent neuromuscular dysfunction in long COVID: A quantitative and single fiber EMG follow-up study","authors":"Benjamin Yamin Ali Khan,&nbsp;Gaia Fanella,&nbsp;Thomas Harbo,&nbsp;Jane Agergaard,&nbsp;Berit Schiøttz-Christensen,&nbsp;Eva Kildal Hejbøl,&nbsp;Henrik Daa Schrøder,&nbsp;Thomas Holm Pedersen,&nbsp;Anders Fuglsang-Fredriksen,&nbsp;Henning Andersen,&nbsp;Lars Østergaard,&nbsp;Hatice Tankisi","doi":"10.1016/j.neucli.2026.103187","DOIUrl":"10.1016/j.neucli.2026.103187","url":null,"abstract":"<div><h3>Objective</h3><div>Persistent symptoms after SARS CoV-2 infection, often designated as \"long COVID”, continue to be an ongoing health issue. Previously, we reported electromyography (EMG) and single fiber EMG (SFEMG) abnormalities in long COVID. This study aimed to assess the long-term neuromuscular manifestations of long COVID.</div></div><div><h3>Methods</h3><div>In this follow-up study, fifty patients (39 females and 11 males, mean age at baseline: 48.1 ± 9.3 years) with long COVID showing myopathic (EMG and/or abnormal SFEMG at diagnosis were re-evaluated. The disease duration was 1.2 ± 0.6 years at baseline. The mean follow-up interval was 1.38 years. Quantitative EMG (qEMG) was performed on the biceps brachii (BB), vastus medialis (VM), and tibialis anterior (TA), while SFEMG was performed on the extensor digitorum communis (EDC) and TA, at baseline and follow-up on the same muscles and side. EMG, SFEMG, and clinical scores were compared using paired parametric or nonparametric tests.</div></div><div><h3>Results</h3><div>Fatigue Assessment Scale (FAS) scores were unchanged (35.8 ± 7.7 vs 34.0 ± 9.4; p &gt; 0.05). Motor unit potential (MUP) amplitudes and durations increased in BB, TA, and VM (p = 0.0001), while the frequency of polyphasic potentials remained unchanged (p &gt; 0.05). SFEMG findings in TA and EDC were also unchanged (p &gt; 0.05). At baseline, 78% of individuals showed myopathic qEMG and 54% abnormal SFEMG; at follow-up, 18% had myopathic qEMG, 56% abnormal SFEMG, and 40% showed normal EMG and SFEMG.</div></div><div><h3>Discussion</h3><div>Myopathic changes decreased over time; however, SFEMG abnormalities and clinical scores remained persistent. These findings suggest ongoing neuromuscular dysfunction, although other mechanisms may also contribute to persistent long COVID symptoms.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 4","pages":"Article 103187"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tibial somatosensory evoked potentials support the diagnosis of tabes dorsalis despite normal spinal MRI","authors":"Kiyoshi Matsukura,&nbsp;Keiichi Hokkoku,&nbsp;Jin Nakamura,&nbsp;Arena Wada,&nbsp;Taiji Mukai,&nbsp;Takashi Chiba,&nbsp;Takamichi Kanbayashi,&nbsp;Yuki Hatanaka,&nbsp;Shunsuke Kobayashi,&nbsp;Masahiro Sonoo","doi":"10.1016/j.neucli.2026.103188","DOIUrl":"10.1016/j.neucli.2026.103188","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 4","pages":"Article 103188"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148642952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reading the palm with MScanFit MUNE in spinal muscular atrophy and Hirayama disease: a pilot study","authors":"Maria Gavriilaki ,&nbsp;Dimitrios Kugiumtzis ,&nbsp;Vasiliki Poulidou ,&nbsp;Evripidis Pityrigkas ,&nbsp;Antonios Frontistis ,&nbsp;Evangelos Papatolis ,&nbsp;Apostolos Moutzourounis ,&nbsp;Sotirios Papagiannopoulos ,&nbsp;Marianthi Arnaoutoglou ,&nbsp;Vasilios K Kimiskidis","doi":"10.1016/j.neucli.2026.103175","DOIUrl":"10.1016/j.neucli.2026.103175","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 3","pages":"Article 103175"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148227088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of non-invasive brain stimulation on gait and corticospinal plasticity in children and adolescents with cerebral palsy: A systematic review","authors":"Mathilde Tardif ,&nbsp;Cloé Dussault-Picard ,&nbsp;Inès Toubal ,&nbsp;Denis Arvisais ,&nbsp;Sarah Lippé ,&nbsp;Yosra Cherni","doi":"10.1016/j.neucli.2026.103174","DOIUrl":"10.1016/j.neucli.2026.103174","url":null,"abstract":"<div><h3>Introduction</h3><div>Cerebral