Neurology Research International最新文献_第2页

Heart Failure Status among Acute Ischemic Stroke Patients: A Hospital-Based Study. 急性缺血性脑卒中患者心衰状况:一项基于医院的研究

IF 1.5

Neurology Research International Pub Date : 2022-08-24 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7348505

Fatemeh Ravandi, Arsh Haj Mohamad Ebrahim Ketabforoush, Fereshteh Azedi, Mohsen Hoshyarkhani, Farimah Fayyaz, Nahid Abbasi Khoshsirat

{"title":"Heart Failure Status among Acute Ischemic Stroke Patients: A Hospital-Based Study.","authors":"Fatemeh Ravandi, Arsh Haj Mohamad Ebrahim Ketabforoush, Fereshteh Azedi, Mohsen Hoshyarkhani, Farimah Fayyaz, Nahid Abbasi Khoshsirat","doi":"10.1155/2022/7348505","DOIUrl":"https://doi.org/10.1155/2022/7348505","url":null,"abstract":"Background: Since heart failure (HF) and ischemic stroke have common risk factors, their concurrent occurrence is likely. Strokes in HF patients could be life-threatening and lead to severe disabilities, longer hospitalization time, and mortality. The present study aims to investigate the prevalence of HF and its severity based on ejection fraction (EF) in patients with acute ischemic stroke.Methods: The present cross-sectional study included acute ischemic stroke patients admitted to Shahid Rajaei hospital in Karaj in 2020-2021. The diagnosis of HF was based on transthoracic echocardiography within 48 hours of symptom onset, and HF was classified into two groups: 41-49% as mildly reduced EF (HFmrEF) and ≤40% as reduced EF (HFrEF). Patients who did not complete cardiac studies were excluded.Results: 257 acute ischemic stroke patients (62.6% male) were included. Among stroke patients, the prevalence of HF, including HFrEF and HFmrEF, was 30.0% (95% CI: 21.4-38.6). HFmrEF and HFrEF was diagnosed in 32 (12.5%) and 45 (17.5%) patients, respectively. HF was significantly associated with older age, hypertension, past myocardial infarction (MI), and arrhythmia. A history of previous MI significantly increased the odds of heart failure (OR: 3.25, 95% CI: 1.82-5.81).Conclusion: There is a high prevalence of HF among acute ischemic stroke patients. Older patients with a history of hypertension and previous MI are at higher risk. Since patients with HF have a higher mortality and morbidity rate after experiencing an ischemic stroke, close cooperation between the neurology and cardiology specialists for providing advanced care for survivors is required.","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40349279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Analysis of Induced Field in the Brain Tissue by Transcranial Magnetic Stimulation Using Halo-V Assembly Coil. Halo-V组合线圈经颅磁刺激脑组织感应场分析。

IF 1.5

Neurology Research International Pub Date : 2022-07-14 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7424564

Khaleda Akhter Sathi, Md Kamal Hosain, Md Azad Hossain

{"title":"Analysis of Induced Field in the Brain Tissue by Transcranial Magnetic Stimulation Using Halo-V Assembly Coil.","authors":"Khaleda Akhter Sathi, Md Kamal Hosain, Md Azad Hossain","doi":"10.1155/2022/7424564","DOIUrl":"https://doi.org/10.1155/2022/7424564","url":null,"abstract":"As a noninvasive neuromodulation technique, transcranial magnetic stimulation (TMS) has already exhibited a great impact in clinical application and scientific research. This study presents a finite element method-based simulation of the Halo-V assembly (HVA) coil placed on the five-shell spherical human head model to examine the distributions of induced electric and magnetic fields. The performance of the designed HVA coil is evaluated by comparing the simulation results with the commercially available Halo-FO8 (HFA) assembly coil and standard single coils including the Halo and V coils. The simulation results indicate that the HVA coil shows an improved focality in terms of electric field distribution than the other single and assembly stimulation coils. Additionally, the effects of a magnetic shield plate and magnetic core on the designed HVA coil are investigated. Results indicate that the magnetic shield plate and magnetic core are proficient in further improving the stimulation focality. Therefore, the HVA TMS coil results in a safe and effective stimulation with enhanced focality of the target region as compared to the existing assembly coil.","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40534540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Association of Proning and Stroke among Deeply Sedated Critically Ill SARS-CoV-2 (COVID-19) Patients. 深度镇静危重SARS-CoV-2 (COVID-19)患者易感与卒中的关系

