Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"Hereditary spastic paraplegia HSP26: clinical and electrophysiological characteristics","authors":"Sezin Yılmaz , H Evren Boran , Gülsüm Kayhan , Bülent Cengiz","doi":"10.1016/j.neucli.2025.103070","DOIUrl":"10.1016/j.neucli.2025.103070","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 4","pages":"Article 103070"},"PeriodicalIF":2.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal lobectomy in bilateral temporal lobe epilepsy: A relook at factors in selection, invasive evaluation and seizure outcome","authors":"Harish Jayakumar ,&nbsp;Siby Gopinath ,&nbsp;Sreelakshmi Narayanan ,&nbsp;Srinath Rajeevan ,&nbsp;Ramaih Rajeshkannan ,&nbsp;Harilal Parasuram ,&nbsp;Ashok Pillai","doi":"10.1016/j.neucli.2025.103064","DOIUrl":"10.1016/j.neucli.2025.103064","url":null,"abstract":"<div><h3>Objectives</h3><div>We sought retrospectively to assess outcomes in bilateral temporal lobe epilepsy (BTLE) patients undergoing resective temporal lobe surgery following invasive EEG lateralization in comparison to unilateral TLE (UTLE).</div></div><div><h3>Methods</h3><div>Patients undergoing surgical intervention for TLE (the vast majority being mesial temporal lobe epilepsy) during a 7-year period were retrospectively categorized as suspected BTLE (sBTLE) or UTLE. Temporal lobectomy was performed in the sBTLE group on the side of maximum number of intracranial EEG seizure onsets. EEG, MRI, laterality of iEEG ictal onset (in sBTLE), seizure outcome and drug tapering data were retrospectively analyzed.</div></div><div><h3>Results</h3><div>Of 148 adult patients undergoing temporal lobe epilepsy surgery, 24 (16.2 %) fit the criteria of sBTLE, amongst whom iEEG ictal onset proved to be unilateral in 14 (uBTLE, 58.3 %) and bilateral in 10 (dBTLE, 41.7 %). Of operated patients in the dBTLE group, the first seizure onset was ipsilateral to the resection in 4 patients (57.1 %) and contralateral in 3 (42.9 %). In the UTLE group, seizure freedom (Engel 1) was achieved in 87.8 % at mean follow-up of 59.2 ± 27.9 months. Seizure freedom was achieved in 92.9 % of uBTLE patients at 52.8 ± 36.6 months. Seven of 10 dBTLE patients underwent resection on the side of maximum number of iEEG seizure onset, and 6 (85.7 %) remained seizure-free at 40.14 ± 25 months. There was no statistically significant difference in seizure-free outcome between UTLE and sBTLE (Pearson Chi-Square test, p-value = 0.67).</div></div><div><h3>Conclusion</h3><div>High seizure freedom rates were observed in both unilateral and bilateral disease following standard temporal lobectomy. However, the study lacks pre- and post-resection neuropsychological data to conclude on the cognitive sequelae of resective surgery in established bilateral mesiotemporal epilepsy.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103064"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced montage electroencephalography: A choice between pragmatism and conventionalism","authors":"Josef Parvizi ,&nbsp;Kapil Gururangan","doi":"10.1016/j.neucli.2025.103063","DOIUrl":"10.1016/j.neucli.2025.103063","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103063"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EMG filling analysis, a new method for the assessment of recruitment of motor units with needle EMG","authors":"Cristina Mariscal ,&nbsp;Javier Navallas ,&nbsp;Armando Malanda ,&nbsp;Silvia Recalde-Villamayor ,&nbsp;Javier Rodriguez-Falces","doi":"10.1016/j.neucli.2025.103059","DOIUrl":"10.1016/j.neucli.2025.103059","url":null,"abstract":"<div><h3>Objectives</h3><div>The progression of recruitment of motor unit potentials (MUPs) during increasing voluntary contraction can provide important information about the motor units (MUs) innervating a muscle. Here, we described a method to quantitate the recruitment level of the intramuscular electromyographic (iEMG) signal during an increasing force level.</div></div><div><h3>Methods</h3><div>Concentric needle EMG signals were recorded from the <em>tibialis anterior</em> of healthy subjects as force was gradually increased from 0 to maximum force. The iEMG filling process was analyzed by measuring the EMG filling factor (FF), calculated from the mean rectified iEMG and the root mean square iEMG.</div></div><div><h3>Results</h3><div>(1) The iEMG activity at low contraction forces was “discrete” (FF&lt;0.3) for all participants. (2) The iEMG activity at maximal effort was “full” (FF&gt;0.5) for 83 % of the participants, whereas it was “incompletely-reduced” (0.3&lt;FF&lt; 0.5) for 17 % of the participants. (3) The FF increased rapidly for forces up to 20 % MVC, and then levelled off for higher forces: thus, the FF curve had a typical exponential shape.