Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"How can neurophysiology help us to decipher emotion(s)?","authors":"Sarah Dominique Rosenberg , Jean-Pascal Lefaucheur","doi":"10.1016/j.neucli.2026.103136","DOIUrl":"10.1016/j.neucli.2026.103136","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 2","pages":"Article 103136"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative EEG enhances early assessment and prognostic stratification of brain dysfunction in infants with abusive head trauma","authors":"Valentin Hess ,&nbsp;Matthieu Doyen ,&nbsp;Rima Nabbout ,&nbsp;Thomas Blauwblomme ,&nbsp;Benjamin Serrand ,&nbsp;Martine Balençon ,&nbsp;Claire Bar ,&nbsp;Olivier Brissaud ,&nbsp;Olivier Klein ,&nbsp;Arnaud Wiedemann ,&nbsp;Mathieu Kuchenbuch","doi":"10.1016/j.neucli.2025.103132","DOIUrl":"10.1016/j.neucli.2025.103132","url":null,"abstract":"<div><h3>Aim</h3><div>To assess the value of quantitative EEG (qEEG) as a diagnostic and prognostic biomarker in infants with abusive head trauma (AHT). Despite its central role in monitoring encephalopathy, EEG remains underused in multimodal evaluations, and its quantitative analysis may provide objective, real-time insights into cerebral dysfunction and long-term outcome.</div></div><div><h3>Methods</h3><div>This retrospective monocentric case–control study included infants under two years with confirmed AHT and age- and sex-matched controls. Clinical and early EEG data were collected. Patients’ outcome was stratified by Pediatric Overall Performance Category score (POPC_1–3 vs. _4–6). Quantitative EEG features were analyzed, and two neural networks were trained using five-fold cross-validation for diagnosis and outcome prediction.</div></div><div><h3>Results</h3><div>84 EEGs from 75 participants were analyzed (46 EEGs from 40 AHT; 38 EEGs from 35 controls). Compared with controls, AHT EEGs showed significantly reduced entropy and Hurst exponent values and increased low-frequency power, reflecting diffuse cortical dysfunction. Within the AHT group, reduced signal complexity and loss of interhemispheric asymmetry correlated with unfavorable outcomes (POPC_4–6, p&lt; 0.01). Machine learning perfectly classified AHT cases versus controls and classified patients into POPC_1-3 or POPC_4-6 groups with 73±14 % accuracy. Combined models distinguished control, POPC_1-3, and POPC_4-6 groups with 90±5 % accuracy.</div></div><div><h3>Discussion</h3><div>Early qEEG provides functional information that complements imaging and clinical findings. qEEG-derived biomarkers may enable early risk stratification, guide neuroprotective strategies, and improve prognostic counseling in infants with AHT. Larger multicenter prospective studies are warranted to validate these exploratory findings and define their clinical applicability.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103132"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and neurophysiological effects of rTMS on chronic post-stroke hand spasticity","authors":"José Luis Guerrero Solano ,&nbsp;Oscar Ayo-Martin ,&nbsp;Tomas Segura","doi":"10.1016/j.neucli.2025.103125","DOIUrl":"10.1016/j.neucli.2025.103125","url":null,"abstract":"<div><div>This observational open-label study evaluates the clinical and neurophysiological effects of multiple sessions of contralesional motor cortex low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on seventeen patients with chronic post-stroke hand spasticity. Results: LF-rTMS improved spasticity (Modified Ashworth Scale, <em>p</em> &lt; 0.001), strength (tip pinch, <em>p</em> = 0.002; grip force, <em>p</em> &lt; 0.001), flexibility (finger tapping test, <em>p</em> = 0.014; tapping test, <em>p</em> = 0.008), motor threshold difference (<em>p</em> &lt; 0.001), and motor evoked potential latency (<em>p</em> = 0.004), with no adverse events reported. Improvement in spasticity persisted after 3 months. Conclusion: LF-rTMS is a safe and effective therapy for chronic post-stroke hand spasticity.