Nature Reviews Neuroscience最新文献_第2页

Examining the biological causes of eating disorders to inform treatment strategies 检查饮食失调的生物学原因，为治疗策略提供信息

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-20 DOI: 10.1038/s41583-025-00940-3

Claire J. Foldi, Kristi R. Griffiths

{"title":"Examining the biological causes of eating disorders to inform treatment strategies","authors":"Claire J. Foldi, Kristi R. Griffiths","doi":"10.1038/s41583-025-00940-3","DOIUrl":"https://doi.org/10.1038/s41583-025-00940-3","url":null,"abstract":"Despite their prevalence, eating disorders (EDs) are under-researched and often misunderstood. A recent focus of research on the biological underpinnings of EDs has helped to reframe our understanding of their origins, but there remain a lack of effective treatment options, high rates of relapse and, unfortunately, high mortality and morbidity. In this Review, we highlight the many facets of normal and pathological feeding behaviour and body weight regulation and suggest that these provide a framework with which to develop integrative methods to study, and ultimately treat, EDs. We propose that a better understanding of the biological causes of ED, and their crucial interactions with psychological and environmental factors, is necessary to progress the field. This can be achieved through a combination of preclinical and clinical investigations, which provide complementary information on these highly complex disorders. In the era of individualized medicine and with the advent of artificial intelligence tools that allow the amalgamation of multimodal data, we hope that a better understanding of the biology of EDs may hold the answer to effectively overcoming the debilitating effects of these conditions.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"29 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellar circuit computations for predictive motor control 预测运动控制的小脑电路计算

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-16 DOI: 10.1038/s41583-025-00936-z

Katrina P. Nguyen, Abigail L. Person

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An intriguing role of repeat-element RNAs in nerve injury repair 重复元件rna在神经损伤修复中的有趣作用

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41583-025-00939-w

Sian Lewis

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Value-free teaching in action 无价值教学的实践

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41583-025-00938-x

Jake Rogers

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Inflammation alters cognition after cancer immunotherapy 炎症改变癌症免疫治疗后的认知

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-05-29 DOI: 10.1038/s41583-025-00935-0

Katherine Whalley

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Sleuthing subjectivity: a review of covert measures of consciousness 侦查主体性：对意识的隐蔽测量的回顾

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-05-23 DOI: 10.1038/s41583-025-00934-1

Sharif I. Kronemer, Peter A. Bandettini, Javier Gonzalez-Castillo

引用次数: 0

On analogies in vertebrate and insect visual systems 关于脊椎动物和昆虫视觉系统的类比

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-05-23 DOI: 10.1038/s41583-025-00932-3

Ryosuke Tanaka, Ruben Portugues

{"title":"On analogies in vertebrate and insect visual systems","authors":"Ryosuke Tanaka, Ruben Portugues","doi":"10.1038/s41583-025-00932-3","DOIUrl":"https://doi.org/10.1038/s41583-025-00932-3","url":null,"abstract":"Despite the large evolutionary distance between vertebrates and insects, the visual systems of these two taxa bear remarkable similarities that have been noted repeatedly, including by pioneering neuroanatomists such as Ramón y Cajal. Fuelled by the advent of transgenic approaches in neuroscience, studies of visual system anatomy and function in both vertebrates and insects have made dramatic progress during the past two decades, revealing even deeper analogies between their visual systems than were noted by earlier observers. Such across-taxa comparisons have tended to focus on either elementary motion detection or relatively peripheral layers of the visual systems. By contrast, the aims of this Review are to expand the scope of this comparison to pathways outside visual motion detection, as well as to deeper visual structures. To achieve these aims, we primarily discuss examples from recent work in larval zebrafish (Danio rerio) and the fruitfly (Drosophila melanogaster), a pair of genetically tractable model organisms with comparatively sized, small brains. In particular, we argue that the brains of both vertebrates and insects are equipped with third-order visual structures that specialize in shared behavioural tasks, including postural and course stabilization, approach and avoidance, and some other behaviours. These wider analogies between the two distant taxa highlight shared behavioural goals and associated evolutionary constraints and suggest that studies on vertebrate and insect vision have a lot to inspire each other.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"18 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroferroptosis in health and diseases 健康和疾病中的神经下垂

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-05-19 DOI: 10.1038/s41583-025-00930-5

Peng Lei, Tara Walker, Scott Ayton

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Indigenous representation in neuroscience scholarship, teaching and care 土著代表在神经科学学术，教学和护理

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-05-16 DOI: 10.1038/s41583-025-00933-2

Melissa L. Perreault, Rudi Taylor-Bragge, Hervé Chneiweiss, Andre D. McLachlan, T. Ryan Gregory, Roksana Khalid, Katherine Bassil, Anna Lydia Svalastog, Minerva R. Velarde, Judy Illes

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Brain mechanisms underlying the inhibitory control of thought 思维抑制控制背后的大脑机制

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-05-16 DOI: 10.1038/s41583-025-00929-y

Michael C. Anderson, Maite Crespo-Garcia, S. Subbulakshmi

{"title":"Brain mechanisms underlying the inhibitory control of thought","authors":"Michael C. Anderson, Maite Crespo-Garcia, S. Subbulakshmi","doi":"10.1038/s41583-025-00929-y","DOIUrl":"https://doi.org/10.1038/s41583-025-00929-y","url":null,"abstract":"Controlling action and thought requires the capacity to stop mental processes. Over the past two decades, evidence has grown that a domain-general inhibitory control mechanism supported by the right lateral prefrontal cortex achieves these functions. However, current views of the neural mechanisms of inhibitory control derive largely from research into the stopping of action. Whereas action stopping is a convenient empirical model, it does not invoke thought inhibition and cannot be used to identify the unique features of this process. Here, we review research that addresses how organisms stop a key process that drives thoughts: memory retrieval. This work has shown that retrieval stopping shares right dorsolateral and ventrolateral prefrontal mechanisms with action stopping, consistent with a domain-general inhibitory control mechanism, but also recruits a distinct fronto-temporal pathway that determines the success of mental control. As part of this pathway, GABAergic inhibition within the hippocampus influences the efficacy of prefrontal control over thought. These unique elements of mental control suggest that hippocampal disinhibition is a transdiagnostic factor underlying intrusive thinking, linking the fronto-temporal control pathway to preclinical models of psychiatric disorders and fear extinction. We suggest that retrieval-stopping deficits may underlie the intrusive thinking that is common across many psychiatric disorders.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"41 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0