Molecules最新文献_第2页

Innovative Approaches to Large-Area Perovskite Solar Cell Fabrication Using Slit Coating. 利用狭缝涂层制造大面积 Perovskite 太阳能电池的创新方法。

IF 4.2 2区化学

Molecules Pub Date : 2024-10-21 DOI: 10.3390/molecules29204976

Yitong Wang, Zetong Cheng, Junguo Li, Kuanxin Lv, Zhenzhen Li, Hang Zhao

{"title":"Innovative Approaches to Large-Area Perovskite Solar Cell Fabrication Using Slit Coating.","authors":"Yitong Wang, Zetong Cheng, Junguo Li, Kuanxin Lv, Zhenzhen Li, Hang Zhao","doi":"10.3390/molecules29204976","DOIUrl":"https://doi.org/10.3390/molecules29204976","url":null,"abstract":"Perovskite solar cells (PSCs) are gaining prominence in the photovoltaic industry due to their exceptional photoelectric performance and low manufacturing costs, achieving a significant power conversion efficiency of 26.4%, which closely rivals that of silicon solar cells. Despite substantial advancements, the effective area of high-efficiency PSCs is typically limited to about 0.1 cm2 in laboratory settings, with efficiency decreasing as the area increases. The limitation poses a major obstacle to commercialization, as large-area, high-quality perovskite films are crucial for commercial applications. This paper reviews current techniques for producing large-area perovskites, focusing on slot-die coating, a method that has attracted attention for its revolutionary potential in PSC manufacturing. Slot-die coating allows for precise control over film thickness and is compatible with roll-to-roll systems, making it suitable for large-scale applications. The paper systematically outlines the characteristics of slot-die coating, along with its advantages and disadvantages in commercial applications, suggests corresponding optimization strategies, and discusses future development directions to enhance the scalability and efficiency of PSCs, paving the way for broader commercial deployment.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Thermoelectric Performance of SnTe via Introducing Resonant Levels. 通过引入共振级提高碲化镉热电性能

IF 4.2 2区化学

Molecules Pub Date : 2024-10-21 DOI: 10.3390/molecules29204974

Manman Yang, Jin Jia, Haijun Yu, Yimin Li, Lu Han, Hairui Sun, Haowen Jia, Yuanyuan Zhu

{"title":"Enhanced Thermoelectric Performance of SnTe via Introducing Resonant Levels.","authors":"Manman Yang, Jin Jia, Haijun Yu, Yimin Li, Lu Han, Hairui Sun, Haowen Jia, Yuanyuan Zhu","doi":"10.3390/molecules29204974","DOIUrl":"https://doi.org/10.3390/molecules29204974","url":null,"abstract":"SnTe has emerged as a non-toxic and environmentally friendly alternative to the high-performance thermoelectric material PbTe, attracting significant interest in sustainable energy applications. In our previous work, we successfully synthesized high-quality SnTe with reduced thermal conductivity under high-pressure conditions. Building on this, in this work, we introduced indium (In) doping to further decrease thermal conductivity under high pressure. By incorporating resonance doping into the SnTe matrix, we aimed to enhance the electrical transport properties while maintaining low thermal conductivity. This approach enhances the Seebeck coefficient to an impressive 153 μVK-1 at 735 K, marking a notable enhancement compared to undoped SnTe. Furthermore, we noted a substantial decrease in total thermal conductivity, dropping from 6.91 to 3.88 Wm-1K-1 at 325 K, primarily due to the reduction in electrical conductivity. The synergistic impact of decreased thermal conductivity and heightened Seebeck coefficient resulted in a notable improvement in the thermoelectric figure of merit (ZT) and average ZT, achieving approximately 0.5 and 0.22 in the doped samples, respectively. These advancements establish Sn1-xInxTe as a promising candidate to replace PbTe in thermoelectric applications, providing a safer and more environmentally sustainable option.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Spin-Labeled Derivative of Gossypol. 一种自旋标记的戈西泊酚衍生物

IF 4.2 2区化学

Molecules Pub Date : 2024-10-21 DOI: 10.3390/molecules29204966

Andrey V Stepanov, Vladimir N Yarovenko, Darina I Nasyrova, Lyubov G Dezhenkova, Igor O Akchurin, Mickhail M Krayushkin, Valentina V Ilyushenkova, Andrey E Shchekotikhin, Evgeny V Tretyakov