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103125"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping emotion with cortical electrical stimulations: A disrupted landscape","authors":"Olivier Aron","doi":"10.1016/j.neucli.2025.103133","DOIUrl":"10.1016/j.neucli.2025.103133","url":null,"abstract":"<div><div>Cortical electrical stimulation (CES) provides a unique window into the neural architecture supporting human emotion by perturbing local circuits while revealing distributed network dynamics. Yet despite decades of clinical use in stereo-EEG and subdural mapping, the emotional phenomena elicited by CES remain conceptually heterogeneous and methodologically inconsistent, reflecting the absence of a unified interpretative framework.</div><div>Here, by outlining the conceptual foundations of emotion and examining the scattered evidence from CES, we show how definitional and methodological divergences undermine cumulative insight. We first situate CES findings relative to competing models of emotion, highlighting how assumptions about discreteness, appraisal, and construction shape the interpretation of evoked responses. We then assess how theoretical stance, emotion features, stimulation parameters, anatomical constraints, and task conditions are reported across studies, revealing major inconsistencies in methodological transparency than may account for systematic biases in affective outcomes.</div><div>Finally, we propose the <em>eMAP operational framework</em>—a minimal reporting structure organised around four pillars: <em>Emotion, Modulation, Architecture</em>, and <em>Phenomenology</em>. This framework aims to guide future research by allowing perturbational evidence to be interpreted in a cumulative and comparable manner, while improving the clinical utility of CES for probing the functional architecture of emotion and refining surgical risk assessment.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103133"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effectiveness of transcranial direct current stimulation and transcutaneous tibial nerve stimulation on the urgency and frequency of women with overactive bladder syndrome: A randomized controlled trial","authors":"Zahra Gorji ,&nbsp;Mohammad Reza Hadian Rasanani ,&nbsp;Michael Nitsche ,&nbsp;Tannaz Ahadi ,&nbsp;Roya Khanmohammadi ,&nbsp;Anahita Torkzadeh","doi":"10.1016/j.neucli.2025.103116","DOIUrl":"10.1016/j.neucli.2025.103116","url":null,"abstract":"<div><h3>Introduction</h3><div>Recent findings suggest that key areas in the brain, particularly the medial prefrontal cortex (mPFC), are important for regulating bladder function. This research explores the potential of transcranial direct current stimulation (tDCS) on the mPFC as an emerging approach to alleviate overactive bladder (OAB) symptoms, in comparison to transcutaneous tibial nerve stimulation (TTNS).</div></div><div><h3>Methods</h3><div>This single-blind, two-arm, parallel, randomized controlled clinical trial with a 1:1 allocation ratio was conducted at Firoozgar Hospital. A total of forty-four women diagnosed with overactive bladder (OAB) were randomly divided into two groups: one group received tDCS (transcranial Direct Current Stimulation) combined with PFMT (Pelvic Floor Muscle Training), and the other received TTNS(Trancutaneous Tibial Nerve Stimulation) combined with PFMT. The primary outcome measure was the quality of life through the International Consultation on Incontinence Questionnaire Lower Urinary Tract Symptoms Quality of Life Module (ICIQ-LUTSqol). Secondary outcome measures included the International Consultation on Incontinence Questionnaire Overactive Bladder Module (ICIQ-OAB), a three-day bladder diary, and assessment of pelvic floor muscle strength using a perineometer.</div></div><div><h3>Results</h3><div>Both groups exhibited improvements in OAB symptoms; however, the tDCS group appeared to show greater reductions in ICIQ-OAB scores and symptom bother (p &lt; 0.05). As measured by the ICIQ-LUTSqol questionnaire, quality of life improved in both groups, with indications of comparatively greater improvements in the tDCS group after treatment and at the one-month follow-up (p = 0.05 and p &lt; 0.05 respectively). Moreover, the number of urinary incontinence episodes tended to decline more markedly in the tDCS group, and this improvement was sustained during the follow-up period (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study’s findings suggest that while both TTNS and tDCS may effectively improve the quality of life in women with overactive bladder (OAB), the improvements observed in the tDCS group appear to be greater. However, further sham-controlled studies are needed to confirm these potential benefits.