Neurology International最新文献_第6页

Dynamics in Redox-Active Molecules Following Ischemic Preconditioning in the Brain 脑缺血预处理后氧化还原活性分子的动态变化

IF 3

Neurology International Pub Date : 2024-05-09 DOI: 10.3390/neurolint16030040

T. Lysikova, A. Tomašcová, M. Kovalska, J. Lehotský, Katarina Leskova Majdova, Peter Kaplán, Z. Tatarkova

{"title":"Dynamics in Redox-Active Molecules Following Ischemic Preconditioning in the Brain","authors":"T. Lysikova, A. Tomašcová, M. Kovalska, J. Lehotský, Katarina Leskova Majdova, Peter Kaplán, Z. Tatarkova","doi":"10.3390/neurolint16030040","DOIUrl":"https://doi.org/10.3390/neurolint16030040","url":null,"abstract":"It is well known that the brain is quite vulnerable to oxidative stress, initiating neuronal loss after ischemia-reperfusion (IR) injury. A potent protective mechanism is ischemic preconditioning (IPC), where proteins are among the primary targets. This study explores redox-active proteins’ role in preserving energy supply. Adult rats were divided into the control, IR, and IPC groups. Protein profiling was conducted to identify modified proteins and then verified through activity assays, immunoblot, and immunohistochemical analyses. IPC protected cortex mitochondria, as evidenced by a 2.26-fold increase in superoxide dismutase (SOD) activity. Additionally, stable core subunits of respiratory chain complexes ensured sufficient energy production, supported by a 16.6% increase in ATP synthase activity. In hippocampal cells, IPC led to the downregulation of energy-related dehydrogenases, while a significantly higher level of peroxiredoxin 6 (PRX6) was observed. Notably, IPC significantly enhanced glutathione reductase activity to provide sufficient glutathione to maintain PRX6 function. Astrocytes may mobilize PRX6 to protect neurons during initial ischemic events, by decreased PRX6 positivity in astrocytes, accompanied by an increase in neurons following both IR injury and IPC. Maintained redox signaling via astrocyte-neuron communication triggers IPC’s protective state. The partnership among PRX6, SOD, and glutathione reductase appears essential in safeguarding and stabilizing the hippocampus.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive Sleep Apnea in Pregnancy: A Comprehensive Review of Maternal and Fetal Implications 妊娠期阻塞性睡眠呼吸暂停：母体和胎儿影响的全面回顾

IF 3

Neurology International Pub Date : 2024-05-07 DOI: 10.3390/neurolint16030039

A. Maniaci, L. La Via, B. Pecorino, Benito Chiofalo, G. Scibilia, Salvatore Lavalle, P. Scollo

{"title":"Obstructive Sleep Apnea in Pregnancy: A Comprehensive Review of Maternal and Fetal Implications","authors":"A. Maniaci, L. La Via, B. Pecorino, Benito Chiofalo, G. Scibilia, Salvatore Lavalle, P. Scollo","doi":"10.3390/neurolint16030039","DOIUrl":"https://doi.org/10.3390/neurolint16030039","url":null,"abstract":"Obstructive sleep apnea (OSA) is a prevalent yet underdiagnosed condition in pregnancy, associated with various maternal and fetal complications. This review synthesizes the current evidence on the epidemiology, pathophysiology, and neurological consequences of OSA in pregnancy, along with the potential management strategies. Articles were sourced from the PubMed, EMBASE, and Cochrane databases until 2023. Our comprehensive review highlights that the incidence of OSA increases during pregnancy due to physiological changes such as weight gain and hormonal fluctuations. OSA in pregnancy is linked with gestational hypertension, pre-eclampsia, gestational diabetes, and potential adverse fetal outcomes such as intrauterine growth restriction and preterm birth. Continuous positive airway pressure (CPAP) therapy remains the most effective management strategy for pregnant women with OSA. However, adherence to CPAP therapy is often suboptimal. This comprehensive review underscores the importance of the early recognition, timely diagnosis, and effective management of OSA in pregnancy to improve both maternal and fetal outcomes. Future research should focus on enhancing screening strategies and improving adherence to CPAP therapy in this population.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Szymanowicz et al. Headache and NOTCH3 Gene Variants in Patients with CADASIL. Neurol. Int. 2023, 15, 1238–1252 更正：Szymanowicz等：《CADASIL患者的头痛和NOTCH3基因变异》。Neurol.2023, 15, 1238-1252

IF 3

Neurology International Pub Date : 2024-05-06 DOI: 10.3390/neurolint16030038

Oliwia Szymanowicz, Izabela Korczowska-Łącka, B. Słowikowski, Małgorzata Wiszniewska, Ada Piotrowska, Ulyana Goutor, Paweł P. Jagodziński, W. Kozubski, J. Dorszewska

