生物银行规模的调控基因组学

IF 52 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2025-09-16 DOI:10.1038/s41576-025-00879-2

Stephen B. Montgomery

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引用次数: 0

摘要

生物库规模的基因表达和蛋白质组学研究为研究基因调控及其对性状和疾病的影响提供了新的机会。从小型队列研究转向具有调控基因组学数据的数千人研究，将加速基因调控和非编码变异在精准健康领域的应用。人类调控基因组学的研究正在生物银行规模上进行，数据来自成千上万的个体。Stephen Montgomery描述了这些数据集将如何推进我们对基因调控变异如何塑造人类特征和疾病的理解。

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Regulatory genomics at biobank scales

Biobank-scale studies of gene expression and proteomics are providing new opportunities to study gene regulation and its effect on traits and diseases. Moving from small cohorts to studies of thousands of people with regulatory genomics data will accelerate the use of gene regulation and non-coding variation in precision health. Studies of human regulatory genomics are being performed at biobank scales, with data from tens of thousands of individuals. Stephen Montgomery describes how these datasets will advance our understanding of how variation in gene regulation shapes human traits and disease.

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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