硅烯醇醚的硫代官能化：合成β-酮类硫化物的有效途径。

IF 4.6 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2025-10-09 DOI:10.3390/molecules30194032

Xinyao Zhao, Hexia Ye, Yajie Fu, Haibo Liu, Xiaojing Bi

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引用次数: 0

摘要

β-酮类硫化物是一类同时含有羰基（C=O）和硫醚（C- s -C）官能团的化合物，在药物化学领域具有重要的应用潜力。本研究采用硅烯醇醚作为底物，在无催化剂和无添加剂的条件下形成C-S键，从而促进了β-酮类硫化物的高效合成。该反应进行迅速有效，具有广泛的底物范围，共合成了31个目标化合物，产率高达95%。

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Thiofunctionalization of Silyl Enol Ether: An Efficient Approach for the Synthesis of β-Keto Sulfides.

β-Keto sulfides are a class of compounds containing both carbonyl (C=O) and thioether (C-S-C) functionalities, exhibiting significant potential in the field of medicinal chemistry. This study employs the silyl enol ether as the substrate, enabling the formation of C-S bonds under catalyst- and additive-free conditions, thereby facilitating the efficient synthesis of β-keto sulfides. The reaction proceeds rapidly and efficiently, exhibiting a broad substrate scope, and a total of 31 target compounds were synthesized with up to 95% yields.

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.