Nature Reviews Genetics最新文献

Multiplexed assays of variant effect for clinical variant interpretation 临床变异解释中变异效应的多重分析

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2025-07-21 DOI: 10.1038/s41576-025-00870-x

Abbye E. McEwen, Malvika Tejura, Shawn Fayer, Lea M. Starita, Douglas M. Fowler

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引用次数: 0

Experimental evolution in an era of molecular manipulation 分子操纵时代的实验进化

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2025-07-21 DOI: 10.1038/s41576-025-00867-6

Joao A. Ascensao, Michael M. Desai

引用次数: 0

When cellular reprogramming meets AI: towards de novo cell design 当细胞重编程与人工智能相遇：走向全新的细胞设计

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2025-07-16 DOI: 10.1038/s41576-025-00878-3

Jian Shu

引用次数: 0

Mapping trait-associated cells with spatial transcriptomics. 利用空间转录组学定位性状相关细胞。

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2025-07-15 DOI: 10.1038/s41576-025-00877-4

Liyang Song

引用次数: 0

The evolutionary foundations of transcriptional regulation in animals 动物转录调控的进化基础

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2025-07-09 DOI: 10.1038/s41576-025-00864-9

Maxwell C. Coyle, Nicole King

{"title":"The evolutionary foundations of transcriptional regulation in animals","authors":"Maxwell C. Coyle, Nicole King","doi":"10.1038/s41576-025-00864-9","DOIUrl":"https://doi.org/10.1038/s41576-025-00864-9","url":null,"abstract":"<p>The development of a single-celled zygote into a complex, multicellular animal is directed by transcription factors and regulatory RNAs that coordinate spatio-temporal gene expression patterns. Given the morphological complexity of animals, some prior work has hypothesized that the origin of animals required the evolution of unique and markedly complex transcriptional regulatory mechanisms. Such postulated animal innovations include the evolution of greater numbers of transcription factors, new transcription factor families, distal enhancers and the emergence of long non-coding RNAs. Here, we revisit these explanations in light of new genomic and functional data from diverse early-branching animals and close relatives of animals, which provide essential phylogenetic context for reconstructing the origin of animals. These experimental models also offer examples of how some animal developmental pathways were built from core mechanisms inherited from their protistan ancestors. These new data provide fresh perspectives on whether animal origins entailed fundamental innovations in transcriptional regulation or whether, alternatively, a gradual accumulation of smaller changes sufficed to generate the complex developmental and cell differentiation mechanisms of early animals.</p>","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"3 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Evolution and regulation of animal sex chromosomes 作者更正：动物性染色体的进化与调控

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2025-07-08 DOI: 10.1038/s41576-025-00876-5

Zexian Zhu, Lubna Younas, Qi Zhou

引用次数: 0

Non-retroviral RNA viruses in eukaryotic genomes 真核生物基因组中的非逆转录病毒RNA病毒

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2025-07-07 DOI: 10.1038/s41576-025-00874-7

Mariangela Bonizzoni

引用次数: 0

Harnessing lateral gene transfer and endosymbiosis for adaptation 利用横向基因转移和内共生来适应