{"title":"A Spin-Labeled Derivative of Gossypol.","authors":"Andrey V Stepanov, Vladimir N Yarovenko, Darina I Nasyrova, Lyubov G Dezhenkova, Igor O Akchurin, Mickhail M Krayushkin, Valentina V Ilyushenkova, Andrey E Shchekotikhin, Evgeny V Tretyakov","doi":"10.3390/molecules29204966","DOIUrl":"https://doi.org/10.3390/molecules29204966","url":null,"abstract":"Gossypol and its derivatives arouse interest due to their broad spectrum of biological activities. Despite its wide potential application, there is no reported example of gossypol derivatives bearing stable radical functional groups. The first gossypol nitroxide hybrid compound was prepared here via formation of a Schiff base. By this approach, synthesis of a gossypol nitroxide conjugate was performed by condensation of gossypol with a 4-amino-TEMPO (4-amino-2,2,6,6-tetramethylpiperidin-1-oxyl) free radical, which afforded the target product in high yield. Its structure was proven by a combination of NMR and EPR spectroscopy, infrared spectroscopy, mass spectrometry, and high-resolution mass spectrometry. In addition, the structure of the gossypol nitroxide was determined by single-crystal X-ray diffraction measurements. In crystals, the paramagnetic Schiff base exists in an enamine-enamine tautomeric form. The tautomer is strongly stabilized by the intra- and intermolecular hydrogen bonds promoted by the resonance of π-electrons in the aromatic system. NMR analyses of the gossypol derivative proved that in solutions, the enamine-enamine tautomeric form prevailed. The gossypol nitroxide at micromolar concentrations suppressed the growth of tumor cells; however, compared to gossypol, the cytotoxicity of the obtained conjugate was substantially lower.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholesteryl Phenolipids as Potential Biomembrane Antioxidants. 胆固醇酚脂作为潜在的生物膜抗氧化剂

IF 4.2 2区化学

Molecules Pub Date : 2024-10-20 DOI: 10.3390/molecules29204959

Vânia Costa, Marlene Costa, Francisca Arques, Mariana Ferreira, Paula Gameiro, Dulce Geraldo, Luís S Monteiro, Fátima Paiva-Martins

{"title":"Cholesteryl Phenolipids as Potential Biomembrane Antioxidants.","authors":"Vânia Costa, Marlene Costa, Francisca Arques, Mariana Ferreira, Paula Gameiro, Dulce Geraldo, Luís S Monteiro, Fátima Paiva-Martins","doi":"10.3390/molecules29204959","DOIUrl":"https://doi.org/10.3390/molecules29204959","url":null,"abstract":"The lipophilization of polyphenols (phenolipids) may increase their affinity for membranes, leading to better antioxidant protection. Cholesteryl esters of caffeic, dihydrocaffeic, homoprotocatechuic and protocatechuic acids were synthetized in a one-step procedure with good to excellent yields of ~50-95%. After evaluation of their radical scavenging capacity by the DPPH method and establishing the anodic peak potential by cyclic voltammetry, their antioxidant capacity against AAPH-induced oxidative stress in soybean PC liposomes was determined. Their interaction with the liposomal membrane was studied with the aid of three fluorescence probes located at different depths in the membrane. The cholesteryl esters showed a better or similar radical scavenging capacity to that of α-tocopherol and a lower anodic peak potential than the corresponding parental phenolic acids. Cholesteryl esters were able to protect liposomes to a similar or greater extent than α-tocopherol. However, despite their antiradical capacity and being able to penetrate and orientate in the membrane in a parallel position to phospholipids, the antioxidant efficiency of cholesteryl esters was deeply dependent on the phenolipid polyphenolic moiety structure. When incorporated during liposome preparation, cholesteryl protocatechuate and caffeate showed more than double the activity of α-tocopherol. Thus, cholesteryl phenolipids may protect biomembranes against oxidative stress to a greater extent than α-tocopherol.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Impact of Water Content in Solvent Systems on Photochemical CO₂ Reduction Catalyzed by Ruthenium Complexes. 探索溶剂体系中水含量对钌络合物催化的光化学二氧化碳还原反应的影响。

