Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"Evaluation of cortical excitability with transcranial magnetic stimulation in patients with obstructive sleep apnea syndrome.","authors":"Tuğçe Akçadağ Çaman, İnan Özdemir, Mahmut Bilal Çaman, Serkan Aksu, Semai Bek, Gülnihal Kutlu","doi":"10.1016/j.neucli.2025.103111","DOIUrl":"https://doi.org/10.1016/j.neucli.2025.103111","url":null,"abstract":"<p><strong>Objectives: </strong>Cognitive impairment constitutes one of the most prevalent sequelae associated with obstructive sleep apnea (OSA). Given the established correlation between chronic hypoxia in patients with OSA and the deterioration of cortical functions, this study hypothesize that levels of cortical excitability diminish in direct relation to the severity of hypoxic episodes.</p><p><strong>Methods: </strong>A cohort of 102 individuals diagnosed with OSA participated. Patients exhibiting a T90 value of ≥30 % were categorized into the desaturated cohort, whereas those with a T90 value of <30 % were designated as the non-desaturated cohort. To evaluate alterations in cortical excitability, Transcranial Magnetic Stimulation (TMS) was employed to quantify various parameters including resting muscle motor evoked potential (MEP) latency and amplitude, resting motor threshold, active muscle MEP latency andamplitude, and active motor threshold in both the dominant and non-dominant abductor pollicis brevis (APB) muscles.</p><p><strong>Results: </strong>The findings indicated that resting dominant APB muscle MEP latency (t=-2.659; p = 0.009), active dominant APB muscle MEP latency (Z=-2.322; p = 0.020), resting non-dominant APB muscle MEP latency (Z=-2.666; p = 0.008), and active motor threshold for dominant APB (Z=-2.410; p = 0.016) were significantly elevated in the desaturated cohort compared to the non-desaturated cohort.</p><p><strong>Conclusion: </strong>This study showed that chronic hypoxia in patients with OSA is associated with modifications in cortical excitability as assessed through TMS. A marked decrease in cortical excitability was identified in the desaturated cohort. It is hypothesized that a disturbance in gamma-aminobutyric acid (GABA) and glutamate transmission could be crucial to understanding OSA and cortical excitability.</p>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 6","pages":"103111"},"PeriodicalIF":2.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of predictors of pain relief with high-frequency repetitive motor cortex transcranial magnetic stimulation among people with fibromyalgia","authors":"Catarina Couras Lins ,&nbsp;Alessandra S. Fonseca ,&nbsp;Pedro Nascimento Martins ,&nbsp;Julio Cesar Barbour Oliveira ,&nbsp;Ana Mércia Fernandes ,&nbsp;Abrahão Fontes Baptista ,&nbsp;Gabriel T. Kubota ,&nbsp;Valquíria Aparecida da Silva ,&nbsp;Manoel Jacobsen Teixeira ,&nbsp;Daniel Ciampi de Andrade","doi":"10.1016/j.neucli.2025.103109","DOIUrl":"10.1016/j.neucli.2025.103109","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify baseline predictors of clinical response to the primary motor cortex high-frequency repetitive transcranial magnetic stimulation (M1 HF-rTMS) in patients with fibromyalgia.</div></div><div><h3>Materials and methods</h3><div>We performed a secondary analysis of 32 women with fibromyalgia from a randomized, double-blind, sham-controlled international multicenter trial registered at clinicaltrials.gov (NCT03658694). Enrolled participants received active or HF-rTMS-over the primary motor cortex (M1). Baseline demographic data, psychological assessments (Hospital Anxiety and Depression Scale, Brief Pain Inventory, Fibromyalgia Impact Questionnaire, Toronto Alexithymia Scale, and Interoception Questionnaire), psychophysical measures (Conditioned Pain Modulation), and structural brain MRI variables were collected and analyzed. Responders were defined as patients who achieved <em>a</em> ≥ 50 % reduction in pain on a numerical rating scale eight weeks after treatment. Associations between baseline variables and response were analyzed using Wilcoxon Rank Sum tests, chi-square tests, and logistic regression where appropriate.</div></div><div><h3>Results</h3><div>At the end of the treatment period, 15 out of 32 participants (47 %) in the active M1 HF-rTMS group and 7 out of 30 (23 %) in the sham group achieved ≥50 % reduction in pain. None of the baseline demographic, clinical, psychological, psychophysical, or neuroimaging variables evaluated were significantly associated with clinical response to M1 HF-rTMS. Although M1 HF-rTMS induced significant antinociceptive effects measured by psychophysical assessments (heat pain threshold), these effects did not predict clinical outcomes.