Molecules最新文献

Mechanistic Study of L-Rhamnose Monohydrate Dehydration Using Terahertz Spectroscopy and Density Functional Theory.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051189

Bingxin Yan, Zeyu Hou, Yuhan Zhao, Bo Su, Cunlin Zhang, Kai Li

{"title":"Mechanistic Study of L-Rhamnose Monohydrate Dehydration Using Terahertz Spectroscopy and Density Functional Theory.","authors":"Bingxin Yan, Zeyu Hou, Yuhan Zhao, Bo Su, Cunlin Zhang, Kai Li","doi":"10.3390/molecules30051189","DOIUrl":"10.3390/molecules30051189","url":null,"abstract":"L-rhamnose has recently gained attention for its potential to enhance vaccine antigenicity. To optimize its use as a vaccine adjuvant, it is important to understand the dehydration behavior of L-rhamnose monohydrate, which plays a critical role in modifying its physicochemical properties. This study investigated the spectroscopic characteristics of L-rhamnose and its monohydrate using terahertz time-domain spectroscopy (THz-TDS), Raman spectroscopy, and powder X-ray diffraction (PXRD). The results indicate that THz-TDS can more effectively distinguish the spectral features of these two compounds and can be used to reflect the structural changes in L-rhamnose monohydrate before and after dehydration. THz spectral data show that dehydration of L-rhamnose occurs at 100 °C, and continuous heating at 100 °C can complete the dehydration process within 6 min. Density functional theory (DFT) calculations revealed that water molecule vibrations significantly affect the THz absorption peaks. These findings indicate that removing water during dehydration causes substantial changes in molecular structure and dynamics. Overall, this study highlights the value of combining THz-TDS with DFT calculations to investigate the structures of carbohydrates and their hydrates, providing an accurate method for understanding the dehydration process and molecular interactions in hydrated systems. This approach holds significant importance for the development of effective vaccine adjuvants.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance and Mechanism of Hydrolyzed Keratin for Hair Photoaging Prevention.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051182

Jiayi Fan, Lei Wu, Jing Wang, Xiaoying Bian, Chongchong Chen, Kuan Chang

{"title":"Performance and Mechanism of Hydrolyzed Keratin for Hair Photoaging Prevention.","authors":"Jiayi Fan, Lei Wu, Jing Wang, Xiaoying Bian, Chongchong Chen, Kuan Chang","doi":"10.3390/molecules30051182","DOIUrl":"10.3390/molecules30051182","url":null,"abstract":"Photoaging is common and represents one of the primary pathways for hair damage in daily life. Hydrolyzed keratin, which is usually derived from wool and consists of a series of polypeptide molecules, has been investigated as a UV damage prevention ingredient for hair care. Scanning Electron Microscopy (SEM) and fluorescent penetration experiments verified that hydrolyzed keratin can deposit on the hair cuticles to form a film and partly penetrate into the hair cortex. This film played as a UV reducer and helped hair resist surface damage and maintain a sleek and healthy morphology after UV radiation. Surprisingly, it was found that hydrolyzed keratin treatment combined with subsequent UV radiation could significantly improve the tensile properties of hair. For hydrolyzed-keratin-treated hair, tensile strength was maintained after UV radiation, while, as a comparison, it decreased by 14.32% for untreated hair. This phenomenon is explained by a UV-induced degradation-penetration mechanism. During UV radiation, an increase in free amino acid content and conductivity was observed for the hydrolyzed keratin solution, demonstrating photodegradation into smaller peptides and amino acids. The degradation of hydrolyzed keratin allowed it to more easily enter the interior of the hair cortex, thereby enhancing its tensile properties by enhancing the chemical bonds.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Sika Deer Antler Peptides on 3T3-L1 Preadipocytes and C57BL/6 Mice via Activating AMPK Signaling and Gut Microbiota.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051173

Tong Sun, Zezhuang Hao, Fanying Meng, Xue Li, Yihua Wang, Haowen Zhu, Yong Li, Yuling Ding