palsy (CP) is the main cause of neuromotor disorders in children and is frequently associated with altered corticospinal excitability, contributing to abnormal gait patterns that limit mobility and quality of life. Therefore, gait training is central to pediatric rehabilitation. Non-invasive brain stimulation (NIBS) has emerged as a complementary modality, although evidence regarding its effects on locomotor function in children remains scarce. This review examined NIBS effects on locomotion and corticospinal excitability in pediatric populations, and mapped stimulation parameters in intervention protocols.</div></div><div><h3>Methods</h3><div>Following PROSPERO protocol CRD42024626430, seven databases were searched (CDSR, CENTRAL, CINAHL, Embase, MEDLINE, SPORTDiscus, and Web of Science).</div></div><div><h3>Results</h3><div>Twenty-four studies involving 725 children with CP met inclusion criteria. NIBS (mostly repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS)) may improve gait parameters (speed, cadence) and functional mobility (endurance, mobility scores). Static balance appeared to improve, whereas dynamic balance findings were inconsistent, and spasticity tended to decrease. NIBS may also enhance corticospinal excitability. tDCS follow-up studies (n=10) suggested potential long-term benefits for walking speed, balance, and mobility. Protocol heterogeneity persisted for rTMS, while tDCS protocols showed consistency (1mA, anode on primary motor cortex).</div></div><div><h3>Conclusion</h3><div>Combined with lower-limb training, NIBS may improve gait speed, endurance, static balance, and functional mobility, and increase corticospinal excitability, potentially reflecting neuromodulatory effects that support functional gains. However, optimal stimulation parameters remain undetermined, particularly for rTMS, and current research is restricted to children with CP. Future studies require long-term follow-ups and neurophysiological evaluations to strengthen evidence for clinical applications.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 3","pages":"Article 103174"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical connectivity abnormalities assessed by TMS-EEG in patients after a transient ischemic attack","authors":"Anne Jakobsen ,&nbsp;Enrico De Martino ,&nbsp;Bruno A.N. Couto ,&nbsp;Margit M. Bach ,&nbsp;Stian Ingemann-Molden ,&nbsp;Thomas Graven-Nielsen ,&nbsp;Boris Modrau ,&nbsp;Jakob Udby Blicher ,&nbsp;Daniel Ciampi de Andrade","doi":"10.1016/j.neucli.2026.103172","DOIUrl":"10.1016/j.neucli.2026.103172","url":null,"abstract":"<div><div>Non-motor symptoms following transient ischaemic attack (TIA) may reflect disruption of cortical GABA-dependent functional connectivity. In this case series, we quantified global cortical dynamics using the perturbational complexity index based on state transitions (PCIst) and intertrial coherence (ITC) derived from transcranial magnetic stimulation-electroencephalography (TMS-EEG). Seven patients who presented with sensory, visual, or motor symptoms during TIA underwent TMS-EEG stimulation of the left primary motor cortex. Individual PCIst and ITC values were classified relative to a normative dataset of 164 healthy participants. Six of seven patients exhibited abnormal PCIst and/or ITC values, with alterations most frequently observed in the beta and alpha frequency bands. Four patients reported persistent post-TIA symptoms, including fatigue, memory difficulties, or impaired concentration. These findings suggest that TIA may be associated with measurable alterations in cortical synchronization, and large-scale brain dynamics. Importantly, it is currently unknown whether the observed alterations preceded the TIA, emerged as its consequence, or were influenced by unmeasured mediators such as premorbid factors such as cognitive or affective symptoms. These preliminary findings support further investigation of TMS-EEG-derived measures as candidate neurophysiological biomarkers of cortical network vulnerability or susceptibility to persistent neuropsychiatric symptoms after TIA.