Integrating ELSI study teams in paediatric genomic research efforts

IF 52 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2025-02-03 DOI:10.1038/s41576-025-00818-1

Raquel G. Hernandez, Simoné Guambaña, Melissa W. VonDran, Patrick M. Van Hoose, Thomas J. Bell, Melissa A. Faith

引用次数: 0

Abstract

Addressing ethical, legal and social implications (ELSI) in genomics requires early integration of specialized teams to enhance community engagement, address disparities and promote health equity. Lessons learnt from the human Developmental Genotype-Tissue Expression (dGTEx) project show how implementing a collaborative framework can support genomic discovery. The promise of paediatric genomics depends on proactively addressing complex ethical and equity issues with sustained community engagement. Hernandez et al. advocate for the integration of ELSI scholars into paediatric genomic study teams to catalyse timely discovery in genomics.

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将ELSI研究团队整合到儿科基因组研究工作中

解决基因组学中的伦理、法律和社会影响问题需要尽早整合专门团队，以加强社区参与，解决差异并促进卫生公平。从人类发育基因型-组织表达（dGTEx）项目中吸取的经验教训表明，实施协作框架可以支持基因组发现。儿科基因组学的前景取决于通过持续的社区参与主动解决复杂的伦理和公平问题。Hernandez等人主张将ELSI学者整合到儿科基因组研究团队中，以催化基因组学的及时发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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