引用次数: 0

Oxidative Stress and Neurodegeneration: Insights and Therapeutic Strategies for Parkinson's Disease. 氧化应激与神经退行性变：帕金森病的见解和治疗策略》。

IF 3

Neurology International Pub Date : 2024-04-29 DOI: 10.3390/neurolint16030037

Erjola Bej, Patrizia Cesare, Anna Rita Volpe, Michele d'Angelo, Vanessa Castelli

引用次数: 0

Pain Catastrophizing: How Far Have We Come. 疼痛灾难化：我们已经走了多远

IF 3

Neurology International Pub Date : 2024-04-26 DOI: 10.3390/neurolint16030036

Katarina Simic, Boris Savic, Nebojsa Nick Knezevic

{"title":"Pain Catastrophizing: How Far Have We Come.","authors":"Katarina Simic, Boris Savic, Nebojsa Nick Knezevic","doi":"10.3390/neurolint16030036","DOIUrl":"10.3390/neurolint16030036","url":null,"abstract":"The perception of pain is strongly influenced by various social, emotional, and cognitive factors. A psychological variable which has consistently been shown to exert its influence on pain is a cognitive process referred to as pain catastrophizing. Numerous studies have found it to be a strong predictor of pain intensity and disability across different clinical populations. It signifies a maladaptive response to pain marked by an exaggerated negative assessment, magnification of symptoms related to pain, and, in general, a tendency to experience marked pain-related worry, as well as experiencing feelings of helplessness when it comes to dealing with pain. Pain catastrophizing has been correlated to many adverse pain-related outcomes, including poor treatment response, unsatisfactory quality of life, and high disability related to both acute and chronic pain. Furthermore, there has been consistent evidence in support of a correlation between pain catastrophizing and mental health disorders, such as anxiety and depression. In this review, we aim to provide a comprehensive overview of the current state of knowledge regarding pain catastrophizing, with special emphasis on its clinical significance, and emerging treatment modalities which target it.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Extensive Study Regarding the Microscopic Anatomy of the Early Fetal Human Optic Nerve. 关于人类胎儿早期视神经显微解剖的广泛研究

IF 3

Neurology International Pub Date : 2024-04-24 DOI: 10.3390/neurolint16030035

Mihai Alin Publik, Florin Mihail Filipoiu, Adrian Vasile Dumitru, Andrei Precup, Ioan-Andrei Petrescu, Iulian Slavu, Raluca Florentina Tulin, Adrian Tulin, Andra Ioana Baloiu, Monica Mihaela Cirstoiu, Octavian Munteanu

{"title":"An Extensive Study Regarding the Microscopic Anatomy of the Early Fetal Human Optic Nerve.","authors":"Mihai Alin Publik, Florin Mihail Filipoiu, Adrian Vasile Dumitru, Andrei Precup, Ioan-Andrei Petrescu, Iulian Slavu, Raluca Florentina Tulin, Adrian Tulin, Andra Ioana Baloiu, Monica Mihaela Cirstoiu, Octavian Munteanu","doi":"10.3390/neurolint16030035","DOIUrl":"10.3390/neurolint16030035","url":null,"abstract":"The development of the optic nerve and its surrounding tissues during the early fetal period is a convoluted period because it spans both the organogenesis period and the fetal period. This study details the microscopic anatomy and histoembryology of the optic nerve in embryos during the early fetal period, including the second half of the first trimester of pregnancy. Serial sections through the orbit of variously aged embryos allowed us to analyze the nerve in both longitudinal and transverse aspects. A histological assessment and description of the structures surrounding and inside the nerve were performed, highlighting the cellular subtypes involved. By employing immunohistochemical techniques, we could characterize the presence and distribution of astrocytes within the optic nerve. Our findings suggest that by the 8th gestational week (WG) the structures are homologs to all the adult ones but with an early appearance so that maturation processes take place afterward. By this age, the axons forming the nerve are definitive adult axons. The glial cells do not yet exhibit adult phenotype, but their aspect becomes adult toward the 13th week. During its development the optic nerve increases in size then, at 14 weeks, it shrinks considerably, possibly through its neural maturation process. The morphological primordium of the blood-nerve barrier can be first noted at 10 WG and at 13 WG the morphological blood-nerve barrier is definitive. The meningeal primordium can be first noted as a layer of agglomerated fibroblasts, later toward 13 WG splitting in pachymeninx and leptomeninges and leaving space for intrinsic blood vessels.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Acute Postoperative Pain in Developing Chronic Pain after Total Knee Arthroplasty. 全膝关节置换术后急性疼痛对形成慢性疼痛的影响

