Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"SEEG around the world","authors":"Aileen McGonigal , Philippe Kahane , Louis Maillard , Giorgio Lo Russo , Patrick Chauvel","doi":"10.1016/j.neucli.2025.103074","DOIUrl":"10.1016/j.neucli.2025.103074","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103074"},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating postoperative motor function using postoperative navigated transcranial magnetic stimulation motor mapping","authors":"Thomas Eibl,&nbsp;Adrian Liebert,&nbsp;Leonard Ritter,&nbsp;Karl-Michael Schebesch","doi":"10.1016/j.neucli.2025.103072","DOIUrl":"10.1016/j.neucli.2025.103072","url":null,"abstract":"<div><h3>Objective</h3><div>Navigated transcranial magnetic stimulation (nTMS) motor mapping has been established in the preoperative workflow of brain tumor patients. This study aimed to evaluate the use of postoperative nTMS motor mapping, which has been rarely performed to evaluate surgery-associated corticospinal tract injuries and functional outcome.</div></div><div><h3>Methods</h3><div>Patients undergoing resection of brain tumors, who received pre- and postoperative nTMS motor mapping were retrospectively evaluated. Further inclusion criteria were postoperative deterioration in motor function or the presence of a preoperative motor deficit MRC ≤3/5 without significant improvement after surgery. Postoperative nTMS was conducted within 14 days after tumor surgery. Corticospinal tracts (CST) were visualized using pre- and postoperative diffusion tensor imaging (DTI). Distances between the tumor and the CST as well as the resection cavity and the CST were measured. Primary outcome was a functionally adequate (MRC ≥4/5) motoric status after 3 months.</div></div><div><h3>Results</h3><div>Seventeen patients were included, mean age was 59.5 ± 14.9 years. Motor evoked potentials (MEP) of at least one extremity were recorded in 14 cases (82.4 %). The positive predictive value (PPV) for motor recovery of postoperative nTMS mapping was 90.5 %, the negative predictive value (NPV) was 38.5 %. Motor thresholds of the operated hemisphere increased significantly after surgery (<em>p</em> = 0.008), whereas the motor thresholds of the contralateral hemisphere remained stable (<em>p</em> = 0.11). Pre- and postoperative CST-visualizations did not differ concerning the distance between CST and lesion or resection cavity.</div></div><div><h3>Conclusion</h3><div>nTMS potentially predicts functional recovery of transient postoperative motor deficits. Further studies are warranted to prove this effect. Motor deficits significantly improved if it was possible to elicit MEPs with nTMS postoperatively.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 4","pages":"Article 103072"},"PeriodicalIF":2.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEEG guided hippocampus-sparing resection in mesial temporal lobe epilepsy","authors":"Mathieu Dhoisne ,&nbsp;Maxime Chochoi ,&nbsp;Morgane Gérard ,&nbsp;Iulia Peciu-Florianu ,&nbsp;Nicolas Reyns ,&nbsp;Hélène Catenoix ,&nbsp;Lucie Plomhause ,&nbsp;Philippe Derambure","doi":"10.1016/j.neucli.2025.103073","DOIUrl":"10.1016/j.neucli.2025.103073","url":null,"abstract":"<div><h3>Objectives</h3><div>Describe the clinical, neurophysiological, and radiological characteristics of patients with mesial temporal lobe epilepsy (TLE) who underwent hippocampus-sparing anterior temporal lobectomy with a particular emphasis on the stereoelectroencephalographic (SEEG) findings that guided the decision to spare the hippocampus.</div></div><div><h3>Methods</h3><div>We included patients who underwent hippocampus-sparing anterior temporal lobectomy and stereoelectroencephalography at Lille University Hospital. We reported their clinical, characteristics as well as the results of their presurgical evaluation, neuroimaging data, and SEEG findings.</div></div><div><h3>Results</h3><div>We report four patients with mesial TLE (three with dominant hemisphere TLE and one with non-dominant hemisphere TLE). In three patients, SEEG captured several seizures originating from the amygdala, with a consistent delay before hippocampal involvement. In the fourth patient, no spontaneous seizure was recorded during monitoring. However, stimulation of the amygdala successfully reproduced a full habitual seizure. All patients underwent hippocampus-sparing anterior temporal lobectomy and have been seizure-free since surgery (two Engel IA and two Engel IB). Post-surgery neuropsychological evaluations were stable or showed improvement in pre-surgical deficits.</div></div><div><h3>Discussion</h3><div>Hippocampus-sparing anterior temporal lobectomy is a safe and effective treatment for patients in whom the hippocampus is not part of the seizure onset zone. SEEG is invaluable when considering hippocampus-sparing resection, as it provides definitive evidence that the hippocampus is not the primary site of seizure onset. Thorough and meticulous SEEG exploration is essential to accurately delineate the seizure onset zone. The decision-making process should integrate SEEG findings with neuroimaging and neuropsychological assessments, relying on a multidisciplinary approach tailored to each patient.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103073"},"PeriodicalIF":2.