IF 4.2 2区化学

Molecules Pub Date : 2024-10-20 DOI: 10.3390/molecules29204960

Yusuke Kuramochi, Masaya Kamiya, Hitoshi Ishida

{"title":"Exploring the Impact of Water Content in Solvent Systems on Photochemical CO2 Reduction Catalyzed by Ruthenium Complexes.","authors":"Yusuke Kuramochi, Masaya Kamiya, Hitoshi Ishida","doi":"10.3390/molecules29204960","DOIUrl":"https://doi.org/10.3390/molecules29204960","url":null,"abstract":"To achieve artificial photosynthesis, it is crucial to develop a catalytic system for CO2 reduction using water as the electron source. However, photochemical CO2 reduction by homogeneous molecular catalysts has predominantly been conducted in organic solvents. This study investigates the impact of water content on catalytic activity in photochemical CO2 reduction in N,N-dimethylacetamide (DMA), using [Ru(bpy)3]2+ (bpy: 2,2'-bipyridine) as a photosensitizer, 1-benzyl-1,4-dihydronicotinamide (BNAH) as an electron donor, and two ruthenium diimine carbonyl complexes, [Ru(bpy)2(CO)2]2+ and trans(Cl)-[Ru(Ac-5Bpy-NHMe)(CO)2Cl2] (5Bpy: 5'-amino-2,2'-bipyridine-5-carboxylic acid), as catalysts. Increasing water content significantly decreased CO and formic acid production. The similar rates of decrease for both catalysts suggest that water primarily affects the formation efficiency of free one-electron-reduced [Ru(bpy)3]2+, rather than the intrinsic catalytic activity. The reduction in cage-escape efficiency with higher water content underscores the challenges in replacing organic solvents with water in photochemical CO2 reduction.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiazolidinedione-Conjugated Lupeol Derivatives as Potent Anticancer Agents Through a Mitochondria-Mediated Apoptotic Pathway. 噻唑烷二酮共轭露贝醇衍生物通过线粒体介导的凋亡途径成为强效抗癌剂

IF 4.2 2区化学

Molecules Pub Date : 2024-10-20 DOI: 10.3390/molecules29204957

Siqi Deng, Yinxu Zhao, Xiaoshan Guo, Xian Hong, Gang Li, Yuchun Wang, Qingyi Li, Ming Bu, Ming Wang

{"title":"Thiazolidinedione-Conjugated Lupeol Derivatives as Potent Anticancer Agents Through a Mitochondria-Mediated Apoptotic Pathway.","authors":"Siqi Deng, Yinxu Zhao, Xiaoshan Guo, Xian Hong, Gang Li, Yuchun Wang, Qingyi Li, Ming Bu, Ming Wang","doi":"10.3390/molecules29204957","DOIUrl":"https://doi.org/10.3390/molecules29204957","url":null,"abstract":"To improve the potential of lupeol against cancer cells, a privileged structure, thiazolidinedione, was introduced into its C-3 hydroxy group with ester, piperazine-carbamate, or ethylenediamine as a linker, and three series of thiazolidinedione-conjugated compounds (6a-i, 9a-i, and 12a-i) were prepared. The target compounds were evaluated for their cytotoxic activities against human lung cancer A549, human breast cancer MCF-7, human hepatocarcinoma HepG2, and human hepatic LO2 cell lines, and the results revealed that most of the compounds displayed improved potency over lupeol. Compound 12i exhibited significant activity against the HepG2 cell line, with an IC50 value of 4.40 μM, which is 9.9-fold more potent than lupeol (IC50 = 43.62 μM). Mechanistic studies suggested that 12i could induce HepG2 cell apoptosis, as evidenced by AO/EB staining and annexin V-FITC/propidium iodide dual staining assays. Western blot analysis suggested that compound 12i can upregulate Bax expression, downregulate Bcl-2 expression, and activate the mitochondria-mediated apoptotic pathway. Collectively, compound 12i is worthy of further investigation to support the discovery of effective agents against cancer.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries. 红参和黄参浆果的化学成分和护肤活性比较研究

IF 4.2 2区化学

Molecules Pub Date : 2024-10-20 DOI: 10.3390/molecules29204962

Yu-Dan Wang, Lu-Sheng Han, Gen-Yue Li, Kai-Li Yang, Yan-Long Shen, Hao Zhang, Jian-Feng Hou, En-Peng Wang

