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Global coordination of brain activity by the breathing cycle 呼吸周期对大脑活动的全面协调
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-04-09 DOI: 10.1038/s41583-025-00920-7
Adriano B. L. Tort, Diego A. Laplagne, Andreas Draguhn, Joaquin Gonzalez
{"title":"Global coordination of brain activity by the breathing cycle","authors":"Adriano B. L. Tort, Diego A. Laplagne, Andreas Draguhn, Joaquin Gonzalez","doi":"10.1038/s41583-025-00920-7","DOIUrl":"https://doi.org/10.1038/s41583-025-00920-7","url":null,"abstract":"<p>Neuronal activities that synchronize with the breathing rhythm have been found in humans and a host of mammalian species, not only in brain areas closely related to respiratory control or olfactory coding but also in areas linked to emotional and higher cognitive functions. In parallel, evidence is mounting for modulations of perception and action by the breathing cycle. In this Review, we discuss the extent to which brain activity locks to breathing across areas, levels of organization and brain states, and the physiological origins of this global synchrony. We describe how waves of sensory activity evoked by nasal airflow spread through brain circuits, synchronizing neuronal populations to the breathing cycle and modulating faster oscillations, cell assembly formation and cross-area communication, thereby providing a mechanistic link from breathing to neural coding, emotion and cognition. We argue that, through evolution, the breathing rhythm has come to shape network functions across species.</p>","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"23 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopamine signals threat-coping behaviour in threat–reward conflicts 多巴胺是威胁-奖励冲突中威胁-应对行为的信号
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-04-02 DOI: 10.1038/s41583-025-00918-1
Jake Rogers
{"title":"Dopamine signals threat-coping behaviour in threat–reward conflicts","authors":"Jake Rogers","doi":"10.1038/s41583-025-00918-1","DOIUrl":"https://doi.org/10.1038/s41583-025-00918-1","url":null,"abstract":"A naturalistic threat–reward conflict reveals that dopamine dynamics in tail of the striatum in mice regulate not only avoidance of potential threats but also learning to overcome them.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"73 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sculpting excitable membranes: voltage-gated ion channel delivery and distribution 雕刻可兴奋膜：电压门控离子通道的传递和分布
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-04-02 DOI: 10.1038/s41583-025-00917-2
Sidharth Tyagi, Grant P. Higerd-Rusli, Elizabeth J. Akin, Stephen G. Waxman, Sulayman D. Dib-Hajj
{"title":"Sculpting excitable membranes: voltage-gated ion channel delivery and distribution","authors":"Sidharth Tyagi, Grant P. Higerd-Rusli, Elizabeth J. Akin, Stephen G. Waxman, Sulayman D. Dib-Hajj","doi":"10.1038/s41583-025-00917-2","DOIUrl":"https://doi.org/10.1038/s41583-025-00917-2","url":null,"abstract":"<p>The polarized and domain-specific distribution of membrane ion channels is essential for neuronal homeostasis, but delivery of these proteins to distal neuronal compartments (such as the axonal ends of peripheral sensory neurons) presents a logistical challenge. Recent developments have enabled the real-time imaging of single protein trafficking and the investigation of the life cycle of ion channels across neuronal compartments. These studies have revealed a highly regulated process involving post-translational modifications, vesicular sorting, motor protein-driven transport and targeted membrane insertion. Emerging evidence suggests that neuronal activity and disease states can dynamically modulate ion channel localization, directly influencing excitability. This Review synthesizes current knowledge on the spatiotemporal regulation of ion channel trafficking in both central and peripheral nervous system neurons. Understanding these processes not only advances our fundamental knowledge of neuronal excitability, but also reveals potential therapeutic targets for disorders involving aberrant ion channel distribution, such as chronic pain and neurodegenerative diseases.</p>","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"58 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shaping preoptic-area neuronal diversity 形成视前区神经元多样性
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-03-31 DOI: 10.1038/s41583-025-00922-5
Sian Lewis
{"title":"Shaping preoptic-area neuronal diversity","authors":"Sian Lewis","doi":"10.1038/s41583-025-00922-5","DOIUrl":"https://doi.org/10.1038/s41583-025-00922-5","url":null,"abstract":"The hypothalamic preoptic area is involved in numerous homeostatic and social behaviours, and the neurons of this area are shown in this study to consist of numerous subtypes that show diverse maturational profiles that correlate with periods of substantial behavioural change such as weaning and puberty.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"22 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stopping speech on demand 按要求停止讲话
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-03-26 DOI: 10.1038/s41583-025-00921-6
Isobel Leake
{"title":"Stopping speech on demand","authors":"Isobel Leake","doi":"10.1038/s41583-025-00921-6","DOIUrl":"https://doi.org/10.1038/s41583-025-00921-6","url":null,"abstract":"A study provides evidence to support a previously unknown function of the premotor cortex in the inhibitory control of speech.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"29 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143713014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autonomic dysfunction in neurodegenerative disease 神经退行性疾病中的自主神经功能障碍
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-03-26 DOI: 10.1038/s41583-025-00911-8
Mara Mather