</div></div><div><h3>Trial registration</h3><div>Iranian Registry of Clinical Trials (IRCT) ID: IRCT20090301001722N26, date of registration: 17 May 2023. <span><span>https://en.irct.ir/</span><svg><path></path></svg></span></div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103116"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A brief history of electrical brain stimulation in humans","authors":"Elisabeth Landré ,&nbsp;Jean-Pierre Vignal","doi":"10.1016/j.neucli.2025.103123","DOIUrl":"10.1016/j.neucli.2025.103123","url":null,"abstract":"<div><div>The concept of cerebral localization originated from cerebral electrical stimulation. Pioneering experiments conducted by Fritsch and Hitzig on dogs, Bartholow on humans and David Ferrier on macaques in the 19th century led to the discovery of the primary motor cortex. Surgical treatment of epileptic patients began with electrical stimulation of the brain by Victor Horsley in 1886. Electrical stimulation of the brain during surgical treatment produced important results in terms of understanding of the cerebral cortex and focal epilepsies. In the 20th century, major developments were the electrocorticography work of Wilder Penfield in Montreal and the stereoelectroencephalography (SEEG) work of Jean Talairach and Jean Bancaud in Paris. The evolution of cerebral electrical stimulation reflects a growing understanding of brain organization and plasticity. This historical perspective highlights how empirical observations have shaped current clinical protocols and research frontiers.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103123"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereo-EEG in an epilepsy surgery program: Initial experience in a tertiary pediatric hospital in Italy","authors":"Alessandro Consales ,&nbsp;Luca Bosisio ,&nbsp;Domenico Tortora ,&nbsp;Mattia Pacetti ,&nbsp;Gianluca Piatelli ,&nbsp;Maria Margherita Mancardi ,&nbsp;Giulia Nobile ,&nbsp;Lino Nobili ,&nbsp;Stefano Francione","doi":"10.1016/j.neucli.2025.103131","DOIUrl":"10.1016/j.neucli.2025.103131","url":null,"abstract":"<div><div>Stereo-EEG is a fundamental part of the diagnostic process for a significant number of selected patients with focal epilepsy. The complexity inherent in planning a SEEG study means that this method can only reasonably be put into practice in treatment centers with multidisciplinary teams dedicated to epilepsy surgery and where teaching and specific training are considered essential for the proper development of a SEEG program. In our short communication, we present the development of the SEEG program at our hospital, which is one of the most important tertiary pediatric centers in Europe.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103131"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing sweating problems in multiple sclerosis: insights from QSART, SUDOSCAN, and COMPASS-31","authors":"Katy Jerčinović ,&nbsp;Katarina Tešija ,&nbsp;Mašan Sredanović ,&nbsp;Ivan Adamec ,&nbsp;Tereza Gabelić ,&nbsp;Barbara Barun ,&nbsp;Magdalena Krbot Skorić ,&nbsp;Mario Habek","doi":"10.1016/j.neucli.2025.103124","DOIUrl":"10.1016/j.neucli.2025.103124","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize sweating issues in people with multiple sclerosis (pwMS) using the Quantitative Sudomotor Axon Reflex Test (QSART) and SUDOSCAN.</div></div><div><h3>Methods</h3><div>In 75 pwMS, sweating symptoms were evaluated using the Composite Autonomic Symptom Score (COMPASS-31). Sweating function was assessed with QSART and SUDOSCAN.</div></div><div><h3>Results</h3><div>Symptomatic sweating problems were observed in 22 (29.3 %) pwMS. Pathological results of the QSART (sudomotor index (SI) &gt;0) were identified in 13 (17.3 %) pwMS, while SUDOSCAN results showed pathology in 8 (10.7 %) pwMS. We found a positive correlation between the QSART volume of the foot and the SUDOSCAN electrochemical skin conductance (ESC) results for the corresponding leg (<em>r</em> = 0.282, <em>p</em> = 0.015). pwMS with cervical spinal cord lesions had higher ESC values for the hand mean, left, and right (69.88±12.84 vs 76.15±9.29, <em>p</em> = 0.022; 69.88±12.82 vs 76.22±9.36, <em>p</em> = 0.021; and 70.33±13.00 vs 76.52±9.27, <em>p</em> = 0.024; respectively).