Nature Reviews Genetics最新文献_第5页

Reconstructing generation intervals over time 随着时间的推移重建世代间隔

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-08-05 DOI: 10.1038/s41576-024-00766-2

Pablo Librado

引用次数: 0

Chromosomal instability as a driver of cancer progression 染色体不稳定性是癌症进展的驱动因素

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-07-29 DOI: 10.1038/s41576-024-00761-7

Xuelan Chen, Albert S. Agustinus, Jun Li, Melody DiBona, Samuel F. Bakhoum

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Epigenetic editing works like a CHARM 表观遗传编辑就像 "CHARM "一样有效

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-07-22 DOI: 10.1038/s41576-024-00765-3

Kirsty Minton

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Evolution and regulation of animal sex chromosomes 动物性染色体的进化与调控。

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-07-18 DOI: 10.1038/s41576-024-00757-3

Zexian Zhu, Lubna Younas, Qi Zhou

{"title":"Evolution and regulation of animal sex chromosomes","authors":"Zexian Zhu, Lubna Younas, Qi Zhou","doi":"10.1038/s41576-024-00757-3","DOIUrl":"10.1038/s41576-024-00757-3","url":null,"abstract":"Animal sex chromosomes typically carry the upstream sex-determining gene that triggers testis or ovary development and, in some species, are regulated by global dosage compensation in response to functional decay of the Y chromosome. Despite the importance of these pathways, they exhibit striking differences across species, raising fundamental questions regarding the mechanisms underlying their evolutionary turnover. Recent studies of non-model organisms, including insects, reptiles and teleosts, have yielded a broad view of the diversity of sex chromosomes that challenges established theories. Moreover, continued studies in model organisms with recently developed technologies have characterized the dynamics of sex determination and dosage compensation in three-dimensional nuclear space and at single-cell resolution. Here, we synthesize recent insights into sex chromosomes from a variety of species to review their evolutionary dynamics with respect to the canonical model, as well as their diverse mechanisms of regulation. Advances in genomic technologies have enabled investigations into a wide range of species. In this Review, the authors describe recent studies in both non-model and model organisms that illustrate the diversity of animal sex chromosomes with respect to their evolutionary histories and mechanistic roles in sex-determination systems.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"26 1","pages":"59-74"},"PeriodicalIF":39.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable DNA rearrangements using bridge RNAs 利用桥式 RNA 进行可编程 DNA 重排

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-07-12 DOI: 10.1038/s41576-024-00763-5

Henry Ertl

引用次数: 0

Decoding protein–RNA interactions using CLIP-based methodologies 利用基于 CLIP 的方法解码蛋白质-RNA 之间的相互作用

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-07-09 DOI: 10.1038/s41576-024-00749-3

Joy S. Xiang, Danielle M. Schafer, Katherine L. Rothamel, Gene W. Yeo

{"title":"Decoding protein–RNA interactions using CLIP-based methodologies","authors":"Joy S. Xiang, Danielle M. Schafer, Katherine L. Rothamel, Gene W. Yeo","doi":"10.1038/s41576-024-00749-3","DOIUrl":"10.1038/s41576-024-00749-3","url":null,"abstract":"Protein–RNA interactions are central to all RNA processing events, with pivotal roles in the regulation of gene expression and cellular functions. Dysregulation of these interactions has been increasingly linked to the pathogenesis of human diseases. High-throughput approaches to identify RNA-binding proteins and their binding sites on RNA — in particular, ultraviolet crosslinking followed by immunoprecipitation (CLIP) — have helped to map the RNA interactome, yielding transcriptome-wide protein–RNA atlases that have contributed to key mechanistic insights into gene expression and gene-regulatory networks. Here, we review these recent advances, explore the effects of cellular context on RNA binding, and discuss how these insights are shaping our understanding of cellular biology. We also review the potential therapeutic applications arising from new knowledge of protein–RNA interactions. RNA-binding proteins regulate the lifecycle of RNA, and their dysregulation is associated with diseases such as cancer and neurodegeneration. Using methods based on ultraviolet crosslinking followed by immunoprecipitation (CLIP), we can now begin to decode the mechanisms of the interactions between RNA-binding proteins and RNA. This Review discusses recent insights from and future applications of these methodologies.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 12","pages":"879-895"},"PeriodicalIF":39.1,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: How germ granules promote germ cell fate 出版商更正：生殖颗粒如何促进生殖细胞的命运

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-07-09 DOI: 10.1038/s41576-024-00764-4

Melissa C. Pamula, Ruth Lehmann

引用次数: 0

Decoding the language of chromatin modifications with MARCS 用 MARCS 解码染色质修饰语言。

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-07-05 DOI: 10.1038/s41576-024-00758-2

Andrey Tvardovskiy, Saulius Lukauskas

引用次数: 0

Revealing gene function with statistical inference at single-cell resolution 以单细胞分辨率的统计推断揭示基因功能

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-07-01 DOI: 10.1038/s41576-024-00750-w

Cole Trapnell

{"title":"Revealing gene function with statistical inference at single-cell resolution","authors":"Cole Trapnell","doi":"10.1038/s41576-024-00750-w","DOIUrl":"10.1038/s41576-024-00750-w","url":null,"abstract":"Single-cell and spatial molecular profiling assays have shown large gains in sensitivity, resolution and throughput. Applying these technologies to specimens from human and model organisms promises to comprehensively catalogue cell types, reveal their lineage origins in development and discern their contributions to disease pathogenesis. Moreover, rapidly dropping costs have made well-controlled perturbation experiments and cohort studies widely accessible, illuminating mechanisms that give rise to phenotypes at the scale of the cell, the tissue and the whole organism. Interpreting the coming flood of single-cell data, much of which will be spatially resolved, will place a tremendous burden on existing computational pipelines. However, statistical concepts, models, tools and algorithms can be repurposed to solve problems now arising in genetic and molecular biology studies of development and disease. Here, I review how the questions that recent technological innovations promise to answer can be addressed by the major classes of statistical tools. Single-cell, spatial and multi-omic profiling technologies generate large-scale data that reveal the output of genome-scale experiments across diverse cells, tissues and organisms. Cole Trapnell reviews the underlying core statistical challenges that need to be tackled to harness the power of these technologies and advance our understanding of gene function in health and disease.","PeriodicalId":19067,"journal":{"name":"Nature Reviews Genetics","volume":"25 9","pages":"623-638"},"PeriodicalIF":39.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charting the evolutionary history of malaria 描绘疟疾的进化史

IF 39.1 1区生物学

Nature Reviews Genetics Pub Date : 2024-06-26 DOI: 10.1038/s41576-024-00756-4

Linda Koch

引用次数: 0