Molecules最新文献_第6页

A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy. 一种具有pH/粘度双重响应的双光子Zn（II）复合光敏剂用于增强肿瘤治疗。

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112430

Yu Zhang, Shao-Qi Guan, Ya-Ping Wang, Mei Pan

引用次数: 0

Tailoring Polymeric Scaffolds with Buddleja globosa Extract for Dual Antimicrobial and Biocompatible Wound Healing Applications. 用巨花提取物裁剪聚合物支架用于双重抗菌和生物相容性伤口愈合应用。

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112428

Ricardo Ceriani, Daniel A Cherif-Pino, Pamela Pérez-Basáez, Marcela Escobar, Patricio Leyton, Caroline R Weinstein-Oppenheimer, Daniel F Moraga-Espinoza, Tania F Bahamondez-Canas

{"title":"Tailoring Polymeric Scaffolds with Buddleja globosa Extract for Dual Antimicrobial and Biocompatible Wound Healing Applications.","authors":"Ricardo Ceriani, Daniel A Cherif-Pino, Pamela Pérez-Basáez, Marcela Escobar, Patricio Leyton, Caroline R Weinstein-Oppenheimer, Daniel F Moraga-Espinoza, Tania F Bahamondez-Canas","doi":"10.3390/molecules30112428","DOIUrl":"10.3390/molecules30112428","url":null,"abstract":"Integrating traditional herbal extracts into modern biomaterials offers a promising route for advanced wound care. A standardized Buddleja globosa Hope extract (BG-126), recognized for its therapeutic value, was incorporated into polymeric scaffolds with variable composition to explore their potential in promoting wound healing and controlling infections. This work aimed to identify the polymeric composition of a scaffold with BG-126 that maximizes its compatibility and antimicrobial properties. Scaffolds were developed by lyophilization using a Box-Behnken design (BBD) with chitosan, hyaluronic acid, and gelatin content as study factors. Thirteen scaffold formulations were tested for their antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa, including biofilm forms, as well as for their biocompatibility with normal human fibroblasts. Structural and physical properties, such as the moisture content and swelling capacity, were evaluated. The best-performing scaffold was analyzed using Raman spectroscopy. The chitosan content was strongly associated with antimicrobial efficacy, while gelatin enhanced fibroblast compatibility (R2 ≥ 0.9). No correlations were identified between the polymeric content and biofilm inhibition or physical properties. BG-126-loaded scaffolds reduced planktonic and biofilm proliferation and improved fibroblast compatibility compared to the control scaffold (without BG-126). The results support the rational design of botanical-loaded scaffolds with targeted properties for wound healing.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12155708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative Ion Formation by the Thermal Surface Ionization of Oxygen-Bearing Gases (O₂, CO₂, CO, NO, and NO₂). 含氧气体（O2, CO2， CO， NO和NO2）的热表面电离形成负离子。

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112420

Patryk Gontarz, Andrzej Pelc

{"title":"Negative Ion Formation by the Thermal Surface Ionization of Oxygen-Bearing Gases (O2, CO2, CO, NO, and NO2).","authors":"Patryk Gontarz, Andrzej Pelc","doi":"10.3390/molecules30112420","DOIUrl":"10.3390/molecules30112420","url":null,"abstract":"The formation of the oxygen negative ion O- from simple molecules such as O2, CO2, CO, NO, and NO2 is of fundamental importance in environmental, atmospheric, and biological processes. This study investigates the mechanisms of O- ion generation from these gases by analyzing the dependence of O- ion current intensity on filament temperature. Optimum temperatures for O- formation were identified for each gas, ranging from 1548 to 1721 °C. A comparison with the calculated thermal decomposition temperatures of the respective compounds indicates that distinct ion formation pathways are involved. For NO2, the process likely involves a two-step dissociation mechanism, with molecular oxygen (O2) formed in the first step, subsequently dissociating into O- and O atoms. In contrast, for CO, O- formation predominantly occurs through electron capture followed by molecular dissociation. These findings underscore the complex nature of negative surface ionization, which includes contributions from the capture of emitted from the cathode electrons by molecules.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12155879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbazole- Versus Phenothiazine-Based Electron Donors for Organic Dye-Sensitized Solar Cells. 有机染料敏化太阳能电池中咔唑与吩噻嗪基电子给体的比较。

