Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"A computational analysis of transcranial magnetic stimulation in patients with cranial defects and skull plate implants","authors":"Minmin Wang ,&nbsp;Li Zhang","doi":"10.1016/j.neucli.2023.102916","DOIUrl":"10.1016/j.neucli.2023.102916","url":null,"abstract":"<div><p>We utilized computational analysis to investigate the impact of skull defects and skull implants on the TMS-induced EF. Our findings revealed a noteworthy alteration in the induced EF when acute skull defects were present. When high-conductivity titanium plates were used, we observed a pronounced increase in the peak EF, accompanied by a shift in the induced EF from the center towards both ends of the implant. These findings underscore the importance of carefully considering skull defects and implant materials during TMS.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102916"},"PeriodicalIF":3.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71484155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudoscan as substitute for quantitative sudomotor axon reflex test in composite autonomic scoring scale and its correlation with composite autonomic symptom scale 31 in type 2 diabetes","authors":"Chih-Cheng Huang ,&nbsp;Yun-Ru Lai ,&nbsp;Ben-Chung Cheng ,&nbsp;Wen-Chan Chiu ,&nbsp;Ting Yin Lin ,&nbsp;Hui Ching Chiang ,&nbsp;Chun-En Aurea Kuo ,&nbsp;Cheng-Hsien Lu","doi":"10.1016/j.neucli.2023.102915","DOIUrl":"10.1016/j.neucli.2023.102915","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to evaluate the feasibility of substituting electrochemical skin conductance measurement using SUDOSCAN for sudomotor function testing in the Composite Autonomic Scoring Scale (CASS) and to correlate the results with the Composite Autonomic Symptom Scale 31 (COMPASS 31) among patients with type 2 diabetes mellitus (T2DM).</p></div><div><h3>Methods</h3><p>Fifty patients with T2DM underwent cardiovascular autonomic function testing and the SUDOSCAN test and completed the COMPASS 31 questionnaire. We developed a SUDOSCAN-based sudomotor subscore as a substitute for the original sudomotor subscore (based on the quantitative sudomotor axon reflex test [QSART]). The modified CASS score (SUDOSCAN-based sudomotor subscore combined with the adrenergic and cardiovagal subscores) and the original CASS score without suomotor assessment (sum of the adrenergic and cardiovagal subscores) were obtained according to the results of the cardiovascular autonomic function and SUDOSCAN tests.</p></div><div><h3>Results</h3><p>The total COMPASS 31 score was significantly correlated with the modified CASS score (<em>p</em> = 0.019 and 0.037 for the raw and weighted scores, respectively) but not with the CASS score without sudomotor assessment. After adding the SUDOSCAN-based sudomotor subscore, the number of patients identified as having diabetic autonomic neuropathy (DAN) increased from 24 (48 %, based on the CASS score without sudomotor assessment) to 35 (70 %, based on the modified CASS score). The modified CASS score enhances the accuracy of assessing autonomic function and improves the diagnosis of diabetic autonomic neuropathy (DAN) among patients with T2DM. In medical settings where QSART is not accessible, SUDOSCAN testing offers a practical and efficient alternative.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102915"},"PeriodicalIF":3.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71484156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iatrogenic encephalopathies are not so rare in psychiatry: A retrospective study about 5217 EEG examinations","authors":"Manuel Dias Alves ,&nbsp;Jean Vion-Dury","doi":"10.1016/j.neucli.2023.102897","DOIUrl":"10.1016/j.neucli.2023.102897","url":null,"abstract":"<div><h3>Objectives</h3><p>Encephalopathy is a severe pathological process induced by multiple factors, which is typically associated with electroencephalogram (EEG) abnormalities. Early diagnosis, management, and treatment improve the patient's prognosis. Psychotropic treatments are a risk for drug-induced encephalopathies. In this study, the prevalence of encephalopathies in a psychiatric hospital has been studied for 5 years (2012 to 2016) using 5217 EEG records.