Nature Reviews Materials最新文献_第7页

A new twist on spin–orbit torques 自旋轨道力矩的新转折

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-06-26 DOI: 10.1038/s41578-024-00700-2

Giulia Pacchioni

引用次数: 0

Switching moiré magnets 切换摩尔磁铁

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-06-26 DOI: 10.1038/s41578-024-00701-1

Giulia Pacchioni

引用次数: 0

Moiré materials under strain 应变下的 Moiré 材料

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-06-26 DOI: 10.1038/s41578-024-00699-6

Giulia Pacchioni

引用次数: 0

Precision drug delivery to the central nervous system using engineered nanoparticles 利用工程纳米颗粒向中枢神经系统精准给药

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-06-25 DOI: 10.1038/s41578-024-00695-w

Jingjing Gao, Ziting (Judy) Xia, Swetharajan Gunasekar, Christopher Jiang, Jeffrey M. Karp, Nitin Joshi

{"title":"Precision drug delivery to the central nervous system using engineered nanoparticles","authors":"Jingjing Gao, Ziting (Judy) Xia, Swetharajan Gunasekar, Christopher Jiang, Jeffrey M. Karp, Nitin Joshi","doi":"10.1038/s41578-024-00695-w","DOIUrl":"10.1038/s41578-024-00695-w","url":null,"abstract":"Development of novel therapies for central nervous system (CNS) disorders has experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse effects. One of the major reasons for limited therapeutic efficacy is the poor penetration of drugs across the blood–brain barrier. Despite the development of multiple drug delivery platforms, the overall drug accumulation in the brain remains sub-optimal. Another critical but overlooked factor is achieving precision delivery to a specific region and cell type in the brain. This specificity is crucial because most neurological disorders exhibit region-specific vulnerabilities. Multiple trials have failed owing to adverse CNS effects induced by nonspecific drug targeting. In this Review, we highlight the key regions and cell types that should be targeted in different CNS diseases. We discuss how physiological barriers and disease-mediated changes in the blood–brain barrier and the overall brain can impact the precision delivery of therapeutics via the systemic route. We then perform a systematic analysis of the current state-of-the-art approaches developed to overcome these barriers and achieve precision targeting at different levels. Finally, we discuss potential approaches to accelerate the development of precision delivery systems and outline the challenges and future research directions. The development of therapeutics for central nervous system disorders suffers from high failure rates owing to poor blood–brain barrier penetration and lack of targeted delivery. This Review discusses how nanoparticles can help to overcome these challenges to enable precision targeting of the brain for different central nervous system diseases.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 8","pages":"567-588"},"PeriodicalIF":79.8,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Materials challenges on the path to gigatonne CO2 electrolysis 实现千兆吨级二氧化碳电解过程中的材料挑战

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-06-24 DOI: 10.1038/s41578-024-00696-9

Blanca Belsa, Lu Xia, Viktoria Golovanova, Bárbara Polesso, Adrián Pinilla-Sánchez, Lara San Martín, Jiaye Ye, Cao-Thang Dinh, F. Pelayo García de Arquer

{"title":"Materials challenges on the path to gigatonne CO2 electrolysis","authors":"Blanca Belsa, Lu Xia, Viktoria Golovanova, Bárbara Polesso, Adrián Pinilla-Sánchez, Lara San Martín, Jiaye Ye, Cao-Thang Dinh, F. Pelayo García de Arquer","doi":"10.1038/s41578-024-00696-9","DOIUrl":"10.1038/s41578-024-00696-9","url":null,"abstract":"CO2 electroreduction (CO2E) is one promising strategy towards decarbonization, offering a path to produce widely used chemicals such as fuels or manufacturing feedstocks using renewable energy and waste CO2 (as opposed to fossil fuels). CO2E performance at the laboratory scale is advancing quickly, including ongoing scale-up and industrialization efforts. To address global CO2 emissions (~37 Gt per year), CO2 electrolysers and components, as well as upstream and downstream associated technologies, must be deployed at the gigawatt scale. This entails considerable challenges beyond performance, such as resource availability, deployment readability and end-of-life system management, which are today overlooked. In this Review, we analyse the impending resource challenges as CO2E deployment approaches gigatonne scale, considering a life cycle assessment focused on the associated materials and their corresponding global warming impact. We identify scalability bottlenecks related to membranes, electrode supports and anode materials, among others, and discuss the need for more stable carbon-efficient systems and materials recycling strategies. We conclude with potential approaches to rationally design materials towards sustainable CO2 capture and electrolysis at the gigatonne scale. CO2 electroreduction aims to decarbonize converting CO2 and clean energy into chemicals. To have an impact, this technology should be scaled up into the gigatonne conversion range. In this Review, the authors analyse challenges related to resource and material scalability bottlenecks to enable the sustainable deployment of CO2 electroreduction.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 8","pages":"535-549"},"PeriodicalIF":79.8,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141448138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The fractional quantum anomalous Hall effect 分数量子反常霍尔效应

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-06-18 DOI: 10.1038/s41578-024-00694-x

Long Ju, Allan H. MacDonald, Kin Fai Mak, Jie Shan, Xiaodong Xu

引用次数: 0

Wound management materials and technologies from bench to bedside and beyond 从工作台到床边及其他地方的伤口处理材料和技术

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-06-17 DOI: 10.1038/s41578-024-00693-y

Canran Wang, Ehsan Shirzaei Sani, Chia-Ding Shih, Chwee Teck Lim, Joseph Wang, David G. Armstrong, Wei Gao