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112423

Daria Slobodinyuk, Alexey Slobodinyuk

{"title":"Carbazole- Versus Phenothiazine-Based Electron Donors for Organic Dye-Sensitized Solar Cells.","authors":"Daria Slobodinyuk, Alexey Slobodinyuk","doi":"10.3390/molecules30112423","DOIUrl":"10.3390/molecules30112423","url":null,"abstract":"Recently, research and development in the field of dye-sensitized solar cells has been actively advanced, as the technology constitutes a potential alternative to silicon-based photovoltaic devices. Modification of the molecular structure of the dye can enhance the adsorption on the TiO2 surface, improve the light absorption capacity, suppress the charge recombination, increase the electron injection rate, and thereby improve the overall performance of the solar cell. Carbazole and phenothiazine are rigid heterocyclic compounds containing nitrogen as a heteroatom with large π-conjugated skeletons. Phenothiazine differs from carbazole by the presence of sulfur as an additional electron-rich heteroatom. The inclusion of this heteroatom in the structure of the compounds can indeed improve the electron-donating properties, affect the conjugation, and thus affect the optical, electronic, and electrochemical properties of the chromophores as a whole. The difference in planarity when comparing carbazole with phenothiazine can be useful from several points of view. The planar structure of carbazole increases the degree of conjugation and the electron transfer capacity, which can increase the photocurrent of the cell. The nonplanar structure of phenothiazine helps to prevent π-stacking aggregation. This review comprehensively summarizes the progress in the field of synthesis of organic dyes for solar cells with an emphasis on the comparative analysis of two electron-donating moieties, carbazole and phenothiazine. In addition, the review describes in detail the relationship between the structure of the compounds (dyes), their properties, and the performance of solar cells.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified Polyethylene Oxide Solid-State Electrolytes with Poly(vinylidene fluoride-hexafluoropropylene). 聚偏氟乙烯-六氟丙烯改性聚氧化物固态电解质。

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112422

Jinwei Yan, Wen Huang, Tangqi Hu, Hai Huang, Chengwei Zhu, Zhijie Chen, Xiaohong Fan, Qihui Wu, Yi Li

{"title":"Modified Polyethylene Oxide Solid-State Electrolytes with Poly(vinylidene fluoride-hexafluoropropylene).","authors":"Jinwei Yan, Wen Huang, Tangqi Hu, Hai Huang, Chengwei Zhu, Zhijie Chen, Xiaohong Fan, Qihui Wu, Yi Li","doi":"10.3390/molecules30112422","DOIUrl":"10.3390/molecules30112422","url":null,"abstract":"Lithium-ion batteries are restricted in development due to safety issues such as poor chemical stability and flammability of organic liquid electrolytes. Replacing liquid electrolytes with solid ones is crucial for improving battery safety and performance. This study aims to enhance the performance of polyethylene oxide (PEO)-based polymer via blending with poly(vinylidene fluoride-hexafluoropropylene) (P(VDF-HFP)). The experimental results showed that the addition of P(VDF-HFP) disrupted the crystalline regions of PEO by increasing the amorphous domains, thus improving lithium-ion migration capability. The electrolyte membrane with 30 wt% P(VDF-HFP) and 70 wt% PEO exhibited the highest ionic conductivity, widest electrochemical window, and enhanced thermal stability, as well as a high lithium-ion transference number (0.45). The cells assembled with this membrane electrolyte demonstrated an excellent rate of performance and cycling stability, retaining specific capacities of 122.39 mAh g-1 after 200 cycles at 0.5C, and 112.77 mAh g-1 after 200 cycles at 1C and 25 °C. The full cell assembled with LiFePO4 as the positive electrode exhibits excellent rate performance and good cycling stability, indicating that prepared solid electrolytes have great potential applications in lithium batteries.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Lignin-Based Zwitterionic Surfactant Facilitates Heavy Oil Viscosity Reduction via Interfacial Modification and Molecular Aggregation Disruption in High-Salinity Reservoirs. 一种基于木质素的两性离子表面活性剂通过界面改性和分子聚集破坏来降低稠油在高盐油藏中的粘度。