</div></div><div><h3>Conclusions</h3><div>No clear baseline predictors of response to M1 HF-rTMS were identified in patients with fibromyalgia, emphasizing the heterogeneity and complexity of the disorder. Further research incorporating larger samples and additional biomarkers is necessary to establish individualized prediction strategies for M1 HF-rTMS therapy in fibromyalgia.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 6","pages":"Article 103109"},"PeriodicalIF":2.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the efficacy of rTMS for the management of pain and psychological aspects in non-central nervous system cancer patients: a systematic review","authors":"Jenny Luisi ,&nbsp;Benedetta Capetti ,&nbsp;Lorenzo Conti ,&nbsp;Roberto Grasso ,&nbsp;Gabriella Pravettoni","doi":"10.1016/j.neucli.2025.103110","DOIUrl":"10.1016/j.neucli.2025.103110","url":null,"abstract":"<div><h3>Objectives</h3><div>Non-invasive brain stimulation techniques—particularly repetitive transcranial magnetic stimulation (rTMS) have emerged as promising alternatives to traditional pharmacological treatments for pain management in non-central nervous system cancer patients. By modulating neural circuits involved in pain processing through mechanisms of neuroplasticity, these interventions may also improve cognitive functioning, psychological aspects, and quality of life (QoL). The present systematic review aims to investigate the use of rTMS for cancer-related pain and psychological aspects.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in three electronic scientific databases-PubMed, Scopus, and Embase. Six studies were identified and included, comprising pilot studies, randomized controlled trials, and one randomized clinical trial. PRISMA 2020 guidelines for systematic review were followed.</div></div><div><h3>Results</h3><div>All these studies investigated the use of rTMS to manage pain and psychological aspects such as QoL in patients with different types of oncological conditions, including breast, non-small cell lung, and gynecological cancer, multiple myeloma, and cell glioma. The results suggest a multidimensional improvement in QoL, well-being, and emotional dimension. Notably, a significant reduction in pain intensity was observed following rTMS treatment across all studies.</div></div><div><h3>Conclusion</h3><div>Although limited in number, current studies suggest that rTMS is a promising non-pharmacological intervention for managing cancer-related pain and enhancing psychological well-being. Further high-quality trials are needed to confirm these findings and establish standardized treatment protocols.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 6","pages":"Article 103110"},"PeriodicalIF":2.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel technique to differentiate positional loss of motor function of the spinal cord from failure to obtain baseline transcranial motor evoked potential (TcMEP) in patients with pre-operative motor deficit","authors":"Uditi Gupta ,&nbsp;Heena Parihar ,&nbsp;Ashok Kumar Jaryal ,&nbsp;Megha Bir ,&nbsp;Bhavuk Garg ,&nbsp;Parin Lalwani","doi":"10.1016/j.neucli.2025.103107","DOIUrl":"10.1016/j.neucli.2025.103107","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 6","pages":"Article 103107"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The placebo effect of tDCS on motor performance: A call for domain-specific methodological considerations","authors":"Everton Borges da Silva ,&nbsp;Mércia Jaynne Leandro de Melo ,&nbsp;Matheus Alves Mendonça ,&nbsp;Daniel de Medeiros Leiros ,&nbsp;Ehsan Amiri ,&nbsp;Daniel Gomes da Silva Machado","doi":"10.1016/j.neucli.2025.103108","DOIUrl":"10.1016/j.neucli.2025.103108","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 6","pages":"Article 103108"},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in brain functional connectivity associated with ongoing neuropathic pain in patients with painful polyneuropathies","authors":"Julie Bismuth ,&nbsp;Renaud Lopes ,&nbsp;Jérôme Hodel ,&nbsp;Jean-Pascal Lefaucheur","doi":"10.1016/j.neucli.2025.103102","DOIUrl":"10.1016/j.neucli.2025.103102","url":null,"abstract":"<div><h3>Objective</h3><div>To assess changes in brain functional connectivity associated with the painful nature of peripheral polyneuropathy.</div></div><div><h3>Methods</h3><div>Resting-state functional magnetic resonance imaging (rs-fMRI) was performed in 26 patients with painful or painless polyneuropathy. According to previously published results, connectivity was studied regarding the default mode network (DMN), intrathalamic and thalamocortical connections, and, the different brain networks (pain matrices) involved in the \"nociceptive\", \"attentional\" and \"emotional\" aspects of the chronic pain experience.