Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"Cortical Stimulation for brain mapping and seizure stimulation, pediatric practices throughout Canada: A national survey and systematic literature review","authors":"Margarita Maltseva ,&nbsp;Juan Pablo Appendino ,&nbsp;Pavlina Cabounova ,&nbsp;Andrea Andrade ,&nbsp;Michelle Kregel ,&nbsp;Aris Hadjinicolaou ,&nbsp;Alexander G. Weil ,&nbsp;Puneet Jain ,&nbsp;Elizabeth Donner ,&nbsp;Felippe Borlot ,&nbsp;David Dufresne ,&nbsp;Linda Huh ,&nbsp;Natarie Liu ,&nbsp;Kenneth A. Myers ,&nbsp;Julia Jacobs","doi":"10.1016/j.neucli.2025.103043","DOIUrl":"10.1016/j.neucli.2025.103043","url":null,"abstract":"<div><h3>Introduction</h3><div>Diagnostic cortical stimulation (CS) in intracranial electroencephalography (iEEG) is an established epilepsy presurgical assessment tool to delineate relevant brain functions and elicit habitual epileptic seizures. Currently, no consensus exists as to whether CS should be routinely performed in pediatric patients. A significant challenge is their limited ability to cooperate during the procedure or to describe non-observable seizure semiology features. Our goal was to identify the spectrum of CS practices in Canada, for both eloquent cortex mapping and seizure stimulation.</div></div><div><h3>Methods</h3><div>An online survey, answered by all 8 Canadian pediatric epilepsy centers, enquired about implantation, stimulation methods, and use of standardized protocols. A systematic literature review extracted detailed stimulation parameters.</div></div><div><h3>Results</h3><div>Most of the institutions (<em>n</em> = 7/8) reported performing CS during presurgical evaluation. Four institutions indicated they perform stimulation in all implanted patients for the purpose of eloquent cortex mapping and seizure stimulation. The majority of physicians had their individual approach to CS. A largely variable approach to CS, mainly in the choice of stimulation parameters (i.e., train and pulse duration), was observed, with the highest variance concerning the purpose of seizure stimulation. The literature review highlighted an overall small sample size and minimal number of publications. Even though there is a rising trend towards stereotactic iEEG implantation, more data were available on subdural EEGs.</div></div><div><h3>Conclusion</h3><div>This study shows individual and sparsely validated approach to CS in pediatric epilepsy. The literature review underscores the urgent need to harmonize pediatric intracranial EEG practices. More multicenter studies are needed to identify safe stimulation thresholds and allow implementation of evidence-based guidelines.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103043"},"PeriodicalIF":2.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143282721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Description of an alternative method for the electrodiagnostic evaluation of the sensory radial nerve","authors":"Martin Moussy ,&nbsp;Julie Rode ,&nbsp;Thierry Maisonobe ,&nbsp;Nagham Khanafer ,&nbsp;Françoise Bouhour ,&nbsp;Antoine Pegat","doi":"10.1016/j.neucli.2025.103058","DOIUrl":"10.1016/j.neucli.2025.103058","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to describe an alternative method for the electrodiagnostic (EDX) evaluation of the sensory radial nerve (SRN).</div></div><div><h3>Methods</h3><div>In this retrospective study, all patients from a French EDX center (November 2022-April 2023) for whom SNAP amplitudes of the same SRN were obtained through both a conventional and an alternative method were included. In the conventional method, the active recording electrode was placed at the base of the snuff box, whereas in the alternative method, it was placed 3<del>-4</del> cm proximally on the lateral border of the radial bone. The SNAP amplitudes of both methods were compared and the ratio of alternative to conventional amplitude was determined within the same patient. A secondary objective was to compare SNAP amplitudes and ratios between patients with peripheral neuropathy and those without (control group).</div></div><div><h3>Results</h3><div>Among the 117 patients included, the mean ± SD SNAP amplitude was 50.0±28.9 µV in the alternative method compared to 31.0±17.9 µV in the conventional method. The ratio of alternative to conventional amplitudes was 1.64±0.4 in all patients. No significant difference in amplitude ratios was found between the peripheral neuropathy group (1.63 ± 0.4) and the control group (1.65 ± 0.3; p =0.75).