Molecules最新文献_第10页

Exercise Attenuates Skeletal Muscle Atrophy in Senescent SAMP8 Mice: Metabolic Insights from NMR-Based Metabolomics. 运动减轻衰老SAMP8小鼠的骨骼肌萎缩：来自核磁共振代谢组学的代谢见解

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092003

Wenfang Wu, Linglin Zhang, Yifen Chen, Caihua Huang, Longhe Yang, Donghai Lin

{"title":"Exercise Attenuates Skeletal Muscle Atrophy in Senescent SAMP8 Mice: Metabolic Insights from NMR-Based Metabolomics.","authors":"Wenfang Wu, Linglin Zhang, Yifen Chen, Caihua Huang, Longhe Yang, Donghai Lin","doi":"10.3390/molecules30092003","DOIUrl":"10.3390/molecules30092003","url":null,"abstract":"Age-related skeletal muscle atrophy is a major health concern in the elderly, contributing to reduced mobility, increased risk of falls, and metabolic dysfunction. The senescence-accelerated prone 8 (SAMP8) mouse model, known for its rapid aging and early cognitive decline, serves as an essential model for studying age-related muscle degeneration. While previous studies have shown that exercise attenuates muscle atrophy by promoting regeneration and improving strength, the underlying metabolic mechanisms remain poorly understood. This study used the SAMP8 model to evaluate the effects of exercise on muscle atrophy and associated metabolic changes. Our results show that exercise promoted muscle growth by reducing body weight, increasing skeletal muscle mass, and decreasing fat accumulation. Furthermore, exercise improved grip strength, muscle tone, and muscle fiber cross-sectional area, thereby preserving muscle functionality. NMR-based metabolomic analysis identified key metabolic pathways modulated by exercise, including glycine, serine, and threonine metabolism; alanine, aspartate, and glutamate metabolism; pyruvate metabolism; and taurine and hypotaurine metabolism. These findings underscore the therapeutic potential of exercise in combating age-related muscle wasting and elucidate the metabolic pathways underlying its benefits.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

¹H-NMR Guided Isolation of Bioactive Compounds from Species of the Genus Piper. 核磁共振引导下胡椒属植物生物活性化合物的分离。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092020

Celso R Oliveira, Megan J Burroughs, Lora A Richards, Lee A Dyer, Federico Urbano-Muñoz, Camryn Lee, Megan Warner, Craig D Dodson, Ian S Wallace, Christopher S Jeffrey

{"title":"1H-NMR Guided Isolation of Bioactive Compounds from Species of the Genus Piper.","authors":"Celso R Oliveira, Megan J Burroughs, Lora A Richards, Lee A Dyer, Federico Urbano-Muñoz, Camryn Lee, Megan Warner, Craig D Dodson, Ian S Wallace, Christopher S Jeffrey","doi":"10.3390/molecules30092020","DOIUrl":"10.3390/molecules30092020","url":null,"abstract":"The discovery of bioactive natural products is often challenged by the complexity of isolating and characterizing active compounds within diverse mixtures. Previously, we introduced a 1H NMR-based weighted gene correlation network analysis (WGCNA) approach to identify spectral features linked to growth inhibitory activity of Piper (Piperaceae) leaf extracts against model plant, fungal, and bacterial organisms. This method enabled us to prioritize specific spectral features linked to bioactivity, offering a targeted approach to natural product discovery. In this study, we validate the predictive capacity of the WGCNA by isolating the compounds responsible for the bioactivity-associated resonances and confirming their antifungal efficacy. Using growth inhibition assays, we verified that the isolated compounds, including three novel antifungal agents, exhibited significant bioactivity. Notably, one of these compounds contains a rare imidazolium heterocyclic motif, marking a new structural class in Piper. These findings substantiate the 1H NMR-based WGCNA as a reliable tool for identifying structural types associated with biological activity, streamlining the process of discovering bioactive natural products in complex extracts.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous Determination of 32 Polyphenolic Compounds in Berries via HPLC-MS/MS. HPLC-MS/MS同时测定浆果中32种多酚类化合物。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092008

