{"title":"一种具有pH/粘度双重响应的双光子Zn（II）复合光敏剂用于增强肿瘤治疗。","authors":"Yu Zhang, Shao-Qi Guan, Ya-Ping Wang, Mei Pan","doi":"10.3390/molecules30112430","DOIUrl":null,"url":null,"abstract":"<p><p>In recent years, an increasing number of studies have shown that novel metal complexes with bio-imaging capabilities could enhance precision oncology, particularly through optimized photosensitizer (PS) design for subcellular organelle targeting photodynamic therapy (PDT). Based on this, we successfully developed a two-photon (TP) fluorescent Zn(II) complex, LIFM-ZY-3, characterized by the specifical targeting capability of lysosome. This complex was capable of monitoring dual changes in pH and viscosity. Additionally, our findings indicated that the complex could generate multiple reactive oxygen species (ROS), including singlet oxygen (<sup>1</sup>O<sub>2</sub>), hydroxyl radicals (•OH), and superoxide anion radicals (O<sub>2</sub><sup>-</sup>) under white light irradiation in vivo and in vitro. These findings underscored the remarkable versatility of LIFM-ZY-3 as an advanced multifunctional PS for both microenvironment monitoring and tumor therapy.</p>","PeriodicalId":19041,"journal":{"name":"Molecules","volume":"30 11","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156442/pdf/","citationCount":"0","resultStr":"{\"title\":\"A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy.\",\"authors\":\"Yu Zhang, Shao-Qi Guan, Ya-Ping Wang, Mei Pan\",\"doi\":\"10.3390/molecules30112430\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In recent years, an increasing number of studies have shown that novel metal complexes with bio-imaging capabilities could enhance precision oncology, particularly through optimized photosensitizer (PS) design for subcellular organelle targeting photodynamic therapy (PDT). Based on this, we successfully developed a two-photon (TP) fluorescent Zn(II) complex, LIFM-ZY-3, characterized by the specifical targeting capability of lysosome. This complex was capable of monitoring dual changes in pH and viscosity. Additionally, our findings indicated that the complex could generate multiple reactive oxygen species (ROS), including singlet oxygen (<sup>1</sup>O<sub>2</sub>), hydroxyl radicals (•OH), and superoxide anion radicals (O<sub>2</sub><sup>-</sup>) under white light irradiation in vivo and in vitro. These findings underscored the remarkable versatility of LIFM-ZY-3 as an advanced multifunctional PS for both microenvironment monitoring and tumor therapy.</p>\",\"PeriodicalId\":19041,\"journal\":{\"name\":\"Molecules\",\"volume\":\"30 11\",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-05-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156442/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecules\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.3390/molecules30112430\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecules","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3390/molecules30112430","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy.
In recent years, an increasing number of studies have shown that novel metal complexes with bio-imaging capabilities could enhance precision oncology, particularly through optimized photosensitizer (PS) design for subcellular organelle targeting photodynamic therapy (PDT). Based on this, we successfully developed a two-photon (TP) fluorescent Zn(II) complex, LIFM-ZY-3, characterized by the specifical targeting capability of lysosome. This complex was capable of monitoring dual changes in pH and viscosity. Additionally, our findings indicated that the complex could generate multiple reactive oxygen species (ROS), including singlet oxygen (1O2), hydroxyl radicals (•OH), and superoxide anion radicals (O2-) under white light irradiation in vivo and in vitro. These findings underscored the remarkable versatility of LIFM-ZY-3 as an advanced multifunctional PS for both microenvironment monitoring and tumor therapy.
期刊介绍：
Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.
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