</div></div><div><h3>Discussion</h3><div>The alternative method, based on a more proximal placement of the recording electrodes, consistently provided larger SNAP amplitudes than the conventional method. This method could be useful in particular clinical settings but could prove more challenging in obese or muscular patients.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103058"},"PeriodicalIF":2.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143327918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereoelectroencephalography at Sainte-Anne Hospital, Paris, France","authors":"Cristina Filipescu ,&nbsp;Elisabeth Landré ,&nbsp;Marc Zanello ,&nbsp;Alessandro Moiraghi ,&nbsp;Charles Mellerio ,&nbsp;Magali Boutin ,&nbsp;Benoît Crépon ,&nbsp;Estelle Pruvost-Robieux ,&nbsp;Anaïs Llorens ,&nbsp;Johan Pallud ,&nbsp;Martine Gavaret","doi":"10.1016/j.neucli.2025.103057","DOIUrl":"10.1016/j.neucli.2025.103057","url":null,"abstract":"<div><div>Stereoelectroencephalography (SEEG), which combines the exploration of identified intracerebral structures using depth electrodes and provides direct recording of local field potentials from multiple brain sites, was designed and developed in the 1950s by Jean Talairach and Jean Bancaud, in Sainte-Anne Hospital, Paris.</div><div>For patients with focal drug-resistant epilepsy, when the non-invasive phase is insufficiently concordant or when relationships between the epileptogenic network and eloquent areas remain to be defined, the main purpose of SEEG is the optimal electrode implantation based on a main hypothesis and questions formulated during the non-invasive phase.</div><div>Following an initial historical overview, the different steps of this non-invasive phase are described. Some of these steps, like semiology analysis, have remained relatively preserved, while others have considerably evolved, such as positron emission tomography combined with 3 Tesla magnetic resonance imaging (MRI), functional MRI (fMRI) and high-resolution EEG.</div><div>We then outline the different steps of the SEEG procedure as performed in our institution. Here also, some steps remain quite unchanged such as intracerebral stimulation, amitriptyline and benzodiazepine tests while some others have strikingly evolved such as frameless robot-assisted, MRI-based implantation, depth-signal analyses and quantifications, and radio-frequency thermocoagulation.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103057"},"PeriodicalIF":2.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How can emotion and familiarity improve own-name oddball paradigms?","authors":"Estelle Pruvost-Robieux ,&nbsp;Sarah Benghanem ,&nbsp;Camille Des Lauriers ,&nbsp;Anaïs Llorens ,&nbsp;Martine Gavaret","doi":"10.1016/j.neucli.2025.103050","DOIUrl":"10.1016/j.neucli.2025.103050","url":null,"abstract":"<div><div>The own-name paradigm is used to assess the depth of consciousness disorders in patients in intensive care units. This auditory oddball paradigm elicits a positive event-related potential at 300 ms (named P300) after the presentation of a deviant auditory stimulus, here the subject's own-name. This P300 likely reflects the neural processing of the novel stimulus, which can trigger a behavioral response. Presence of a P300 response is considered to be indicative of a good prognosis for recovering to wakefulness in post-anoxic coma patients. However, its prognostic performance is insufficient and some disorders of consciousness patients without a P300 response will nevertheless awake. The auditory P300 response is influenced by the acoustic characteristics of the stimuli. The use of stimuli with an emotional valence may recruit additional brain networks besides the auditory and attentional ones and potentially improve the prognostic value of the P300 response. Moreover, better characterization of the recruitment of different brain networks involved in these P300 responses in response to emotional stimuli would help in understanding the surface event-related potentials. Here, we present two kind of emotional acoustic features that can be used in these paradigms: “smiling” versus “rough” voice and the familiarity of the voice.