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The phenotypic consequences of enhancer evolution 增强子进化的表型后果
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-29 DOI: 10.1038/s41576-024-00800-3
Julie Jung, Thomas King
{"title":"The phenotypic consequences of enhancer evolution","authors":"Julie Jung, Thomas King","doi":"10.1038/s41576-024-00800-3","DOIUrl":"https://doi.org/10.1038/s41576-024-00800-3","url":null,"abstract":"In this Journal Club, Julie Jung and Thomas King recount a paper by Chan et al. that identified the regulatory changes underlying recurrent phenotypic evolution in stickleback fish.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"127 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Context-specific regulatory variants in precision medicine and agriculture 精准医疗和农业中针对具体情况的调控变体
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-29 DOI: 10.1038/s41576-024-00798-8
Lingzhao Fang
{"title":"Context-specific regulatory variants in precision medicine and agriculture","authors":"Lingzhao Fang","doi":"10.1038/s41576-024-00798-8","DOIUrl":"https://doi.org/10.1038/s41576-024-00798-8","url":null,"abstract":"Lingzhao Fang recalls how a 2002 paper by Brem et al., which investigated the genetic basis of natural variation in gene expression in budding yeast, and the GTEx atlas of genetic regulatory effects across human tissues inspired the FarmGTEx project to accelerate precision agriculture.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"11 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causal inference for epigenetic ageing 表观遗传老化的因果推理
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-29 DOI: 10.1038/s41576-024-00799-7
Kejun Ying
{"title":"Causal inference for epigenetic ageing","authors":"Kejun Ying","doi":"10.1038/s41576-024-00799-7","DOIUrl":"10.1038/s41576-024-00799-7","url":null,"abstract":"In this Tools of the Trade article, Kejun Ying describes epigenome-wide Mendelian randomization, which integrates Mendelian randomization into a DNA-methylation-based epigenetic clock to identify CpG sites with potential causal links to lifespan and healthspan.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 1","pages":"3-3"},"PeriodicalIF":39.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cohesin and CTCF emerge as building blocks of 3D genome structure 凝聚素和 CTCF 成为三维基因组结构的基石
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-25 DOI: 10.1038/s41576-024-00795-x
Julia Horsfield
{"title":"Cohesin and CTCF emerge as building blocks of 3D genome structure","authors":"Julia Horsfield","doi":"10.1038/s41576-024-00795-x","DOIUrl":"https://doi.org/10.1038/s41576-024-00795-x","url":null,"abstract":"In this Journal Club, Julia Horsfield recounts two papers that demonstrated how cohesin and CTCF together organize the genome and regulate gene expression.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"2 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How the waxing and waning of a mutation determines HIV treatment success 突变的消长如何决定艾滋病治疗的成败
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-21 DOI: 10.1038/s41576-024-00791-1
Pleuni S. Pennings
{"title":"How the waxing and waning of a mutation determines HIV treatment success","authors":"Pleuni S. Pennings","doi":"10.1038/s41576-024-00791-1","DOIUrl":"10.1038/s41576-024-00791-1","url":null,"abstract":"In this Journal Club, Pleuni Pennings recalls two papers that connected the evolutionary dynamics of HIV variants with therapeutic outcomes, illustrating how evolutionary insights can inform public health decisions.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 1","pages":"6-6"},"PeriodicalIF":39.1,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional specificity in biomolecular condensates revealed by genetic complementation 通过基因互补揭示生物分子凝聚体的功能特异性
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-21 DOI: 10.1038/s41576-024-00780-4
Benjamin R. Sabari, Anthony A. Hyman, Denes Hnisz
{"title":"Functional specificity in biomolecular condensates revealed by genetic complementation","authors":"Benjamin R. Sabari, Anthony A. Hyman, Denes Hnisz","doi":"10.1038/s41576-024-00780-4","DOIUrl":"https://doi.org/10.1038/s41576-024-00780-4","url":null,"abstract":"<p>Biomolecular condensates are thought to create subcellular microenvironments that regulate specific biochemical activities. Extensive in vitro work has helped link condensate formation to a wide range of cellular processes, including gene expression, nuclear transport, signalling and stress responses. However, testing the relationship between condensate formation and function in cells is more challenging. In particular, the extent to which the cellular functions of condensates depend on the nature of the molecular interactions through which the condensates form is a major outstanding question. Here, we review results from recent genetic complementation experiments in cells, and highlight how genetic complementation provides important insights into cellular functions and functional specificity of biomolecular condensates. Combined with observations from human genetic disease, these experiments suggest that diverse condensate-promoting regions within cellular proteins confer different condensate compositions, biophysical properties and functions.</p>","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"215 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethical governance for genomic data science in the cloud 云端基因组数据科学的道德管理
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-18 DOI: 10.1038/s41576-024-00789-9
Vasiliki Rahimzadeh, Sarah C. Nelson, Adrian Thorogood, Jonathan Lawson, Stephanie M. Fullerton
{"title":"Ethical governance for genomic data science in the cloud","authors":"Vasiliki Rahimzadeh, Sarah C. Nelson, Adrian Thorogood, Jonathan Lawson, Stephanie M. Fullerton","doi":"10.1038/s41576-024-00789-9","DOIUrl":"https://doi.org/10.1038/s41576-024-00789-9","url":null,"abstract":"Cloud platforms offer distinct advantages, but questions remain about how to ethically and efficiently manage human genomic data in the cloud. Data governance needs to be adapted to ensure transparency and security for research participants, as well as equitable and sustainable access for researchers. Rahimzadeh et al. discuss the ethical, legal and social implications of storing and analysing human genomic data in the cloud and provide recommendations and new research directions for future, trustworthy cloud-based genomic data access and management.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"31 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A brief history of metabolic gradient theory 代谢梯度理论简史
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-16 DOI: 10.1038/s41576-024-00790-2
Berna Sozen
{"title":"A brief history of metabolic gradient theory","authors":"Berna Sozen","doi":"10.1038/s41576-024-00790-2","DOIUrl":"10.1038/s41576-024-00790-2","url":null,"abstract":"In this Journal Club, Berna Sozen recalls the metabolic gradient theory proposed by Charles Manning Child in the early 20th century, which posited that metabolic gradients drive cellular differentiation and tissue patterning.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 1","pages":"5-5"},"PeriodicalIF":39.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell expression profiling has its roots in in situ techniques 单细胞表达谱分析源于原位技术
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-09 DOI: 10.1038/s41576-024-00787-x
Shila Ghazanfar
{"title":"Single-cell expression profiling has its roots in in situ techniques","authors":"Shila Ghazanfar","doi":"10.1038/s41576-024-00787-x","DOIUrl":"10.1038/s41576-024-00787-x","url":null,"abstract":"In this Journal Club, Shila Ghazanfar highlights a seminal paper by Levsky et al. that paved the way for contemporary single-cell spatial transcriptomics.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 12","pages":"828-828"},"PeriodicalIF":39.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142385114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic cell–cell communication in cancer 癌症中的全身细胞-细胞通讯
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-08 DOI: 10.1038/s41576-024-00785-z
Edroaldo Lummertz da Rocha
{"title":"Systemic cell–cell communication in cancer","authors":"Edroaldo Lummertz da Rocha","doi":"10.1038/s41576-024-00785-z","DOIUrl":"10.1038/s41576-024-00785-z","url":null,"abstract":"In this Journal Club article, Edroaldo Lummertz da Rocha discusses two papers that provided important insights into how tumour cells communicate with distant organs to establish pre-metastatic niches.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 1","pages":"4-4"},"PeriodicalIF":39.1,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142384360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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