Yuan Wang, Lijie Xing, Jinlei Zhang, Yongfa Chen, Shiling Lu

{"title":"Simultaneous Determination of 32 Polyphenolic Compounds in Berries via HPLC-MS/MS.","authors":"Yuan Wang, Lijie Xing, Jinlei Zhang, Yongfa Chen, Shiling Lu","doi":"10.3390/molecules30092008","DOIUrl":"10.3390/molecules30092008","url":null,"abstract":"An HPLC-MS/MS method for the simultaneous determination of 32 polyphenolic compounds in berries was established. For method validation, the berry samples were extracted with 80% ethanol, purified on an HLB column, and separated on a C18 column via gradient elution with an acetonitrile-water mobile phase system before mass spectrometry detection with electrospray ionization in negative mode and multiple reaction monitoring. The results revealed that the 32 polyphenolic compounds had a good linear relationship in the concentration range of 1-500 μg/L, with R2 > 0.99, limits of detection, limits of quantitation, and recoveries of 0.2-0.6 μg/kg, 0.3-1.0 μg/kg, and 82.8-104.8%, respectively, and RSDs < 5.8%. The contents of polyphenolic compounds in the berries were determined, with 23 polyphenolic compounds in sea buckthorn, 18 in mulberry, 17 in black wolfberry, and 12 in red wolfberry. Eight polyphenolic compounds were found in all 4 kinds of berries, including 4-hydroxybenzoic acid, p-coumaric acid, ferulic acid, erucic acid, rutin, hypericin, kaempferol-3-O-rutinoside, and daffinoside. Additionally, six polyphenolic compounds, catechin, syringic acid, isorhamnetin-3-O-galactoside, isorhamnetin-3-O-glucoside, cinnamic acid, and isorhamnetin, were detected only in sea buckthorn.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squaramide-Catalyzed Asymmetric Michael Addition/Cyclization Reaction for the Synthesis of Chiral Bisspiro Barbituric Acid-Oxindole Derivatives. squar酰胺催化不对称Michael加成/环化反应合成手性双螺巴比妥酸-氧吲哚衍生物。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30092000

De-Jun Qiao, Da-Ming Du

引用次数: 0

Ti-Supported Oxide Coatings Based on MWO₄ (M = Fe, Co, Ni): Plasma Electrolytic Synthesis, Characterization and Catalytic Properties in S, N-Heterocycles Peroxide Oxidation. 基于MWO4 （M = Fe, Co, Ni）的ti负载氧化物涂层：等离子体电解合成、表征及其在S， n -杂环过氧化氧化中的催化性能

IF 4.2 2区化学

Molecules Pub Date : 2025-04-30 DOI: 10.3390/molecules30091998

Irina G Tarkhanova, Vladimir M Zelikman, Irina V Lukiyanchuk, Marina S Vasilyeva, Vladimir V Tkachev, Vladimir V Korochentsev, Daria H Shlyk

{"title":"Ti-Supported Oxide Coatings Based on MWO4 (M = Fe, Co, Ni): Plasma Electrolytic Synthesis, Characterization and Catalytic Properties in S, N-Heterocycles Peroxide Oxidation.","authors":"Irina G Tarkhanova, Vladimir M Zelikman, Irina V Lukiyanchuk, Marina S Vasilyeva, Vladimir V Tkachev, Vladimir V Korochentsev, Daria H Shlyk","doi":"10.3390/molecules30091998","DOIUrl":"10.3390/molecules30091998","url":null,"abstract":"In this study, catalytically active coatings on titanium were synthesized by plasma electrolytic oxidation (PEO) in aqueous electrolytes based on sodium tungstate with the addition of sodium phosphate or sodium borate and chelate complexes of iron, cobalt or nickel. Taking into account the EDX, XPS and XRD data, the oxide-phosphate coatings (PWFe, PWCo, PWNi) contained crystalline titanium oxide and amorphous tungstates and/or phosphates of iron triad metals. Amorphization was facilitated by high phosphorus concentrations (up to 6 at.%). Replacing phosphate with borate in the electrolyte with Ni(II)-EDTA complexes led to the crystallization of WO3 and NiWO4 in the PEO coatings (BWNi). All formed PEO coatings were active in reactions of the oxidative desulfurization (ODS) of thiophene and dibenzothiophene and oxidative denitrogenation (ODN) of pyridine, as well as in the simultaneous removal of S- and N-containing substrates from their mixture. The stability of samples with MWO4 increased in the following series: PWNi < PWCo < PW < PWFe < BWNi. Replacing phosphate with borate in the electrolyte resulted in the preparation of catalysts with enhanced stability and activity. In contrast to PWM catalysts, the BWNi catalyst had selectivity toward the oxidation of pyridine in its mixture with thiophene.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of Volatile Organic Compounds in Different Parts of Ginseng Powder Using Gas Chromatography-Ion Mobility Spectrometry. 气相色谱-离子迁移谱法对比分析人参粉中不同部位挥发性有机物。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-29 DOI: 10.3390/molecules30091965