{"title":"The Effects of Sika Deer Antler Peptides on 3T3-L1 Preadipocytes and C57BL/6 Mice via Activating AMPK Signaling and Gut Microbiota.","authors":"Tong Sun, Zezhuang Hao, Fanying Meng, Xue Li, Yihua Wang, Haowen Zhu, Yong Li, Yuling Ding","doi":"10.3390/molecules30051173","DOIUrl":"10.3390/molecules30051173","url":null,"abstract":"(1) Background: To explore the anti-obesity effects and mechanisms of sika deer velvet antler peptides (sVAP) on 3T3-L1 preadipocytes and in high-fat diet (HFD)-induced obese mice. (2) Methods: sVAP fractions of different molecular weights were obtained via enzymatic hydrolysis and ultrafiltration. Their anti-lipid effects on 3T3-L1 cells were assessed with Oil Red O staining. The optimal fraction was tested in HFD-induced obese C57BL/6 mice to explore anti-obesity mechanisms. Peptide purification used LC-MS/MS, followed by sequence analysis and molecular docking for activity prediction. (3) Results: The peptide with the best anti-obesity activity was identified as sVAP-3K (≤3 kDa). sVAP-3K reduced lipid content and proliferation in 3T3-L1 cells, improved lipid profiles and ameliorated adipocyte degeneration in HFD mice, promoted the growth of beneficial gut microbiota, and maintained lipid metabolism. Additionally, sVAP-3K activated the AMP-activated protein kinase (AMPK) signaling pathway, regulating adipogenic transcription factors. sVAP-3K exhibited ten major components (peak area ≥ 1.03 × 108), with four of the most active components being newly discovered natural oligopeptides: RVDPVNFKL (m/z 363.21371), GGEFTPVLQ (m/z 474.24643), VDPENFRL (m/z 495.25735), and VDPVNFK (m/z 818.44043). (4) Conclusion: This study identifies four novel oligopeptides in sVAP-3K as key components for anti-obesity effects, offering new evidence for developing natural weight-loss drugs from sika deer velvet.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051187

Sisi Pu, Yangyang Pan, Zuoyang Wang, Huimin Liu, Jianhui Zhang, Qian Zhang, Meng Wang

{"title":"Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor.","authors":"Sisi Pu, Yangyang Pan, Zuoyang Wang, Huimin Liu, Jianhui Zhang, Qian Zhang, Meng Wang","doi":"10.3390/molecules30051187","DOIUrl":"10.3390/molecules30051187","url":null,"abstract":"Overdose intake of acetaminophen (APAP) causes liver injury involving hepatic drug metabolism and activation of oxidative stress pathways, and forsythiaside A (FA) has hepatoprotective pharmacological activity, but knowledge of the mechanism of FA treatment for APAP liver injury is still lacking the literature. In this study, we investigated the effects of FA on the pregnane X receptor (PXR) by molecular docking and reporter gene assays. In addition, we explored the effects of FA on oxidative stress, endoplasmic reticulum stress (ERS), apoptosis, and hepatic pathology by interfering with PXR in ex vivo and in vivo models. The results showed that FA decreased the PXR protein expression level and effectively reduced the oxidative stress level in the APAP model. In addition, FA reduced the expression of ERS pathway ProteinkinaseR-likeERkinase (PERK)-translation initiation factor 2 (eIF-2α)-activating transcription factor 4 (ATF4) by inhibiting PXR, and at the same time, decreased the expression of apoptotic proteins C/EBP homologous protein (CHOP), Bax, Caspase 3, and Caspase 7, and elevated the expression of apoptosis-suppressing protein Bcl-2, which ultimately treated the hepatic pathology injury of APAP in mice. The present study confirmed that FA improved APAP metabolism by inhibiting PXR-mediated CYP1A2 and CYP3A11 and alleviated APAP-induced hepatic impairment by inhibiting hepatic oxidative stress, ERS, and apoptosis.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of CL-20 with Controllable Particle Size Using Microfluidic Technology.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051176

Zihao Zhang, Jin Yu, Yujia Wen, Hanyu Jiang, Siyu Xu, Yubao Shao, Ergang Yao, Heng Li, Fengqi Zhao