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 3","pages":"Article 103172"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The split elbow sign in amyotrophic lateral sclerosis: A systematic review and meta-analysis","authors":"Vasiliki Poulidou ,&nbsp;Vasilis-Spyridon Tseriotis ,&nbsp;Alessandro Bombaci ,&nbsp;Steve Vucic ,&nbsp;Nathan Pavey ,&nbsp;Sotirios Papagiannopoulos ,&nbsp;Vasilios K Kimiskidis ,&nbsp;Marianthi Arnaoutoglou","doi":"10.1016/j.neucli.2025.103134","DOIUrl":"10.1016/j.neucli.2025.103134","url":null,"abstract":"<div><h3>Introduction</h3><div>Amyotrophic lateral sclerosis (ALS) patients can exhibit split phenomena, with preferential weakness of specific muscle groups. The aim of this review is to investigate the split elbow (SE) phenomenon (different weakness/wasting pattern between biceps and triceps) as a potential clinical and neurophysiological feature in ALS.</div></div><div><h3>Methods</h3><div>Our study was reported according to the PRISMA statement and registered in PROSPERO (CRD42024528359). MEDLINE, SCOPUS, Web of Science, and grey literature sources were searched using the terms “split elbow” and “amyotrophic lateral sclerosis” up to April 2025. English-written peer-reviewed, randomized, non-randomized, observational, diagnostic accuracy, and case-control studies were included. Study quality was assessed using Joanna Briggs Institute critical appraisal tool. Regarding muscle strength, we pooled the standardized mean difference of normalized Medical Research Council (MRC) scores using random effects. We used a bivariate random-effects model to evaluate SE index (SEI_CMAP, compound muscle action potential of biceps/triceps) in distinguishing ALS from controls.</div></div><div><h3>Results</h3><div>Seven studies with 1941 ALS patients (61.8 % male) met inclusion criteria. Pooled standardized mean difference (triceps – biceps MRC scores) was -0.17 [95 % CI, -1.03 to 0.69], <em>p</em> = 0.63, indicating no significant difference in muscle strength between elbow flexion and extension. Between-study heterogeneity was high (I² = 97.1 % [95.5 %; 98.2 %], <em>p</em> &lt; 0.0001). The SEI_CMAP demonstrated only moderate accuracy in distinguishing ALS from controls (pooled sensitivity, specificity, and AUC of 0.789 [0.655–0.880], 0.580 [0.487–0.668], and 0.661, respectively).</div></div><div><h3>Conclusions</h3><div>Current evidence does not support a consistent SE pattern in ALS. Methodological variability and small sample sizes limit the generalizability of available findings, indicating that the SE is unlikely to provide meaningful diagnostic utility in routine clinical practice.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 2","pages":"Article 103134"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiology of pleasant touch: From peripheral mechanisms to clinical implications of caressing","authors":"Jean-Pascal Lefaucheur","doi":"10.1016/j.neucli.2025.103135","DOIUrl":"10.1016/j.neucli.2025.103135","url":null,"abstract":"<div><div>While tactile perception has long been studied through the lens of discriminative touch, recent research has highlighted the existence of a distinct affective touch system. Pleasant touch refers to specific forms of light tactile stimulation, such as gentle stroking or caressing applied to hairy skin. This type of sensation is primarily conveyed by unmyelinated C-tactile (CT) afferents expressing a subclass of mechanoreceptors with low-threshold activation and slow-to-intermediate adaptation. Importantly, CT firing correlates strongly with subjective pleasantness ratings but not with intensity or localization accuracy, indicating a preferential role in affective rather than perceptual encoding. After reaching the superficial layers of the dorsal horn of the spinal cord, the projections ascend via pathways associated with interoception. Following thalamic relay, pleasant tactile information induces strong activation of a vast network including the posterior