IF 1.5

Neurology Research International Pub Date : 2022-06-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6348888

Keith Moon Q Saberon, Jo-Ann Rosario Soliven

{"title":"The Association of Proning and Stroke among Deeply Sedated Critically Ill SARS-CoV-2 (COVID-19) Patients.","authors":"Keith Moon Q Saberon, Jo-Ann Rosario Soliven","doi":"10.1155/2022/6348888","DOIUrl":"https://doi.org/10.1155/2022/6348888","url":null,"abstract":"There has been an increasing incidence of stroke cases among SARS-CoV-2 (COVID-19) patients who were deeply sedated and underwent proning positioning. We reviewed the association of proning and sedations used to the development of stroke, including demographic profiles of patients with COVID-19 infection in the critical care unit. There was a significant association seen among COVID-19 patients in the ICU who underwent proning to the development of stroke, with up to 15 times risk of having stroke (p value = 0.007) than those who were not proned during their course of ICU stay. Patients who were given propofol and fentanyl as sedation during proning for more than 24 hours was significantly associated with the development of stroke (p value = 0.004). Patient risk factors were also studied (age variability, hypertension, diabetes, smoking, and alcoholism) and showed that patients who were alcoholic beverage drinkers were significantly associated to the development of stroke during proning (p value = <0.001). The usual risk factors for stroke in the general population (hypertension, diabetes, and cigarette smoking) were not associated with stroke development during proning, strengthening the fact that proning during COVID-19 infection is an independent risk factor for the development of stroke thus needing stroke surveillance during the duration of proning.","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40553254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Off-Label Drugs and Nutrition Supplements among Patients with Amyotrophic Lateral Sclerosis in Norway 挪威肌萎缩性侧索硬化症患者使用说明书外药物和营养补充剂

IF 1.5

Neurology Research International Pub Date : 2022-04-12 DOI: 10.1155/2022/1789946

Gard Aasmund Skulstad Johanson, O. Tysnes, T. Bjerknes

引用次数: 0

The Assessment of Knowledge about Tourette's Syndrome among Medical Students and Primary Physicians in Riyadh, Saudi Arabia: A Cross-Sectional Study 沙特阿拉伯利雅得医科学生和初级医生对妥瑞氏综合征知识的评估:一项横断面研究

IF 1.5

Neurology Research International Pub Date : 2022-02-28 DOI: 10.1155/2022/3018305

Anas A. Alalwan, Mohammad A. Alkhamis, A. Samman, Enan H. M. Alsharif, Omar E Tarabzoni, I. Khatri

