Nature Reviews Genetics最新文献_第5页

Building and applying pangenome references to capture genetic diversity 构建和应用泛基因组参考文献捕捉遗传多样性

IF 42.7 1区生物学

Nature Reviews Genetics Pub Date : 2026-07-16 DOI: 10.1038/s41576-026-00987-7

Hufsah Ashraf, Daniel Doerr, Jana Ebler, Tobias Marschall

引用次数: 0

Folding a broken genome: the versatile roles of cohesin in genome maintenance 折叠一个破碎的基因组：粘接蛋白在基因组维护中的多功能作用

IF 51.4 1区生物学

Nature Reviews Genetics Pub Date : 2026-07-13 DOI: 10.1038/s41576-026-00988-6

Alberto Marin-Gonzalez, Taekjip Ha (, )

{"title":"Folding a broken genome: the versatile roles of cohesin in genome maintenance","authors":"Alberto Marin-Gonzalez, Taekjip Ha \u0000 (, )","doi":"10.1038/s41576-026-00988-6","DOIUrl":"10.1038/s41576-026-00988-6","url":null,"abstract":"Cohesin is a protein complex that shapes 3D genome organization through two distinct mechanisms. First, cohesin tethers replicated chromatids from DNA replication until mitosis. This process, known as sister chromatid cohesion, ensures accurate chromosome segregation and enables high-fidelity DNA repair through homologous recombination between the sister chromatids. Second, cohesin organizes the genome during interphase by dynamically extruding chromatin loops, structures that have key roles in gene regulation. Recent work has shown that, in addition to the well-established repair functions of sister chromatid cohesion, cohesin-mediated chromatin looping is closely linked to the repair of DNA double-strand breaks — one of the most toxic DNA lesions. In this Review, we discuss the central roles of cohesin in maintaining genome stability, with emphasis on the cellular response to DNA double-strand breaks. We review how dynamic loop structures facilitate signalling of repair events and promote long-range chromatin motions that underpin the repair process. Overall, its dual mode of action — cohesion and loop extrusion — positions cohesin as a central regulator of chromatin architecture and genome maintenance. The protein complex cohesin shapes 3D genome organization through both cohesion and loop extrusion. The authors review the roles of these two mechanistic functions in the cellular response to DNA double-strand breaks, wherein cohesin acts to signal the presence of DNA damage, establish a repair environment, and catalyse the DNA repair process.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 10","pages":"762-778"},"PeriodicalIF":51.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic analysis of imaging-derived phenotypes. 成像衍生表型的遗传分析。

IF 51.4 1区生物学

Nature Reviews Genetics Pub Date : 2026-07-06 DOI: 10.1038/s41576-026-00989-5

Yiming Bian, Joshua M Akey

引用次数: 0

Genetic origins and constraints of evolutionary innovation 进化创新的遗传起源和约束

IF 51.4 1区生物学

Nature Reviews Genetics Pub Date : 2026-06-19 DOI: 10.1038/s41576-026-00983-x

引用次数: 0

Single-cell four-omics with CHARM 单细胞四组学与CHARM。

IF 51.4 1区生物学

Nature Reviews Genetics Pub Date : 2026-06-12 DOI: 10.1038/s41576-026-00986-8

Yujie Chen

引用次数: 0

Molecular integration of seasonal temperature signals in flowering time control 季节温度信号在花期调控中的分子整合。

IF 51.4 1区生物学

Nature Reviews Genetics Pub Date : 2026-06-11 DOI: 10.1038/s41576-026-00979-7

Miguel Montez, Anna Schulten, Govind Menon, Caroline Dean

{"title":"Molecular integration of seasonal temperature signals in flowering time control","authors":"Miguel Montez, Anna Schulten, Govind Menon, Caroline Dean","doi":"10.1038/s41576-026-00979-7","DOIUrl":"10.1038/s41576-026-00979-7","url":null,"abstract":"Many plants sense and respond to temperature signals over long seasonal timescales to robustly time the transition to reproductive development — a process that will have to cope with the rapidly changing climate. Decades of genetic and molecular analyses have identified many genes influencing flowering in response to environmental signals. Among these, the regulation of one gene, FLOWERING LOCUS C (FLC), is central to requiring and responding to the prolonged cold of winter, aligning flowering with spring. Recent advances in our mechanistic understanding of FLC regulation suggest that, in contrast to a classic temperature signalling cascade, different aspects of natural fluctuating temperatures are monitored in parallel over various timescales and integrated through chromatin memory mechanisms, providing a robust way to accommodate climate variation. Dissecting the complexity and the source of adaptive variation in these flowering mechanisms helps in understanding the consequences of climate change with far-reaching implications for crop improvement. Plants must accurately time flowering by integrating seasonal temperature cues to ensure reproductive success. This Review describes how two mechanisms — rapid transcriptional responses and long-term epigenetic memory — work together in parallel to robustly control flowering time, and it highlights that variation in these processes provides important information for the future of crops under a changing climate.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 9","pages":"695-707"},"PeriodicalIF":51.4,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148227086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RBPscan measures protein–RNA interactions in living cells RBPscan测量活细胞中蛋白质- rna的相互作用。

IF 51.4 1区生物学

Nature Reviews Genetics Pub Date : 2026-06-08 DOI: 10.1038/s41576-026-00985-9

Dmitry A. Kretov, Daniel Cifuentes

引用次数: 0

Revisiting retinal and macular degeneration in the genomics era 重新审视基因组时代的视网膜和黄斑变性。

IF 51.4 1区生物学

Nature Reviews Genetics Pub Date : 2026-06-02 DOI: 10.1038/s41576-026-00960-4

Anand Swaroop, Botond Roska

引用次数: 0

How evolution builds three morphs from one genome 进化是如何从一个基因组构建出三种变体的。

IF 51.4 1区生物学

Nature Reviews Genetics Pub Date : 2026-06-01 DOI: 10.1038/s41576-026-00984-w

Sarah Kocher

引用次数: 0

Advancing the applications of liquid biopsies in oncology 推进液体活检在肿瘤学中的应用。

IF 51.4 1区生物学

Nature Reviews Genetics Pub Date : 2026-05-29 DOI: 10.1038/s41576-026-00974-y

Sara Valpione, Alexandra Clipson, Dominic G. Rothwell, Caroline Dive, Florent Mouliere

{"title":"Advancing the applications of liquid biopsies in oncology","authors":"Sara Valpione, Alexandra Clipson, Dominic G. Rothwell, Caroline Dive, Florent Mouliere","doi":"10.1038/s41576-026-00974-y","DOIUrl":"10.1038/s41576-026-00974-y","url":null,"abstract":"Liquid biopsies are increasingly important tools for precision oncology. Although their ability to detect the minute amounts of cancer biomarkers present in biofluids is improving, limitations remain regarding accurate detection of certain pathologies, analytical validation, application range and broad clinical utility. Emerging methods harness multi-omic data from a range of circulating analytes that can be released from various sources via distinct biological processes, thereby providing complementary and more sensitive information. Modulating the cellular release of these analytes and their half-lives in blood can be exploited to inform on cancer detection, treatment selection, response and/or toxicity. Simultaneously, efforts to miniaturize liquid biopsies to capitalize on their minimally invasive nature will accelerate turnaround time and enable continuous and ideally remote monitoring of circulating analytes. Together, these advances towards next-generation liquid biopsies will substantially improve patient experience. In this Review, Valpione et al. discuss how the current applications of liquid biopsies in precision oncology might be expanded to provide a more holistic and personalized view of cancer and to improve cancer diagnosis and treatment.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"27 9","pages":"724-738"},"PeriodicalIF":51.4,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0