</p></div><div><h3>Methods</h3><p>EEGs were performed i) systematically on patient admission, ii) in response to inexplicable modifications of consciousness or behavior, or when metabolic anomalies occurred, and iii) to perform therapeutic monitoring in outpatient consultations. When encephalopathy was suspected, the clinical data (age, sex and concomitant treatment) and biological data (plasma levels of medications) were collected.</p></div><div><h3>Results</h3><p>Encephalopathy was suspected in 189 patients. Following EEG examination, and monitoring of clinical course, encephalopathy was subsequently determined to be highly probable for 52 patients, (giving a prevalence of 1% per year), and low suspicion of encephalopathy in the other 137 patients. The suspicion of encephalopathy was made on both clinical (n=28) and non-clinical (n=24) signs. Involved drugs were mainly valproic acid (n=14), lithium (n=11) and clozapine (n=11) in the highly probable encephalopathy group.</p></div><div><h3>Conclusions</h3><p>Our study demonstrates the importance of EEG in the diagnosis and monitoring of encephalopathies in a psychiatric hospital. Clinical symptoms of encephalopathies are polymorphic and sometimes atypical. This diagnosis is underestimated in a context where behavior or consciousness disorders are generally not attributed to psychotropic drugs used in psychiatry.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 5","pages":"Article 102897"},"PeriodicalIF":3.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased theta-low gamma phase-amplitude coupling in resting electroencephalography after intermittent theta burst stimulation","authors":"Jie Zhang ,&nbsp;Chunwei Ying ,&nbsp;Zhenying Qian ,&nbsp;Xiong Jiao ,&nbsp;Xiaochen Tang ,&nbsp;Gai Kong ,&nbsp;Junfeng Sun ,&nbsp;Jijun Wang ,&nbsp;Yingying Tang","doi":"10.1016/j.neucli.2023.102899","DOIUrl":"10.1016/j.neucli.2023.102899","url":null,"abstract":"<div><h3>Objective</h3><p>Intermittent theta burst stimulation (iTBS) is based on the phase-amplitude coupling (PAC) pattern. We aimed to investigate the effect of iTBS on PAC in resting electroencephalography (EEG), which may provide insight into the underlying mechanism.</p></div><div><h3>Methods</h3><p>Twenty-one healthy volunteers were recruited and received both active and sham neuroimaging-guided iTBS on two separate days, which was precisely delivered to the right superior temporal gyrus. On each experimental day, resting EEG was recorded before and after stimulation for each participant. PACs across electrodes and frequency bands were calculated and compared to investigate the effect of iTBS.</p></div><div><h3>Results</h3><p>Theta (4–6 Hz) -low gamma (45–55 Hz) PAC over the stimulation site had a significant interaction effect, which increased after the active iTBS but did not differ after the sham iTBS. No significant interaction effect occurred in other cross-frequency couplings such as delta-low gamma, alpha-low gamma, delta-high gamma, theta-high gamma, or alpha-high gamma PAC in the region of interest.</p></div><div><h3>Conclusion</h3><p>iTBS selectively modulated theta-low gamma PAC at the stimulation area, which exhibited both region- and frequency- specificity. This suggests that PAC may be a bridge connecting external neuromodulation to internal neuroplasticity.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 5","pages":"Article 102899"},"PeriodicalIF":3.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of hypercortisolism on the frequency and magnitude of sleep EEG waves in patients with Cushing syndrome: A spectral analysis study","authors":"Duygu Kurt Gok ,&nbsp;Sevda İsmailogullari ,&nbsp;Ramazan Aldemir ,&nbsp;Mahmut Tokmakci ,&nbsp;Sedat Tarik Firat ,&nbsp;Zuleyha Karaca ,&nbsp;Fahrettin Kelestimur ,&nbsp;Gokmen Zararsiz","doi":"10.1016/j.neucli.2023.102893","DOIUrl":"10.1016/j.neucli.2023.102893","url":null,"abstract":"<div><h3>Objectives</h3><p>Our aim was to investigate the effects of endogenous chronic hypercortisolism on sleep electroencephalogram (EEG) and differences between the adrenocorticotropic hormone (ACTH)-dependent and independent Cushing Syndrome (CS) patients through a sleep spectral analysis program.