Is enhancer-driven gene regulation all wrapped up?

IF 52 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2025-09-16 DOI:10.1038/s41576-025-00880-9

Wendy A. Bickmore

引用次数: 0

Abstract

The idea that the regulation of our genome is influenced by its three-dimensional (3D) organization dates to early cytological studies of heterochromatin and euchromatin within the nucleus. However, advances in the ability to analyse and perturb 3D genome organization now enable the functional relationship between gene regulation and 3D organization to be explored at unparalleled spatial and genomic resolution. In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.

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增强子驱动的基因调控已经结束了吗？

基因组调控受其三维（3D）组织影响的观点可以追溯到细胞核内异染色质和常染色质的早期细胞学研究。然而，分析和干扰三维基因组组织能力的进步，现在使基因调控和三维组织之间的功能关系能够以无与伦比的空间和基因组分辨率进行探索。在这篇评论中，Wendy Bickmore讨论了三维基因组组织如何促进远端增强子与其靶启动子之间的通信以调节基因表达的机制模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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