发布求助
文献互助 智能选刊 最新文献

Nature Reviews Genetics最新文献

筛选
英文 中文
Immune-evasive DNA integration with INSTALL 免疫逃避DNA与INSTALL的整合。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-05-13 DOI: 10.1038/s41576-026-00971-1
Connor J. Tou
{"title":"Immune-evasive DNA integration with INSTALL","authors":"Connor J. Tou","doi":"10.1038/s41576-026-00971-1","DOIUrl":"10.1038/s41576-026-00971-1","url":null,"abstract":"In this Tools of the Trade article, Connor Tou presents INSTALL, a recombinase-driven, kilobase-scale DNA integration method that employs partially duplexed circular single-stranded DNA to evade the cellular immune system.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 8","pages":"580-580"},"PeriodicalIF":51.4,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The unbearable presence of senescent cells in ageing 衰老细胞在衰老过程中不可忍受的存在。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-05-12 DOI: 10.1038/s41576-026-00975-x
Chanhee Kang  (, )
{"title":"The unbearable presence of senescent cells in ageing","authors":"Chanhee Kang \u0000 (, )","doi":"10.1038/s41576-026-00975-x","DOIUrl":"10.1038/s41576-026-00975-x","url":null,"abstract":"Chanhee Kang highlights two papers by Baker et al. and Acosta et al. that established a role for senescent cells in age-related pathologies and revealed how the senescence-associated secretory phenotype (SASP) can influence neighbouring cells.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 9","pages":"666-666"},"PeriodicalIF":51.4,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resolving structural variants in pangenome graphs with Swave 用Swave解析泛基因组图中的结构变异。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-05-11 DOI: 10.1038/s41576-026-00972-0
Songbo Wang
{"title":"Resolving structural variants in pangenome graphs with Swave","authors":"Songbo Wang","doi":"10.1038/s41576-026-00972-0","DOIUrl":"10.1038/s41576-026-00972-0","url":null,"abstract":"In this Tools of the Trade article, Songbo Wang introduces Swave, an AI-enhanced sequence-to-image method capable of detecting complex SVs from pangenome graphs.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 10","pages":"739-739"},"PeriodicalIF":51.4,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147875093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolutionary genetics of ageing 衰老的进化遗传学。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-05-11 DOI: 10.1038/s41576-026-00959-x
Handan Melike Dönertaş, Linda Partridge
{"title":"Evolutionary genetics of ageing","authors":"Handan Melike Dönertaş, Linda Partridge","doi":"10.1038/s41576-026-00959-x","DOIUrl":"10.1038/s41576-026-00959-x","url":null,"abstract":"Modern humans now routinely survive to advanced ages, in far greater proportions than ancestral populations, and thus experience the consequences of molecular pathways optimized for youth yet still active in old age. Natural selection weakens over the course of adulthood, creating a selection ‘shadow’ in which deleterious late-acting mutations accumulate and alleles with early-life benefits persist despite late-life costs. An evolutionary lens helps us to understand puzzling patterns — from conserved longevity pathways spanning the tree of life to a 100-fold variation in maximum lifespan across vertebrates — and explains why age-related diseases share genetic architectures. Advances in comparative genomics, large-scale human genetic studies and multi-omics ageing biomarkers now enable rigorous testing of evolutionary predictions. This Review integrates evolutionary genetics with molecular mechanisms to clarify why ageing evolves, how it varies across species and individuals, and how these insights can guide healthspan extension. Modern humans increasingly live long enough to experience late-life consequences of genetic and molecular systems shaped by natural selection. In this Review, the authors integrate evolutionary genetics and genetic evidence to explain why ageing evolves, why longevity varies across species and individuals, and how these insights inform healthspan extension.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 9","pages":"708-723"},"PeriodicalIF":51.4,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147875131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA design across eras: from covariance models to modern generative AI 跨越时代的RNA设计：从协方差模型到现代生成人工智能。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-05-08 DOI: 10.1038/s41576-026-00967-x