{"title":"The Assessment of Knowledge about Tourette's Syndrome among Medical Students and Primary Physicians in Riyadh, Saudi Arabia: A Cross-Sectional Study","authors":"Anas A. Alalwan, Mohammad A. Alkhamis, A. Samman, Enan H. M. Alsharif, Omar E Tarabzoni, I. Khatri","doi":"10.1155/2022/3018305","DOIUrl":"https://doi.org/10.1155/2022/3018305","url":null,"abstract":"Background Tourette's syndrome (TS), a chronic, often disabling neuropsychiatric disorder characterized by motor and vocal tics, is frequently misdiagnosed, or patients are delayed in diagnosis. There is severe deficiency of research about Tourette's syndrome (TS) in the Middle East region. Objectives To evaluate the knowledge and attitude of medical students and primary care physicians (PCPs) about TS and tic disorders. Methods IRB approved, cross-sectional study. A total of 316 medical students of King Saud bin Abdulaziz University and 59 primary care physicians of Riyadh participated. Convenient, cluster sampling was used. A validated, self-administered questionnaire was used. Sum of all knowledge questions was calculated. Data were analyzed using SPSS software. Results Survey was completed by 375 students and physicians, of whom 253 (67.5%) were men. Mean general knowledge score was 61.5 (±12.04) out of 100. Majority (66.1%) knew the diagnostic criteria for TS; only 46.1% considered antipsychotics as effective treatment. Only 25.1% had ever heard of habit reversal; 70% wanted to learn more. Only 10% of physicians had treated a patient with TS. There was no difference in knowledge between men and women (p=0.776). Board-certified physicians had a higher knowledge score (p < 0.05). Family physicians demonstrated higher level of knowledge compared to other physicians (p < 0.05). There was no difference between knowledge of students of different years (p=0.859) or between students and physicians (p=0.569). Conclusion There was alarming lack of knowledge about Tourette syndrome at various level of medical training and practice including students and physicians. Those who achieved board certification and practiced as family physicians fared better in knowledge about Tourette's syndrome.","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79158056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Brain Connectivity and Network Analysis in Amyotrophic Lateral Sclerosis. 肌萎缩侧索硬化症的脑连通性和网络分析。

IF 1.5

Neurology Research International Pub Date : 2022-02-07 eCollection Date: 2022-01-01 DOI: 10.1155/2022/1838682

Vijay Renga

{"title":"Brain Connectivity and Network Analysis in Amyotrophic Lateral Sclerosis.","authors":"Vijay Renga","doi":"10.1155/2022/1838682","DOIUrl":"https://doi.org/10.1155/2022/1838682","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no effective treatment or cure. ALS is characterized by the death of lower motor neurons (LMNs) in the spinal cord and upper motor neurons (UMNs) in the brain and their networks. Since the lower motor neurons are under the control of UMN and the networks, cortical degeneration may play a vital role in the pathophysiology of ALS. These changes that are not apparent on routine imaging with CT scans or MRI brain can be identified using modalities such as diffusion tensor imaging, functional MRI, arterial spin labelling (ASL), electroencephalogram (EEG), magnetoencephalogram (MEG), functional near-infrared spectroscopy (fNIRS), and positron emission tomography (PET) scan. They can help us generate a representation of brain networks and connectivity that can be visualized and parsed out to characterize and quantify the underlying pathophysiology in ALS. In addition, network analysis using graph measures provides a novel way of understanding the complex network changes occurring in the brain. These have the potential to become biomarker for the diagnosis and treatment of ALS. This article is a systematic review and overview of the various connectivity and network-based studies in ALS.","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39809854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Determinants of Cerebral Palsy in Pediatric Patients in Northern Ethiopia: A Hospital-Based Study. 埃塞俄比亚北部儿童脑瘫的决定因素:一项基于医院的研究

IF 1.5

Neurology Research International Pub Date : 2021-12-20 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9993912

Peter E Ekanem, Anne C K Nyaga, Niguse Tsegay, Haftamu Ebuy, Elizabeth A Imbusi, Regina Ekanem, Nissi Peter