</p></div><div><h3>Methods</h3><p>A total of 32 patients diagnosed as having endogenous CS (12 ACTH-dependent and 20 ACTH-independent) and a control group comprising 16 healthy individuals were included in the study. Polysomnographic analysis was performed. Blood samples were collected at 08:00 AM for analysis of ACTH and basal cortisol, and at 00:00 AM for midnight cortisol levels. The frequency and power of the slow wave activity (SWA), theta, alpha, and beta waves of the first and last non-rapid eye movement (NREM) cycles were measured with a spectral analysis program.</p></div><div><h3>Results</h3><p>The CS patient group had higher SWA power, especially in the first NREM cycle. In the ACTH-dependent group, SWA maximum and mean power values were higher in the frontal channels in the first NREM, compared to the last NREM sleep stage (<em>p</em>&lt;0.05).</p></div><div><h3>Conclusion</h3><p>Cortisol has been found to be associated with SWA waves, making these waves higher in power, especially in the first NREM phase. This difference was much less pronounced in the final NREM sleep stage. The difference between the first and last NREM sleep stages with respect to the power of SWA in the frontal channel in the ACTH-dependent group suggests that not only cortisol but also high levels of ACTH affect the power of slow waves during sleep.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 5","pages":"Article 102893"},"PeriodicalIF":3.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10128624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Patient State Index a reliable parameter as guide to anaesthesiology in cranial neurosurgery? A first intraoperative study and a literature review","authors":"Riccardo Carrai ,&nbsp;Cristiana Martinelli ,&nbsp;Fabrizio Baldanzi ,&nbsp;Simonetta Gabbanini ,&nbsp;Camilla Bonaudo ,&nbsp;Agnese Pedone ,&nbsp;Capelli Federico ,&nbsp;Riccardo Caramelli ,&nbsp;Maddalena Spalletti ,&nbsp;Francesco Lolli ,&nbsp;Antonello Grippo ,&nbsp;Luca Bucciardini ,&nbsp;Alessandro Della Puppa ,&nbsp;Tommaso Agostino Ninone ,&nbsp;Andrea Amadori","doi":"10.1016/j.neucli.2023.102910","DOIUrl":"10.1016/j.neucli.2023.102910","url":null,"abstract":"<div><h3>Background</h3><p>Patient State Index (PSI) and Suppression Ratio (SR) are two indices calculated by quantitative analysis of EEG used to estimate the depth of anaesthesia but their validation in neurosurgery must be done. Our aim was to investigate the congruity PSI and SR with raw EEG monitoring in neurosurgery.</p></div><div><h3>Methods</h3><p>We included 34 patients undergoing elective cranial neurosurgery. Each patient was monitored by a SedLine device (PSI and SR) and by raw EEG. To appraise the agreement between PSI, SR and EEG Suppr%, Bland-Altman analysis was used. We also correlated the PSI and SR recorded at different times during surgery to the degree of suppression of the raw EEG data by Spearman's rank correlation coefficient. For a comparison with previous data we made an international literature review according to PRISMA protocol.</p></div><div><h3>Results</h3><p>At all recording times, we found that there is a strong agreement between PSI and raw EEG. We also found a significant correlation for both PSI and SR with the EEG suppression percentage (<em>p</em> &lt; 0.05), but with a broad dispersion of the individual values within the confidence interval.</p></div><div><h3>Conclusion</h3><p>The Masimo SedLine processed EEG monitoring system can be used as a guide in the anaesthetic management of patients during elective cranial neurosurgery, but the anaesthesiologist must be aware that previous correlations between PSI and SR with the suppression percentage may not always be valid in all individual patients. The use of an extended visual raw EEG evaluated by an expert electroencephalographer might help to provide better guidance.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 5","pages":"Article 102910"},"PeriodicalIF":3.