Annalisa Marsico
{"title":"RNA design across eras: from covariance models to modern generative AI","authors":"Annalisa Marsico","doi":"10.1038/s41576-026-00967-x","DOIUrl":"10.1038/s41576-026-00967-x","url":null,"abstract":"In this Journal Club, Annalisa Marsico describes a 1994 paper by Eddy and Durbin that formalized RNA sequence analysis with covariance models, which are powerful tools more recently applied to generative machine learning models for RNA design.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 9","pages":"665-665"},"PeriodicalIF":51.4,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prime editing: redefining precision genome editing 启动编辑：重新定义精确基因组编辑。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-05-05 DOI: 10.1038/s41576-026-00965-z
Qiupeng Lin
{"title":"Prime editing: redefining precision genome editing","authors":"Qiupeng Lin","doi":"10.1038/s41576-026-00965-z","DOIUrl":"10.1038/s41576-026-00965-z","url":null,"abstract":"In this Journal Club article, Qiupeng Lin recalls the 2019 paper by Anzalone et al. that introduced prime editing, and reflects on the impact of this technology on genome biology and beyond.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 8","pages":"583-583"},"PeriodicalIF":51.4,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrition signals the brain to reactivate quiescent neural stem cells 营养会向大脑发出信号，重新激活静止的神经干细胞。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-05-01 DOI: 10.1038/s41576-026-00963-1
Hongyan Wang
{"title":"Nutrition signals the brain to reactivate quiescent neural stem cells","authors":"Hongyan Wang","doi":"10.1038/s41576-026-00963-1","DOIUrl":"10.1038/s41576-026-00963-1","url":null,"abstract":"In this Journal Club article, Hongyan Wang highlights two papers that elucidated the signalling mechanisms and inter-organ communication involved in neural stem cell reactivation in Drosophila melanogaster.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 8","pages":"581-581"},"PeriodicalIF":51.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The epigenetic nature of X chromosome inactivation X染色体失活的表观遗传性质。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-04-29 DOI: 10.1038/s41576-026-00964-0
Claudia Isabelle Keller Valsecchi
{"title":"The epigenetic nature of X chromosome inactivation","authors":"Claudia Isabelle Keller Valsecchi","doi":"10.1038/s41576-026-00964-0","DOIUrl":"10.1038/s41576-026-00964-0","url":null,"abstract":"In this Journal Club, Claudia Keller Valsecchi recalls two seminal studies by Csankovszki et al. and by Wutz and Jaenisch that defined X-chromosome inactivation as an epigenetic process by revealing when Xist is required and when silencing becomes Xist-independent.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 8","pages":"582-582"},"PeriodicalIF":51.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of DNA specificity in chromatin remodelling 染色质重构中DNA特异性的机制。
IF 52 1区 生物学
Nature Reviews Genetics Pub Date : 2026-04-29 DOI: 10.1038/s41576-026-00961-3
Lu Bai
{"title":"Mechanisms of DNA specificity in chromatin remodelling","authors":"Lu Bai","doi":"10.1038/s41576-026-00961-3","DOIUrl":"10.1038/s41576-026-00961-3","url":null,"abstract":"In this Journal Club, Lu Bai highlights a 2021 paper by Donovan et al. that brought mechanistic clarity to the question of how chromatin remodellers achieve DNA specificity, which had been difficult to address beyond correlated localization patterns between chromatin remodellers and transcription factors.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 6","pages":"428-428"},"PeriodicalIF":52.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When the genome learned its own vocabulary 当基因组学会了自己的词汇。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-04-27 DOI: 10.1038/s41576-026-00966-y
Maria Brbić
{"title":"When the genome learned its own vocabulary","authors":"Maria Brbić","doi":"10.1038/s41576-026-00966-y","DOIUrl":"10.1038/s41576-026-00966-y","url":null,"abstract":"In this Journal Club article, Maria Brbić discusses DeepSEA, a pioneering deep convolutional neural network to predict functional effects of non-coding variants, and its influence on computational genomics.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 8","pages":"584-584"},"PeriodicalIF":51.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书