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103050"},"PeriodicalIF":2.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative recordings from the posterior superior insula in awake humans with peripheral neuropathic pain","authors":"Raíssa Benocci Thibes ,&nbsp;Pedro Henrique Martins da Cunha ,&nbsp;Jorge Dornellys da Silva Lapa ,&nbsp;Liu Dongyang ,&nbsp;Denise Spinola Pinheiro ,&nbsp;Ricardo Ferrareto Iglesio ,&nbsp;Kleber Paiva Duarte ,&nbsp;Valquiria Aparecida Silva ,&nbsp;Gabriel Taricani Kubota ,&nbsp;Manoel Jacobsen Teixeira ,&nbsp;Luis Garcia-Larrea ,&nbsp;Hélène Bastiji ,&nbsp;João Ricardo Sato ,&nbsp;Daniel Ciampi de Andrade","doi":"10.1016/j.neucli.2025.103056","DOIUrl":"10.1016/j.neucli.2025.103056","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>The activity profile of the posterior insula in neuropathic pain (NeP) remains largely unexplored. To address this and examine its modulation by somatosensory stimulation, we recorded local field potentials (LFP) in awake patients with NeP undergoing deep brain stimulation (DBS) electrode implantation to the posterior-superior insula (PSI) for analgesic purposes.</div></div><div><h3>Materials and Methods</h3><div>Six patients (one woman; 32–45 years), experiencing refractory peripheral NeP and having previously responded to non-invasive stimulation of the PSI underwent stereotactic implantation of DBS electrodes to the PSI as part of a phase II clinical trial. The averaged power of frequencies of LFP and their peaks were calculated during rest and under thermal painful and mechanical non-painful stimulation.</div></div><div><h3>Results</h3><div>At rest, amplitude peaks within the delta (average min-max.: 2.2 Hz; 1.3–3.7) and theta (6.1 Hz, varying between 5.7 and 6.8 Hz) bands were identified. Compared to rest, both tonic thermal painful, and mechanical non-painful stimulation led to similar mean decreases in gamma power (-24.46 ± 70.56, and -19.56 ± 3.08; respectively). Painful stimuli caused an increase in all the other frequency bands, mainly in alpha and beta ranges, while non-painful stimulation led to decreases in power in all frequencies above 4Hz. Painful tonic stimulation was associated with a significantly greater power variability, both in amplitude and frequency, compared to nonpainful mechanical stimulation.</div></div><div><h3>Conclusion</h3><div>The posterior insula resting state activity in awake patients with chronic NeP was characterized by predominant theta oscillations. Painful and innocuous stimulation led to opposite spectral changes, with a much larger variability across the whole frequency spectrum for painful stimuli, relative to both resting state and non-painful stimulation.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103056"},"PeriodicalIF":2.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the efficacy of transcranial direct current stimulation (tDCS) in managing neuropathic pain-induced emotional consequences: Insights from animal models","authors":"Bahrie Ramadan,&nbsp;Vincent Van Waes","doi":"10.1016/j.neucli.2025.103055","DOIUrl":"10.1016/j.neucli.2025.103055","url":null,"abstract":"<div><div>Neuropathic pain is a global health concern due to its severity and its detrimental impact on patients’ quality of life. It is primarily characterized by sensory alterations, most commonly hyperalgesia and allodynia. As the disease progresses, patients with neuropathic pain develop co-occurring emotional disorders, such as anxiety and depression, which further complicate therapeutic management. While pharmacotherapy remains the first-line treatment, limitations in its efficacy and the prevalence of side effects often leave patients with insufficient pain relief. Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, has recently emerged as a promising alternative for chronic pain management. This review provides an overview of preclinical studies examining the effects of tDCS in rodent models of neuropathic pain. It specifically highlights the potential of tDCS to modulate the emotional-affective component of pain, with a focus on identifying optimal cortical targets for stimulation to enhance the translational application of tDCS in managing pain-related emotional disorders.