{"title":"Preparation of CL-20 with Controllable Particle Size Using Microfluidic Technology.","authors":"Zihao Zhang, Jin Yu, Yujia Wen, Hanyu Jiang, Siyu Xu, Yubao Shao, Ergang Yao, Heng Li, Fengqi Zhao","doi":"10.3390/molecules30051176","DOIUrl":"10.3390/molecules30051176","url":null,"abstract":"As a typical high-energy-density material, the sensitivity of CL-20 severely limits its application in explosives and propellants. Adjusting its structure at the microscopic level can effectively solve such problems. In this study, a microfluidic recrystallization technique was used to prepare ε-CL-20 with three different particle sizes, with narrow particle size distributions (D50 = 2.77 μm, 17.22 μm and 50.35 μm). The prepared samples had fewer surface defects compared to the raw material. As the particle size decreased, the density of CL-20 increased and its impact sensitivity was significantly reduced. The activation energy of the CL-20 prepared using microfluidic technology increased with increases in particle size. Laser ignition experiments revealed that smaller CL-20 particles had the highest energy release efficiency, while larger particles exhibited a higher energy density and more stable energy release. The combustion performance and safety of CL-20 can be effectively improved by improving the crystal size distribution and surface morphology. Controllable preparation of multiple particle sizes of CL-20 was achieved using microfluidic recrystallization technology, which provides a reference for the preparation of multiple particle sizes of other energetic materials.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051181

Darko Mitrović, Dragana Zaklan, Maja Đanić, Bojan Stanimirov, Karmen Stankov, Hani Al-Salami, Nebojša Pavlović

{"title":"The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery.","authors":"Darko Mitrović, Dragana Zaklan, Maja Đanić, Bojan Stanimirov, Karmen Stankov, Hani Al-Salami, Nebojša Pavlović","doi":"10.3390/molecules30051181","DOIUrl":"10.3390/molecules30051181","url":null,"abstract":"Nano-drug delivery systems provide targeted solutions for addressing various drug delivery challenges, leveraging nanotechnology to enhance drug solubility and permeability. Liposomes, explored for several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or other surfactants, along with amphiphilic bile salts, and they show superior stability and pharmacokinetic behavior in comparison to conventional vesicular systems (liposomes and niosomes). Bilosomes enhance skin penetration, fluidize the stratum corneum, and improve drug stability. In oral applications, bilosomes overcome drawbacks, offering improved bioavailability, controlled release, and reduced side effects. Vaccines using bilosomes demonstrate efficacy, and bilosomes for intranasal, inhalation, ocular, and buccal applications enhance drug delivery, offering targeted, efficient, and controlled activities. Formulations vary based on active substances and optimization techniques, showcasing the versatility and potential of bilosomes across diverse drug delivery routes. Therefore, the aim of this comprehensive review was to critically explore the state-of-the-art of bilosomes in drug delivery and potential therapeutic applications.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of Amorphous and Biodegradable Copolymers: A Molecular Dynamics Study Using a Multi-Technique Approach.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051175

Alovidin Nazirov, Jacek Klinowski, John Nobleman

{"title":"Comparative Analysis of Amorphous and Biodegradable Copolymers: A Molecular Dynamics Study Using a Multi-Technique Approach.","authors":"Alovidin Nazirov, Jacek Klinowski, John Nobleman","doi":"10.3390/molecules30051175","DOIUrl":"10.3390/molecules30051175","url":null,"abstract":"We investigate the molecular dynamics of glycolide/lactide/caprolactone (Gly/Lac/Cap) copolymers using differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), 1H second-moment, 1H spin-lattice relaxation time (T1) analysis, and 13C solid-state NMR over a temperature range of 100-413 K. Activation energies and correlation times of the biopolymer chains were determined. At low temperatures, relaxation is governed by the anisotropic threefold reorientation of methyl (-CH3) groups in lactide. A notable change in T1 at ~270 K and 294 K suggests a transition in amorphous phase mobility due to translational diffusion, while a second relaxation minimum (222-312 K) is linked to CH2 group dynamics influenced by caprolactone. The activation energy increases from 5.9 kJ/mol (methyl motion) to 22-33 kJ/mol (segmental motion) as the caprolactone content rises, enhancing the molecular mobility. Conversely, lactide restricts motion by limiting rotational freedom, thereby slowing global dynamics. DSC confirms that increasing ε-caprolactone lowers the glass transition temperature, whereas higher glycolide and lactide content raises it. The onset temperature of main-chain molecular motion varies with the composition, with greater ε-caprolactone content enhancing flexibility. These findings highlight the role of composition in tuning relaxation behavior and molecular mobility in copolymers.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study on the Electrochemical Performance of SLMed Al6061/TiB2 Composite Anodes Caused by Laser Power.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051183