and anterior insula, the orbitofrontal cortex, the medial prefrontal cortex, the anterior cingulate cortex, and the ventral striatum. The literature converges on the idea that pleasant touch relies on a specialized neurophysiological system integrating peripheral CT afferents, insular processing, and neurochemical modulation, mainly involving oxytocin, dopamine, and opioid transmission. It impacts on autonomic nervous system regulation and physiological homeostasis, as shown by anti-stress effects of skin-to-skin contact in infants. Affective touch conveyed by CT afferents supports emotional regulation, social bonding, and well-being. In addition, pleasant touch has a therapeutic potential, especially in the pain domain, but also in other conditions dominated by negative thoughts, such as depressive disorders. Thus, the clinical utility of \"affective touch therapy\", even by means of robotic haptic stimulation, offers promising prospects for the treatment of anxiety-depressive or pain disorders, based on the neurophysiological effects of CT afferent activation.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 2","pages":"Article 103135"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How can neurophysiology help us to decipher emotion(s)?","authors":"Sarah Dominique Rosenberg ,&nbsp;Jean-Pascal Lefaucheur","doi":"10.1016/j.neucli.2026.103136","DOIUrl":"10.1016/j.neucli.2026.103136","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 2","pages":"Article 103136"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative EEG enhances early assessment and prognostic stratification of brain dysfunction in infants with abusive head trauma","authors":"Valentin Hess ,&nbsp;Matthieu Doyen ,&nbsp;Rima Nabbout ,&nbsp;Thomas Blauwblomme ,&nbsp;Benjamin Serrand ,&nbsp;Martine Balençon ,&nbsp;Claire Bar ,&nbsp;Olivier Brissaud ,&nbsp;Olivier Klein ,&nbsp;Arnaud Wiedemann ,&nbsp;Mathieu Kuchenbuch","doi":"10.1016/j.neucli.2025.103132","DOIUrl":"10.1016/j.neucli.2025.103132","url":null,"abstract":"<div><h3>Aim</h3><div>To assess the value of quantitative EEG (qEEG) as a diagnostic and prognostic biomarker in infants with abusive head trauma (AHT). Despite its central role in monitoring encephalopathy, EEG remains underused in multimodal evaluations, and its quantitative analysis may provide objective, real-time insights into cerebral dysfunction and long-term outcome.</div></div><div><h3>Methods</h3><div>This retrospective monocentric case–control study included infants under two years with confirmed AHT and age- and sex-matched controls. Clinical and early EEG data were collected. Patients’ outcome was stratified by Pediatric Overall Performance Category score (POPC_1–3 vs. _4–6). Quantitative EEG features were analyzed, and two neural networks were trained using five-fold cross-validation for diagnosis and outcome prediction.</div></div><div><h3>Results</h3><div>84 EEGs from 75 participants were analyzed (46 EEGs from 40 AHT; 38 EEGs from 35 controls). Compared with controls, AHT EEGs showed significantly reduced entropy and Hurst exponent values and increased low-frequency power, reflecting diffuse cortical dysfunction. Within the AHT group, reduced signal complexity and loss of interhemispheric asymmetry correlated with unfavorable outcomes (POPC_4–6, p&lt; 0.01). Machine learning perfectly classified AHT cases versus controls and classified patients into POPC_1-3 or POPC_4-6 groups with 73±14 % accuracy. Combined models distinguished control, POPC_1-3, and POPC_4-6 groups with 90±5 % accuracy.</div></div><div><h3>Discussion</h3><div>Early qEEG provides functional information that complements imaging and clinical findings. qEEG-derived biomarkers may enable early risk stratification, guide neuroprotective strategies, and improve prognostic counseling in infants with AHT. Larger multicenter prospective studies are warranted to validate these exploratory findings and define their clinical applicability.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103132"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}