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré syndrome in patients with Charcot-Marie-Tooth type 1A disease, probably a non-random association","authors":"Jean-Baptiste Davion ,&nbsp;Jérôme Devaux ,&nbsp;Céline Tard ,&nbsp;Armelle Magot ,&nbsp;François Cassim ,&nbsp;Yann Péréon","doi":"10.1016/j.neucli.2025.103071","DOIUrl":"10.1016/j.neucli.2025.103071","url":null,"abstract":"<div><h3>Objective</h3><div>To describe four cases of Charcot-Marie-Tooth disease type 1A (CMT1A) who developed Guillain-Barré syndrome (GBS), respectively the most frequent genetic and inflammatory neuropathies.</div></div><div><h3>Methods</h3><div>We described the patients’ clinical and electrodiagnostic characteristics.</div></div><div><h3>Results</h3><div>Our CMT1A patients developed typical GBS at various ages (3 to 76 years). GBS-related clinical manifestations were different within patients, with various severity degrees of seve (weakness, respiratory failure). Nerve conduction studies revealed more severe demyelinating features than expected in patients with no CMT1A. High cerebrospinal fluid protein level was found in 3 patients. GBS outcome was mainly good, although some patients only slowly improved.</div></div><div><h3>Conclusions</h3><div>Our cases are close to the previously described cases of acute worsening in CMT1A, and presented with many electrophysiological features of GBS. Overall, GBS prognosis does not seem worse in CMT1A patients than in other patients. If GBS and CMT1A were independent, the expected frequency of co-occurrence of GBS and CMT1A in our two French regions should be 1 case every 137 years. As we observed 4 cases in only 5 years, we suspect that CMT1A is a risk factor of GBS.</div></div><div><h3>Significance</h3><div>These cases bring further evidence for a non-random link between inflammatory and genetic neuropathies.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 4","pages":"Article 103071"},"PeriodicalIF":2.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fear in the neuropsychiatric aspects of epilepsy: What role for the amygdala?","authors":"Alexis Tarrada ,&nbsp;Yassine Jamal Eddine","doi":"10.1016/j.neucli.2025.103062","DOIUrl":"10.1016/j.neucli.2025.103062","url":null,"abstract":"<div><div>Fear is essential for survival; however, its dysregulation may lead to various neuropsychiatric disorders. Understanding the neural networks involved in the expression of fear is useful for elaborating therapeutic interventions (pharmacological or psychoeducation). We aimed to summarize suspected roles of amygdala, but also of other structures such as insula, frontal and temporal associative cortices, and brainstem. Three pathways can be distinguished leading to the expression of fear: indirect, direct and interoceptive, comprising the amygdala as a “hub of fear”. Moreover, temporal epilepsies that imply fear as a “spontaneous” symptom may constitute an interesting model for understanding physiological mechanisms of fear.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 4","pages":"Article 103062"},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"F waves in amyotrophic lateral sclerosis: A systematic review and meta-analysis","authors":"Ioannis Liampas ,&nbsp;Dimitra Veltsista ,&nbsp;Alexandra Germeni ,&nbsp;Paraskevi Batzikosta ,&nbsp;Emilia Michou ,&nbsp;Zinovia Kefalopoulou ,&nbsp;Elisabeth Chroni","doi":"10.1016/j.neucli.2025.103061","DOIUrl":"10.1016/j.neucli.2025.103061","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review and meta-analysis aimed to determine the pattern of F-wave abnormalities and their potential utility in the early diagnosis of amyotrophic lateral sclerosis (ALS).</div></div><div><h3>Methods</h3><div>Medline and Embase were thoroughly searched. We primarily emphasized F-wave recordings from the abductor digiti minimi, following stimulation of the ulnar nerve at the wrist. Data from case-control studies involving individuals with ALS versus healthy controls (HC) or other well-defined patient groups were reviewed and -if appropriate- quantitatively synthesized.</div></div><div><h3>Results</h3><div>Twenty-nine studies were included in this systematic review and 17 of them in the analytic part. The pattern of F-abnormalities in ALS compared to HC was as follows: decreased persistence (MD=20.25 %,15.67–24.84 %), mildly prolonged minimum latency (MD=1.59msec,1.11–2.06msec), increased maximum amplitude (MD=196μV,106–287μV) and elevated Index total Freps (MD=33.9 %,26.0–41.8 %). Affected limbs (with substantial weakness in clinical examination and/or muscle wasting and/or abnormal nerve conduction studies) exhibited more marked abnormalities in persistence, minimum latency, and Index total Freps, whereas abnormalities in these parameters were very mild in clinically unaffected limbs. More prominent increases in maximum amplitude accompanied pyramidal dysfunction. Of note, isolated upper motor neuron (UMN) disorders exhibited a comparable increase in Index total Freps without a decrease in persistence.</div></div><div><h3>Conclusions</h3><div>The pattern of F wave abnormalities may raise suspicion of involvement of the under-study lower motor neuron (LMN) pool in ALS. These findings may identify LMN dysfunction even at a preclinical stage and prompt extensive electromyographic investigations. UMN involvement may to some extent differentiate the profile of F wave abnormalities in ALS.