Jitai Han, Kui Zhu, Chenglong Li, Yin Li, Sida Tang, Peng Li

{"title":"A Study on the Electrochemical Performance of SLMed Al6061/TiB2 Composite Anodes Caused by Laser Power.","authors":"Jitai Han, Kui Zhu, Chenglong Li, Yin Li, Sida Tang, Peng Li","doi":"10.3390/molecules30051183","DOIUrl":"10.3390/molecules30051183","url":null,"abstract":"Aluminum-air batteries have attracted more attention in recent years due to the theoretical possibility of replacing lithium batteries. Al6061/0.5wt.%TiB2 is considered a suitable anode material due to decreased hydrogenation corrosion. In this work, laser power was optimized via a selective laser melting process to increase the electrochemical and discharge performance of an Al composite anode. Relative density was studied in this work, and the formation mechanism caused by molten pool morphology was also researched using finite element analysis and experiments. The self-corrosion rate, open-circuit potential, polarization curve, EIS curve, and constant-current discharge performance were all studied in the following section, and the relationship between anode quality and laser power was discussed accordingly. The testing results revealed that when laser power reached 340 W, the Al6061/0.5wt.%TiB2 composite anode reached a relative optimal condition as defects reduced to a minimum value at this point, which resulted in overall anode performance increasing in the electrochemical and discharge test.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Analysis of the Synergistic Effects of Bimetallic Oxides in CoM/γ-Al₂O₃ (M = Cu, Fe, or Ni) Catalysts for Enhancing Toluene Combustion Efficiency.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051188

Yuwei Tang, Xu Yang, Qinglong Zhang, Dongmei Lv, Shufeng Zuo, Jing Li

{"title":"Comprehensive Analysis of the Synergistic Effects of Bimetallic Oxides in CoM/γ-Al2O3 (M = Cu, Fe, or Ni) Catalysts for Enhancing Toluene Combustion Efficiency.","authors":"Yuwei Tang, Xu Yang, Qinglong Zhang, Dongmei Lv, Shufeng Zuo, Jing Li","doi":"10.3390/molecules30051188","DOIUrl":"10.3390/molecules30051188","url":null,"abstract":"Catalytic combustion is an efficient and economic technology for eliminating volatile organic compounds (VOCs) in industrial environments. This study evaluated the synergistic catalytic properties of bimetallic oxides, viz., CoM/γ-Al2O3 (M = Cu, Fe, or Ni), for improving the combustion efficiency of toluene. The CoM/γ-Al2O3 catalysts were prepared by an impregnation method and characterized by using advanced techniques. Among the bimetallic catalysts, CoCu/γ-Al2O3 exhibited the best performance. The findings revealed that owing to the strong synergistic interaction between Cu, Co, and the γ-Al2O3 support, the active species in the CoCu/γ-Al2O3 catalyst were effectively stabilized, and they significantly enhanced the redox performance and acidity of the catalyst, demonstrating superior catalytic activity and sulfur resistance. Conversely, the CoFe/γ-Al2O3 catalyst performed poorly, exhibiting a significant decline in its activity owing to sulfur poisoning. The insights from this study provide theoretical support for designing efficient, sulfur-resistant catalysts that are crucial to reducing industrial VOC emissions.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability.

IF 4.2 2区化学

Molecules Pub Date : 2025-03-06 DOI: 10.3390/molecules30051184

Lei Hu, Yiqing Luo, Jiaxin Yang, Chunsong Cheng

引用次数: 0