</div></div><div><h3>Conclusions</h3><div>The iEMG filling method can be considered of general applicability since the FF increased over a wide range in all healthy participants.</div></div><div><h3>Significance</h3><div>The EMG filling analysis may have potential to detect scenarios of MU loss and remodelling in neurogenic and motor neuron diseases.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 4","pages":"Article 103059"},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does hyperventilation increase the diagnostic sensitivity of routine electroencephalography in adults with suspected epilepsy?","authors":"Seyda Erdoğan,&nbsp;Gökhan Pek,&nbsp;Canan Duman İlki,&nbsp;Cem Dinler,&nbsp;İlke Şahin,&nbsp;Ali Cem Ekşi,&nbsp;Musap Rasim Ceylan,&nbsp;Nijat Abbaszade,&nbsp;Eray Ergül,&nbsp;Özden Şener","doi":"10.1016/j.neucli.2025.103060","DOIUrl":"10.1016/j.neucli.2025.103060","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to explore the role of hyperventilation (HV) during routine EEG recordings in the diagnosis of adults with epilepsy.</div></div><div><h3>Methods</h3><div>During the COVID-19 pandemic we removed HV from routine EEG recordings due to the transmission risks. Routine EEGs conducted in the year before and after the COVID-19 pandemic were re-evaluated.</div></div><div><h3>Results</h3><div>A total of 167 HV + and 199 HV - EEGs were analyzed. To ensure comparability between the two groups with respect to age and conditions that could contraindicate HV, patients ≥ 55 years and with any conditions contraindicating HV were excluded from both groups. In patients with a diagnosis of epilepsy the prevalence of epileptiform abnormalities was 26.7 % in the HV + and 24.5 % in the HV - group (<em>p</em> = 0.727).</div></div><div><h3>Conclusions</h3><div>This study did not reveal any evidence indicating that HV improves the diagnostic sensitivity of routine EEG in adults with epilepsy. In adults, hyperventilation during routine EEG recordings may be most useful in incre in patients with a history of absence seizures or seizures triggered by hyperventilation.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 4","pages":"Article 103060"},"PeriodicalIF":2.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical Stimulation for brain mapping and seizure stimulation, pediatric practices throughout Canada: A national survey and systematic literature review","authors":"Margarita Maltseva ,&nbsp;Juan Pablo Appendino ,&nbsp;Pavlina Cabounova ,&nbsp;Andrea Andrade ,&nbsp;Michelle Kregel ,&nbsp;Aris Hadjinicolaou ,&nbsp;Alexander G. Weil ,&nbsp;Puneet Jain ,&nbsp;Elizabeth Donner ,&nbsp;Felippe Borlot ,&nbsp;David Dufresne ,&nbsp;Linda Huh ,&nbsp;Natarie Liu ,&nbsp;Kenneth A. Myers ,&nbsp;Julia Jacobs","doi":"10.1016/j.neucli.2025.103043","DOIUrl":"10.1016/j.neucli.2025.103043","url":null,"abstract":"<div><h3>Introduction</h3><div>Diagnostic cortical stimulation (CS) in intracranial electroencephalography (iEEG) is an established epilepsy presurgical assessment tool to delineate relevant brain functions and elicit habitual epileptic seizures. Currently, no consensus exists as to whether CS should be routinely performed in pediatric patients. A significant challenge is their limited ability to cooperate during the procedure or to describe non-observable seizure semiology features. Our goal was to identify the spectrum of CS practices in Canada, for both eloquent cortex mapping and seizure stimulation.</div></div><div><h3>Methods</h3><div>An online survey, answered by all 8 Canadian pediatric epilepsy centers, enquired about implantation, stimulation methods, and use of standardized protocols. A systematic literature review extracted detailed stimulation parameters.</div></div><div><h3>Results</h3><div>Most of the institutions (<em>n</em> = 7/8) reported performing CS during presurgical evaluation. Four institutions indicated they perform stimulation in all implanted patients for the purpose of eloquent cortex mapping and seizure stimulation. The majority of physicians had their individual approach to CS. A largely variable approach to CS, mainly in the choice of stimulation parameters (i.e., train and pulse duration), was observed, with the highest variance concerning the purpose of seizure stimulation. The literature review highlighted an overall small sample size and minimal number of publications. Even though there is a rising trend towards stereotactic iEEG implantation, more data were available on subdural EEGs.