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Small variant calling in the era of long-read sequencing. 长读测序时代的小变异呼唤。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-20 DOI: 10.1038/s41576-026-01020-7
Zhenxian Zheng, Fritz J Sedlazeck, Ruibang Luo
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引用次数: 0
Towards equitable population epigenomics: implications for global health. 迈向公平的人口表观基因组学：对全球健康的影响。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-19 DOI: 10.1038/s41576-026-01027-0
{"title":"Towards equitable population epigenomics: implications for global health.","authors":"","doi":"10.1038/s41576-026-01027-0","DOIUrl":"https://doi.org/10.1038/s41576-026-01027-0","url":null,"abstract":"","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":" ","pages":""},"PeriodicalIF":51.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards a rational terminology for cell types. 为细胞类型建立一个合理的术语。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-16 DOI: 10.1038/s41576-026-01028-z
Yuanzhen Zhu, Guang Li, Peter W H Holland, Günter P Wagner, Sebastian M Shimeld
{"title":"Towards a rational terminology for cell types.","authors":"Yuanzhen Zhu, Guang Li, Peter W H Holland, Günter P Wagner, Sebastian M Shimeld","doi":"10.1038/s41576-026-01028-z","DOIUrl":"https://doi.org/10.1038/s41576-026-01028-z","url":null,"abstract":"","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":" ","pages":""},"PeriodicalIF":51.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene regulation at the early human maternal-fetal interface. 人类早期母胎界面的基因调控。
IF 51.4 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-12 DOI: 10.1038/s41576-026-01014-5
Ana Paredes, Christina E Kim, Roser Vento-Tormo
{"title":"Gene regulation at the early human maternal-fetal interface.","authors":"Ana Paredes, Christina E Kim, Roser Vento-Tormo","doi":"10.1038/s41576-026-01014-5","DOIUrl":"https://doi.org/10.1038/s41576-026-01014-5","url":null,"abstract":"<p><p>Pregnancy is a distinct physiological context in which the mother hosts and nurtures the development of a genetically distinct fetus. Healthy pregnancy outcomes rely on successful placental development, during which specialized placental cells with fetal genotype, known as trophoblasts, drive the establishment of the maternal-fetal interface, a balanced tissue ecosystem that supports fetal development while safeguarding maternal well-being. Advances in single-cell, single-nuclei and spatial genomics technologies, along with data science, are now providing an unprecedented view of trophoblast regulation, which drives their differentiation into diverse cell subtypes that dynamically transform the maternal niche. More specifically, these cells modulate the immune system and remodel the vasculature to facilitate communication with maternal cells, leading to the successful formation of the maternal-fetal interface. These advances, when combined with in vitro modelling, hold promise for inferring causality in mechanisms that govern genome regulation, cellular behaviour and ultimately pregnancy homeostasis and maladaptive responses.</p>","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":" ","pages":""},"PeriodicalIF":51.4,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping genetic risk to regulatory networks at single-cell resolution 在单细胞分辨率上绘制基因风险调控网络
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-07 DOI: 10.1038/s41576-026-01025-2
Yunlong Ma
{"title":"Mapping genetic risk to regulatory networks at single-cell resolution","authors":"Yunlong Ma","doi":"10.1038/s41576-026-01025-2","DOIUrl":"https://doi.org/10.1038/s41576-026-01025-2","url":null,"abstract":"","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"305 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histone acetylation finds its link to transcription 组蛋白乙酰化发现其与转录的联系
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-07 DOI: 10.1038/s41576-026-01024-3
Liling Wan
{"title":"Histone acetylation finds its link to transcription","authors":"Liling Wan","doi":"10.1038/s41576-026-01024-3","DOIUrl":"https://doi.org/10.1038/s41576-026-01024-3","url":null,"abstract":"","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"9 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How cells remember sex 细胞如何记忆性别
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-06 DOI: 10.1038/s41576-026-01023-4
Bruno Hudry
{"title":"How cells remember sex","authors":"Bruno Hudry","doi":"10.1038/s41576-026-01023-4","DOIUrl":"https://doi.org/10.1038/s41576-026-01023-4","url":null,"abstract":"","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"222 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The African DSI DataBank: a federated infrastructure for Africa’s genomic and biodiversity data 非洲DSI数据库：非洲基因组和生物多样性数据的联邦基础设施
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-06 DOI: 10.1038/s41576-026-01017-2
ThankGod Echezona Ebenezer,Achraf El Allali,Ichrak Hayah,Abdoallah Sharaf,Sadik Muzemil,Sarah Chidi Ihenko,Chukwuike Ebuzome,Zahra Mungloo-Dilmohamud,Andrews Frimpong Adu,Stanford Kwenda,Semir Bechir Suheil Gaouar,Yedomon Ange Bovys Zoclanclounon,Yonas Gebremichael Difer,Zewdu Edea,Emmanuel Hala Kwon-Ndung,Samson Pandam Salifu,Bupe Ruhama Mwambingu,Craig John Kinnear,Anne WT Muigai,Julian Onyewuonyeoma Osuji,Bouabid Badaoui
{"title":"The African DSI DataBank: a federated infrastructure for Africa’s genomic and biodiversity data","authors":"ThankGod Echezona Ebenezer,Achraf El Allali,Ichrak Hayah,Abdoallah Sharaf,Sadik Muzemil,Sarah Chidi Ihenko,Chukwuike Ebuzome,Zahra Mungloo-Dilmohamud,Andrews Frimpong Adu,Stanford Kwenda,Semir Bechir Suheil Gaouar,Yedomon Ange Bovys Zoclanclounon,Yonas Gebremichael Difer,Zewdu Edea,Emmanuel Hala Kwon-Ndung,Samson Pandam Salifu,Bupe Ruhama Mwambingu,Craig John Kinnear,Anne WT Muigai,Julian Onyewuonyeoma Osuji,Bouabid Badaoui","doi":"10.1038/s41576-026-01017-2","DOIUrl":"https://doi.org/10.1038/s41576-026-01017-2","url":null,"abstract":"","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"4 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding epithelial–mesenchymal transitions with multi-omics 用多组学解码上皮-间质转化
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-05 DOI: 10.1038/s41576-026-01015-4
Nitin Narwade,M. Angela Nieto
{"title":"Decoding epithelial–mesenchymal transitions with multi-omics","authors":"Nitin Narwade,M. Angela Nieto","doi":"10.1038/s41576-026-01015-4","DOIUrl":"https://doi.org/10.1038/s41576-026-01015-4","url":null,"abstract":"","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"32 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is genome-wide epigenetic reprogramming a eutherian innovation? 全基因组表观遗传重编程是一种动物创新吗？
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2026-10-05 DOI: 10.1038/s41576-026-01021-6
Ozren Bogdanovic
{"title":"Is genome-wide epigenetic reprogramming a eutherian innovation?","authors":"Ozren Bogdanovic","doi":"10.1038/s41576-026-01021-6","DOIUrl":"https://doi.org/10.1038/s41576-026-01021-6","url":null,"abstract":"","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"4 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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