</div></div><div><h3>Conclusions</h3><div>People with MS frequently experience sweating problems. Using various methods to identify sweating issues in pwMS reveals differences in the causes of these problems in pwMS.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103124"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of beta-neurofeedback on beta-bursts in Parkinson’s disease patients as evidenced through deep brain recordings","authors":"Oliver Bichsel ,&nbsp;Stephen Bacchi ,&nbsp;Mehdi Hajiabadi ,&nbsp;Franziska Schmidt ,&nbsp;Lennart Stieglitz","doi":"10.1016/j.neucli.2025.103122","DOIUrl":"10.1016/j.neucli.2025.103122","url":null,"abstract":"<div><h3>Objectives</h3><div>Increased beta-oscillations (13–35 Hz) in the basal ganglia have been linked to Parkinsonian motor symptoms. Deep brain stimulation (DBS) approaches have been proposed to mitigate pathological beta-activity, with some leading to a global suppression of this activity and others selectively trimming beta-bursts leading to a redistribution of beta-bursts towards shorter, more physiological, durations. Recently, DBS electrode-guided neurofeedback has been explored as an alternative, endogenous technique enabling patients to acquire mental strategies to modulate ongoing subthalamic beta-activity. Here, we investigated the effect of DBS-neurofeedback on beta-burst prevalence, amplitude, and duration.</div></div><div><h3>Methods</h3><div>We characterised the local field potential (LFP) in the subthalamic nucleus (STN) in terms of beta-burst prevalence, amplitude and length during DBS electrode-guided neurofeedback-modulation of ongoing subthalamic beta-activity.</div></div><div><h3>Results</h3><div>We previously showed that a cohort of eight Parkinson’s disease (PD) patients with externalised DBS electrodes was able to volitionally control ongoing beta-oscillatory activity by visual neurofeedback within minutes of training, which was also accompanied by an improvement in motor performance. Here, we additionally demonstrate a decrease in beta-burst (&gt; 0.1 s) durations, amplitude and prevalence when transitioning from rest to downregulation after neurofeedback-learning. In addition, downregulation vs. upregulation also resulted in shorter and lower amplitude beta-bursts (&gt;0.1 s) after neurofeedback.</div></div><div><h3>Discussion</h3><div>DBS electrode-guided neurofeedback enabled patients with PD to exert control over subthalamic beta-oscillations, with downregulation in particular leading to a redistribution of beta-burst characteristics towards more physiological states. This technique may represent a complementary approach to existing DBS strategies by providing patients with an endogenous means of modulating pathological beta-activity.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103122"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocochleography: Techniques and practical considerations","authors":"Fabrice Giraudet,&nbsp;Ludivine Beaud-Henry,&nbsp;Salim Ismail,&nbsp;Mathieu Marx,&nbsp;Quentin Legois","doi":"10.1016/j.neucli.2025.103130","DOIUrl":"10.1016/j.neucli.2025.103130","url":null,"abstract":"<div><div>Electrocochleography (Ecog) is an electrophysiological technique that focuses on wave I of auditory brainstem responses (ABRs) detects others electrical potentials generated by the cochlea. It provides an objective tool for assessing inner ear function. The equipment is the same as that used for ABRs, with a few minor adjustments to parameters, equipment, and placement of the active electrode. Clinical indications for Ecog are becoming increasingly widespread from the diagnosis of auditory neuropathies, endocochlear hydrops, monitoring changes in intracranial pressure, evaluation of superior semicircular canal dehiscence as well as intraoperative cochlear monitoring. Ecog is now an indispensable tool in audiological and electrophysiological practices. It highlights physiological mechanisms and improves our understanding of different pathological entities.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"56 1","pages":"Article 103130"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}