An intriguing role of repeat-element RNAs in nerve injury repair

IF 34.7 1区医学 Q1 Neuroscience

Nature Reviews Neuroscience Pub Date : 2025-06-06 DOI:10.1038/s41583-025-00939-w

Sian Lewis

引用次数: 0

Abstract

A polyA-tail-directed RNA sequencing approach that was used to investigate transcriptomic changes in dorsal root ganglia following nerve crush revealed unexpected upregulation of a specific set of B2-SINE transcriptional regulators that facilitate neuronal repair by co-ordinating axon transport and local translation.

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重复元件rna在神经损伤修复中的有趣作用

一项用于研究神经挤压后背根神经节转录组变化的多尾定向RNA测序方法揭示了一组特定的B2-SINE转录调节因子的意外上调，这些调节因子通过协调轴突运输和局部翻译促进神经元修复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neuroscience 医学-神经科学

CiteScore

35.00

自引率

0.60%

发文量

104

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neuroscience is a journal that is part of the Nature Reviews portfolio. It focuses on the multidisciplinary science of neuroscience, which aims to provide a complete understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience have made it possible to tackle longstanding neurobiological questions. However, the wealth of knowledge generated by these advancements has created a need for new tools to organize and communicate this information efficiently. Nature Reviews Neuroscience aims to fulfill this need by offering an authoritative, accessible, topical, and engaging resource for scientists interested in all aspects of neuroscience. The journal covers subjects such as cellular and molecular neuroscience, development of the nervous system, sensory and motor systems, behavior, regulatory systems, higher cognition and language, computational neuroscience, and disorders of the brain. Editorial decisions for the journal are made by a team of full-time professional editors who are PhD-level scientists.