Nature Reviews Genetics最新文献_第10页

Unveiling the expanding protein universe of life 揭开不断扩大的生命蛋白质宇宙的神秘面纱。

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2024-02-29 DOI: 10.1038/s41576-024-00716-y

Hajk-Georg Drost

引用次数: 0

Targeting and engineering long non-coding RNAs for cancer therapy 长非编码 RNA 的靶向和工程设计用于癌症治疗。

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-02-29 DOI: 10.1038/s41576-024-00693-2

Michela Coan, Simon Haefliger, Samir Ounzain, Rory Johnson

{"title":"Targeting and engineering long non-coding RNAs for cancer therapy","authors":"Michela Coan, Simon Haefliger, Samir Ounzain, Rory Johnson","doi":"10.1038/s41576-024-00693-2","DOIUrl":"10.1038/s41576-024-00693-2","url":null,"abstract":"RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or employing RNA molecules for therapeutic purposes. Amongst the most promising targets are long non-coding RNAs (lncRNAs), which regulate oncogenic molecular networks in a cell type-restricted manner. lncRNAs are distinct from protein-coding genes in important ways that increase their therapeutic potential yet also present hurdles to conventional clinical development. Advances in genome editing, oligonucleotide chemistry, multi-omics and RNA engineering are paving the way for efficient and cost-effective lncRNA-focused drug discovery pipelines. In this Review, we present the emerging field of lncRNA therapeutics for oncology, with emphasis on the unique strengths and challenges of lncRNAs within the broader RNATx framework. We outline the necessary steps for lncRNA therapeutics to deliver effective, durable, tolerable and personalized treatments for cancer. Therapeutics that target long non-coding RNAs (lncRNAs) are promising treatments for cancer. In this Review, the authors discuss how technological advances have helped improve drug discovery pipelines for lncRNAs and overview their strengths and challenges as oncological therapeutics.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":null,"pages":null},"PeriodicalIF":39.1,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The continuum of transcription factor affinities 转录因子亲和力的连续性

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2024-02-27 DOI: 10.1038/s41576-024-00713-1

Carl G. de Boer

引用次数: 0

Plant pangenomes for crop improvement, biodiversity and evolution 用于作物改良、生物多样性和进化的植物泛基因组。

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-02-20 DOI: 10.1038/s41576-024-00691-4

Mona Schreiber, Murukarthick Jayakodi, Nils Stein, Martin Mascher

{"title":"Plant pangenomes for crop improvement, biodiversity and evolution","authors":"Mona Schreiber, Murukarthick Jayakodi, Nils Stein, Martin Mascher","doi":"10.1038/s41576-024-00691-4","DOIUrl":"10.1038/s41576-024-00691-4","url":null,"abstract":"Plant genome sequences catalogue genes and the genetic elements that regulate their expression. Such inventories further research aims as diverse as mapping the molecular basis of trait diversity in domesticated plants or inquiries into the origin of evolutionary innovations in flowering plants millions of years ago. The transformative technological progress of DNA sequencing in the past two decades has enabled researchers to sequence ever more genomes with greater ease. Pangenomes — complete sequences of multiple individuals of a species or higher taxonomic unit — have now entered the geneticists’ toolkit. The genomes of crop plants and their wild relatives are being studied with translational applications in breeding in mind. But pangenomes are applicable also in ecological and evolutionary studies, as they help classify and monitor biodiversity across the tree of life, deepen our understanding of how plant species diverged and show how plants adapt to changing environments or new selection pressures exerted by human beings. Plant pangenomes have had a transformative impact on crop enhancement, biodiversity conservation and evolutionary research. This Review delves into the application of plant pangenomes for understanding trait diversity, aiding breeding, biodiversity classification and monitoring, and illuminating evolutionary innovations.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":null,"pages":null},"PeriodicalIF":39.1,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The origin and evolution of Wnt signalling Wnt 信号的起源和演变。

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2024-02-19 DOI: 10.1038/s41576-024-00699-w

Michaela Holzem, Michael Boutros, Thomas W. Holstein

{"title":"The origin and evolution of Wnt signalling","authors":"Michaela Holzem, Michael Boutros, Thomas W. Holstein","doi":"10.1038/s41576-024-00699-w","DOIUrl":"10.1038/s41576-024-00699-w","url":null,"abstract":"The Wnt signal transduction pathway has essential roles in the formation of the primary body axis during development, cellular differentiation and tissue homeostasis. This animal-specific pathway has been studied extensively in contexts ranging from developmental biology to medicine for more than 40 years. Despite its physiological importance, an understanding of the evolutionary origin and primary function of Wnt signalling has begun to emerge only recently. Recent studies on very basal metazoan species have shown high levels of conservation of components of both canonical and non-canonical Wnt signalling pathways. Furthermore, some pathway proteins have been described also in non-animal species, suggesting that recruitment and functional adaptation of these factors has occurred in metazoans. In this Review, we summarize the current state of research regarding the evolutionary origin of Wnt signalling, its ancestral function and the characteristics of the primal Wnt ligand, with emphasis on the importance of genomic studies in various pre-metazoan and basal metazoan species. This Review discusses the evolutionary origin of Wnt signalling, its ancestral function and the characteristics of the primal Wnt ligand. It emphasizes the importance of genomic studies in pre-metazoan and basal metazoan species to understanding the evolutionary origin of signalling pathways.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":null,"pages":null},"PeriodicalIF":42.7,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequencing and characterizing short tandem repeats in the human genome 人类基因组中短串联重复序列的测序和特征描述。

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2024-02-16 DOI: 10.1038/s41576-024-00692-3

Hope A. Tanudisastro, Ira W. Deveson, Harriet Dashnow, Daniel G. MacArthur

{"title":"Sequencing and characterizing short tandem repeats in the human genome","authors":"Hope A. Tanudisastro, Ira W. Deveson, Harriet Dashnow, Daniel G. MacArthur","doi":"10.1038/s41576-024-00692-3","DOIUrl":"10.1038/s41576-024-00692-3","url":null,"abstract":"Short tandem repeats (STRs) are highly polymorphic sequences throughout the human genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable STR loci are known, some of which regulate gene expression and influence complex traits, such as height. Moreover, variants in at least 60 STR loci cause genetic disorders, including Huntington disease and fragile X syndrome. Accurately identifying and genotyping STR variants is challenging, in particular mapping short reads to repetitive regions and inferring expanded repeat lengths. Recent advances in sequencing technology and computational tools for STR genotyping from sequencing data promise to help overcome this challenge and solve genetically unresolved cases and the ‘missing heritability’ of polygenic traits. Here, we compare STR genotyping methods, analytical tools and their applications to understand the effect of STR variation on health and disease. We identify emergent opportunities to refine genotyping and quality-control approaches as well as to integrate STRs into variant-calling workflows and large cohort analyses. This Review describes tools and approaches for characterizing short tandem repeats in the human genome from whole-genome sequencing data. Furthermore, the authors discuss how these recent developments have helped to better understand the effect of short tandem repeats on human health and disease.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":null,"pages":null},"PeriodicalIF":42.7,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fitness effects of mutations throughout evolution 突变在整个进化过程中对健康的影响

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2024-02-16 DOI: 10.1038/s41576-024-00707-z

Henry Ertl

引用次数: 0

Single-cell sequencing of diverse microorganisms 各种微生物的单细胞测序。

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2024-02-16 DOI: 10.1038/s41576-024-00708-y

Henry Ertl

引用次数: 0

A TRIP to understand gene regulation 了解基因调控的 TRIP。