IF 3

Neurology International Pub Date : 2024-04-18 DOI: 10.3390/neurolint16020034

N. Knezevic, Osman Syed, Christopher Kabir, Aisha Patel, Isabel Rao Shuai, Antony R. Tharian

{"title":"The Impact of Acute Postoperative Pain in Developing Chronic Pain after Total Knee Arthroplasty.","authors":"N. Knezevic, Osman Syed, Christopher Kabir, Aisha Patel, Isabel Rao Shuai, Antony R. Tharian","doi":"10.3390/neurolint16020034","DOIUrl":"https://doi.org/10.3390/neurolint16020034","url":null,"abstract":"While total knee arthroplasties (TKAs) are performed with the intent to reduce pain, chronic postsurgical pain (CPSP) is one of the most well-documented complications that can occur following surgery. This study aimed to assess whether perioperative factors, focusing on acute postsurgical pain and perioperative opioid consumption, were associated with the development of chronic postsurgical pain. Under general anesthesia, 108 patients underwent TKA and were treated postoperatively with a multimodal analgesia approach. Numeric Rating Scale (NRS) pain scores at rest and with movement were recorded on postoperative days 0-3, 7, 14, and 30. Patients were sent a survey to assess chronic pain at months 22-66, which was examined as a single-group post hoc analysis. Based on the responses, patients were either classified into the CPSP or non-CPSP patient group. Chronic postsurgical pain was defined as an NRS score ≥ 4 with movement and the presence of resting pain. The primary outcome was a change in NRS. There were no differences in NRS pain scores with movement in the first 30 days postoperatively between patients with CPSP and without CPSP. Each unit increase in resting pain on postoperative days 3 and 14 was associated with significantly greater odds of CPSP presence (OR = 1.52; OR = 1.61, respectively), with a trend towards greater odds of CPSP at days 7 and 30 (OR = 1.33; OR = 1.43, respectively). We found that very intense pain in the initial phase seems to be related to the development of CPSP after TKA.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140687142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thecaloscopy Reduces the Risk of Recurrent Perineural (Tarlov) Cysts after Microsurgical Resection. 膀胱镜检查可降低显微外科切除术后复发会阴（Tarlov）囊肿的风险。

IF 3

Neurology International Pub Date : 2024-04-17 DOI: 10.3390/neurolint16020033

M. Luchtmann, A. Klammer, Mircea-Alin Iova, André Roth, Vijay Kumar Chanamolu, C. Mawrin, J. Warnke

{"title":"Thecaloscopy Reduces the Risk of Recurrent Perineural (Tarlov) Cysts after Microsurgical Resection.","authors":"M. Luchtmann, A. Klammer, Mircea-Alin Iova, André Roth, Vijay Kumar Chanamolu, C. Mawrin, J. Warnke","doi":"10.3390/neurolint16020033","DOIUrl":"https://doi.org/10.3390/neurolint16020033","url":null,"abstract":"Sacral Tarlov cysts (TCs), often asymptomatic, can cause significant pain and severe neurological dysfunction. Conventional treatments are generally associated with high recurrence and complication rates. Specifically, the substantial recurrence rates, which can reach as high as 50%, significantly impact long-term outcomes. Recent evidence increasingly supports the hypothesis that the formation of Tarlov cysts (TCs) may be associated with inflammatory processes within the nerve root sheath, further exacerbated by elevated cerebrospinal fluid (CSF) pressure. This retrospective study explores thecaloscopy, combined with surgical techniques, as a more effective alternative. We observed a total of 78 patients, 48 of whom underwent endoscopic fenestration of the arachnoid sheath in addition to microsurgical resection of the TC. We found that the fenestration of the arachnoid sheath at the level of lumbosacral spinal nerve root entry led to a significantly decreased risk of developing recurrent TCs (5/48 vs. 9/30). Only one of the patients suffered from a persistent new bladder dysfunction after microsurgical resection. This presented technique provides a promising treatment path for the future management of TCs, offering a safe and more effective treatment option compared to previous methods. Additionally, the advantages of the thecaloscopy provide pathophysiological implications regarding the development of perineural cysts.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurocognitive Impairment and Social Cognition in Parkinson's Disease Patients. 帕金森病患者的神经认知障碍和社交认知。

IF 3

Neurology International Pub Date : 2024-04-16 DOI: 10.3390/neurolint16020032

T. Doskas, Konstantinos Vadikolias, Konstantinos T. Ntoskas, George D. Vavougios, D. Tsiptsios, Polyxeni Stamati, Ioannis Liampas, V. Siokas, L. Messinis, G. Nasios, E. Dardiotis