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112419

Qiutao Wu, Tao Liu, Xinru Xu, Jingyi Yang

{"title":"A Lignin-Based Zwitterionic Surfactant Facilitates Heavy Oil Viscosity Reduction via Interfacial Modification and Molecular Aggregation Disruption in High-Salinity Reservoirs.","authors":"Qiutao Wu, Tao Liu, Xinru Xu, Jingyi Yang","doi":"10.3390/molecules30112419","DOIUrl":"10.3390/molecules30112419","url":null,"abstract":"The development of eco-friendly surfactants is pivotal for enhanced oil recovery (EOR). In this study, a novel lignin-derived zwitterionic surfactant (DMS) was synthesized through a two-step chemical process involving esterification and free radical polymerization, utilizing renewable alkali lignin, maleic anhydride, dimethylamino propyl methacrylamide (DMAPMA), and sulfobetaine methacrylate (SBMA) as precursors. Comprehensive characterization via 1H NMR, FTIR, and XPS validated the successful integration of amphiphilic functionalities. Hydrophilic-lipophilic balance (HLB) analysis showed a strong tendency to form stable oil-in-water (O/W) emulsions. The experimental results showed a remarkable 91.6% viscosity reduction in Xinjiang heavy crude oil emulsions at an optimum dosage of 1000 mg/L. Notably, DMS retained an 84.8% viscosity reduction efficiency under hypersaline conditions (total dissolved solids, TDS = 200,460 mg/L), demonstrating exceptional salt tolerance. Mechanistic insights derived from zeta potential measurements and molecular dynamics simulations revealed dual functionalities: interfacial modification by DMS-induced O/W phase inversion and electrostatic repulsion (zeta potential: -30.89 mV) stabilized the emulsion while disrupting π-π interactions between asphaltenes and resins, thereby mitigating macromolecular aggregation in the oil phase. As a green, bio-based viscosity suppressor, DMS exhibits significant potential for heavy oil recovery in high-salinity reservoirs, addressing the persistent challenge of salinity-induced inefficacy in conventional chemical solutions and offering a sustainable pathway for enhanced oil recovery.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12155679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Mechanochromic and Solvatochromic Luminescence of Cyclometalated Heteroleptic Platinum(II) Complexes with Benzoylthiourea Derivatives. 苯甲酰硫脲衍生物环金属化杂电铂配合物的机械致变色和溶剂致变色发光研究。

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112415

Monica Iliş, Marilena Ferbinteanu, Cristina Tablet, Viorel Cîrcu

{"title":"Investigation of Mechanochromic and Solvatochromic Luminescence of Cyclometalated Heteroleptic Platinum(II) Complexes with Benzoylthiourea Derivatives.","authors":"Monica Iliş, Marilena Ferbinteanu, Cristina Tablet, Viorel Cîrcu","doi":"10.3390/molecules30112415","DOIUrl":"10.3390/molecules30112415","url":null,"abstract":"Two novel cyclometalated platinum(II) complexes based on 2-phenylpyridine (ppy) and 2,4-difluorophenylpyridine (dfppy) ligands in combination with a benzoylthiourea (4-(decyloxy)-N-((4-(decyloxy)phenyl)carbamothioyl)benzamide, BTU) functionalized with decyloxy alkyl chains as auxiliary ligands were synthesized and characterized for their mechanochromic and photophysical properties. Structural characterization was achieved through IR and NMR spectroscopy, single-crystal X-ray diffraction, and TD-DFT calculations. Both complexes exhibit significant photoluminescence with quantum yields up to 28.3% in a 1% PMMA film. The transitions in solution-phase spectra were assigned to mixed metal-to-ligand (MLCT) and intraligand (ILCT) charge-transfer characteristics. Temperature-dependent studies and thermal analyses confirm reversible phase transitions without mesomorphic behavior despite the presence of the two long alkyl chains. Both complexes displayed reversible mechanochromic and solvatochromic luminescence, with a change in emission color from green to red-orange emissions upon grinding and solvent treatment or heating at 80 °C.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Multilayer Magnetic Janus Sub-Micrometric Particles for Lipase Catalysis in Pickering Emulsion. 用于酸洗乳中脂肪酶催化的多层磁性Janus亚微米颗粒的研制。

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112429

Wei Wang, Xiangyao Chen, Wen-Can Huang, Simiao Di, Jie Luo

{"title":"Development of Multilayer Magnetic Janus Sub-Micrometric Particles for Lipase Catalysis in Pickering Emulsion.","authors":"Wei Wang, Xiangyao Chen, Wen-Can Huang, Simiao Di, Jie Luo","doi":"10.3390/molecules30112429","DOIUrl":"10.3390/molecules30112429","url":null,"abstract":"This study presents a multilayer magnetic Janus sub-micrometric particle (MMJSP) as a nanoreactor for lipase catalysis. The core of the nanoparticle is constructed from a core-shell Fe3O4@SiO2 framework, which serves as a precursor for the sequential amino and aldehyde modifications using 3-aminopropyltriethoxysilane and benzaldehyde. Following localized etching and subsequent modification with N,N-dimethyldodecylamine, a Janus nanoparticle with distinct hydrophilic and hydrophobic domains is synthesized. The resulting MMJSP demonstrates a stable attachment to the reaction interface and significantly enhances lipase performance, exhibiting 1.4-fold and 1.6-fold enhancements in activity after immobilization during 1 h hydrolysis and 24 h esterification reactions, respectively. Additionally, the storage stability of the immobilized lipase is improved by 100% over a period of 30 days. Reusability assessments reveal that the immobilized enzyme retains 80.7% activity after 10 cycles of esterification and 80.6% after 50 cycles of hydrolysis, with the magnetic properties allowing for rapid separation and recovery of the immobilized enzyme.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12157209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Composition, Anti-Tyrosinase and Antioxidant Potential of Essential Oils from Acorus calamus (L.) and Juniperus communis (L.). 菖蒲和杜松精油的化学成分、抗酪氨酸酶活性及抗氧化活性研究