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 4","pages":"Article 103061"},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary spastic paraplegia HSP26: clinical and electrophysiological characteristics","authors":"Sezin Yılmaz ,&nbsp;H Evren Boran ,&nbsp;Gülsüm Kayhan ,&nbsp;Bülent Cengiz","doi":"10.1016/j.neucli.2025.103070","DOIUrl":"10.1016/j.neucli.2025.103070","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 4","pages":"Article 103070"},"PeriodicalIF":2.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal lobectomy in bilateral temporal lobe epilepsy: A relook at factors in selection, invasive evaluation and seizure outcome","authors":"Harish Jayakumar ,&nbsp;Siby Gopinath ,&nbsp;Sreelakshmi Narayanan ,&nbsp;Srinath Rajeevan ,&nbsp;Ramaih Rajeshkannan ,&nbsp;Harilal Parasuram ,&nbsp;Ashok Pillai","doi":"10.1016/j.neucli.2025.103064","DOIUrl":"10.1016/j.neucli.2025.103064","url":null,"abstract":"<div><h3>Objectives</h3><div>We sought retrospectively to assess outcomes in bilateral temporal lobe epilepsy (BTLE) patients undergoing resective temporal lobe surgery following invasive EEG lateralization in comparison to unilateral TLE (UTLE).</div></div><div><h3>Methods</h3><div>Patients undergoing surgical intervention for TLE (the vast majority being mesial temporal lobe epilepsy) during a 7-year period were retrospectively categorized as suspected BTLE (sBTLE) or UTLE. Temporal lobectomy was performed in the sBTLE group on the side of maximum number of intracranial EEG seizure onsets. EEG, MRI, laterality of iEEG ictal onset (in sBTLE), seizure outcome and drug tapering data were retrospectively analyzed.</div></div><div><h3>Results</h3><div>Of 148 adult patients undergoing temporal lobe epilepsy surgery, 24 (16.2 %) fit the criteria of sBTLE, amongst whom iEEG ictal onset proved to be unilateral in 14 (uBTLE, 58.3 %) and bilateral in 10 (dBTLE, 41.7 %). Of operated patients in the dBTLE group, the first seizure onset was ipsilateral to the resection in 4 patients (57.1 %) and contralateral in 3 (42.9 %). In the UTLE group, seizure freedom (Engel 1) was achieved in 87.8 % at mean follow-up of 59.2 ± 27.9 months. Seizure freedom was achieved in 92.9 % of uBTLE patients at 52.8 ± 36.6 months. Seven of 10 dBTLE patients underwent resection on the side of maximum number of iEEG seizure onset, and 6 (85.7 %) remained seizure-free at 40.14 ± 25 months. There was no statistically significant difference in seizure-free outcome between UTLE and sBTLE (Pearson Chi-Square test, p-value = 0.67).</div></div><div><h3>Conclusion</h3><div>High seizure freedom rates were observed in both unilateral and bilateral disease following standard temporal lobectomy. However, the study lacks pre- and post-resection neuropsychological data to conclude on the cognitive sequelae of resective surgery in established bilateral mesiotemporal epilepsy.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103064"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced montage electroencephalography: A choice between pragmatism and conventionalism","authors":"Josef Parvizi ,&nbsp;Kapil Gururangan","doi":"10.1016/j.neucli.2025.103063","DOIUrl":"10.1016/j.neucli.2025.103063","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103063"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EMG filling analysis, a new method for the assessment of recruitment of motor units with needle EMG","authors":"Cristina Mariscal ,&nbsp;Javier Navallas ,&nbsp;Armando Malanda ,&nbsp;Silvia Recalde-Villamayor ,&nbsp;Javier Rodriguez-Falces","doi":"10.1016/j.neucli.2025.103059","DOIUrl":"10.1016/j.neucli.2025.103059","url":null,"abstract":"<div><h3>Objectives</h3><div>The progression of recruitment of motor unit potentials (MUPs) during increasing voluntary contraction can provide important information about the motor units (MUs) innervating a muscle. Here, we described a method to quantitate the recruitment level of the intramuscular electromyographic (iEMG) signal during an increasing force level.</div></div><div><h3>Methods</h3><div>Concentric needle EMG signals were recorded from the <em>tibialis anterior</em> of healthy subjects as force was gradually increased from 0 to maximum force. The iEMG filling process was analyzed by measuring the EMG filling factor (FF), calculated from the mean rectified iEMG and the root mean square iEMG.</div></div><div><h3>Results</h3><div>(1) The iEMG activity at low contraction forces was “discrete” (FF&lt;0.3) for all participants. (2) The iEMG activity at maximal effort was “full” (FF&gt;0.5) for 83 % of the participants, whereas it was “incompletely-reduced” (0.3&lt;FF&lt; 0.5) for 17 % of the participants. (3) The FF increased rapidly for forces up to 20 % MVC, and then levelled off for higher forces: thus, the FF curve had a typical exponential shape.</div></div><div><h3>Conclusions</h3><div>The iEMG filling method can be considered of general applicability since the FF increased over a wide range in all healthy participants.</div></div><div><h3>Significance</h3><div>The EMG filling analysis may have potential to detect scenarios of MU loss and remodelling in neurogenic and motor neuron diseases.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 4","pages":"Article 103059"},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}