{"title":"A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries.","authors":"Yu-Dan Wang, Lu-Sheng Han, Gen-Yue Li, Kai-Li Yang, Yan-Long Shen, Hao Zhang, Jian-Feng Hou, En-Peng Wang","doi":"10.3390/molecules29204962","DOIUrl":"https://doi.org/10.3390/molecules29204962","url":null,"abstract":"This study was conducted to investigate the differences in chemical composition between red (RGBs) and yellow ginseng berries (YGBs) and their whitening and anti-aging skincare effects. The differences in the chemical composition between RGB and YGB were analyzed by ultra-high-performance liquid chromatography tandem quadrupole electrostatic field orbit trap mass spectrometry (UHPLC-Q-Exactive-MS/MS) combined with multivariate statistics. An aging model was established using UVB radiation induction, and the whitening and anti-aging effects of the two ginseng berries were verified in vitro and in vivo using cell biology (HaCaT and B16-F10 cells) and zebrafish model organisms. A total of 31 differential compounds, including saponins, flavonoids, phenolic acids, and other chemical constituents, were identified between the two groups. Superoxide dismutase (SOD) activity was more significantly increased (p < 0.05) and malondialdehyde (MDA) content was more significantly decreased (p < 0.01) in RGB more than YGB induced by UVB ultraviolet radiation. In terms of whitening effects, YGB was more effective in inhibiting the melanin content of B16-F10 cells (p < 0.01). The results of zebrafish experiments were consistent with those of in vitro experiments and cell biology experiments. The DCFH fluorescence staining results revealed that both ginseng berries were able to significantly reduce the level of reactive oxygen species (ROS) in zebrafish (p < 0.01). Comparison of chemical composition and skin care activities based on RGB and YGB can provide a theoretical basis for the deep development and utilization of ginseng berry resources.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on the Electrochemical Impedance Spectroscopy Evolution of Sodium-Ion Batteries in Different States. 钠离子电池在不同状态下的电化学阻抗光谱演变研究。

IF 4.2 2区化学

Molecules Pub Date : 2024-10-20 DOI: 10.3390/molecules29204963

Xiong Shu, Yongjing Li, Bowen Yang, Qiong Wang, Konlayutt Punyawudho

{"title":"Research on the Electrochemical Impedance Spectroscopy Evolution of Sodium-Ion Batteries in Different States.","authors":"Xiong Shu, Yongjing Li, Bowen Yang, Qiong Wang, Konlayutt Punyawudho","doi":"10.3390/molecules29204963","DOIUrl":"https://doi.org/10.3390/molecules29204963","url":null,"abstract":"Sodium-ion batteries (SIBs) have emerged as a promising alternative to lithium-ion batteries (LIBs) due to the abundant availability of sodium, lower costs, and comparable electrochemical performance characteristics. A thorough understanding of their performance features is essential for the widespread adoption and application of SIBs. Therefore, in this study, we investigate the output characteristics and electrochemical impedance spectroscopy (EIS) features of sodium-ion batteries (SIBs) under various states. The research results show that, unlike conventional lithium iron phosphate (LFP) batteries, SIBs exhibit a strong linear relationship between state of charge (SOC) and open-circuit voltage (OCV) across various SOC and temperature conditions. Additionally, the discharge capacity of the battery remains relatively stable within a temperature range of 15 °C to 35 °C; when the temperatures are outside this range, the available capacity of the sodium-ion battery reduces significantly. Moreover, the EIS profiles in the high-frequency region are predominantly influenced by the ohmic internal resistance, which remains largely unaffected by SOC variations. In contrast, the low-frequency region demonstrates a significant correlation between SOC and impedance, with higher SOC values resulting in reduced impedance, indicated by smaller semicircle radii in the EIS curves. This finds highlights that EIS profiling can effectively monitor SOC and state of health (SOH) in SIBs, offering a clear correlation between impedance parameters and the battery's operational state. The research not only advances our understanding of the electrochemical properties of SIBs but also provides a valuable reference for the design and application of sodium-ion battery systems in various scenarios.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticoagulant Effect of Snow mountain garlic: In Vitro Evaluation of Aqueous Extract. 雪山大蒜的抗凝血作用：水提取物的体外评估

IF 4.2 2区化学

Molecules Pub Date : 2024-10-20 DOI: 10.3390/molecules29204958

Isabel Clark-Montoya, Yolanda Terán-Figueroa, Denisse de Loera, Darío Gaytán-Hernández, Jorge Alejandro Alegría-Torres, Rosa Del Carmen Milán-Segovia

