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Genetic conflict and its resolution between the sexes 两性之间的基因冲突及其解决方法
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-11-06 DOI: 10.1038/s41576-024-00802-1
Abderrahman Khila
{"title":"Genetic conflict and its resolution between the sexes","authors":"Abderrahman Khila","doi":"10.1038/s41576-024-00802-1","DOIUrl":"https://doi.org/10.1038/s41576-024-00802-1","url":null,"abstract":"Abderrahman Khila highlights an important 2015 paper by Barson et al. that demonstrated how sexual conflict in Atlantic salmon affects genetic evolution.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"68 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring biodiversity through museomics 通过博物馆学探索生物多样性
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-11-06 DOI: 10.1038/s41576-024-00801-2
Charles C. Davis, Sandra Knapp
{"title":"Exploring biodiversity through museomics","authors":"Charles C. Davis, Sandra Knapp","doi":"10.1038/s41576-024-00801-2","DOIUrl":"https://doi.org/10.1038/s41576-024-00801-2","url":null,"abstract":"Natural history collections are unparalleled resources for studying biodiversity across multiple dimensions. As multi-omic tools are being applied to museum specimens, the emerging field of museomics is undergoing a rapid and exciting transformation, with new opportunities, challenges and confrontations with past legacies. In this Comment, the authors showcase how the emerging field of museomics — the application of multi-omic tools to natural history collections — is undergoing a rapid and exciting transformation, with new opportunities, challenges and confrontations with past legacies.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"110 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The design and engineering of synthetic genomes 合成基因组的设计与工程
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-11-06 DOI: 10.1038/s41576-024-00786-y
Joshua S. James, Junbiao Dai, Wei Leong Chew, Yizhi Cai
{"title":"The design and engineering of synthetic genomes","authors":"Joshua S. James, Junbiao Dai, Wei Leong Chew, Yizhi Cai","doi":"10.1038/s41576-024-00786-y","DOIUrl":"https://doi.org/10.1038/s41576-024-00786-y","url":null,"abstract":"<p>Synthetic genomics seeks to design and construct entire genomes to mechanistically dissect fundamental questions of genome function and to engineer organisms for diverse applications, including bioproduction of high-value chemicals and biologics, advanced cell therapies, and stress-tolerant crops. Recent progress has been fuelled by advancements in DNA synthesis, assembly, delivery and editing. Computational innovations, such as the use of artificial intelligence to provide prediction of function, also provide increasing capabilities to guide synthetic genome design and construction. However, translating synthetic genome-scale projects from idea to implementation remains highly complex. Here, we aim to streamline this implementation process by comprehensively reviewing the strategies for design, construction, delivery, debugging and tailoring of synthetic genomes as well as their potential applications.</p>","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"36 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Slide-tags enables spatial single-nucleus sequencing 滑动标签实现空间单核测序
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-11-04 DOI: 10.1038/s41576-024-00797-9
Andrew J. C. Russell
{"title":"Slide-tags enables spatial single-nucleus sequencing","authors":"Andrew J. C. Russell","doi":"10.1038/s41576-024-00797-9","DOIUrl":"10.1038/s41576-024-00797-9","url":null,"abstract":"In this Tools of the Trade article, Andrew Russell describes Slide-tags, a method for scalable, spatially resolved single-nucleus sequencing.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 2","pages":"78-78"},"PeriodicalIF":39.1,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The phenotypic consequences of enhancer evolution 增强子进化的表型后果
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-29 DOI: 10.1038/s41576-024-00800-3
Julie Jung, Thomas King
{"title":"The phenotypic consequences of enhancer evolution","authors":"Julie Jung,&nbsp;Thomas King","doi":"10.1038/s41576-024-00800-3","DOIUrl":"10.1038/s41576-024-00800-3","url":null,"abstract":"In this Journal Club, Julie Jung and Thomas King recount a paper by Chan et al. that identified the regulatory changes underlying recurrent phenotypic evolution in stickleback fish.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 2","pages":"79-79"},"PeriodicalIF":39.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Context-specific regulatory variants in precision medicine and agriculture 精准医疗和农业中针对具体情况的调控变体
