Neurobehavioral toxicology and teratology最新文献_第4页

Effects of intraperitoneal carbon disulfide on sensory-evoked potentials of Fischer-344 rats. 腹腔注射二硫化碳对fisher -344大鼠感觉诱发电位的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

C S Rebert, S S Sorenson, G T Pryor

引用次数: 0

Prenatal diazepam: chronic anxiety and deficits in brain receptors in mature rat progeny. 产前安定:成熟大鼠后代的慢性焦虑和脑受体缺陷。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

G T Livezey, T J Marczynski, L Isaac

引用次数: 0

Temporal changes in dopaminergic and serotonergic function caused by administration of trimethyltin to adult rats. 三甲基锡对成年大鼠多巴胺能和血清素能功能的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

D L DeHaven, M R Krigman, R B Mailman

{"title":"Temporal changes in dopaminergic and serotonergic function caused by administration of trimethyltin to adult rats.","authors":"D L DeHaven, M R Krigman, R B Mailman","doi":"","DOIUrl":"","url":null,"abstract":"Previous studies have demonstrated that at day 7 following treatment, administration of 3 or 7 mg/kg trimethyltin (TMT) to male Long-Evans rats caused decreases in the concentrations of DA in nucleus accumbens, and perturbed serotonergic function in regions of brain that receive serotonergic innervation from the raphe nuclei. The present series of experiments extended these observations by examining the time course of these events from 14 to 28 days after treatment. Following a dose of 7 mg/kg, changes in serotonergic function, as evidenced by increased turnover and decreased concentrations of 5-HT, were present in striatum, olfactory tubercle, septum and frontal cortex. In nucleus accumbens, concentrations of DA were decreased up to 21 days, while in frontal cortex concentrations of DOPAC and HVA were elevated only at 14 days. In concert with our previous studies, these data indicate that administration of TMT continues to affect serotonergic systems up to 28 days, and dopaminergic systems up to 21 days after exposure, with striatum, nucleus accumbens, olfactory tubercle and septum exhibiting persistent effects due to administration of this neurotoxicant. These prolonged alterations in serotonergic function suggest that this system may play an important role in the response to intoxication with TMT.","PeriodicalId":19112,"journal":{"name":"Neurobehavioral toxicology and teratology","volume":"8 5","pages":"475-9"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13578326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral changes persisting into adulthood after neonatal benzodiazepine administration in the rat. 大鼠在给予新生儿苯二氮卓类药物后，行为改变持续到成年。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

S E File

{"title":"Behavioral changes persisting into adulthood after neonatal benzodiazepine administration in the rat.","authors":"S E File","doi":"","DOIUrl":"","url":null,"abstract":"The day after birth male pups of hooded Lister rats were randomly fostered to form experimental litters of eight. Within each litter pups were randomly assigned among the following groups: vehicle control; diazepam (1, 5 or 10 mg/kg); lorazepam (0.25, 0.5, 1 or 2.5 mg/kg). Injections were given daily from day 1 until weaning at day 21. The pups were then tested as adults, from day 65. There were no effects of neonatal treatment when the pups were tested undrugged in 3 animal tests of anxiety, but in the social interaction test the neonatal diazepam treatment significantly reduced the anxiogenic effects of yohimbine. The neonatal diazepam treatment significantly enhanced the sedative effects of a challenge dose of chlordiazepoxide in the holeboard. Passive avoidance acquisition and retention were unaffected by the early treatment. Neonatal treatment with both benzodiazepines reduced the incidence of myoclonic jerks when the pups were challenged with pentylenetetrazole. Both neonatal treatments enhanced aggressive acts displayed when the residents were confronted with an intruder in their home-cages. However, when the rats that had been treated neonatally with lorazepam were themselves intruding into another's territory, they were significantly more submissive.","PeriodicalId":19112,"journal":{"name":"Neurobehavioral toxicology and teratology","volume":"8 5","pages":"453-61"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14014840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral and neurochemical effects after combined perinatal treatment of rats with lead and disulfiram. 铅双硫仑对大鼠围产期行为和神经化学的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