</div></div><div><h3>Conclusion</h3><div>This study shows individual and sparsely validated approach to CS in pediatric epilepsy. The literature review underscores the urgent need to harmonize pediatric intracranial EEG practices. More multicenter studies are needed to identify safe stimulation thresholds and allow implementation of evidence-based guidelines.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103043"},"PeriodicalIF":2.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143282721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Description of an alternative method for the electrodiagnostic evaluation of the sensory radial nerve","authors":"Martin Moussy ,&nbsp;Julie Rode ,&nbsp;Thierry Maisonobe ,&nbsp;Nagham Khanafer ,&nbsp;Françoise Bouhour ,&nbsp;Antoine Pegat","doi":"10.1016/j.neucli.2025.103058","DOIUrl":"10.1016/j.neucli.2025.103058","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to describe an alternative method for the electrodiagnostic (EDX) evaluation of the sensory radial nerve (SRN).</div></div><div><h3>Methods</h3><div>In this retrospective study, all patients from a French EDX center (November 2022-April 2023) for whom SNAP amplitudes of the same SRN were obtained through both a conventional and an alternative method were included. In the conventional method, the active recording electrode was placed at the base of the snuff box, whereas in the alternative method, it was placed 3<del>-4</del> cm proximally on the lateral border of the radial bone. The SNAP amplitudes of both methods were compared and the ratio of alternative to conventional amplitude was determined within the same patient. A secondary objective was to compare SNAP amplitudes and ratios between patients with peripheral neuropathy and those without (control group).</div></div><div><h3>Results</h3><div>Among the 117 patients included, the mean ± SD SNAP amplitude was 50.0±28.9 µV in the alternative method compared to 31.0±17.9 µV in the conventional method. The ratio of alternative to conventional amplitudes was 1.64±0.4 in all patients. No significant difference in amplitude ratios was found between the peripheral neuropathy group (1.63 ± 0.4) and the control group (1.65 ± 0.3; p =0.75).</div></div><div><h3>Discussion</h3><div>The alternative method, based on a more proximal placement of the recording electrodes, consistently provided larger SNAP amplitudes than the conventional method. This method could be useful in particular clinical settings but could prove more challenging in obese or muscular patients.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103058"},"PeriodicalIF":2.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143327918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereoelectroencephalography at Sainte-Anne Hospital, Paris, France","authors":"Cristina Filipescu ,&nbsp;Elisabeth Landré ,&nbsp;Marc Zanello ,&nbsp;Alessandro Moiraghi ,&nbsp;Charles Mellerio ,&nbsp;Magali Boutin ,&nbsp;Benoît Crépon ,&nbsp;Estelle Pruvost-Robieux ,&nbsp;Anaïs Llorens ,&nbsp;Johan Pallud ,&nbsp;Martine Gavaret","doi":"10.1016/j.neucli.2025.103057","DOIUrl":"10.1016/j.neucli.2025.103057","url":null,"abstract":"<div><div>Stereoelectroencephalography (SEEG), which combines the exploration of identified intracerebral structures using depth electrodes and provides direct recording of local field potentials from multiple brain sites, was designed and developed in the 1950s by Jean Talairach and Jean Bancaud, in Sainte-Anne Hospital, Paris.</div><div>For patients with focal drug-resistant epilepsy, when the non-invasive phase is insufficiently concordant or when relationships between the epileptogenic network and eloquent areas remain to be defined, the main purpose of SEEG is the optimal electrode implantation based on a main hypothesis and questions formulated during the non-invasive phase.</div><div>Following an initial historical overview, the different steps of this non-invasive phase are described. Some of these steps, like semiology analysis, have remained relatively preserved, while others have considerably evolved, such as positron emission tomography combined with 3 Tesla magnetic resonance imaging (MRI), functional MRI (fMRI) and high-resolution EEG.</div><div>We then outline the different steps of the SEEG procedure as performed in our institution. Here also, some steps remain quite unchanged such as intracerebral stimulation, amitriptyline and benzodiazepine tests while some others have strikingly evolved such as frameless robot-assisted, MRI-based implantation, depth-signal analyses and quantifications, and radio-frequency thermocoagulation.