空间miromics：迈向microrna在空间生物学中的整合

IF 52 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2025-02-06 DOI:10.1038/s41576-025-00819-0

Agustín Robles-Remacho, Mats Nilsson

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引用次数: 0

摘要

空间转录组学工具能够检测和定位生物组织中数百到数千个转录本。然而，大多数技术并不是为检测microrna而设计的。现有的技术应该扩展，以纳入这些关键的分子调节因子，并使更全面的转录组学研究成为可能，这将塑造空间miRNomics的新领域。在这篇评论中，Agustín Robles-Remacho和Mats Nilsson强调了利用空间转录组学检测和定位生物组织中的microrna的机遇和挑战，并主张增加现有空间转录组学方法的发展。

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Spatial miRNomics: towards the integration of microRNAs in spatial biology

Spatial transcriptomics tools enable the detection and localization of hundreds to thousands of transcripts in biological tissues. However, most technologies are not designed to detect microRNAs. Existing technologies should be expanded to incorporate these key molecular regulators and enable more-comprehensive transcriptomic studies that will shape the new field of spatial miRNomics. In this Comment, Agustín Robles-Remacho and Mats Nilsson highlight the opportunities and challenges of using spatial transcriptomics to detect and localize microRNAs in biological tissues, and advocate for the increased development of existing spatial transcriptomics methods.

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

期刊介绍： At Nature Reviews Genetics, our goal is to be the leading source of reviews and commentaries for the scientific communities we serve. We are dedicated to publishing authoritative articles that are easily accessible to our readers. We believe in enhancing our articles with clear and understandable figures, tables, and other display items. Our aim is to provide an unparalleled service to authors, referees, and readers, and we are committed to maximizing the usefulness and impact of each article we publish. Within our journal, we publish a range of content including Research Highlights, Comments, Reviews, and Perspectives that are relevant to geneticists and genomicists. With our broad scope, we ensure that the articles we publish reach the widest possible audience. As part of the Nature Reviews portfolio of journals, we strive to uphold the high standards and reputation associated with this esteemed collection of publications.