A Oskarsson, T Ljungberg, L Ståhle, U Tossman, U Ungerstedt

{"title":"Behavioral and neurochemical effects after combined perinatal treatment of rats with lead and disulfiram.","authors":"A Oskarsson, T Ljungberg, L Ståhle, U Tossman, U Ungerstedt","doi":"","DOIUrl":"","url":null,"abstract":"Lead exposure during pregnancy and lactation is known to result in various neurochemical and behavioral disturbances. Dithiocarbamates are known to markedly increase lead levels in the brain. However, the neurotoxicity due to combined treatment with lead and dithiocarbamates is not known. Behavioral and neurochemical effects of lead and disulfiram (tetraethylthiuram disulfide) given singly or in combination, were studied in rats. Pregnant rats were treated with lead (0.25% Pb in the drinking water), with disulfiram (0.1 mmol/kg PO twice a week) or with both lead and disulfiram from day 1 of pregnancy until parturition. After parturition the offspring were exposed to lead via the milk of the dams while the disulfiram (0.1 mmol/kg SC twice a week) was given directly to the offspring. At weaning, 26 days after parturition, the treatment was discontinued and after 2 more weeks behavioral and neurochemical studies were started. Neither lead alone nor disulfiram alone caused any significant effects in the behavior activity measurements. However, in combination the two compounds caused an increase in home cage activity and an increased behavioral reactivity as measured in a holeboard apparatus. Extracellular levels of some neurotransmitters and amino acids were measured in the caudate nucleus using the intracerebral dialysis technique. The levels of dopamine were significantly increased in both the lead-treated and the lead plus disulfiram-treated groups. The levels of the metabolites of dopamine (DOPAC and HVA) and serotonin (5-HIAA) were increased in the group treated with lead plus disulfiram.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":19112,"journal":{"name":"Neurobehavioral toxicology and teratology","volume":"8 5","pages":"591-9"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14904043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal exposure to ethanol potentiates morphine-induced hypothermia in adult rats. 产前暴露于乙醇增强吗啡诱导的成年大鼠体温过低。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

L R Nelson, J W Lewis, N Kokka, B J Branch, A N Taylor

引用次数: 0

The effects of neonatal administration of clonazepam on passive avoidance and on social, aggressive and exploratory behavior of adolescent male rats. 新生儿给予氯硝西泮对青春期雄性大鼠被动回避及社交、攻击和探索行为的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

S E File

{"title":"The effects of neonatal administration of clonazepam on passive avoidance and on social, aggressive and exploratory behavior of adolescent male rats.","authors":"S E File","doi":"","DOIUrl":"","url":null,"abstract":"Male offspring of hooded Lister rats were fostered at birth to form experimental litters of eight. Within each litter pups were randomly allocated among drug groups. Administration of clonazepam (1-5 mg/kg/day) to pups from neonatal days 1-21 resulted in high mortality, at least partly due to impaired ultrasonic calling. Pups treated with 0.1, 0.5 or 1 mg/kg/day throughout the preweaning period were then tested undrugged during adolescence to assess any lasting behavioral changes. There were no significant changes in the social interaction test or in the acquisition or retention of a passive avoidance task. However, neonatal treatment with clonazepam (0.1 mg/kg) did produce significantly less exploratory head-dipping and locomotor activity in a holeboard. This dose also enhanced offensive behaviors when rats were resident in their home-cages and confronted with an intruder, but increased submissive behaviors when the treated rats were intruding into another rat's territory. Treatment with higher doses of clonazepam (0.5 and 1 mg/kg) produced more dominance behaviors when the pups were intruders. Since the main behavioral changes were found in the lowest dose group, which did not show any weight loss, they are unlikely to be secondary to changes in the risk of mortality.","PeriodicalId":19112,"journal":{"name":"Neurobehavioral toxicology and teratology","volume":"8 5","pages":"447-52"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14902362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological evidence of climbing fiber plasticity after long-term alcohol intake. 长期饮酒后攀爬纤维可塑性的形态学证据。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

M A Tavares, M M Paula-Barbosa, A Cadete-Leite

引用次数: 0

Testing strategies in behavioral teratology: II. Discrimination learning. 行为畸形学的检测策略:2。歧视学习。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

G Schreiner, B Ulbrich, R Bass

引用次数: 0

Behavioral and developmental effects in rats following in utero exposure to 2,4-D/2,4,5-t mixture. 子宫内暴露于2,4- d /2,4,5-t混合物对大鼠行为和发育的影响。

Neurobehavioral toxicology and teratology Pub Date : 1986-09-01

F K Mohammad, V E St Omer

引用次数: 0