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103057"},"PeriodicalIF":2.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How can emotion and familiarity improve own-name oddball paradigms?","authors":"Estelle Pruvost-Robieux ,&nbsp;Sarah Benghanem ,&nbsp;Camille Des Lauriers ,&nbsp;Anaïs Llorens ,&nbsp;Martine Gavaret","doi":"10.1016/j.neucli.2025.103050","DOIUrl":"10.1016/j.neucli.2025.103050","url":null,"abstract":"<div><div>The own-name paradigm is used to assess the depth of consciousness disorders in patients in intensive care units. This auditory oddball paradigm elicits a positive event-related potential at 300 ms (named P300) after the presentation of a deviant auditory stimulus, here the subject's own-name. This P300 likely reflects the neural processing of the novel stimulus, which can trigger a behavioral response. Presence of a P300 response is considered to be indicative of a good prognosis for recovering to wakefulness in post-anoxic coma patients. However, its prognostic performance is insufficient and some disorders of consciousness patients without a P300 response will nevertheless awake. The auditory P300 response is influenced by the acoustic characteristics of the stimuli. The use of stimuli with an emotional valence may recruit additional brain networks besides the auditory and attentional ones and potentially improve the prognostic value of the P300 response. Moreover, better characterization of the recruitment of different brain networks involved in these P300 responses in response to emotional stimuli would help in understanding the surface event-related potentials. Here, we present two kind of emotional acoustic features that can be used in these paradigms: “smiling” versus “rough” voice and the familiarity of the voice.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103050"},"PeriodicalIF":2.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative recordings from the posterior superior insula in awake humans with peripheral neuropathic pain","authors":"Raíssa Benocci Thibes ,&nbsp;Pedro Henrique Martins da Cunha ,&nbsp;Jorge Dornellys da Silva Lapa ,&nbsp;Liu Dongyang ,&nbsp;Denise Spinola Pinheiro ,&nbsp;Ricardo Ferrareto Iglesio ,&nbsp;Kleber Paiva Duarte ,&nbsp;Valquiria Aparecida Silva ,&nbsp;Gabriel Taricani Kubota ,&nbsp;Manoel Jacobsen Teixeira ,&nbsp;Luis Garcia-Larrea ,&nbsp;Hélène Bastiji ,&nbsp;João Ricardo Sato ,&nbsp;Daniel Ciampi de Andrade","doi":"10.1016/j.neucli.2025.103056","DOIUrl":"10.1016/j.neucli.2025.103056","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>The activity profile of the posterior insula in neuropathic pain (NeP) remains largely unexplored. To address this and examine its modulation by somatosensory stimulation, we recorded local field potentials (LFP) in awake patients with NeP undergoing deep brain stimulation (DBS) electrode implantation to the posterior-superior insula (PSI) for analgesic purposes.</div></div><div><h3>Materials and Methods</h3><div>Six patients (one woman; 32–45 years), experiencing refractory peripheral NeP and having previously responded to non-invasive stimulation of the PSI underwent stereotactic implantation of DBS electrodes to the PSI as part of a phase II clinical trial. The averaged power of frequencies of LFP and their peaks were calculated during rest and under thermal painful and mechanical non-painful stimulation.</div></div><div><h3>Results</h3><div>At rest, amplitude peaks within the delta (average min-max.: 2.2 Hz; 1.3–3.7) and theta (6.1 Hz, varying between 5.7 and 6.8 Hz) bands were identified. Compared to rest, both tonic thermal painful, and mechanical non-painful stimulation led to similar mean decreases in gamma power (-24.46 ± 70.56, and -19.56 ± 3.08; respectively). Painful stimuli caused an increase in all the other frequency bands, mainly in alpha and beta ranges, while non-painful stimulation led to decreases in power in all frequencies above 4Hz. Painful tonic stimulation was associated with a significantly greater power variability, both in amplitude and frequency, compared to nonpainful mechanical stimulation.</div></div><div><h3>Conclusion</h3><div>The posterior insula resting state activity in awake patients with chronic NeP was characterized by predominant theta oscillations. Painful and innocuous stimulation led to opposite spectral changes, with a much larger variability across the whole frequency spectrum for painful stimuli, relative to both resting state and non-painful stimulation.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 3","pages":"Article 103056"},"PeriodicalIF":2.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}