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103055"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing epilepsy care in Argentina: Use of SEEG in a developing setting","authors":"Silvia Oddo ,&nbsp;Brenda Giagante ,&nbsp;Eduardo Seoane,&nbsp;Pablo Seoane,&nbsp;Juan P Princich,&nbsp;Nuria Campora,&nbsp;Alejandro Nasimbera,&nbsp;Silvia Kochen","doi":"10.1016/j.neucli.2025.103045","DOIUrl":"10.1016/j.neucli.2025.103045","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study is to describe a population of patients with drug resistant epilepsy who underwent stereoelectroencephalography (SEEG) for epilepsy presurgical evaluation in a high complexity public hospital in Argentina.</div></div><div><h3>Methods</h3><div>We included patients from 2014 to 2023. We conducted a retrospective study of patients with drug-resistant epilepsy admitted to the Video-EEG unit. We selected patients who underwent SEEG and analyzed those patients in whom surgery was performed. The variables studied were MRI findings, epileptogenic zone (EZ) location, type of surgery performed, neuropsychological evaluation, post-surgical evolution and histopathology.</div></div><div><h3>Results</h3><div>In the study period, 49 patients underwent SEEG. Magnetic resonance imaging (MRI) was normal in 21/49 (43 %). Eighteen patients (37.5 %) had bilateral implantation, 16 (32.7 %) had unilateral right hemisphere implantation and 15 (31.3 %) unilateral left sided implantation. Surgical treatment was indicated in 30 (61,2 %) patients. Post-surgery outcome according to the International League Against Epilepsy (ILAE) classification, was ILAE I 26.6 % and ILAE II 30 %.</div></div><div><h3>Conclusion</h3><div>Our experience highlights that, with proper training and resource allocation, high-quality epilepsy care, including advanced diagnostic procedures like SEEG, is achievable in Argentina and may be possible in other developing regions.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103045"},"PeriodicalIF":2.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining quantified EEG with clinical measures to better predict outcomes of acute disorders of consciousness","authors":"Huimin Zhang ,&nbsp;Shuting Chai ,&nbsp;Dawei Shan,&nbsp;Gang Liu,&nbsp;Yan Zhang","doi":"10.1016/j.neucli.2025.103048","DOIUrl":"10.1016/j.neucli.2025.103048","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the application of the neuronal recovery model (i.e., the ABCD model derived from EEG power spectral analysis) in forecasting outcomes for patients with acute disorders of consciousness (DOC).</div></div><div><h3>Methods</h3><div>Patients with acute DOC were enrolled, and clinical assessments, including the Glasgow Coma Scale (GCS), Full Outline of UnResponsiveness (FOUR), and Coma Recovery Scale-Revised (CRS-R) scores, along with electroencephalography (EEG), were documented on the first day post-enrollment. The ABCD model, derived from EEG power spectral data reflecting frequency bands, categorized brain activity into four distinct groups (A, B, C, D). Outcome prognoses were evaluated using the Glasgow Outcome Scale-Extended (GOSE) six months after enrollment. Statistical analyses were performed to assess the correlation between the ABCD model and clinical assessments, and to investigate the predictive value of EEG and clinical assessments for the long-term prognosis.</div></div><div><h3>Results</h3><div>A total of 93 patients with acute DOC were included; the median age was 64 years (interquartile range 52, 72), of which 52 patients had favorable outcomes. Significant correlations were observed between the ABCD model and both the FOUR and CRS-R scores. The CRS-R and ABCD model demonstrated relatively good predictive value for six-month prognoses, with Area Under the Curve (AUC) values of 0.695 and 0.678, respectively (<em>P</em> &lt; 0.05). Furthermore, the combination of the CRS-R score and ABCD model exhibited the highest predictive value with an AUC of 0.746.</div></div><div><h3>Conclusions</h3><div>The ABCD model effectively predicted the prognosis of patients with acute DOC in combination with CRS-R.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103048"},"PeriodicalIF":2.