Manshu Zou, Ximing Yu, Yuhuan Liu, Lijun Zhu, Feilin Ou, Chang Lei

{"title":"Comparative Analysis of Volatile Organic Compounds in Different Parts of Ginseng Powder Using Gas Chromatography-Ion Mobility Spectrometry.","authors":"Manshu Zou, Ximing Yu, Yuhuan Liu, Lijun Zhu, Feilin Ou, Chang Lei","doi":"10.3390/molecules30091965","DOIUrl":"10.3390/molecules30091965","url":null,"abstract":"The main root, reed head, and fibrous root are three different main edible medicinal parts of ginseng (Panax ginseng C. A. Meyer). When processed into ginseng products, such as ginseng powder, they exhibit similar colors and odors, easily confused in market circulation. However, there are differences in their pharmacological activity and clinical indications. Therefore, the identification of the different parts of ginseng powder is crucial for ensuring the quality, safety, and efficacy of medicinal ginseng products. In this study, we utilized gas chromatography-ion mobility spectrometry (GC-IMS) to analyze volatile organic components (VOCs) in main root, reed head, and fibrous root of ginseng. It was found that the composition of VOCs in different parts of ginseng powder was similar, but the content was different in all samples, and a total of 68 signal peaks was detected and 65 VOCs identified. In addition, combined with fingerprint analysis, principal component analysis (PCA), Euclidean distance, partial-least squares discriminant analysis (PLS-DA), and cluster analysis (CA), it clearly showed the significant differences between VOCs in different parts of ginseng powder. Our findings reveal that GC-IMS combined with chemometrics is a reliable method for distinguishing the active parts of ginseng powder, and provides essential data support for different parts of ginseng processing and functional product development.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Polylactic Acid (PLA) Films Incorporating Almond Peel Extracts for Food Preservation. 含有杏仁皮提取物的食品保鲜用活性聚乳酸（PLA）薄膜。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-29 DOI: 10.3390/molecules30091988

Laia Martin-Perez, Carolina Contreras, Amparo Chiralt, Chelo Gonzalez-Martinez

{"title":"Active Polylactic Acid (PLA) Films Incorporating Almond Peel Extracts for Food Preservation.","authors":"Laia Martin-Perez, Carolina Contreras, Amparo Chiralt, Chelo Gonzalez-Martinez","doi":"10.3390/molecules30091988","DOIUrl":"10.3390/molecules30091988","url":null,"abstract":"Almond peel extracts, containing 0.2-0.8% (w/w) phenolic compounds with notable antioxidant and antimicrobial activities, could be used as a natural source of active compounds for the development of active films for food preservation. In this study, almond peel extracts obtained by subcritical water extraction at 160 and 180 °C were incorporated into PLA films (PLA-E160 and PLA-E180). The films were characterized in terms of their microstructure, mechanical, barrier, optical and thermal properties. Furthermore, the release of phenolic compounds and hydroximethylfurfural (HFM) into food simulants with different polarity was evaluated, as well as the film's potential antioxidant and antimicrobial activities. To validate their effectiveness as active packaging materials, shelf-life studies were conducted on fresh orange juice and sunflower oil packaged using PLA-160 films. The results show that the incorporation of the almond peel extracts led to significant changes in the films' microstructure and mechanical properties, which became darker, mechanically less resistant, and stretchable (p < 0.05), with slightly lower thermal stability than neat PLA films. The release of phenolic compounds and HFM from extract-enriched films was promoted in the 95% ethanol simulant due to the matrix swelling and relaxation. Food products packaged with PLA-E160 exhibited slower oxidative degradation during storage, as indicated by the higher ascorbic acid content and hue color in orange juice and lower peroxide content in sunflower oil. Nevertheless, both in vivo and in vitro studies showed no antimicrobial effectiveness from the films, likely due to the limited release of active compounds to the surrounding medium. Thus, almond peel extract conferred valuable properties to PLA films, effectively reducing oxidative reactions in food products sensitive to these deterioration processes.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Modal Design, Synthesis, and Biological Evaluation of Novel Fusidic Acid Derivatives. 新型氟西地酸衍生物的多模态设计、合成和生物学评价。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-29 DOI: 10.3390/molecules30091983

Luqi Wang, Zhiyuan Geng, Yuhang Liu, Linhui Cao, Yao Liu, Hourui Zhang, Yi Bi, Jing Lu

{"title":"Multi-Modal Design, Synthesis, and Biological Evaluation of Novel Fusidic Acid Derivatives.","authors":"Luqi Wang, Zhiyuan Geng, Yuhang Liu, Linhui Cao, Yao Liu, Hourui Zhang, Yi Bi, Jing Lu","doi":"10.3390/molecules30091983","DOIUrl":"10.3390/molecules30091983","url":null,"abstract":"Fusidic acid (FA), a tetracyclic triterpenoid, has been approved to treat methicillin-resistant Staphylococcus aureus (MRSA) infections. However, there are few reports about FA derivatives with high efficacy superior to FA, manifesting the difficulty of discovering the derivatives based on experience-based drug design. In this study, we employed a stepwise method to discover novel FA derivatives. First, molecular dynamics (MD) simulations were performed to identify the molecular mechanism of FA against elongation factor G (EF-G) and drug resistance. Then, we utilized a scaffold decorator to design novel FA derivatives at the 3- and 21-positions of FA. The ligand-based and structure-based screening models, including Chemprop and RTMScore, were employed to identify promising hits from the generated set. Ten generated FA derivatives with high efficacy in the Chemprop and RTMScore models were synthesized for in vitro testing. Compounds 4 and 10 demonstrated a 2-fold increase in potency against MRSA strains compared to FA. This study highlights the significant impact of AI-based methods on the design of novel FA derivatives with drug efficacy, which provides a new approach for drug discovery.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Synthesis and Property Study of NH-Ac-Anchored Multilayer 3D Polymers. nh - ac -锚定多层三维聚合物的合成及性能研究。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-29 DOI: 10.3390/molecules30091981