{"title":"Autonomic dysfunction in neurodegenerative disease","authors":"Mara Mather","doi":"10.1038/s41583-025-00911-8","DOIUrl":"https://doi.org/10.1038/s41583-025-00911-8","url":null,"abstract":"<p>In addition to their more studied cognitive and motor effects, neurodegenerative diseases are also associated with impairments in autonomic function — the regulation of involuntary physiological processes. These autonomic impairments manifest in different ways and at different stages depending on the specific disease. The neural networks responsible for autonomic regulation in the brain and body have characteristics that render them particularly susceptible to the prion-like spread of protein aggregation involved in neurodegenerative diseases. Specifically, the axons of these neurons — in both peripheral and central networks — are long and poorly myelinated axons, which make them preferential targets for pathological protein aggregation. Moreover, cortical regions integrating information about the internal state of the body are highly connected with other brain regions, which increases the likelihood of intersection with pathological pathways and prion-like spread of abnormal proteins. This leads to an autonomic ‘signature’ of dysfunction, characteristic of each neurodegenerative disease, that is linked to the affected networks and regions undergoing pathological aggregation.</p>","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"28 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How microglia contribute to the induction and maintenance of neuropathic pain 小胶质细胞如何促进神经性疼痛的诱导和维持
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-03-24 DOI: 10.1038/s41583-025-00914-5
Marzia Malcangio, George Sideris-Lampretsas
{"title":"How microglia contribute to the induction and maintenance of neuropathic pain","authors":"Marzia Malcangio, George Sideris-Lampretsas","doi":"10.1038/s41583-025-00914-5","DOIUrl":"https://doi.org/10.1038/s41583-025-00914-5","url":null,"abstract":"<p>Neuropathic pain is a debilitating condition caused by damage to the nervous system that results in changes along the pain pathway that lead to persistence of the pain sensation. Unremitting pain conditions are associated with maladaptive plasticity, disruption of neuronal activity that favours excitation over inhibition, and engagement of immune cells. The substantial progress made over the last two decades in the neuroimmune interaction research area points to a mechanistic role of spinal cord microglia, which are resident immune cells of the CNS. Microglia respond to and modulate neuronal activity during establishment and persistence of neuropathic pain states, and microglia–neuron pathways provide targets that can be exploited to attenuate abnormal neuronal activity and provide pain relief.</p>","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"3 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disentangling sources of variability in decision-making 解开决策中可变性的来源
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-03-20 DOI: 10.1038/s41583-025-00916-3
Jade S. Duffy, Mark A. Bellgrove, Peter R. Murphy, Redmond G. O’Connell
{"title":"Disentangling sources of variability in decision-making","authors":"Jade S. Duffy, Mark A. Bellgrove, Peter R. Murphy, Redmond G. O’Connell","doi":"10.1038/s41583-025-00916-3","DOIUrl":"https://doi.org/10.1038/s41583-025-00916-3","url":null,"abstract":"<p>Even the most highly-trained observers presented with identical choice-relevant stimuli will reliably exhibit substantial trial-to-trial variability in the timing and accuracy of their choices. Despite being a pervasive feature of choice behaviour and a prominent phenotype for numerous clinical disorders, the capability to disentangle the sources of such intra-individual variability (IIV) remains limited. In principle, computational models of decision-making offer a means of parsing and estimating these sources, but methodological limitations have prevented this potential from being fully realized in practice. In this Review, we first discuss current limitations of algorithmic models for understanding variability in decision-making behaviour. We then highlight recent advances in behavioural paradigm design, novel analyses of cross-trial behavioural and neural dynamics, and the development of neurally grounded computational models that are now making it possible to link distinct components of IIV to well-defined neural processes. Taken together, we demonstrate how these methods are opening up new avenues for systematically analysing the neural origins of IIV, paving the way for a more refined, holistic understanding of decision-making in health and disease.</p>","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"214 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Musical neurodynamics 音乐神经动力学
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-03-18 DOI: 10.1038/s41583-025-00915-4
Eleanor E. Harding, Ji Chul Kim, Alexander P. Demos, Iran R. Roman, Parker Tichko, Caroline Palmer, Edward W. Large
{"title":"Musical neurodynamics","authors":"Eleanor E. Harding, Ji Chul Kim, Alexander P. Demos, Iran R. Roman, Parker Tichko, Caroline Palmer, Edward W. Large","doi":"10.1038/s41583-025-00915-4","DOIUrl":"https://doi.org/10.1038/s41583-025-00915-4","url":null,"abstract":"<p>A great deal of research in the neuroscience of music suggests that neural oscillations synchronize with musical stimuli. Although neural synchronization is a well-studied mechanism underpinning expectation, it has even more far-reaching implications for music. In this Perspective, we survey the literature on the neuroscience of music, including pitch, harmony, melody, tonality, rhythm, metre, groove and affect. We describe how fundamental dynamical principles based on known neural mechanisms can explain basic aspects of music perception and performance, as summarized in neural resonance theory. Building on principles such as resonance, stability, attunement and strong anticipation, we propose that people anticipate musical events not through predictive neural models, but because brain–body dynamics physically embody musical structure. The interaction of certain kinds of sounds with ongoing pattern-forming dynamics results in patterns of perception, action and coordination that we collectively experience as music. Statistically universal structures may have arisen in music because they correspond to stable states of complex, pattern-forming dynamical systems. This analysis of empirical findings from the perspective of neurodynamic principles sheds new light on the neuroscience of music and what makes music powerful.</p>","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"183 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Parkinson's disease. 了解帕金森病。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2019-12-11 DOI: 10.1038/s41583-019-0254-x
{"title":"Understanding Parkinson's disease.","authors":"","doi":"10.1038/s41583-019-0254-x","DOIUrl":"10.1038/s41583-019-0254-x","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":" ","pages":""},"PeriodicalIF":34.7,"publicationDate":"2019-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37448781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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