{"title":"Determinants of Cerebral Palsy in Pediatric Patients in Northern Ethiopia: A Hospital-Based Study.","authors":"Peter E Ekanem, Anne C K Nyaga, Niguse Tsegay, Haftamu Ebuy, Elizabeth A Imbusi, Regina Ekanem, Nissi Peter","doi":"10.1155/2021/9993912","DOIUrl":"https://doi.org/10.1155/2021/9993912","url":null,"abstract":"Introduction: Cerebral palsy is the most common neurologic disorder of childhood with lifelong implications in majority of patients. Knowledge of the determinants of cerebral palsy is important for accurate mobilization of resources in obstetric, perinatal, and infant care besides implementation of prevention systems. In Ethiopia, however, this knowledge gap exists as there are no published studies on determinants of cerebral palsy in the country.Objective: To assess the determinants of cerebral palsy in pediatric patients attending Ayder Comprehensive Specialized Referral Hospital between April 2019 and August 2019.Methods: An unmatched case-control study was conducted among 50 pediatric cerebral palsy patients and 100 controls, pediatric patients without cerebral palsy or other motor or central nervous system illnesses, attending Ayder Comprehensive Specialized Hospital, Mekelle, Ethiopia. The data were analyzed using SPSS version 27.Results: Significant factors were operative vaginal delivery (AOR: 9.49, 95% CI: 1.31-68.88), central nervous system infections (AOR: 0.02, 95% CI: 0-0.58), neonatal admissions (AOR: 0.13, 95% CI: 0.03-0.61), and unknown maternal education status (AOR: 18.64, 95% CI: 2.15-161.73).Conclusion: Operative vaginal delivery, central nervous system infections in infancy, neonatal hospital admissions, and unknown maternal education status were found to be significant determinants for cerebral palsy. This knowledge aids focused hospital and regional health bureau development and implementation of prevention strategies for cerebral palsy, besides improvement of obstetric and neonatal healthcare services, and provides baseline data to the scientific community for further research.","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39633219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Limb Muscle Reinnervation with the Nerve-Muscle-Endplate Grafting Technique: An Anatomical Feasibility Study. 采用神经-肌肉-终板移植技术进行肢体肌肉神经移植的解剖学可行性研究。

IF 1.5

Neurology Research International Pub Date : 2021-12-08 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6009342

Liancai Mu, Jingming Chen, Jing Li, Stanislaw Sobotka, Themba Nyirenda

{"title":"Limb Muscle Reinnervation with the Nerve-Muscle-Endplate Grafting Technique: An Anatomical Feasibility Study.","authors":"Liancai Mu, Jingming Chen, Jing Li, Stanislaw Sobotka, Themba Nyirenda","doi":"10.1155/2021/6009342","DOIUrl":"10.1155/2021/6009342","url":null,"abstract":"Background: Peroneal nerve injuries results in tibialis anterior (TA) muscle paralysis. TA paralysis could cause \"foot drop,\" a disabling condition that can make walking difficult. As current treatment methods result in poor functional recovery, novel treatment approaches need to be studied. The aim of this study was to explore anatomical feasibility of limb reinnervation with our recently developed nerve-muscle-endplate grafting (NMEG) in the native motor zone (NMZ).Methods: As the NMEG-NMZ technique involves in nerves and motor endplates (MEPs), the nerve supply patterns and locations of the MEP bands within the gastrocnemius (GM) and TA muscles of rats were investigated using Sihler's stain and whole-mount acetylcholinesterase (AChE) staining, respectively. Five adult rats underwent TA nerve transaction. The denervated TA was reinnervated by transferring an NMEG pedicle from the ipsilateral lateral GM. At the end of a 3-month recovery period, maximal muscle force was measured to document functional recovery.Results: The results showed that the TA was innervated by the deep peroneal nerve. A single MEP band was located obliquely in the middle of the TA. The GM was composed of two neuromuscular compartments, lateral (GM-l) and medial (GM-m), each of which was innervated by a separate nerve branch derived from the tibial nerve and had a vertically positioned MEP band. The locations of MEP bands in the GM and TA muscles and nerve supply patterns demonstrated that an NMEG pedicle can be harvested from the GM-l and implanted into the NMZ within the TA muscle. The NMEG-NMZ pilot study showed that this technique resulted in optimal muscle force recovery.Conclusion: NMEG-NMZ surgery is feasible for limb reinnervation. Specifically, the denervated TA caused by peroneal nerve injuries can be reinnervated with a NMEG from the GM-l.","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein. SP/NK1R系统通过抑制Glutaredoxin蛋白介导的GBM细胞ROS生成。

IF 1.5

Neurology Research International Pub Date : 2021-12-07 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9966000