{"title":"Anticoagulant Effect of Snow mountain garlic: In Vitro Evaluation of Aqueous Extract.","authors":"Isabel Clark-Montoya, Yolanda Terán-Figueroa, Denisse de Loera, Darío Gaytán-Hernández, Jorge Alejandro Alegría-Torres, Rosa Del Carmen Milán-Segovia","doi":"10.3390/molecules29204958","DOIUrl":"https://doi.org/10.3390/molecules29204958","url":null,"abstract":"Snow mountain garlic is traditionally eaten by Himalayan locals for its medicinal properties. Although different species of the genus Allium are known to have other biological effects, such as antiplatelet and antithrombotic activities, little is known about the anticoagulant effect of Snow mountain garlic, a member of the genus Allium. Therefore, the present study examined the in vitro anticoagulant effect of the aqueous extract, the lyophilized aqueous extract, and the isoflavone extract from the lyophilized aqueous extract of Snow mountain garlic in samples from 50 human blood donors. Compared to the control, concentrations of 25, 12.5, and 6.25 mg/100 µL lengthened the clotting times of prothrombin, and concentrations of 25 and 12.5 mg/100 µL lengthened the activated partial thromboplastin time (p ˂ 0.05). The isoflavone extract from the lyophilized aqueous extract containing isoflavones, organosulfur compounds, a polyphenol, and a steroid glycoside showed a significant effect (p ˂ 0.05) on the prothrombin time and the activated partial thromboplastin time at a dose of 20 µL (volume) compared to the control. The results regarding the use of Snow mountain garlic as a preventive measure and aid in treating thromboembolic disease are promising.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virucidal Coatings Active Against SARS-CoV-2. 对 SARS-CoV-2 有效的杀病毒涂层

IF 4.2 2区化学

Molecules Pub Date : 2024-10-20 DOI: 10.3390/molecules29204961

Anna I Barabanova, Eduard V Karamov, Viktor F Larichev, Galina V Kornilaeva, Irina T Fedyakina, Ali S Turgiev, Alexander V Naumkin, Boris V Lokshin, Andrey V Shibaev, Igor I Potemkin, Olga E Philippova

{"title":"Virucidal Coatings Active Against SARS-CoV-2.","authors":"Anna I Barabanova, Eduard V Karamov, Viktor F Larichev, Galina V Kornilaeva, Irina T Fedyakina, Ali S Turgiev, Alexander V Naumkin, Boris V Lokshin, Andrey V Shibaev, Igor I Potemkin, Olga E Philippova","doi":"10.3390/molecules29204961","DOIUrl":"https://doi.org/10.3390/molecules29204961","url":null,"abstract":"Three types of coatings (contact-based, release-based, and combined coatings with both contact-based and release-based actions) were prepared and tested for the ability to inactivate SARS-CoV-2. In these coatings, quaternary ammonium surfactants were used as active agents since quaternary ammonium compounds are some of the most commonly used disinfectants. To provide contact-based action, the glass and silicon surfaces with covalently attached quaternary ammonium cationic surfactant were prepared using a dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride modifier. Surface modification was confirmed by attenuated total reflection infrared spectroscopy, X-ray photoelectron spectroscopy (XPS), scanning electron microscopy, and contact angle measurements. The grafting density of the modifier was estimated by XPS and elemental analysis. To provide release-based action, the widely used quaternary ammonium cationic disinfectant, benzalkonium chloride (BAC), and a newly synthesized cationic gemini surfactant, C18-4-C18, were bound non-covalently to the surface either through hydrophobic or electrostatic interactions. Virus titration revealed that the surfaces with combined contact-based and release-based action and the surfaces with only release-based action completely inactivate SARS-CoV-2. Coatings containing only covalently bound disinfectant are much less effective; they only provide up to 1.25 log10 reduction in the virus titer, probably because of the low disinfectant content in the surface monolayer. No pronounced differences in the activity between the flat and structured surfaces were observed for any of the coatings under study. Comparative studies of free and electrostatically bound disinfectants show that binding to the surface of nanoparticles diminishes the activity. These data indicate that SARS-CoV-2 is more sensitive to the free disinfectants.","PeriodicalId":19041,"journal":{"name":"Molecules","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0