{"title":"Wound management materials and technologies from bench to bedside and beyond","authors":"Canran Wang, Ehsan Shirzaei Sani, Chia-Ding Shih, Chwee Teck Lim, Joseph Wang, David G. Armstrong, Wei Gao","doi":"10.1038/s41578-024-00693-y","DOIUrl":"10.1038/s41578-024-00693-y","url":null,"abstract":"Chronic wounds represent a major global health problem, causing staggering economic and social burdens. The pursuit of effective wound healing strategies demands a multidisciplinary approach, and advances in material sciences and bioengineering have paved the way for the development of novel wound healing biomaterials and technologies. In this Review, we provide an overview of the history and challenges of wound management and highlight the current state of the art in wound healing biomaterials alongside the emerging technologies poised to transform the landscape of chronic wound treatment and monitoring. Moreover, we discuss the clinical and commercial considerations associated with wound healing strategies, including the regulatory pathways and key steps in the translational process. Furthermore, we highlight existing translational gaps and offer a nuanced understanding of the challenges that persist in translating innovative concepts into mainstream clinical practices. Continued innovations and interdisciplinary collaboration will pave the way for better wound care outcomes and potentially markedly improved quality of life for a steadily increasing and ageing population. Chronic wounds, a global health crisis, demand innovative approaches for healing and monitoring. This Review explores the progression of wound care, highlighting advanced biomaterials, emerging technologies and the intricate process of transforming laboratory breakthroughs into clinically applied solutions.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 8","pages":"550-566"},"PeriodicalIF":79.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Nonlinear and quantum photonics using integrated optical materials 作者更正：使用集成光学材料的非线性和量子光子学

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-06-04 DOI: 10.1038/s41578-024-00697-8

Avik Dutt, Aseema Mohanty, Alexander L. Gaeta, Michal Lipson

引用次数: 0

Advanced material technologies for space and terrestrial medicine 用于太空和地面医学的先进材料技术

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-06-03 DOI: 10.1038/s41578-024-00691-0

Corrine Ying Xuan Chua, Miguel Jimenez, Maedeh Mozneb, Giovanni Traverso, Ray Lugo, Arun Sharma, Clive N. Svendsen, William R. Wagner, Robert Langer, Alessandro Grattoni

{"title":"Advanced material technologies for space and terrestrial medicine","authors":"Corrine Ying Xuan Chua, Miguel Jimenez, Maedeh Mozneb, Giovanni Traverso, Ray Lugo, Arun Sharma, Clive N. Svendsen, William R. Wagner, Robert Langer, Alessandro Grattoni","doi":"10.1038/s41578-024-00691-0","DOIUrl":"10.1038/s41578-024-00691-0","url":null,"abstract":"The medical risks of spaceflight are amplified as humans venture into longer-duration and greater-distance deep space voyages. During space missions, astronauts face the extremes of known health hazards, such as cosmic radiation and microgravity, as well as threats of the as-yet-unknown. For these missions to be productive and successful, ensuring the astronauts’ safety and well-being is of foremost priority, and this could be achieved through innovations in space medicine. This Perspective explores the use of material technologies for delivery of space medicine in the context of health maintenance and preventive care, as well as treatment for non-emergency and emergency needs. We highlight innovative drug delivery systems, living pharmacies, regenerative medicine, and 3D printing and bioprinting approaches for health-care provision, and we share our vision on their potential applications in space. Finally, we discuss the benefits of space medicine research and its implications for advancing terrestrial health care. Space exploration amplifies medical risks to human health. Innovation in space medicine, drug delivery, regenerative medicine and 3D printing is key for astronaut health. This Perspective explores advanced material technologies for space health care and their applicability to terrestrial medicine.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 11","pages":"808-821"},"PeriodicalIF":79.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A microscopic perspective on moiré materials 摩尔纹材料的微观视角

IF 79.8 1区材料科学

Nature Reviews Materials Pub Date : 2024-05-31 DOI: 10.1038/s41578-024-00682-1

Kevin P. Nuckolls, Ali Yazdani

{"title":"A microscopic perspective on moiré materials","authors":"Kevin P. Nuckolls, Ali Yazdani","doi":"10.1038/s41578-024-00682-1","DOIUrl":"10.1038/s41578-024-00682-1","url":null,"abstract":"Contemporary quantum materials research is guided by themes of topology and electronic correlations. A confluence of these two themes is engineered in moiré materials, an emerging class of highly tunable, strongly correlated 2D materials designed by the rotational or lattice misalignment of atomically thin crystals. In moiré materials, dominant Coulomb interactions among electrons give rise to collective electronic phases, often with robust topological properties. Identifying the mechanisms responsible for these exotic phases is fundamental to our understanding of strongly interacting quantum systems and to our ability to engineer new material properties for potential future technological applications. In this Review, we highlight the contributions of local spectroscopic, thermodynamic and electromagnetic probes to the budding field of moiré materials research. These techniques have not only identified many of the underlying mechanisms of the correlated insulators, generalized Wigner crystals, unconventional superconductors, moiré ferroelectrics and topological orbital ferromagnets found in moiré materials, but have also uncovered fragile quantum phases that have evaded spatially averaged global probes. Furthermore, we highlight recently developed local probe techniques, including local charge sensing and quantum interference probes, that have uncovered new physical observables in moiré materials. Moiré materials are an emerging class of strongly correlated quantum materials designed by the rotational or lattice misalignment of 2D crystals. This Review discusses how local probe techniques are uniquely positioned to elucidate the microscopic mechanisms underlying the electronic phases in moiré materials.","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"9 7","pages":"460-480"},"PeriodicalIF":79.8,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141182487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0