Negeen Mehrabani, Mohammad Reza Vaezi Kakhki, Hossein Javid, Safieh Ebrahimi, Seyed Isaac Hashemy

{"title":"The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein.","authors":"Negeen Mehrabani, Mohammad Reza Vaezi Kakhki, Hossein Javid, Safieh Ebrahimi, Seyed Isaac Hashemy","doi":"10.1155/2021/9966000","DOIUrl":"https://doi.org/10.1155/2021/9966000","url":null,"abstract":"Altered redox balance is among the main contributing factors developing glioblastoma multiforme (GBM), a highly aggressive grade IV brain tumor. Neuropeptide substance P (SP) plays a key role in modifying the cellular redox environment by activating the neurokinin-1 receptor (NK1R). In this study, we aimed to investigate the redox-modulating properties of both SP and a commercially available NK1R antagonist, aprepitant in GBM cells. To detect the effect of aprepitant on the viability of U87 glioblastoma cells, resazurin assay was applied. The level of intracellular ROS was assessed using 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) assay. The expression of glutaredoxin, a well-known redox-active protein, was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Concurrently, the activity of glutaredoxin was also analyzed by a commercial kit (ZellBio GmbH). We found that SP increased the intracellular levels of reactive oxygen species (ROS) in U87 GBM cells, and aprepitant remarkably decreased this effect. We also explored the effects of SP/NK1R signaling on the glutaredoxin system as a major cellular redox buffer in GBM cells. SP reduced both expression and enzymatic activity of glutaredoxin, and these effects were significantly decreased by aprepitant. In conclusion, our results suggest a possible involvement of SP/NK1R signaling in GBM pathogenesis through oxidative stress and offering new insight for the application of aprepitant as a redox-modulating strategy in GBM patients.","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39845685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Investigation of the Possible Correlation between Idiopathic Parkinson's Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study. 埃及患者中特发性帕金森病与糖尿病之间可能存在的相关性调查：一项试点研究。

IF 1.5

Neurology Research International Pub Date : 2021-11-12 eCollection Date: 2021-01-01 DOI: 10.1155/2021/2838669

Afnan AwadAllah Elgnainy, Mohammad Ismail Hamed, Wael Osman Mohamed, Nagwa Ali Sabri

{"title":"Investigation of the Possible Correlation between Idiopathic Parkinson's Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study.","authors":"Afnan AwadAllah Elgnainy, Mohammad Ismail Hamed, Wael Osman Mohamed, Nagwa Ali Sabri","doi":"10.1155/2021/2838669","DOIUrl":"10.1155/2021/2838669","url":null,"abstract":"Objectives: To study the diabetes-Parkinson's disease (PD) linkage.Methods: The investigators recorded the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ) score for 60 diabetic patients: 30 patients were treated with metformin-inclusive sulfonylurea and 30 patients were treated with sulphonylurea(s) monotherapy and matched with 30 controls. We evaluated blood glucose kinetics during a 75 g oral glucose tolerance test for (22) nondiabetic parkinsonian patients and (10) controls. The motor complications scores were recorded for all parkinsonian patients using the relevant parts of the Unified Parkinson's Disease Rating Scale (UPDRS) part IV.Results: Diabetics recorded higher scores of RBDSQ than controls (p < 0.001), with no differences related to antidiabetic therapy. In nondiabetic PD patients, after oral glucose, blood glucose was significantly higher at T1 (p < 0.001) than controls. Moreover, the total area under the time curve for blood glucose levels was significantly higher in PD compared to controls (281.22 ± 52.25 vs. 245.65 ± 48.63 mg.hr./dL; p=0.013). Higher blood glucose levels were associated with motor abnormalities. Diabetic PD patients recorded higher scores of UPDRS (p < 0.001).Conclusion: Diabetes mellitus and Parkinson's disease are linked, which raises concerns about either of them, probably increasing the risk of the other. This trial is registered with NCT03685357.","PeriodicalId":19124,"journal":{"name":"Neurology Research International","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39643941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0