{"title":"腹腔注射二硫化碳对fisher -344大鼠感觉诱发电位的影响。","authors":"C S Rebert, S S Sorenson, G T Pryor","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Sensory-evoked potentials (EPs) were studied in male Fischer-344 rats to characterize the electrophysiologic concomitants of carbon disulfide (CS2) neurotoxicity. Behavioral measures also studied were forelimb and hindlimb grip strengths and performance of a conditioned avoidance response task. CS2 (172, 286, and 400 mg/kg) administered intraperitoneally five days per week for eleven weeks caused a decrease in grip strength, interfered with escape from shock, and disturbed visual and auditory EPs. Latency of the fifth but not the first component of the brainstem auditory-evoked response was prolonged, indicating an effect on central auditory tract conduction. Conduction velocity in the ventral caudal nerve and latencies of somatosensory EP components were unaffected.</p>","PeriodicalId":19112,"journal":{"name":"Neurobehavioral toxicology and teratology","volume":"8 5","pages":"543-9"},"PeriodicalIF":0.0000,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of intraperitoneal carbon disulfide on sensory-evoked potentials of Fischer-344 rats.\",\"authors\":\"C S Rebert, S S Sorenson, G T Pryor\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Sensory-evoked potentials (EPs) were studied in male Fischer-344 rats to characterize the electrophysiologic concomitants of carbon disulfide (CS2) neurotoxicity. Behavioral measures also studied were forelimb and hindlimb grip strengths and performance of a conditioned avoidance response task. CS2 (172, 286, and 400 mg/kg) administered intraperitoneally five days per week for eleven weeks caused a decrease in grip strength, interfered with escape from shock, and disturbed visual and auditory EPs. Latency of the fifth but not the first component of the brainstem auditory-evoked response was prolonged, indicating an effect on central auditory tract conduction. Conduction velocity in the ventral caudal nerve and latencies of somatosensory EP components were unaffected.</p>\",\"PeriodicalId\":19112,\"journal\":{\"name\":\"Neurobehavioral toxicology and teratology\",\"volume\":\"8 5\",\"pages\":\"543-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1986-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurobehavioral toxicology and teratology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurobehavioral toxicology and teratology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of intraperitoneal carbon disulfide on sensory-evoked potentials of Fischer-344 rats.
Sensory-evoked potentials (EPs) were studied in male Fischer-344 rats to characterize the electrophysiologic concomitants of carbon disulfide (CS2) neurotoxicity. Behavioral measures also studied were forelimb and hindlimb grip strengths and performance of a conditioned avoidance response task. CS2 (172, 286, and 400 mg/kg) administered intraperitoneally five days per week for eleven weeks caused a decrease in grip strength, interfered with escape from shock, and disturbed visual and auditory EPs. Latency of the fifth but not the first component of the brainstem auditory-evoked response was prolonged, indicating an effect on central auditory tract conduction. Conduction velocity in the ventral caudal nerve and latencies of somatosensory EP components were unaffected.
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