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of reduced electroencephalography montages for seizure detection: A frequentist and Bayesian meta-analysis","authors":"Yu-Chen Lin ,&nbsp;Hui-An Lin ,&nbsp;Ming-Long Chang ,&nbsp;Sheng-Feng Lin","doi":"10.1016/j.neucli.2025.103044","DOIUrl":"10.1016/j.neucli.2025.103044","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate the diagnostic accuracy of reduced montage electroencephalography (EEG) for seizure detection and provide evidence-based recommendations.</div></div><div><h3>Methods</h3><div>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a diagnostic meta-analysis to assess the sensitivity and specificity of reduced EEG montages in detecting seizure activity. A hierarchical summary receiver operating characteristic curve (HSROC) model was used to estimate the area under the curve (AUC). Subgroup analyses were conducted to identify sources of heterogeneity. Bayesian estimates were used for validation.</div></div><div><h3>Results</h3><div>Across 8 studies encompassing 3,458 reduced EEG montage samples, all studies used a reduced EEG montage with 7 to 10 electrodes. The pooled sensitivity was 0.75 (95 % CI: 0.68–0.80), and the pooled specificity was 0.97 (95 % CI: 0.95–0.98). The HSROC model had an AUC of 0.96 (95 % CI: 0.93–0.97). Variations in study results were attributed to factors such as the number of electrodes (pooled sensitivity of 0.66 for studies employing &lt;8 leads and 0.77 for studies employing ≥8 leads) and montage design coverage (pooled sensitivity of 0.64 for studies employing subhairline montage and 0.77 for studies employing above-hairline montage). The Bayesian and frequentist findings agreed with each other and had a pooled sensitivity of 0.74 (95 % HPD: 0.65–0.83) and pooled specificity of 0.97 (95 % highest posterior density 0.95–0.98).</div></div><div><h3>Conclusion</h3><div>Reduced EEG montages with 8 or more electrodes are feasible for seizure detection, especially in emergency settings where rapid detection is crucial.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103044"},"PeriodicalIF":2.7,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEEG seizure onset patterns in mesial temporal lobe epilepsy: A cohort study with 76 patients","authors":"Du Cai ,&nbsp;Xiu Wang ,&nbsp;Wenhan Hu ,&nbsp;Jiajie Mo ,&nbsp;Baotian Zhao ,&nbsp;Zhong Zheng ,&nbsp;Lin Sang ,&nbsp;Xiaoqiu Shao ,&nbsp;Chao Zhang ,&nbsp;Jianguo Zhang ,&nbsp;Kai Zhang","doi":"10.1016/j.neucli.2024.103040","DOIUrl":"10.1016/j.neucli.2024.103040","url":null,"abstract":"<div><h3>Objectives</h3><div>In the present study with a large cohort, we aimed to characterize intracerebral seizure onset patterns (SOP) of mesial temporal lobe epilepsy (mTLE), with or without hippocampal sclerosis (HS) as identified via magnetic resonance imaging (MRI).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 255 seizures of 76 consecutive patients with mTLE explored by stereoelectroencephalography (SEEG), including HS-mTLE (<em>n</em> = 52) and non-HS- mTLE (<em>n</em> = 24). Relevant results were obtained by a combination of spectral analysis and manual review. High-frequency oscillations (HFO) were quantified across different SOP by an automatic detection method.</div></div><div><h3>Results</h3><div>We identified six SOP according to previous work by Lagarde et al.: (1) Low-voltage fast activity (LVFA); (2) Rhythmic spikes followed by LVFA; (3) Burst of spikes followed by LVFA; (4) Periodic spikes or spike-wave followed by LVFA; (5) Rhythmic spike or spike-wave; (6) Theta or alpha sharp activity. Notably, Periodic spikes or spike-wave followed by LVFA had a high prevalence in all seizures (37 %). A significant association was established between Periodic spike followed by LVFA and HS-mTLE (<span><math><mi>P</mi></math></span> &lt; 0.05). Furthermore, the counts of ripples and fast ripples were significantly higher in SOP displaying LVFA compared to those that did not (<em>P</em> &lt; 0.05). Rhythmic spikes followed by LVFA had the best prognosis (92 % seizure-free), while Burst of spikes followed by LVFA were linked to poorest prognosis (67 % SF).</div></div><div><h3>Conclusion</h3><div>HS-mTLE and non-HS-mTLE exhibit distinct SOP characteristics, which can offer valuable prognostic insights with a more informative interpretation of ictal iEEG for clinical guidance.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 1","pages":"Article 103040"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}