</div></div><div><h3>Results</h3><div>No change in DMN connectivity was found between groups. Thalamocortical connectivity was reduced in patients with painful polyneuropathy, especially for the thalamic cluster connected to the motor cortex, while intra-thalamic (mediolateral) connectivity was increased in patients with painless polyneuropathy. Intra-connectivity was increased within the pain matrices, especially the \"nociceptive\" matrix, in patients with painful polyneuropathy, while inter-connectivity was increased between the \"attentional\" and \"emotional\" pain matrices in patients with painless polyneuropathy. Increased connectivity between the posterior insula and parietal operculum positively correlated with the neuropathic pain symptom score and impact of pain on daily functioning.</div></div><div><h3>Conclusions</h3><div>Painful polyneuropathy was characterized by increased intra-connectivity within each pain matrix and reduced thalamocortical connectivity of certain thalamic clusters, notably linked to the motor cortex. Conversely, painless polyneuropathy was characterized by increased connectivity within the thalamus and between the different pain matrices. Although various methodological limitations must be acknowledged (small sample size, lack of a control group of healthy subjects or measurement of pain intensity during neuroimaging examination), these results provide new information on the changes in brain connectivity associated with painful polyneuropathies. This study also brings new arguments to explain the efficacy of motor cortex stimulation in the treatment of chronic neuropathic pain.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103102"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reticular formation: An integrative network for postural control","authors":"FJF Viseux ,&nbsp;M Simoneau ,&nbsp;GM Pamboris ,&nbsp;N Sturbois-Nachef ,&nbsp;CT Bonnet ,&nbsp;M Martinez Carrasco ,&nbsp;L Defebvre ,&nbsp;M Billot ,&nbsp;A Delval","doi":"10.1016/j.neucli.2025.103100","DOIUrl":"10.1016/j.neucli.2025.103100","url":null,"abstract":"<div><div>The reticular formation (RF), a complex network within the brainstem, plays a pivotal role in postural control, by integrating multisensory information and coordinating motor responses, to maintain balance and stability. This theoretical review synthesizes current knowledge on the anatomical and functional organization of the RF, highlighting its contributions to muscle tone regulation, anticipatory postural adjustments (APA), and gaze stability. Anatomically divided into median, paramedian, and lateral columns, the RF operates through both ascending and descending pathways. The ascending reticular activating system (ARAS) regulates arousal and alertness, while the descending reticulospinal tracts modulate postural muscle tone and motor coordination. Functionally, the RF maintains baseline muscle tone via excitatory and inhibitory pathways and supports APA by preparing the body for movement-induced perturbations. Moreover, the RF is integral to the coordination of eye and head movements, ensuring visual stability during motion. Collectively, these mechanisms position the RF as a central integrator of posture and movement, with implications for understanding motor control and informing interventions in neurorehabilitation and movement optimization.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103100"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of reference electrode position on diagnostic accuracy of split hand index in ALS","authors":"Sepideh Omidbakhsh ,&nbsp;Hatice Tankisi","doi":"10.1016/j.neucli.2025.103101","DOIUrl":"10.1016/j.neucli.2025.103101","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103101"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is segmenting ECG features a viable tool for seizure detection?","authors":"Ewan S. Nurse ,&nbsp;Mark J. Cook","doi":"10.1016/j.neucli.2025.103099","DOIUrl":"10.1016/j.neucli.2025.103099","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103099"},"PeriodicalIF":2.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol considerations for single and paired pulse transcranial magnetic stimulation in Parkinson’s disease","authors":"Anjali Sivaramakrishnan ,&nbsp;Harry T. Jordan ,&nbsp;Cathy M. Stinear","doi":"10.1016/j.neucli.2025.103097","DOIUrl":"10.1016/j.neucli.2025.103097","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103097"},"PeriodicalIF":2.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}