{"title":"Neurocognitive Impairment and Social Cognition in Parkinson's Disease Patients.","authors":"T. Doskas, Konstantinos Vadikolias, Konstantinos T. Ntoskas, George D. Vavougios, D. Tsiptsios, Polyxeni Stamati, Ioannis Liampas, V. Siokas, L. Messinis, G. Nasios, E. Dardiotis","doi":"10.3390/neurolint16020032","DOIUrl":"https://doi.org/10.3390/neurolint16020032","url":null,"abstract":"In addition to motor symptoms, neurocognitive impairment (NCI) affects patients with prodromal Parkinson's disease (PD). NCI in PD ranges from subjective cognitive complaints to dementia. The purpose of this review is to present the available evidence of NCI in PD and highlight the heterogeneity of NCI phenotypes as well as the range of factors that contribute to NCI onset and progression. A review of publications related to NCI in PD up to March 2023 was performed using PubMed/Medline. There is an interconnection between the neurocognitive and motor symptoms of the disease, suggesting a common underlying pathophysiology as well as an interconnection between NCI and non-motor symptoms, such as mood disorders, which may contribute to confounding NCI. Motor and non-motor symptom evaluation could be used prognostically for NCI onset and progression in combination with imaging, laboratory, and genetic data. Additionally, the implications of NCI on the social cognition of afflicted patients warrant its prompt management. The etiology of NCI onset and its progression in PD is multifactorial and its effects are equally grave as the motor effects. This review highlights the importance of the prompt identification of subjective cognitive complaints in PD patients and NCI management.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[125I]IPC-Lecanemab: Synthesis and Evaluation of Aβ-Plaque-Binding Antibody and Comparison with Small-Molecule [18F]Flotaza and [125I]IBETA in Postmortem Human Alzheimer's Disease. [125I]IPC-Lecanemab：Aβ-Plaque 结合型抗体的合成与评估，以及与小分子 [18F]Flotaza 和 [125I]IBETA 在死后人类阿尔茨海默病中的比较。

IF 3

Neurology International Pub Date : 2024-04-08 DOI: 10.3390/neurolint16020031

Christopher Liang, Cayz G. Paclibar, Noresa L. Gonzaga, Stephanie A. Sison, Harman S. Bath, Agnes P. Biju, Jogeshwar Mukherjee

{"title":"[125I]IPC-Lecanemab: Synthesis and Evaluation of Aβ-Plaque-Binding Antibody and Comparison with Small-Molecule [18F]Flotaza and [125I]IBETA in Postmortem Human Alzheimer's Disease.","authors":"Christopher Liang, Cayz G. Paclibar, Noresa L. Gonzaga, Stephanie A. Sison, Harman S. Bath, Agnes P. Biju, Jogeshwar Mukherjee","doi":"10.3390/neurolint16020031","DOIUrl":"https://doi.org/10.3390/neurolint16020031","url":null,"abstract":"Therapeutic antibodies for reducing Aβ plaque load in Alzheimer's disease (AD) is currently making rapid progress. The diagnostic imaging of Aβ plaque load in AD has been underway and is now used in clinical studies. Here, we report our preliminary findings on imaging a therapeutic antibody, Lecanemab, in a postmortem AD brain anterior cingulate. [125I]5-iodo-3-pyridinecarboxamido-Lecanemab ([125I]IPC-Lecanemab) was prepared by coupling N-succinimidyl-5-([125I]iodo)-3-pyridinecarboxylate with Lecanemab in modest yields. The distinct binding of [125I]IPC-Lecanemab to Aβ-rich regions in postmortem human AD brains was higher in grey matter (GM) containing Aβ plaques compared to white matter (WM) (GM/WM was 1.6). Anti-Aβ immunostaining was correlated with [125I]IPC-Lecanemab regional binding in the postmortem AD human brains. [125I]IPC-Lecanemab binding was consistent with the binding of Aβ small molecules, [18F]flotaza and [125I]IBETA, in the same subjects. [18F]Flotaza and [125I]IBETA, however, exhibited significantly higher GM/WM ratios (>20) compared to [125I]IPC-Lecanemab. Our results suggest that radiolabeled [125I]IPC-Lecanemab retains the ability to bind to Aβ in human AD and may therefore be useful as a PET imaging radiotracer when labeled as [124I]IPC-Lecanemab. The ability to directly visualize in vivo a promising therapeutic antibody for AD may be useful in treatment planning and dosing and could be complimentary to small-molecule diagnostic imaging to assess outcomes of therapeutic interventions.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0