My Phan, Hao Liu, Lina M Delgado, Hammed Olawale Faleke, Sai Zhang, Anthony F Cozzolino, Dimitri Pappas, Guigen Li

{"title":"The Synthesis and Property Study of NH-Ac-Anchored Multilayer 3D Polymers.","authors":"My Phan, Hao Liu, Lina M Delgado, Hammed Olawale Faleke, Sai Zhang, Anthony F Cozzolino, Dimitri Pappas, Guigen Li","doi":"10.3390/molecules30091981","DOIUrl":"10.3390/molecules30091981","url":null,"abstract":"This study reports the synthesis, characterization, and property analysis of four novel multilayer 3D polymers (1A to 1D) with 1,3-phenyl bridge architectures spanning 248 to 320 layers. High-molecular-weight polymers were successfully synthesized via catalytic Suzuki-Miyaura cross-coupling over a four-day reaction period. Structures, thermal, and optical properties were examined using multiple analytical techniques. Fourier transform-infrared (FT-IR) spectroscopy was used to study the hydrogen bonding within the polymer system, suggesting the formation of the polymer through the Suzuki-Miyaura coupling reaction. Ultraviolet-visible (UV-vis) spectroscopy indicated strong electronic delocalization, with maximum absorbance peaks between 257 and 280 nm. Thermal characterization, using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA), was used to investigate the thermal stability. TGA results showed that all four polymers retained more than 20% of their initial mass at 1000 °C, indicating good thermal stability across the series. DSC analysis revealed that polymer 1A exhibited a glass transition temperature (Tg) of 167 °C, indicating the presence of a network formed by aromatic conjugation and hydrogen bonding. Furthermore, the subtle Tg step observed for 1A suggests a degree of crystallinity within the polymer matrix, which was further supported by X-ray diffraction (XRD) analysis. Aggregation-induced emission (AIE) experiments provided further insights into intermolecular packing, and scanning electron microscopy (SEM) contributed to a better understanding of the morphology of the obtained polymers. These results highlight the potential of these polymers as thermally stable and conductive materials for biomedical and industrial applications.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the Rheological Properties of BGAP Adhesive and Its Propellant. BGAP胶粘剂及其推进剂的流变性能研究。

IF 4.2 2区化学

Molecules Pub Date : 2025-04-29 DOI: 10.3390/molecules30091967

Yubao Shao, Siyu Xu, Huixiang Xu, Wuxi Xie, Zihao Zhang, Ergang Yao, Hanyu Jiang

{"title":"Study on the Rheological Properties of BGAP Adhesive and Its Propellant.","authors":"Yubao Shao, Siyu Xu, Huixiang Xu, Wuxi Xie, Zihao Zhang, Ergang Yao, Hanyu Jiang","doi":"10.3390/molecules30091967","DOIUrl":"10.3390/molecules30091967","url":null,"abstract":"In order to study the curing process of branched polyazide glycidyl ether (BGAP) binder and its propellant slurry at 50 to 70 °C, the rheological properties of BGAP binder and its propellant slurry were studied by chemical rheology. The results show that the viscosity coefficient of the uncured BGAP decreases gradually when the temperature increases, and when the plasticization ratio is 1.1, the viscosity coefficient of BGAP decreases first and then remains unchanged. After adding the curing agent, the chemical rheology method can be used to calculate whether the BGAP curing system still conforms to the power-law equation in a short time. The kinetic equation of the curing reaction, expressed by apparent viscosity, is deduced from the double Arrhenius equation, which can be expressed by η(T,t) = 10.16 exp (-1.72/T) exp [17.27 t exp (-5.21/T)]. After using BGAP as the adhesive to make a propellant slurry with a liquid material component of 25%, the effect of the particle size of Al powder in the solid filler component on the curing process of the slurry was studied, and the 200 nm Al powder could not be made into a slurry under this formulation. The curing kinetics equations of the slurry with Al powder particle sizes of 5 μm, 15 μm, and 29 μm under this formula were obtained by measuring the viscosity of the slurry over time at 50-70 °C. The results showed that the smaller the Al powder particle size, the lower the viscous flow activation energy of the slurry and the higher the curing reaction activation energy.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 9","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0