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Nuclear receptors — studying genes to understand hormones 核受体--研究基因以了解激素
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-05-22 DOI: 10.1038/s41576-024-00745-7
Jessica Tollkuhn
{"title":"Nuclear receptors — studying genes to understand hormones","authors":"Jessica Tollkuhn","doi":"10.1038/s41576-024-00745-7","DOIUrl":"10.1038/s41576-024-00745-7","url":null,"abstract":"In this Journal Club, Jessica Tollkuhn discusses how a paper describing genome-wide application of chromatin immunoprecipitation (ChIP)-on-chip inspired her own research into oestrogen-based gene regulation in the brain.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 9","pages":"602-602"},"PeriodicalIF":39.1,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BANKSY: scalable cell typing and domain segmentation for spatial omics BANKSY：用于空间全息图学的可扩展细胞分型和域分割。
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-05-15 DOI: 10.1038/s41576-024-00743-9
Vipul Singhal, Nigel Chou
{"title":"BANKSY: scalable cell typing and domain segmentation for spatial omics","authors":"Vipul Singhal, Nigel Chou","doi":"10.1038/s41576-024-00743-9","DOIUrl":"10.1038/s41576-024-00743-9","url":null,"abstract":"In this Tools of the Trade article, Vipul Singhal and Nigel Chou describe BANKSY, a machine learning tool that harnesses gene expression gradients from the neighbourhood of a cell for cell typing and domain segmentation.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 8","pages":"527-528"},"PeriodicalIF":39.1,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Miller spreads and the power of observation 米勒的传播和观察力
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-05-13 DOI: 10.1038/s41576-024-00739-5
Mustafa Mir
{"title":"Miller spreads and the power of observation","authors":"Mustafa Mir","doi":"10.1038/s41576-024-00739-5","DOIUrl":"10.1038/s41576-024-00739-5","url":null,"abstract":"Mustafa Mir reflects on a 1976 paper by McKnight and Miller, in which they developed a technique to directly visualize gene regulatory dynamics.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 9","pages":"601-601"},"PeriodicalIF":39.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulation of epigenetically induced cancers 表观遗传诱发癌症的调控失调
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-05-13 DOI: 10.1038/s41576-024-00742-w
Henry Ertl
{"title":"Dysregulation of epigenetically induced cancers","authors":"Henry Ertl","doi":"10.1038/s41576-024-00742-w","DOIUrl":"10.1038/s41576-024-00742-w","url":null,"abstract":"A study in Nature finds that transient perturbation of the Polycomb complex and target epigenome can irreversibly induce cancer cell fates.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 7","pages":"456-456"},"PeriodicalIF":42.7,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetics of glycosylation in mammalian development and disease 哺乳动物发育和疾病中的糖基化遗传学。
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-05-09 DOI: 10.1038/s41576-024-00725-x
Pamela Stanley
{"title":"Genetics of glycosylation in mammalian development and disease","authors":"Pamela Stanley","doi":"10.1038/s41576-024-00725-x","DOIUrl":"10.1038/s41576-024-00725-x","url":null,"abstract":"Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the development of all tissues. Analyses of glycosylation mutants in cultured mammalian cells and model organisms have been key to defining glycosylation pathways and the biological functions of glycans. More recently, applications of genome sequencing have revealed the breadth of rare congenital disorders of glycosylation in humans and the influence of genetics on the synthesis of glycans relevant to infectious diseases, cancer progression and diseases of the immune system. This improved understanding of glycan synthesis and functions is paving the way for advances in the diagnosis and treatment of glycosylation-related diseases, including the development of glycoprotein therapeutics through glycosylation engineering. In this Review, Stanley summarizes the role of genetics in mammalian glycosylation, highlighting how advances in genetic and genomic technologies are helping to characterize the genes involved and contributing to the development of therapies for diseases related to glycosylation.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 10","pages":"715-729"},"PeriodicalIF":39.1,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tandem repeat variation of human centromeres 人类中心粒的串联重复变异
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-05-08 DOI: 10.1038/s41576-024-00741-x
Kirsty Minton
{"title":"Tandem repeat variation of human centromeres","authors":"Kirsty Minton","doi":"10.1038/s41576-024-00741-x","DOIUrl":"10.1038/s41576-024-00741-x","url":null,"abstract":"Logsdon et al. report the second complete sequence of all centromeres from a single human genome, enabling comparative analyses of the variation in tandemly repeating α-satellite DNA.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 7","pages":"455-455"},"PeriodicalIF":42.7,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140881289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging role of tandem repeats in complex traits 串联重复序列在复杂性状中的新作用
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-05-07 DOI: 10.1038/s41576-024-00736-8
Michael Lamkin, Melissa Gymrek
{"title":"The emerging role of tandem repeats in complex traits","authors":"Michael Lamkin, Melissa Gymrek","doi":"10.1038/s41576-024-00736-8","DOIUrl":"10.1038/s41576-024-00736-8","url":null,"abstract":"Tandem repeats are a large source of genetic variation but are challenging to analyse and have been missing from most genome-wide studies. Results now suggest that systematic incorporation of tandem repeats into complex trait analyses is likely to yield a rich source of causal variants and new biological insights. In this Comment, Lamkin and Gymrek discuss recent results that suggest that the systematic incorporation of tandem repeats into complex trait analyses will yield a rich source of causal variants and new biological insights.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 7","pages":"452-453"},"PeriodicalIF":42.7,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140845112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prime editing sensors enable multiplexed genome editing 主编辑传感器实现了多路复用基因组编辑
IF 42.7 1区 生物学
Nature Reviews Genetics Pub Date : 2024-04-29 DOI: 10.1038/s41576-024-00737-7
Samuel I. Gould
{"title":"Prime editing sensors enable multiplexed genome editing","authors":"Samuel I. Gould","doi":"10.1038/s41576-024-00737-7","DOIUrl":"10.1038/s41576-024-00737-7","url":null,"abstract":"In this Tools of the Trade article, Samuel Gould explains how prime editing sensors can improve experimental efficiency and can be designed using a computational tool he created and named PEGG.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 7","pages":"454-454"},"PeriodicalIF":42.7,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140808422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid pathogen surveillance: field-ready sequencing solutions 快速病原体监测：现场就绪的测序解决方案
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-04-29 DOI: 10.1038/s41576-024-00734-w
Kirstyn Brunker
{"title":"Rapid pathogen surveillance: field-ready sequencing solutions","authors":"Kirstyn Brunker","doi":"10.1038/s41576-024-00734-w","DOIUrl":"10.1038/s41576-024-00734-w","url":null,"abstract":"In this Journal Club, Kirstyn Brunker highlights two papers published in 2017 that showcase how the emergence of portable sequencing capabilities improved the real-time response to infectious disease outbreaks on a global scale.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 8","pages":"532-532"},"PeriodicalIF":39.1,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140808411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The hidden world of transient enhancers 瞬态增强器的隐秘世界
IF 39.1 1区 生物学
Nature Reviews Genetics Pub Date : 2024-04-29 DOI: 10.1038/s41576-024-00735-9
Renée Beekman
{"title":"The hidden world of transient enhancers","authors":"Renée Beekman","doi":"10.1038/s41576-024-00735-9","DOIUrl":"10.1038/s41576-024-00735-9","url":null,"abstract":"Renée Beekman discusses the possibilities for research into transient enhancers by highlighting a recent paper by Vermunt et al. that identifies how they can modulate gene silencing dynamics.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 8","pages":"533-533"},"PeriodicalIF":39.1,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140808468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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