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-29 DOI: 10.1038/s41576-024-00798-8
Lingzhao Fang
{"title":"Context-specific regulatory variants in precision medicine and agriculture","authors":"Lingzhao Fang","doi":"10.1038/s41576-024-00798-8","DOIUrl":"10.1038/s41576-024-00798-8","url":null,"abstract":"Lingzhao Fang recalls how a 2002 paper by Brem et al., which investigated the genetic basis of natural variation in gene expression in budding yeast, and the GTEx atlas of genetic regulatory effects across human tissues inspired the FarmGTEx project to accelerate precision agriculture.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 2","pages":"81-81"},"PeriodicalIF":39.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causal inference for epigenetic ageing 表观遗传老化的因果推理
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-29 DOI: 10.1038/s41576-024-00799-7
Kejun Ying
{"title":"Causal inference for epigenetic ageing","authors":"Kejun Ying","doi":"10.1038/s41576-024-00799-7","DOIUrl":"10.1038/s41576-024-00799-7","url":null,"abstract":"In this Tools of the Trade article, Kejun Ying describes epigenome-wide Mendelian randomization, which integrates Mendelian randomization into a DNA-methylation-based epigenetic clock to identify CpG sites with potential causal links to lifespan and healthspan.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 1","pages":"3-3"},"PeriodicalIF":39.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cohesin and CTCF emerge as building blocks of 3D genome structure 凝聚素和 CTCF 成为三维基因组结构的基石
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-25 DOI: 10.1038/s41576-024-00795-x
Julia Horsfield
{"title":"Cohesin and CTCF emerge as building blocks of 3D genome structure","authors":"Julia Horsfield","doi":"10.1038/s41576-024-00795-x","DOIUrl":"10.1038/s41576-024-00795-x","url":null,"abstract":"In this Journal Club, Julia Horsfield recounts two papers that demonstrated how cohesin and CTCF together organize the genome and regulate gene expression.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 2","pages":"80-80"},"PeriodicalIF":39.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How the waxing and waning of a mutation determines HIV treatment success 突变的消长如何决定艾滋病治疗的成败
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-21 DOI: 10.1038/s41576-024-00791-1
Pleuni S. Pennings
{"title":"How the waxing and waning of a mutation determines HIV treatment success","authors":"Pleuni S. Pennings","doi":"10.1038/s41576-024-00791-1","DOIUrl":"10.1038/s41576-024-00791-1","url":null,"abstract":"In this Journal Club, Pleuni Pennings recalls two papers that connected the evolutionary dynamics of HIV variants with therapeutic outcomes, illustrating how evolutionary insights can inform public health decisions.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 1","pages":"6-6"},"PeriodicalIF":39.1,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional specificity in biomolecular condensates revealed by genetic complementation 通过基因互补揭示生物分子凝聚体的功能特异性
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-10-21 DOI: 10.1038/s41576-024-00780-4
Benjamin R. Sabari, Anthony A. Hyman, Denes Hnisz
{"title":"Functional specificity in biomolecular condensates revealed by genetic complementation","authors":"Benjamin R. Sabari, Anthony A. Hyman, Denes Hnisz","doi":"10.1038/s41576-024-00780-4","DOIUrl":"https://doi.org/10.1038/s41576-024-00780-4","url":null,"abstract":"<p>Biomolecular condensates are thought to create subcellular microenvironments that regulate specific biochemical activities. Extensive in vitro work has helped link condensate formation to a wide range of cellular processes, including gene expression, nuclear transport, signalling and stress responses. However, testing the relationship between condensate formation and function in cells is more challenging. In particular, the extent to which the cellular functions of condensates depend on the nature of the molecular interactions through which the condensates form is a major outstanding question. Here, we review results from recent genetic complementation experiments in cells, and highlight how genetic complementation provides important insights into cellular functions and functional specificity of biomolecular condensates. Combined with observations from human genetic disease, these experiments suggest that diverse condensate-promoting regions within cellular proteins confer different condensate compositions, biophysical properties and functions.</p>","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"215 1","pages":""},"PeriodicalIF":42.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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