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71484154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with epilepsy without cognitive impairment show altered brain networks in multiple frequency bands in an audiovisual integration task","authors":"Yang Xi ,&nbsp;Zhu Lan ,&nbsp;Ying Chen ,&nbsp;Qiushi Zhang ,&nbsp;Zhenyu Wu ,&nbsp;Guangjian Li","doi":"10.1016/j.neucli.2023.102888","DOIUrl":"10.1016/j.neucli.2023.102888","url":null,"abstract":"<div><h3>Objectives</h3><p>Comorbid cognitive and behavioral deficits are often observed in patients with epilepsy. It is not clear whether the brain networks of patients with epilepsy without cognitive decline differs from that of healthy controls in different frequency bands in the task-state. The purpose of our study was to explore whether epilepsy affects the structure of brain networks associated with cognitive processing, even when patients with epilepsy do not have cognitive impairment.</p></div><div><h3>Methods</h3><p>We designed an audiovisual discrimination task and recorded electroencephalogram (EEG) data from healthy controls and patients with epilepsy. We established constructed time-varying brain networks across the delta, theta, alpha, and beta bands on the task-state EEG data during audiovisual integration processing.</p></div><div><h3>Results</h3><p>The results showed changes in the structure of the brain networks in the theta, alpha, and beta bands in patients with epilepsy who had no cognitive deficit. No significant difference in the connectivity strength, clustering coefficient, characteristic path length, or global efficiency was noted between patients and healthy controls. Moreover, the structure of brain networks in patients showed no correlation with the behavioral performance.</p></div><div><h3>Conclusion</h3><p>The repeated abnormal firing of neurons in the brain of patients with epilepsy may inhibit it from optimizing networks into more efficient structures. Epilepsy might affect decision-making ability by damaging the neural activity in the beta band and preventing its correlation with decision-making behaviors.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 5","pages":"Article 102888"},"PeriodicalIF":3.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10148874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural symphony of risky decision making in children with ADHD: Insights from transcranial alternating current stimulation and cognitive modeling","authors":"Vahid Nejati ,&nbsp;Zahra Famininejad ,&nbsp;Jamal Amani Rad","doi":"10.1016/j.neucli.2023.102898","DOIUrl":"10.1016/j.neucli.2023.102898","url":null,"abstract":"<div><h3>Background</h3><p>The ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) are key brain regions involved in risky decision making, affected in individuals with attention deficit hyperactivity disorder (ADHD). This study aims to examine how entrainment of these areas impacts the process and outcome of risky decision making in children with ADHD.</p></div><div><h3>Methods</h3><p>Eighteen children with ADHD performed the balloon analogue risk-taking task (BART) during five different sessions of tACS (1.5 mA, 6 Hz), separated by one-week intervals, via (1) two channels with synchronized stimulation over the left dlPFC and right vmPFC, (2) the same electrode placement with anti-phase stimulation, (3) stimulation over the left dlPFC only, (4) stimulation over right vmPFC only, and (5) sham stimulation. Four-parameter and constant-sensitivity models were used to model the data.</p></div><div><h3>Results</h3><p>The study showed that synchronized stimulation was associated with a reduction in positive prior belief, risk propensity, and deterministic selection. Desynchronized stimulation was associated with accelerated learning from initial selections. Isolated stimulation of the dlPFC leads to riskier decision enhanced learning updates and risk propensity, whereas isolated stimulation of the vmPFC facilitated faster learning and increased probabilistic selection.</p></div><div><h3>Conclusion</h3><p>The results highlight the important roles of the dlPFC and vmPFC and their communication in decision making, showcasing their impact on various aspects of the decision-making process. The findings provide valuable insights into the complex interplay between cognitive and emotional factors in shaping our choices.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 5","pages":"Article 102898"},"PeriodicalIF":3.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10137945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis","authors":"José Castro ,&nbsp;Michael Swash ,&nbsp;Mamede de Carvalho","doi":"10.1016/j.neucli.2022.102843","DOIUrl":"10.1016/j.neucli.2022.102843","url":null,"abstract":"<div><h3>Objectives</h3><p>We investigated the cutaneous silent period (CutSP) as a measure of upper motor neuron (UMN) dysfunction in amyotrophic lateral sclerosis.