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112417

Hubert Sytykiewicz, Iwona Łukasik, Sylwia Goławska

{"title":"Chemical Composition, Anti-Tyrosinase and Antioxidant Potential of Essential Oils from Acorus calamus (L.) and Juniperus communis (L.).","authors":"Hubert Sytykiewicz, Iwona Łukasik, Sylwia Goławska","doi":"10.3390/molecules30112417","DOIUrl":"10.3390/molecules30112417","url":null,"abstract":"The essential oils (EOs) represent a natural source of diverse phytoconstituents that may exert a wide range of health-promoting effects, including antioxidative, anti-inflammatory, antimicrobial, and immunomodulatory activities. Compounds with antioxidative and anti-tyrosinase properties present in EOs may suppress excessive melanin production and protect skin cells from oxidative stress factors that often aggravate the pigmentation process. Acorus calamus L. and Juniperus communis L. plants have been traditionally used in phytotherapy, either individually or in combination. However, the biological and pharmacological effects of the essential oils derived from A. calamus rhizomes (EOA) and J. communis cone-berries (EOJ) remain underexplored. This study aimed to evaluate (1) the chemical composition of both EOA and EOJ using the gas chromatography-mass spectrometry (GC-MS) technique; (2) the anti-tyrosinase activity of the two examined EOs; and (3) their antioxidant potential against DPPH and ABTS free radicals. In addition, the anti-tyrosinase and antioxidant activities of mixtures of EOA and EOJ were also investigated. GC-MS analyses identified 48 and 81 chemical compounds in the EOA and EOJ, respectively. The main constituents of the EOA were sesquiterpenoids, including acorenone (18.1%), preisocalamendiol (12.0%), shyobunone (7.5%), and isoshyobunone (5.7%). In contrast, EOJ was primarily composed of α-pinene (22%), a monoterpene. In vitro analyses demonstrated that both individual and combined EOs exhibited notable antioxidant and anti-tyrosinase activities. The health-promoting potential of these EOs is discussed.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents. 二水合硫氰酸红霉素在六种纯溶剂和两种二元溶剂中的热力学行为。

IF 4.2 2区化学

Molecules Pub Date : 2025-05-31 DOI: 10.3390/molecules30112424

Jin Feng, Xunhui Li, Lianjie Zhai, Peizhou Li, Ting Qin, Na Wang, Lu Zhou, Baoxin Zhang, Ting Wang, Xin Huang, Hongxun Hao

{"title":"Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents.","authors":"Jin Feng, Xunhui Li, Lianjie Zhai, Peizhou Li, Ting Qin, Na Wang, Lu Zhou, Baoxin Zhang, Ting Wang, Xin Huang, Hongxun Hao","doi":"10.3390/molecules30112424","DOIUrl":"10.3390/molecules30112424","url":null,"abstract":"Thermodynamic parameters play a crucial role in analyzing and optimizing crystallization processes. In this investigation, the solubility profiles of erythromycin thiocyanate dihydrate were determined gravimetrically under atmospheric pressure (0.1 MPa) across six monosolvent systems (methanol, n-propanol, methyl acetate, ethyl acetate, propyl acetate, and water) and two binary solvent mixtures (water-methanol and water-n-propanol), spanning a temperature range of 278.15-318.15 K. The results showed that the solubility of erythromycin thiocyanate dihydrate is apparently affected by temperature and solvent type. For pure solvents, erythromycin thiocyanate dihydrate has higher solubility in alcohol solvents, and lower solubility in ester solvents and water. In mixed solvent systems, erythromycin thiocyanate dihydrate exhibits reduced solubility with higher water content. The experimental solubility values in monosolvent systems were correlated using the Apelblat, Yaws, and Van't Hoff models, with the Apelblat model showing the best fitting effect. The Apelblat model, Apelblat Jouyban Acre model, and CNIBS/R-K model were employed for data correlation in binary solvent systems, with the Apelblat model and CNIBS/R-K model showing better fitting results.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0