</p></div><div><h3>Methods</h3><p>The onset latency, duration, and amount of EMG suppression of the CutSP were compared with clinical UMN signs in 24 patients with amyotrophic lateral sclerosis (ALS). UMN signs were quantified using a clinical index and transcranial magnetic stimulation (TMS). Central motor conduction time (CMCT), cortical motor threshold and motor evoked potential amplitudes were assessed as measures of UMN dysfunction. CutSP was studied in abductor digit minimi (ADM) and tibialis anterior (TA) EMG recordings following stimulation of the 5th finger and sural nerves respectively. Non-parametric tests and binomial logistic regression were applied to evaluate the data.</p></div><div><h3>Results</h3><p>CutSP onset latency was increased in ALS patients, compared to healthy controls, both for ADM and TA muscles. In limbs with clinical UMN signs or abnormal TMS findings, the CutSP onset latency was particularly increased. There was a significant positive correlation between CutSP onset latency and the UMN score in both upper and lower limbs. In TA muscles there was also a negative correlation between CutSP onset latency and EMG suppression. The logistic regression model based on CutSP parameters correctly classified more than 70% of the cases regarding the presence of clinical signs of UMN lesion, in both upper and lower limbs. The results were not significant for TMS.</p></div><div><h3>Conclusion</h3><p>We conclude that upper limb CutSP changes associates with UMN lesion in ALS. This neurophysiological measurement merits further investigation in ALS.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 4","pages":"Article 102843"},"PeriodicalIF":3.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10591494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromuscular fatigue in autoimmune myasthenia gravis: A cross-sectional study","authors":"Simone Birnbaum ,&nbsp;Tarek Sharshar ,&nbsp;Jacques Ropers ,&nbsp;Pierre Portero ,&nbsp;Jean-Yves Hogrel","doi":"10.1016/j.neucli.2023.102844","DOIUrl":"10.1016/j.neucli.2023.102844","url":null,"abstract":"<div><h3>Objectives</h3><p>To investigate the presence of increased neuromuscular fatigue (NMF) in individuals with myasthenia gravis (IwMG), compared to healthy controls. A secondary aim was to assess associations between NMF, strength and perceived health-related quality of life (HRQoL) and symptom severity in IwMG.</p></div><div><h3>Methods</h3><p>In this cross-sectional study, we assessed NMF using classical myoelectrical indicators (root mean square: RMS, mean power frequency: MPF) obtained from surface electromyography (sEMG) during a sustained submaximal isometric contraction of the right Biceps Brachii and the right Vastus Lateralis and by evaluating the post-effort decline in peak torque following a fatiguing task consisting of a 40-second sustained isometric contraction. Relationships with MG-specific clinical scores (Myasthenia Muscle Score for symptom severity, MGQOL-15-F for HRQoL) were investigated.</p></div><div><h3>Results</h3><p>Forty-one females with MG were compared to 18 control females of similar age. IwMG demonstrated reduced strength in both muscle groups, compared to control subjects. In both populations and both limbs, NMF was demonstrated by an increase in RMS and a decrease in MPF. However, IwMG did not demonstrate greater NMF based on these myoelectrical indicators nor based on post-effort peak torque decline.</p></div><div><h3>Discussion</h3><p>Despite a decrease in baseline strength, IwMG did not display greater NMF in this specific experimental paradigm. This cohort consisted of individuals with mild-to-moderately severe MG which was well-controlled and stable. Further studies are warranted to identify simple and reliable methods to measure NMF in MG and to understand the relationship between NMF and perceived fatigue in activities of daily living for IwMG.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 4","pages":"Article 102844"},"PeriodicalIF":3.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10777349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}